JP2003507380A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2003507380A5 JP2003507380A5 JP2001517527A JP2001517527A JP2003507380A5 JP 2003507380 A5 JP2003507380 A5 JP 2003507380A5 JP 2001517527 A JP2001517527 A JP 2001517527A JP 2001517527 A JP2001517527 A JP 2001517527A JP 2003507380 A5 JP2003507380 A5 JP 2003507380A5
- Authority
- JP
- Japan
- Prior art keywords
- azaindole
- indolizinyl
- hexahydro
- octahydro
- naphthalenesulfonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 14
- 125000001624 naphthyl group Chemical group 0.000 description 4
- -1 2,6-dimethoxybenzoyl Chemical group 0.000 description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000012453 solvate Substances 0.000 description 2
- BJWXITQMNYHOQB-UHFFFAOYSA-N (2,6-dichlorophenyl)-[3-(1-methyl-3,6-dihydro-2h-pyridin-4-yl)pyrrolo[3,2-c]pyridin-1-yl]methanone Chemical compound C1N(C)CCC(C=2C3=CN=CC=C3N(C(=O)C=3C(=CC=CC=3Cl)Cl)C=2)=C1 BJWXITQMNYHOQB-UHFFFAOYSA-N 0.000 description 1
- UIXDVQSRWYQJHJ-UHFFFAOYSA-N (2,6-dichlorophenyl)-[3-(1-methylpiperidin-4-yl)pyrrolo[3,2-c]pyridin-1-yl]methanone Chemical compound C1CN(C)CCC1C(C1=CN=CC=C11)=CN1C(=O)C1=C(Cl)C=CC=C1Cl UIXDVQSRWYQJHJ-UHFFFAOYSA-N 0.000 description 1
- TYNVLZIAWGVTJU-UHFFFAOYSA-N (4-fluorophenyl)-[3-(1-methyl-3,6-dihydro-2h-pyridin-4-yl)pyrrolo[2,3-b]pyridin-1-yl]methanone Chemical compound C1N(C)CCC(C=2C3=CC=CN=C3N(C(=O)C=3C=CC(F)=CC=3)C=2)=C1 TYNVLZIAWGVTJU-UHFFFAOYSA-N 0.000 description 1
- WGFKJBUKBWWQRR-UHFFFAOYSA-N (4-methoxyphenyl)-[3-(1-methyl-3,6-dihydro-2h-pyridin-4-yl)pyrrolo[2,3-b]pyridin-1-yl]methanone Chemical compound C1=CC(OC)=CC=C1C(=O)N1C2=NC=CC=C2C(C=2CCN(C)CC=2)=C1 WGFKJBUKBWWQRR-UHFFFAOYSA-N 0.000 description 1
- CSGQRPHJYSLUOB-UHFFFAOYSA-N 1-(4-fluorophenyl)sulfonyl-3-(1-methyl-3,6-dihydro-2h-pyridin-4-yl)pyrrolo[2,3-b]pyridine Chemical compound C1N(C)CCC(C=2C3=CC=CN=C3N(C=2)S(=O)(=O)C=2C=CC(F)=CC=2)=C1 CSGQRPHJYSLUOB-UHFFFAOYSA-N 0.000 description 1
- PMWBNLNNRYVXEV-UHFFFAOYSA-N 1-(4-methoxyphenyl)sulfonyl-3-(1-methyl-3,6-dihydro-2h-pyridin-4-yl)pyrrolo[2,3-b]pyridine Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N1C2=NC=CC=C2C(C=2CCN(C)CC=2)=C1 PMWBNLNNRYVXEV-UHFFFAOYSA-N 0.000 description 1
- MIDYODKZIIWWHK-UHFFFAOYSA-N 1-(benzenesulfonyl)-3-(1-methyl-3,6-dihydro-2h-pyridin-4-yl)pyrrolo[2,3-b]pyridine Chemical compound C1N(C)CCC(C=2C3=CC=CN=C3N(C=2)S(=O)(=O)C=2C=CC=CC=2)=C1 MIDYODKZIIWWHK-UHFFFAOYSA-N 0.000 description 1
- HIJXDWIOHRJBSG-UHFFFAOYSA-N 1-(benzenesulfonyl)-3-(1-methyl-3,6-dihydro-2h-pyridin-4-yl)pyrrolo[3,2-c]pyridine Chemical compound C1N(C)CCC(C=2C3=CN=CC=C3N(C=2)S(=O)(=O)C=2C=CC=CC=2)=C1 HIJXDWIOHRJBSG-UHFFFAOYSA-N 0.000 description 1
- LIXZPQVPTSYTPT-UHFFFAOYSA-N 1-(benzenesulfonyl)-3-(1-methylpiperidin-4-yl)pyrrolo[3,2-c]pyridine Chemical compound C1CN(C)CCC1C1=CN(S(=O)(=O)C=2C=CC=CC=2)C2=CC=NC=C12 LIXZPQVPTSYTPT-UHFFFAOYSA-N 0.000 description 1
- KUYBTFPEERPPTD-UHFFFAOYSA-N 2-(1-naphthalen-1-ylsulfonylpyrrolo[3,2-c]pyridin-3-yl)-2,3,4,6,7,8,9,9a-octahydro-1h-quinolizine Chemical compound C1=C(C2CC3CCCCN3CC2)C2=CN=CC=C2N1S(=O)(=O)C1=CC=CC2=CC=CC=C12 KUYBTFPEERPPTD-UHFFFAOYSA-N 0.000 description 1
- VEPOXPKPYHBHDK-UHFFFAOYSA-N 2-[3-(1,2,3,5,6,7,8,8a-octahydroindolizin-7-yl)-2,5-dichlorophenyl]sulfonyl-1h-pyrrolo[3,2-c]pyridine Chemical compound N1=CC=C2NC(S(=O)(=O)C=3C(Cl)=C(C4CC5CCCN5CC4)C=C(C=3)Cl)=CC2=C1 VEPOXPKPYHBHDK-UHFFFAOYSA-N 0.000 description 1
- FXIXQCNASYENJN-UHFFFAOYSA-N 3-(1,2,3,5,6,7,8,8a-octahydroindolizin-7-yl)-1-(benzenesulfonyl)pyrrolo[3,2-c]pyridine Chemical compound C1=C(C2CC3CCCN3CC2)C2=CN=CC=C2N1S(=O)(=O)C1=CC=CC=C1 FXIXQCNASYENJN-UHFFFAOYSA-N 0.000 description 1
- ZBEMBSSWUTWKCX-UHFFFAOYSA-N 3-(1,2,3,5,6,7,8,8a-octahydroindolizin-7-yl)-1-naphthalen-1-ylsulfonylpyrrolo[2,3-c]pyridine Chemical compound C1=C(C2CC3CCCN3CC2)C2=CC=NC=C2N1S(=O)(=O)C1=CC=CC2=CC=CC=C12 ZBEMBSSWUTWKCX-UHFFFAOYSA-N 0.000 description 1
- MVJAGLGXNLMRTO-UHFFFAOYSA-N 3-(1,2,3,5,6,7,8,8a-octahydroindolizin-7-yl)-1-naphthalen-1-ylsulfonylpyrrolo[3,2-b]pyridine Chemical compound C1=C(C2CC3CCCN3CC2)C2=NC=CC=C2N1S(=O)(=O)C1=CC=CC2=CC=CC=C12 MVJAGLGXNLMRTO-UHFFFAOYSA-N 0.000 description 1
- GXIKJOYLWCYVQN-UHFFFAOYSA-N 3-(1,2,3,5,6,7,8,8a-octahydroindolizin-7-yl)-1h-pyrrolo[2,3-c]pyridine Chemical compound N1=CC=C2C(C3CC4CCCN4CC3)=CNC2=C1 GXIKJOYLWCYVQN-UHFFFAOYSA-N 0.000 description 1
- ALOYIHSIDZIWBV-UHFFFAOYSA-N 3-(1,2,3,5,6,7,8,8a-octahydroindolizin-7-yl)-1h-pyrrolo[3,2-b]pyridine Chemical compound C1=CN=C2C(C3CC4CCCN4CC3)=CNC2=C1 ALOYIHSIDZIWBV-UHFFFAOYSA-N 0.000 description 1
- SHUJGWWKEOGIKB-UHFFFAOYSA-N 3-(1,2,3,5,6,7,8,8a-octahydroindolizin-7-yl)-1h-pyrrolo[3,2-c]pyridine Chemical compound C1=NC=C2C(C3CC4CCCN4CC3)=CNC2=C1 SHUJGWWKEOGIKB-UHFFFAOYSA-N 0.000 description 1
- LOLMEVLMDDIURX-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1-(4-chlorophenyl)sulfonylpyrrolo[2,3-b]pyridine Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)N1C2=NC=CC=C2C(C=2CC3CCCN3CC=2)=C1 LOLMEVLMDDIURX-UHFFFAOYSA-N 0.000 description 1
- FBCOYBBVGZOJHZ-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1-(4-chlorophenyl)sulfonylpyrrolo[3,2-c]pyridine Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)N1C2=CC=NC=C2C(C=2CC3CCCN3CC=2)=C1 FBCOYBBVGZOJHZ-UHFFFAOYSA-N 0.000 description 1
- NCAXBIMSXYSCKX-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1-(4-fluorophenyl)sulfonylpyrrolo[2,3-b]pyridine Chemical compound C1=CC(F)=CC=C1S(=O)(=O)N1C2=NC=CC=C2C(C=2CC3CCCN3CC=2)=C1 NCAXBIMSXYSCKX-UHFFFAOYSA-N 0.000 description 1
- GHWNZIPAARWORE-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1-(4-fluorophenyl)sulfonylpyrrolo[3,2-c]pyridine Chemical compound C1=CC(F)=CC=C1S(=O)(=O)N1C2=CC=NC=C2C(C=2CC3CCCN3CC=2)=C1 GHWNZIPAARWORE-UHFFFAOYSA-N 0.000 description 1
- NDWHDDHSRAPPGC-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyridine Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N1C2=NC=CC=C2C(C=2CC3CCCN3CC=2)=C1 NDWHDDHSRAPPGC-UHFFFAOYSA-N 0.000 description 1
- FANGSOMZRLKCRU-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1-(4-methylphenyl)sulfonylpyrrolo[3,2-c]pyridine Chemical compound C1=CC(C)=CC=C1S(=O)(=O)N1C2=CC=NC=C2C(C=2CC3CCCN3CC=2)=C1 FANGSOMZRLKCRU-UHFFFAOYSA-N 0.000 description 1
- AWYUZTSYTKLODW-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1-(benzenesulfonyl)pyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2CC3CCCN3CC=2)C2=CC=CN=C2N1S(=O)(=O)C1=CC=CC=C1 AWYUZTSYTKLODW-UHFFFAOYSA-N 0.000 description 1
- BSYSGGLVESLGTK-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1-(benzenesulfonyl)pyrrolo[3,2-c]pyridine Chemical compound C1=C(C=2CC3CCCN3CC=2)C2=CN=CC=C2N1S(=O)(=O)C1=CC=CC=C1 BSYSGGLVESLGTK-UHFFFAOYSA-N 0.000 description 1
- DKMNUGORMDRDSC-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1-naphthalen-1-ylsulfonylpyrrolo[2,3-c]pyridine Chemical compound C1=C(C=2CC3CCCN3CC=2)C2=CC=NC=C2N1S(=O)(=O)C1=CC=CC2=CC=CC=C12 DKMNUGORMDRDSC-UHFFFAOYSA-N 0.000 description 1
- NSQLQBSRFTUZMT-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1-naphthalen-1-ylsulfonylpyrrolo[3,2-c]pyridine Chemical compound C1=C(C=2CC3CCCN3CC=2)C2=CN=CC=C2N1S(=O)(=O)C1=CC=CC2=CC=CC=C12 NSQLQBSRFTUZMT-UHFFFAOYSA-N 0.000 description 1
- VSLFARANIWFODR-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1-naphthalen-2-ylsulfonylpyrrolo[2,3-b]pyridine Chemical compound C1=C(C=2CC3CCCN3CC=2)C2=CC=CN=C2N1S(=O)(=O)C1=CC=C(C=CC=C2)C2=C1 VSLFARANIWFODR-UHFFFAOYSA-N 0.000 description 1
- XGDVMSACWHVPTH-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1-naphthalen-2-ylsulfonylpyrrolo[3,2-c]pyridine Chemical compound C1=C(C=2CC3CCCN3CC=2)C2=CN=CC=C2N1S(=O)(=O)C1=CC=C(C=CC=C2)C2=C1 XGDVMSACWHVPTH-UHFFFAOYSA-N 0.000 description 1
- PGAVHYCWYWOJFQ-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1h-pyrrolo[2,3-b]pyridine Chemical compound C1=CC=C2C(C=3CC4CCCN4CC=3)=CNC2=N1 PGAVHYCWYWOJFQ-UHFFFAOYSA-N 0.000 description 1
- SAIMZEWINXIYCT-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1h-pyrrolo[2,3-c]pyridine Chemical compound N1=CC=C2C(C=3CC4CCCN4CC=3)=CNC2=C1 SAIMZEWINXIYCT-UHFFFAOYSA-N 0.000 description 1
- BQZSPRXNXIAPCX-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1h-pyrrolo[3,2-b]pyridine Chemical compound C1=CN=C2C(C=3CC4CCCN4CC=3)=CNC2=C1 BQZSPRXNXIAPCX-UHFFFAOYSA-N 0.000 description 1
- VMSVWNATGMTCJN-UHFFFAOYSA-N 3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)-1h-pyrrolo[3,2-c]pyridine Chemical compound C1=NC=C2C(C=3CC4CCCN4CC=3)=CNC2=C1 VMSVWNATGMTCJN-UHFFFAOYSA-N 0.000 description 1
- RVMWHFCJSMACCF-UHFFFAOYSA-N 3-(1-methyl-3,6-dihydro-2h-pyridin-4-yl)-1h-pyrrolo[3,2-c]pyridine Chemical compound C1N(C)CCC(C=2C3=CN=CC=C3NC=2)=C1 RVMWHFCJSMACCF-UHFFFAOYSA-N 0.000 description 1
- GAKAACVLHNWCAS-UHFFFAOYSA-N 3-(1-methylpiperidin-4-yl)-1h-pyrrolo[3,2-c]pyridine Chemical compound C1CN(C)CCC1C1=CNC2=CC=NC=C12 GAKAACVLHNWCAS-UHFFFAOYSA-N 0.000 description 1
- IJAWXADAXNQWQU-UHFFFAOYSA-N [3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)pyrrolo[2,3-b]pyridin-1-yl]-(2,6-dichlorophenyl)methanone Chemical compound ClC1=CC=CC(Cl)=C1C(=O)N1C2=NC=CC=C2C(C=2CC3CCCN3CC=2)=C1 IJAWXADAXNQWQU-UHFFFAOYSA-N 0.000 description 1
- NRJBSWIXUSQBTR-UHFFFAOYSA-N [3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)pyrrolo[2,3-b]pyridin-1-yl]-phenylmethanone Chemical compound C1=C(C=2CC3CCCN3CC=2)C2=CC=CN=C2N1C(=O)C1=CC=CC=C1 NRJBSWIXUSQBTR-UHFFFAOYSA-N 0.000 description 1
- NJGJYYJRKPMKJU-UHFFFAOYSA-N [3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)pyrrolo[3,2-c]pyridin-1-yl]-(2,6-dichlorophenyl)methanone Chemical compound ClC1=CC=CC(Cl)=C1C(=O)N1C2=CC=NC=C2C(C=2CC3CCCN3CC=2)=C1 NJGJYYJRKPMKJU-UHFFFAOYSA-N 0.000 description 1
- QTYPXLJOSPIRQV-UHFFFAOYSA-N [3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)pyrrolo[3,2-c]pyridin-1-yl]-(2,6-dimethoxyphenyl)methanone Chemical compound COC1=CC=CC(OC)=C1C(=O)N1C2=CC=NC=C2C(C=2CC3CCCN3CC=2)=C1 QTYPXLJOSPIRQV-UHFFFAOYSA-N 0.000 description 1
- IOWGFNLEWKXDGN-UHFFFAOYSA-N [3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)pyrrolo[3,2-c]pyridin-1-yl]-(2-chlorophenyl)methanone Chemical compound ClC1=CC=CC=C1C(=O)N1C2=CC=NC=C2C(C=2CC3CCCN3CC=2)=C1 IOWGFNLEWKXDGN-UHFFFAOYSA-N 0.000 description 1
- GQFNRPSMGBVAET-UHFFFAOYSA-N [3-(1,2,3,5,8,8a-hexahydroindolizin-7-yl)pyrrolo[3,2-c]pyridin-1-yl]-phenylmethanone Chemical compound C1=C(C=2CC3CCCN3CC=2)C2=CN=CC=C2N1C(=O)C1=CC=CC=C1 GQFNRPSMGBVAET-UHFFFAOYSA-N 0.000 description 1
- RQCPJSGQGXUPTB-UHFFFAOYSA-N [3-(1-methyl-3,6-dihydro-2h-pyridin-4-yl)pyrrolo[2,3-b]pyridin-1-yl]-phenylmethanone Chemical compound C1N(C)CCC(C=2C3=CC=CN=C3N(C(=O)C=3C=CC=CC=3)C=2)=C1 RQCPJSGQGXUPTB-UHFFFAOYSA-N 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14834399P | 1999-08-12 | 1999-08-12 | |
| US60/148,343 | 1999-08-12 | ||
| PCT/IB2000/001122 WO2001012629A1 (en) | 1999-08-12 | 2000-08-14 | Azaindoles having serotonin receptor affinity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003507380A JP2003507380A (ja) | 2003-02-25 |
| JP2003507380A5 true JP2003507380A5 (https=) | 2007-10-11 |
| JP4969004B2 JP4969004B2 (ja) | 2012-07-04 |
Family
ID=22525363
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001517527A Expired - Fee Related JP4969004B2 (ja) | 1999-08-12 | 2000-08-14 | セロトニン受容体親和性を有するアザインドール |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1204662B1 (https=) |
| JP (1) | JP4969004B2 (https=) |
| AT (1) | ATE268330T1 (https=) |
| AU (1) | AU779832B2 (https=) |
| CA (1) | CA2382247C (https=) |
| DE (1) | DE60011269T2 (https=) |
| DK (1) | DK1204662T3 (https=) |
| ES (1) | ES2222219T3 (https=) |
| MX (1) | MXPA02001473A (https=) |
| WO (1) | WO2001012629A1 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10030037A1 (de) | 2000-06-17 | 2001-12-20 | Mann & Hummel Filter | Zylindrische Filterpatrone mit Stützrohr |
| ITRM20010356A1 (it) * | 2001-06-21 | 2002-12-23 | Sigma Tau Ind Farmaceuti | "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina. |
| TW200301251A (en) | 2001-12-20 | 2003-07-01 | Wyeth Corp | Azaindolylalkylamine derivatives as 5-hydroxytryptamine-6 ligands |
| ATE335477T1 (de) * | 2001-12-20 | 2006-09-15 | Wyeth Corp | Indolylalkylamin-derivate als 5-hydroxytryptamin- 6 liganden |
| GB0202679D0 (en) * | 2002-02-05 | 2002-03-20 | Glaxo Group Ltd | Novel compounds |
| WO2003080608A2 (en) * | 2002-03-27 | 2003-10-02 | Glaxo Group Limited | Quinoline and aza-indole derivatives and their use as 5-ht6 ligands |
| UA78999C2 (en) * | 2002-06-04 | 2007-05-10 | Wyeth Corp | 1-(aminoalkyl)-3-sulfonylazaindoles as ligands of 5-hydroxytryptamine-6 |
| EP1897881A3 (en) | 2002-06-20 | 2009-03-18 | Biovitrum AB (publ) | Compounds useful for the treatment of obesity, type II diabetes and CNS disorders |
| TW200403243A (en) | 2002-07-18 | 2004-03-01 | Wyeth Corp | 1-Heterocyclylalkyl-3-sulfonylazaindole or-azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
| CA2514656A1 (en) * | 2003-01-31 | 2004-08-12 | Pfizer Products Inc. | 5ht7 antagonists and inverse agonists |
| WO2004074286A1 (en) * | 2003-02-14 | 2004-09-02 | Wyeth | Heterocyclyl-3-sulfonylazaindole or -azaindazole derivatives as 5-hydroxytryptamine-6 ligands |
| WO2005009996A1 (en) * | 2003-07-23 | 2005-02-03 | Wyeth | Sulfonyldihydro- benzimidazolone compounds as 5-hydroxytryptamine-6 ligands |
| ES2222828B1 (es) | 2003-07-30 | 2006-04-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 1-sulfonilindoles, su preparacion y su aplicacion como medicamentos. |
| EP1984351A1 (en) | 2006-02-17 | 2008-10-29 | Memory Pharmaceuticals Corporation | Compounds having 5-ht6 receptor affinity |
| CA2655694C (en) * | 2006-07-03 | 2014-12-16 | Biovitrum Ab (Publ) | 1,4-substituted indoles useful for modulation of the 5-ht6 receptor |
| JP2014515368A (ja) * | 2011-05-26 | 2014-06-30 | 第一三共株式会社 | プロテインキナーゼ阻害剤としての複素環化合物 |
| EP3083588B1 (en) | 2013-12-20 | 2020-12-09 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic compounds and their application in pharmaceuticals |
| EP3166924B1 (en) | 2014-07-08 | 2019-02-20 | Sunshine Lake Pharma Co., Ltd. | Aromatic heterocyclic derivatives and pharmaceutical applications thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9406128A (pt) * | 1993-03-01 | 1996-02-27 | Merck Sharp & Dohme | Uso de um composto processo para o tratamento e/ou prevençao de distúrbios psicóticos composto composiçao farmacêutica processos para a preparaçao de um composto e de uma composiçao farmacêutica |
| US5846982A (en) * | 1996-06-14 | 1998-12-08 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| EP0875513A1 (en) * | 1997-04-14 | 1998-11-04 | Eli Lilly And Company | Substituted heteroaromatic 5-HT 1F agonists |
| US5905084A (en) * | 1997-11-14 | 1999-05-18 | Eli Lilly And Company | 5-HTIF -agonists effective in treating migraine |
| US6562809B1 (en) * | 1998-09-18 | 2003-05-13 | Nps Allelix Corp. | 3-bicycloindole compounds |
-
2000
- 2000-08-14 EP EP00949846A patent/EP1204662B1/en not_active Expired - Lifetime
- 2000-08-14 WO PCT/IB2000/001122 patent/WO2001012629A1/en not_active Ceased
- 2000-08-14 AU AU63103/00A patent/AU779832B2/en not_active Ceased
- 2000-08-14 DK DK00949846T patent/DK1204662T3/da active
- 2000-08-14 ES ES00949846T patent/ES2222219T3/es not_active Expired - Lifetime
- 2000-08-14 AT AT00949846T patent/ATE268330T1/de active
- 2000-08-14 MX MXPA02001473A patent/MXPA02001473A/es active IP Right Grant
- 2000-08-14 JP JP2001517527A patent/JP4969004B2/ja not_active Expired - Fee Related
- 2000-08-14 CA CA2382247A patent/CA2382247C/en not_active Expired - Fee Related
- 2000-08-14 DE DE60011269T patent/DE60011269T2/de not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2003507380A5 (https=) | ||
| JP2005053931A5 (https=) | ||
| JP2004532209A5 (https=) | ||
| JP2005539088A5 (https=) | ||
| JP2006501292A5 (https=) | ||
| JP2002541233A5 (https=) | ||
| RU2218337C2 (ru) | Производные тиазола, способ их получения и фармацевтическая композиция на их основе | |
| JP2007510662A5 (https=) | ||
| JP2002513668A5 (https=) | ||
| JP2005532287A5 (https=) | ||
| CA2382247A1 (en) | Azaindoles having serotonin receptor affinity | |
| JP2005507872A5 (https=) | ||
| RU97100794A (ru) | Тризамещенные фенильные производные, полезные в качестве ингибиторов фосфодиэстеразы iv | |
| JP2003267957A5 (https=) | ||
| WO2005113537B1 (en) | Urea antagonists of p2y1 receptor useful in the treatment of thrombotic conditions | |
| JP2007508359A5 (https=) | ||
| JP2004501940A5 (https=) | ||
| JP2005530811A5 (https=) | ||
| JP2002030084A5 (https=) | ||
| JP2002527414A5 (https=) | ||
| NO991384L (no) | Substituerte heterocykler som anti-tumormidler | |
| JP2003502367A5 (https=) | ||
| JP2002505286A5 (https=) | ||
| JP2005504084A5 (https=) | ||
| JP2009520695A5 (https=) |