JP2002541233A5 - - Google Patents

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Publication number
JP2002541233A5
JP2002541233A5 JP2000610814A JP2000610814A JP2002541233A5 JP 2002541233 A5 JP2002541233 A5 JP 2002541233A5 JP 2000610814 A JP2000610814 A JP 2000610814A JP 2000610814 A JP2000610814 A JP 2000610814A JP 2002541233 A5 JP2002541233 A5 JP 2002541233A5
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Japan
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JP2000610814A
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English (en)
Japanese (ja)
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JP2002541233A (ja
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Priority claimed from IT1999MI000753A external-priority patent/IT1311924B1/it
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Publication of JP2002541233A5 publication Critical patent/JP2002541233A5/ja
Pending legal-status Critical Current

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JP2000610814A 1999-04-13 2000-04-11 医薬化合物 Pending JP2002541233A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT1999MI000753A IT1311924B1 (it) 1999-04-13 1999-04-13 Composti farmaceutici.
IT99A000753 1999-04-13
PCT/EP2000/003234 WO2000061537A2 (en) 1999-04-13 2000-04-11 Pharmaceutical compounds

Publications (2)

Publication Number Publication Date
JP2002541233A JP2002541233A (ja) 2002-12-03
JP2002541233A5 true JP2002541233A5 (https=) 2009-07-02

Family

ID=11382686

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000610814A Pending JP2002541233A (ja) 1999-04-13 2000-04-11 医薬化合物

Country Status (21)

Country Link
US (2) US6869974B1 (https=)
EP (1) EP1169294B1 (https=)
JP (1) JP2002541233A (https=)
KR (2) KR20060122986A (https=)
CN (1) CN1230416C (https=)
AT (1) ATE380170T1 (https=)
AU (1) AU778989B2 (https=)
BR (1) BR0009702A (https=)
CA (1) CA2370412C (https=)
DE (1) DE60037313T2 (https=)
ES (1) ES2296616T3 (https=)
HU (1) HUP0203378A3 (https=)
IL (2) IL145601A0 (https=)
IT (1) IT1311924B1 (https=)
MX (1) MXPA01010210A (https=)
NO (1) NO20014927L (https=)
NZ (1) NZ514267A (https=)
PL (1) PL350777A1 (https=)
RU (1) RU2237657C2 (https=)
WO (1) WO2000061537A2 (https=)
ZA (1) ZA200108127B (https=)

Families Citing this family (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1288123B1 (it) 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
IT1303671B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali dell'acido nitrico con farmaci attivi nel trattamento dipatologie del sistema respiratorio
US6852739B1 (en) * 1999-02-26 2005-02-08 Nitromed Inc. Methods using proton pump inhibitors and nitric oxide donors
IT1311924B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
CA2393724A1 (en) 1999-12-23 2001-06-28 Nitromed, Inc. Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
CA2410632A1 (en) 2000-06-22 2001-12-27 David S. Garvey Nitrosated and nitrosylated taxanes, compositions and methods of use
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
IT1319201B1 (it) * 2000-10-12 2003-09-26 Nicox Sa Farmaci per il diabete.
JP4092203B2 (ja) 2000-12-21 2008-05-28 ニトロメッド,インク. 新規のシクロオキシゲナーゼ2選択的阻害剤としての置換アリール化合物、組成物、および使用方法
NZ526540A (en) 2000-12-25 2004-11-26 Sankyo Co Medicinal compositions containing aspirin and 2-acetoxy-5-(alpha-cyclopropylcarbonyl-2-flurobenzyl-4,5,6,7-tetrahydrothieno[3,2-c]pyridine useful in preventing thrombus or embolus diseases
EP1219306A1 (en) 2000-12-29 2002-07-03 Nicox S.A. Compositions comprising cyclodextrins and NO- releasing drugs
CA2446064A1 (en) 2001-05-02 2002-11-07 Nitromed, Inc. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
ITMI20010985A1 (it) * 2001-05-15 2002-11-15 Nicox Sa Farmaci per il morbo di alzheimer
SE0101702D0 (sv) * 2001-05-15 2001-05-15 Ardenia Investments Ltd Novel potentiating compounds
DE10125883A1 (de) 2001-05-28 2002-12-12 Serumwerk Bernburg Ag Arzneimittel enthaltend einen Effektor des Glutathionmetabolismus zusammen mit alpha-Liponsäure im Rahmen der Nierenersatztherapie
ITMI20011240A1 (it) * 2001-06-13 2002-12-13 Nicox Sa Farmaci per le vasculopatie
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
ITMI20011744A1 (it) * 2001-08-09 2003-02-09 Nicox Sa Farmaci per le vasculopatie
US7011854B2 (en) 2002-02-04 2006-03-14 Alfama-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO, compounds having the ability to release CO and pharmaceutical compositions thereof
JP2005537223A (ja) * 2002-04-05 2005-12-08 ニトロメッド,インク. 酸化窒素供与体、組成物および使用法
AU2003231255A1 (en) 2002-05-02 2003-12-31 Osteoscreen, Inc. Methods and compositions for stimulating bone growth using nitric oxide releasing bisphosphonate conjugates (no-bisphosphonate)
WO2003103602A2 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
ITMI20021399A1 (it) * 2002-06-25 2003-12-29 Nicox Sa Inibitori della cicloossigenasi 2
ITMI20021392A1 (it) * 2002-06-25 2003-12-29 Nicox Sa Forme farmaceutiche per la somministrazione orale di farmaci liquidi a temperatura ambiente dotate di migliore biodisponibilita'
ITMI20021391A1 (it) 2002-06-25 2003-12-29 Nicox Sa Nitroderivati di inibitori della cicloossigenasi-2
AU2003279622A1 (en) 2002-06-28 2004-01-19 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
CA2491127A1 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
AU2003261281A1 (en) 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
WO2004012659A2 (en) 2002-08-01 2004-02-12 Nitromed, Inc. Nitrosated proton pump inhibitors, compositions and methods of use
ITMI20021861A1 (it) * 2002-08-29 2004-02-29 Nicox Sa Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.
US7166638B2 (en) 2003-05-27 2007-01-23 Nicox S.A. Statin derivatives
US7169805B2 (en) 2003-05-28 2007-01-30 Nicox S.A. Captopril derivatives
ATE424199T1 (de) 2003-06-19 2009-03-15 Nicox Sa Enalapril-nitroxy-derivate und verwandte verbindungen als ace-hemmer zur behandlung von kardiovaskulären erkrankungen
PL1653950T3 (pl) * 2003-07-31 2008-08-29 Nicox Sa Pochodne nitrooksylowe losartanu, walsartanu, kandesartanu, telmisartanu, eprosartanu i olmesartanu jako antagonisty receptorów angiotensyny II do leczenia chorób sercowo-naczyniowych
RU2006119528A (ru) * 2003-12-02 2008-01-10 Никокс С.А. (Fr) Нитрооксипроизводные карведилола и других бета-блокаторов в качестве антигипертензивных средств
CA2554716A1 (en) * 2004-01-22 2005-08-04 Nitromed, Inc. Nitrosated and/or nitrosylated compounds, compositions and methods of use
US7067659B2 (en) * 2004-04-23 2006-06-27 Duke University Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof
AR054181A1 (es) 2004-08-26 2007-06-06 Nicholas Piramal India Ltd Prodrogas que contienen enlaces bio-divisibles. composiiciones farmaceuticas
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
US20070122509A1 (en) * 2004-12-02 2007-05-31 Molecular Research Center, Inc. Antioxidant dietary supplement compositions and methods for maintaining healthy skin
US9579298B2 (en) 2004-12-02 2017-02-28 Piotr Chomczynski Antioxidant dietary supplement compositions and methods for maintaining healthy skin
EP1836160A1 (en) * 2004-12-24 2007-09-26 CTG Pharma S.r.l. Compounds for treating metabolic syndrome
WO2007016677A2 (en) * 2005-08-02 2007-02-08 Nitromed, Inc. Nitric oxide enhancing antimicrobial compounds, compositions and methods of use
CA2651851C (en) 2006-05-19 2012-10-02 Mary Kay, Inc. Glyceryl and glycol acid compounds
DK2057139T3 (da) * 2006-07-18 2013-11-18 Antibe Holdings Inc Hydrogensulfidderivater af non-steroide anti-inflammatoriske lægemidler
UA102216C2 (ru) * 2006-07-18 2013-06-25 Антиб Терапьютикс Инк. 4-гидрокситиобензамидные производной лекарственных веществ
TW200831079A (en) 2006-12-13 2008-08-01 Merck & Co Inc Angiotensin II receptor antagonists
US7709634B2 (en) * 2007-09-20 2010-05-04 Apotex Pharmachem Inc. Amorphous form of rifaximin and processes for its preparation
EP2291182A1 (en) * 2008-05-13 2011-03-09 Genmedica Therapeutics SL Salicylate conjugates useful for treating metabolic disorders
MD4009C2 (ro) * 2008-07-15 2010-08-31 Институт Химии Академии Наук Молдовы Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos
CA2775370A1 (en) * 2008-09-24 2010-04-01 Nitrogenix Inc. Nitric oxide releasing amino acid ester compound, composition and method of use
US7807716B2 (en) * 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
US9085508B2 (en) 2008-09-24 2015-07-21 Oral Delivery Technology Ltd. Nitric oxide releasing amino acid ester compound, composition and method of use
EP2194048A1 (en) * 2008-12-02 2010-06-09 Dirk Sartor Nitrate esters for the treatment of vascular and metabolic diseases
CN102421424A (zh) * 2009-03-16 2012-04-18 根梅迪卡治疗公司 用于治疗代谢性疾病的组合疗法
CA2755069A1 (en) * 2009-03-16 2010-09-23 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
CN102498088A (zh) * 2009-09-15 2012-06-13 帝斯曼知识产权资产管理有限公司 硝基氧基酯及其制备和用途
WO2011056561A1 (en) 2009-10-27 2011-05-12 Beth Israel Deaconess Medical Center Methods and compositions for the generation and use of conformation-specific antibodies
WO2011057386A1 (en) * 2009-11-13 2011-05-19 Oral Delivery Technology Ltd. Composition and prophylactic device for enhancing sexual performance or pleasure
IT1397212B1 (it) * 2009-12-29 2013-01-04 Flamma Spa Derivati di amminoalcoli e loro attivita' terapeutica
AR081268A1 (es) 2010-06-02 2012-07-18 Cardiolynx Ag Derivados de nitrato de pioglitazona
CN102442908A (zh) * 2010-10-14 2012-05-09 天津药物研究院 制备萘普西诺的中间体及方法
GB201020811D0 (en) * 2010-12-08 2011-01-19 Solvotrin Innovations Ltd Compounds
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
US9163044B2 (en) 2011-04-19 2015-10-20 Alfama, Inc. Carbon monoxide releasing molecules and uses thereof
WO2012149334A2 (en) 2011-04-27 2012-11-01 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
ES2628634T3 (es) 2011-07-21 2017-08-03 Alfama, Inc. Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas
KR102158895B1 (ko) 2013-03-12 2020-09-22 마리 케이 인코포레이티드 보존 시스템
CA3042642A1 (en) 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
WO2015086838A2 (en) * 2013-12-13 2015-06-18 Conaris Research Institute Ag A pharmaceutical composition containing combinations of nicotinamide and 5-aminosalicylic acid for beneficially influencing the intestinal microbiota and/or treating gastrointestinal inflammation
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
JP2017509587A (ja) 2013-12-27 2017-04-06 ノーバス・インターナショナル・インコーポレイテッドNovus International,Inc. エトキシル化界面活性剤
CA2955229C (en) 2014-07-17 2020-03-10 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
ES2632808T3 (es) 2014-09-04 2017-09-15 Nicox Science Ireland Compuestos de carnosina donadores de óxido nítrico
WO2016064873A1 (en) 2014-10-20 2016-04-28 Pharmaceutical Manufacturing Research Services, Inc. Extended release abuse deterrent liquid fill dosage form
CN104478727A (zh) * 2014-12-22 2015-04-01 江西本草天工科技有限责任公司 一种阿魏酸释放一氧化氮的衍生物及其用途
CN105061286B (zh) * 2015-09-08 2017-11-24 上海蓝木化工有限公司 一种炔基取代吡咯类化合物的合成方法
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions
PL3588666T3 (pl) 2017-08-14 2022-10-10 Lg Energy Solution, Ltd. Pakiet akumulatorowy o ulepszonych parametrach kontroli temperatury
WO2019074870A1 (en) * 2017-10-09 2019-04-18 The Broad Institute, Inc. COMPOSITIONS AND METHODS FOR DISCOVERING COMBINATORY DRUG IN DROPLETS OF THE NANOLITRE ORDER
CN109942455A (zh) * 2019-03-10 2019-06-28 陕西科技大学 具有抗肿瘤活性的棉酚-依氟鸟氨酸席夫碱化合物及其合成方法
CN111087301B (zh) * 2019-12-23 2022-05-20 河南中医药大学 布洛芬咖啡酸酯的合成方法及其在制备免疫抑制药物中的应用
CN111087302B (zh) * 2019-12-23 2022-05-20 河南中医药大学 布洛芬阿魏酸酯的合成方法及其在制备免疫抑制药物中的应用
CN116744904A (zh) * 2020-12-24 2023-09-12 参天制药株式会社 含有依匹斯汀或其盐和硫系抗氧化剂的经皮施予用医药组合物
CN115500355B (zh) * 2022-09-09 2024-02-09 广东省农业科学院果树研究所 利用Podophyllotoxin和Gentisic acid防治荔枝霜疫霉病
US12564326B2 (en) 2022-10-25 2026-03-03 GE Precision Healthcare LLC Non-invasive bilirubin detection using induced photoreaction
CN116375698B (zh) * 2023-06-05 2023-08-01 中国林业科学研究院林产化学工业研究所 具有靶向抗肿瘤活性的漆酚基异羟肟酸型hdac抑制剂及其制备方法和应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE2269T1 (de) 1978-12-21 1983-02-15 Gruppo Lepetit S.P.A. 3h-naphtho(1,2-d)imidazole, verfahren zu deren herstellung, verbindungen zur verwendung als entzuendungshemmende und antimikrobielle mittel und sie enthaltende zusammensetzungen zu dieser verwendung.
IT1134458B (it) * 1980-11-26 1986-08-13 Real Sas Di Alberto Reiner Derivato della n-acetil-cisteina ad attivita' terapeutica,procedimento per la sua preparazione e relative composizioni farmaceutiche
IT1190987B (it) * 1982-09-07 1988-02-24 Pharma Edmond Srl Tioesteri dell'acido acetilsalicilico,procedimento per la loro preparazione e composizioni farmaceutiche che li conttengono
ES8609231A1 (es) * 1985-12-03 1986-09-01 Farmhispania Procedimiento de obtencion del n-acetil-3(2-(acetiloxi)ben- zoilmercapto)alanina
JPS6316177A (ja) * 1986-07-08 1988-01-23 Sanden Corp 容量可変型圧縮機
IT1213301B (it) * 1986-07-14 1989-12-20 Zambon Spa Composizioni per il trattamento del le sindromi da ischemia e riperfusione
IT1256345B (it) * 1992-08-20 1995-12-01 Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione
IT1256450B (it) 1992-11-26 1995-12-05 Soldato Piero Del Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione
DE69412109T2 (de) 1993-10-06 1999-01-21 Nicox S.A., Paris Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung
SI0759899T1 (en) 1994-05-10 1999-12-31 Nicox S.A. Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
IT1288123B1 (it) * 1996-09-04 1998-09-10 Nicox Sa Uso di nitroderivati per l'incontinenza urinaria
WO1998047534A1 (de) * 1997-04-18 1998-10-29 Klinge Pharma Gmbh Stabilisiertes arzneimittel enthaltend cysteinylderivate
IT1311921B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1311924B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.

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