JP2002541233A5 - - Google Patents
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- JP2002541233A5 JP2002541233A5 JP2000610814A JP2000610814A JP2002541233A5 JP 2002541233 A5 JP2002541233 A5 JP 2002541233A5 JP 2000610814 A JP2000610814 A JP 2000610814A JP 2000610814 A JP2000610814 A JP 2000610814A JP 2002541233 A5 JP2002541233 A5 JP 2002541233A5
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- 150000001875 compounds Chemical class 0.000 description 5
- 125000000217 alkyl group Chemical group 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- 0 *C*C(NC(*)CC1=NCN=C1)=O Chemical compound *C*C(NC(*)CC1=NCN=C1)=O 0.000 description 1
- 206010048554 Endothelial dysfunction Diseases 0.000 description 1
- 108009000578 Oxidative Stress Proteins 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
Description
【特許請求の範囲】
【請求項１】 一般式(I)を有する化合物又はその塩:
A-B-C-N(O)2 (I)
[式中、
Aは、以下の基：
【化１】
【化２】
【化３】
【化４】
【化５】
から選択され；
Bは、以下の基：
【化６】
から選択され；
Cは二価の-Tc-Y- 基、ここで、Tc = (CO)またはOであり；
Yはアルキレンオキシ基 -R'O-（ここでR'は線状または分枝状のC1-C20 アルキルである）]。
【請求項２】 R'が、C 1 -C 6 アルキルである請求項１に記載の化合物。
【請求項３】 R'が、C 2 -C 4 アルキルである請求項１に記載の化合物。
【請求項４】 以下の：
【化７】
【化８】
【化９】
【化１０】
【化１１】
【化１２】
【化１３】
【化１４】
から選択される請求項１による化合物。
【請求項５】 請求項１〜４のいずれか１項による化合物又はその塩と賦形剤とを含む医薬組成物。
【請求項６】 酸化ストレス及び／又は内皮機能不全に関連した疾患の治療のために用いられる請求項５に記載の医薬組成物。
【請求項１】 一般式(I)を有する化合物又はその塩:
A-B-C-N(O)2 (I)
[式中、
Aは、以下の基：
【化１】
Bは、以下の基：
【化６】
Cは二価の-Tc-Y- 基、ここで、Tc = (CO)またはOであり；
Yはアルキレンオキシ基 -R'O-（ここでR'は線状または分枝状のC1-C20 アルキルである）]。
【請求項２】 R'が、C 1 -C 6 アルキルである請求項１に記載の化合物。
【請求項３】 R'が、C 2 -C 4 アルキルである請求項１に記載の化合物。
【請求項４】 以下の：
【化７】
【請求項５】 請求項１〜４のいずれか１項による化合物又はその塩と賦形剤とを含む医薬組成物。
【請求項６】 酸化ストレス及び／又は内皮機能不全に関連した疾患の治療のために用いられる請求項５に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999MI000753A IT1311924B1 (it) | 1999-04-13 | 1999-04-13 | Composti farmaceutici. |
| IT99A000753 | 1999-04-13 | ||
| PCT/EP2000/003234 WO2000061537A2 (en) | 1999-04-13 | 2000-04-11 | Pharmaceutical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002541233A JP2002541233A (ja) | 2002-12-03 |
| JP2002541233A5 true JP2002541233A5 (ja) | 2009-07-02 |
Family
ID=11382686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000610814A Pending JP2002541233A (ja) | 1999-04-13 | 2000-04-11 | 医薬化合物 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6869974B1 (ja) |
| EP (1) | EP1169294B1 (ja) |
| JP (1) | JP2002541233A (ja) |
| KR (2) | KR20020005667A (ja) |
| CN (1) | CN1230416C (ja) |
| AT (1) | ATE380170T1 (ja) |
| AU (1) | AU778989B2 (ja) |
| BR (1) | BR0009702A (ja) |
| CA (1) | CA2370412C (ja) |
| DE (1) | DE60037313T2 (ja) |
| ES (1) | ES2296616T3 (ja) |
| HU (1) | HUP0203378A3 (ja) |
| IL (2) | IL145601A0 (ja) |
| IT (1) | IT1311924B1 (ja) |
| MX (1) | MXPA01010210A (ja) |
| NO (1) | NO20014927L (ja) |
| NZ (1) | NZ514267A (ja) |
| PL (1) | PL350777A1 (ja) |
| RU (1) | RU2237657C2 (ja) |
| WO (1) | WO2000061537A2 (ja) |
| ZA (1) | ZA200108127B (ja) |
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1288123B1 (it) | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
| IT1303671B1 (it) * | 1998-07-28 | 2001-02-23 | Nicox Sa | Sali dell'acido nitrico con farmaci attivi nel trattamento dipatologie del sistema respiratorio |
| US6852739B1 (en) * | 1999-02-26 | 2005-02-08 | Nitromed Inc. | Methods using proton pump inhibitors and nitric oxide donors |
| IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| MXPA02006312A (es) | 1999-12-23 | 2004-06-21 | Nitromed Inc | Inhibidores de ciclooxigenasa-2 nitrosilatados y nitrosados, composiciones y metodos para utilizarse. |
| DE60131537T2 (de) | 2000-06-22 | 2008-10-23 | Nitromed, Inc., Lexington | Nitrosierte und nitrosylierte taxane, zubereitungen und methoden der verwendung |
| IT1319201B1 (it) * | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per il diabete. |
| IT1319202B1 (it) | 2000-10-12 | 2003-09-26 | Nicox Sa | Farmaci per le malattie a base infiammatoria. |
| DE60122939T2 (de) | 2000-12-21 | 2007-01-11 | Nitromed, Inc., Bedford | Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren |
| PL206138B1 (pl) | 2000-12-25 | 2010-07-30 | Daiichi Sankyo Company Limiteddaiichi Sankyo Company Limited | Kompozycja farmaceutyczna zawierająca aspirynę oraz zestaw i zastosowanie składników kompozycji |
| EP1219306A1 (en) * | 2000-12-29 | 2002-07-03 | Nicox S.A. | Compositions comprising cyclodextrins and NO- releasing drugs |
| DE60233140D1 (de) | 2001-05-02 | 2009-09-10 | Nitromed Inc | Nitrosiertes und nitrosyliertes nebivolol und seine metaboliten, zusammensetzungen und anwendungsverfahren |
| ITMI20010985A1 (it) * | 2001-05-15 | 2002-11-15 | Nicox Sa | Farmaci per il morbo di alzheimer |
| SE0101702D0 (sv) | 2001-05-15 | 2001-05-15 | Ardenia Investments Ltd | Novel potentiating compounds |
| DE10125883A1 (de) | 2001-05-28 | 2002-12-12 | Serumwerk Bernburg Ag | Arzneimittel enthaltend einen Effektor des Glutathionmetabolismus zusammen mit alpha-Liponsäure im Rahmen der Nierenersatztherapie |
| ITMI20011240A1 (it) * | 2001-06-13 | 2002-12-13 | Nicox Sa | Farmaci per le vasculopatie |
| ITMI20011307A1 (it) * | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per l'epilessia |
| ITMI20011744A1 (it) * | 2001-08-09 | 2003-02-09 | Nicox Sa | Farmaci per le vasculopatie |
| EP2319518A1 (en) | 2002-02-04 | 2011-05-11 | ALFAMA-Investigacao e Desenvolvimento de Produtos Farmaceuticos Lda. | Use of CO-releasing compounds for the manufacture of a medicament for the treatment of inflammatory diseases |
| CA2480832A1 (en) * | 2002-04-05 | 2003-10-23 | Nitromed, Inc. | Nitric oxide donors, compositions and methods of use |
| EP1539185A4 (en) * | 2002-05-02 | 2006-04-05 | Osteoscreen Inc | METHODS AND COMPOSITIONS FOR STIMULATING BONE GROWTH USING NITRIC OXIDE FREEZING BISPHOSPHONATE CONJUGATES |
| US7220749B2 (en) | 2002-06-11 | 2007-05-22 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| ITMI20021392A1 (it) * | 2002-06-25 | 2003-12-29 | Nicox Sa | Forme farmaceutiche per la somministrazione orale di farmaci liquidi a temperatura ambiente dotate di migliore biodisponibilita' |
| ITMI20021399A1 (it) * | 2002-06-25 | 2003-12-29 | Nicox Sa | Inibitori della cicloossigenasi 2 |
| ITMI20021391A1 (it) | 2002-06-25 | 2003-12-29 | Nicox Sa | Nitroderivati di inibitori della cicloossigenasi-2 |
| US7163958B2 (en) | 2002-07-03 | 2007-01-16 | Nitromed Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| CA2493156A1 (en) | 2002-07-29 | 2004-02-05 | Nitromed, Inc. | Cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| CA2493618A1 (en) | 2002-08-01 | 2004-02-12 | Nitromed, Inc. | Nitrosated proton pump inhibitors, compositions and methods of use |
| ITMI20021861A1 (it) * | 2002-08-29 | 2004-02-29 | Nicox Sa | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
| WO2006066894A1 (en) * | 2004-12-24 | 2006-06-29 | Ctg Pharma S.R.L. | Compounds for treating metabolic syndrome |
| US7166638B2 (en) | 2003-05-27 | 2007-01-23 | Nicox S.A. | Statin derivatives |
| US7169805B2 (en) | 2003-05-28 | 2007-01-30 | Nicox S.A. | Captopril derivatives |
| CN1809345A (zh) | 2003-06-19 | 2006-07-26 | 尼科克斯公司 | 依那普利－硝基衍生物和相关化合物作为ace抑制剂用于治疗心血管疾病 |
| AU2004260830B2 (en) * | 2003-07-31 | 2010-04-29 | Nicox S.A. | Nitrooxy derivatives of losartan, valsatan, candesartan, telmisartan, eprosartan and olmesartan as angiotensin-II receptor blockers for the treatment of cardiovascular diseases |
| KR20060120677A (ko) * | 2003-12-02 | 2006-11-27 | 니콕스 에스. 에이. | 항고혈압제로서의 카베디롤의 니트로옥시유도체 및 다른베타차단제들 |
| AU2005207037A1 (en) * | 2004-01-22 | 2005-08-04 | Nitromed, Inc. | Nitrosated and/or nitrosylated compounds, compositions and methods of use |
| US7067659B2 (en) * | 2004-04-23 | 2006-06-27 | Duke University | Reactive oxygen generating enzyme inhibitor with nitric oxide bioactivity and uses thereof |
| AU2005281359A1 (en) | 2004-08-26 | 2006-03-16 | Apparao Satyam | Prodrugs and codrugs containing novel bio-cleavable disulfide linkers |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| US9579298B2 (en) | 2004-12-02 | 2017-02-28 | Piotr Chomczynski | Antioxidant dietary supplement compositions and methods for maintaining healthy skin |
| US20070122509A1 (en) * | 2004-12-02 | 2007-05-31 | Molecular Research Center, Inc. | Antioxidant dietary supplement compositions and methods for maintaining healthy skin |
| US20090018091A1 (en) * | 2005-08-02 | 2009-01-15 | Nitromed, Inc. | Nitric Oxide Enhancing Antimicrobial Compounds, Compositions and Methods of Use |
| KR101239344B1 (ko) | 2006-05-19 | 2013-03-05 | 마리 케이 인코포레이티드 | 글리세릴 및 글리콜산 화합물 |
| UA113841C2 (xx) * | 2006-07-18 | 2017-03-27 | Сірководневі похідні нестероїдних протизапальних лікарських засобів | |
| KR101495520B1 (ko) | 2006-07-18 | 2015-02-26 | 안티브 홀딩스 인크. | 약제의 4-하이드록시티오벤즈아미드 유도체 |
| TW200831079A (en) | 2006-12-13 | 2008-08-01 | Merck & Co Inc | Angiotensin II receptor antagonists |
| US7709634B2 (en) * | 2007-09-20 | 2010-05-04 | Apotex Pharmachem Inc. | Amorphous form of rifaximin and processes for its preparation |
| AU2009248057B2 (en) * | 2008-05-13 | 2013-02-21 | Genmedica Therapeutics Sl | Salicylate conjugates useful for treating metabolic disorders |
| MD4009C2 (ro) * | 2008-07-15 | 2010-08-31 | Институт Химии Академии Наук Молдовы | Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos |
| US9085508B2 (en) | 2008-09-24 | 2015-07-21 | Oral Delivery Technology Ltd. | Nitric oxide releasing amino acid ester compound, composition and method of use |
| US7807716B2 (en) * | 2008-09-24 | 2010-10-05 | Oral Delivery Technology Ltd. | Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use |
| JP2012503606A (ja) * | 2008-09-24 | 2012-02-09 | ニトロジェニックス インコーポレイティッド | 酸化窒素放出アミノ酸エステル化合物、組成物、および使用方法 |
| EP2194048A1 (en) * | 2008-12-02 | 2010-06-09 | Dirk Sartor | Nitrate esters for the treatment of vascular and metabolic diseases |
| AU2010224866C1 (en) * | 2009-03-16 | 2015-01-15 | Genmedica Therapeutics Sl | Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders |
| US20100239552A1 (en) * | 2009-03-16 | 2010-09-23 | Genmedica Therapeutics Sl | Combination Therapies for Treating Metabolic Disorders |
| US9162969B2 (en) | 2009-09-15 | 2015-10-20 | Dsm Ip Assets B.V. | Nitrooxyesters, their preparation and use |
| US8771693B2 (en) | 2009-10-27 | 2014-07-08 | Beth Israel Deaconess Medical Center, Inc. | Methods and compositions for the generation and use of conformation-specific antibodies |
| WO2011057386A1 (en) * | 2009-11-13 | 2011-05-19 | Oral Delivery Technology Ltd. | Composition and prophylactic device for enhancing sexual performance or pleasure |
| IT1397212B1 (it) * | 2009-12-29 | 2013-01-04 | Flamma Spa | Derivati di amminoalcoli e loro attivita' terapeutica |
| TW201204355A (en) | 2010-06-02 | 2012-02-01 | Cardiolynx Ag | Nitrate derivatives of pioglitazone |
| CN102442908A (zh) * | 2010-10-14 | 2012-05-09 | 天津药物研究院 | 制备萘普西诺的中间体及方法 |
| GB201020811D0 (en) | 2010-12-08 | 2011-01-19 | Solvotrin Innovations Ltd | Compounds |
| US8466197B2 (en) | 2010-12-14 | 2013-06-18 | Genmedica Therapeutics Sl | Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders |
| ES2656237T3 (es) | 2011-04-19 | 2018-02-26 | Alfama, Inc. | Moléculas liberadoras de monóxido de carbono y usos de las mismas |
| US10487114B2 (en) | 2011-04-27 | 2019-11-26 | Beth Israel Deaconess Medical Center, Inc. | Methods for administering peptides for the generation of effective c/s conformation-specific antibodies to a human subject in need thereof |
| JP6134710B2 (ja) | 2011-07-21 | 2017-05-24 | アルファーマ インコーポレイテッドＡｌｆａｍａ，Ｉｎｃ． | 一酸化ルテニウム放出分子およびその使用 |
| EP2967045B1 (en) | 2013-03-12 | 2019-06-26 | Mary Kay, Inc. | Preservative system |
| WO2015023675A2 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| KR20160088436A (ko) * | 2013-12-13 | 2016-07-25 | 코나리스 리써치 인스티튜트 아게 | 니코틴아미드 및 5-아미노살리실산의 조합을 포함하는, 장내 세균총에 유익한 영향을 미치거나 및/또는 위장 염증을 치료하기 위한 약학 조성물 |
| WO2015095391A1 (en) | 2013-12-17 | 2015-06-25 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| WO2015100225A1 (en) | 2013-12-27 | 2015-07-02 | Novus International Inc. | Ethoxylated surfactants |
| WO2016010771A1 (en) | 2014-07-17 | 2016-01-21 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| ES2632808T3 (es) | 2014-09-04 | 2017-09-15 | Nicox Science Ireland | Compuestos de carnosina donadores de óxido nítrico |
| JP2017531026A (ja) | 2014-10-20 | 2017-10-19 | ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド | 徐放性乱用抑止性液体充填剤形 |
| CN104478727A (zh) * | 2014-12-22 | 2015-04-01 | 江西本草天工科技有限责任公司 | 一种阿魏酸释放一氧化氮的衍生物及其用途 |
| CN105061286B (zh) * | 2015-09-08 | 2017-11-24 | 上海蓝木化工有限公司 | 一种炔基取代吡咯类化合物的合成方法 |
| US10584306B2 (en) | 2017-08-11 | 2020-03-10 | Board Of Regents Of The University Of Oklahoma | Surfactant microemulsions |
| WO2019035571A1 (ko) | 2017-08-14 | 2019-02-21 | 주식회사 엘지화학 | 온도 조절 성능이 개선된 배터리 팩 |
| EP3694527A4 (en) * | 2017-10-09 | 2021-07-14 | The Broad Institute, Inc. | COMPOSITIONS AND METHODS OF COMBINATORIAL DRUG DISCOVERY IN NANOLITER DROPLETS |
| CN109942455A (zh) * | 2019-03-10 | 2019-06-28 | 陕西科技大学 | 具有抗肿瘤活性的棉酚-依氟鸟氨酸席夫碱化合物及其合成方法 |
| CN111087301B (zh) * | 2019-12-23 | 2022-05-20 | 河南中医药大学 | 布洛芬咖啡酸酯的合成方法及其在制备免疫抑制药物中的应用 |
| CN111087302B (zh) * | 2019-12-23 | 2022-05-20 | 河南中医药大学 | 布洛芬阿魏酸酯的合成方法及其在制备免疫抑制药物中的应用 |
| JP7171971B1 (ja) * | 2020-12-24 | 2022-11-15 | 参天製薬株式会社 | エピナスチン又はその塩と硫黄系抗酸化剤を含有する経皮投与用医薬組成物 |
| CN115500355B (zh) * | 2022-09-09 | 2024-02-09 | 广东省农业科学院果树研究所 | 利用Podophyllotoxin和Gentisic acid防治荔枝霜疫霉病 |
| CN116375698B (zh) * | 2023-06-05 | 2023-08-01 | 中国林业科学研究院林产化学工业研究所 | 具有靶向抗肿瘤活性的漆酚基异羟肟酸型hdac抑制剂及其制备方法和应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2964567D1 (en) | 1978-12-21 | 1983-02-24 | Lepetit Spa | New 3h-naphtho(1,2-d)imidazoles, processes for preparing them, compounds for use as antiinflammatory and antimicrobial agents and compositions for that use containing them |
| IT1134458B (it) * | 1980-11-26 | 1986-08-13 | Real Sas Di Alberto Reiner | Derivato della n-acetil-cisteina ad attivita' terapeutica,procedimento per la sua preparazione e relative composizioni farmaceutiche |
| IT1190987B (it) * | 1982-09-07 | 1988-02-24 | Pharma Edmond Srl | Tioesteri dell'acido acetilsalicilico,procedimento per la loro preparazione e composizioni farmaceutiche che li conttengono |
| ES8609231A1 (es) * | 1985-12-03 | 1986-09-01 | Farmhispania | Procedimiento de obtencion del n-acetil-3(2-(acetiloxi)ben- zoilmercapto)alanina |
| JPS6316177A (ja) * | 1986-07-08 | 1988-01-23 | Sanden Corp | 容量可変型圧縮機 |
| IT1213301B (it) * | 1986-07-14 | 1989-12-20 | Zambon Spa | Composizioni per il trattamento del le sindromi da ischemia e riperfusione |
| IT1256345B (it) * | 1992-08-20 | 1995-12-01 | Esteri nitrici di derivati dell'acido 2-(2,6-di-alo-fenilammino) fenilacetico e procedimento per la loro preparazione | |
| IT1256450B (it) | 1992-11-26 | 1995-12-05 | Soldato Piero Del | Esteri nitrici con attivita' farmacologica e procedimento per la loro preparazione |
| WO1995009831A1 (en) | 1993-10-06 | 1995-04-13 | Nicox S.A. | Nitric esters having anti-inflammatory and/or analgesic activity and process for their preparation |
| RU2145595C1 (ru) | 1994-05-10 | 2000-02-20 | Никокс С.А. | Нитроксисоединения и фармацевтическая композиция на их основе, имеющие противовоспалительную, анальгетическую и антитромбоцитарную активности |
| IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
| IT1288123B1 (it) * | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
| AU2387997A (en) * | 1997-04-18 | 1998-11-13 | Klinge Pharma Gmbh | Stabilized medicaments containing cysteinyl derivatives |
| IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1311921B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
-
1999
- 1999-04-13 IT IT1999MI000753A patent/IT1311924B1/it active
-
2000
- 2000-04-11 BR BR0009702-0A patent/BR0009702A/pt not_active IP Right Cessation
- 2000-04-11 KR KR1020017012913A patent/KR20020005667A/ko not_active Application Discontinuation
- 2000-04-11 US US09/926,326 patent/US6869974B1/en not_active Expired - Fee Related
- 2000-04-11 JP JP2000610814A patent/JP2002541233A/ja active Pending
- 2000-04-11 HU HU0203378A patent/HUP0203378A3/hu unknown
- 2000-04-11 WO PCT/EP2000/003234 patent/WO2000061537A2/en active IP Right Grant
- 2000-04-11 DE DE60037313T patent/DE60037313T2/de not_active Expired - Lifetime
- 2000-04-11 PL PL00350777A patent/PL350777A1/xx not_active IP Right Cessation
- 2000-04-11 ES ES00925203T patent/ES2296616T3/es not_active Expired - Lifetime
- 2000-04-11 EP EP00925203A patent/EP1169294B1/en not_active Expired - Lifetime
- 2000-04-11 RU RU2001127576A patent/RU2237657C2/ru not_active IP Right Cessation
- 2000-04-11 MX MXPA01010210A patent/MXPA01010210A/es not_active Application Discontinuation
- 2000-04-11 AU AU44001/00A patent/AU778989B2/en not_active Ceased
- 2000-04-11 CA CA2370412A patent/CA2370412C/en not_active Expired - Fee Related
- 2000-04-11 IL IL14560100A patent/IL145601A0/xx unknown
- 2000-04-11 CN CNB008087059A patent/CN1230416C/zh not_active Expired - Fee Related
- 2000-04-11 NZ NZ514267A patent/NZ514267A/en unknown
- 2000-04-11 AT AT00925203T patent/ATE380170T1/de not_active IP Right Cessation
- 2000-04-11 KR KR1020067023929A patent/KR20060122986A/ko active IP Right Grant
-
2001
- 2001-10-03 ZA ZA200108127A patent/ZA200108127B/xx unknown
- 2001-10-10 NO NO20014927A patent/NO20014927L/no not_active Application Discontinuation
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2004
- 2004-12-30 US US11/024,857 patent/US7378412B2/en not_active Expired - Fee Related
-
2007
- 2007-08-14 IL IL185264A patent/IL185264A0/en unknown
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