JP2002518502A5 - - Google Patents

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Publication number
JP2002518502A5
JP2002518502A5 JP2000555901A JP2000555901A JP2002518502A5 JP 2002518502 A5 JP2002518502 A5 JP 2002518502A5 JP 2000555901 A JP2000555901 A JP 2000555901A JP 2000555901 A JP2000555901 A JP 2000555901A JP 2002518502 A5 JP2002518502 A5 JP 2002518502A5
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JP
Japan
Prior art keywords
pharmaceutical composition
tumor
wavelength
light
exposing
Prior art date
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Pending
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JP2000555901A
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English (en)
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JP2002518502A (ja
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Priority claimed from US09/102,394 external-priority patent/US5952366A/en
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Publication of JP2002518502A publication Critical patent/JP2002518502A/ja
Publication of JP2002518502A5 publication Critical patent/JP2002518502A5/ja
Pending legal-status Critical Current

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Description

【特許請求の範囲】
【請求項1】 次式の化合物:
【化1】
Figure 2002518502
(式中、R1、R2及びR3は、独立に、3〜約10個の炭素原子のアルキルである、但し、R1とR2は、一緒に、少なくとも6個の炭素原子を含む)。
【請求項2】 R1とR2が、3〜8個の炭素原子のアルキルであり、R3がメチル又はエチルである、請求項1に記載の化合物。
【請求項3】 R1がヘプチルであり、R2がヘキシルであり、R3がメチルである、請求項1に記載の化合物。
【請求項4】 請求項1に記載の化合物を含む、腫瘍を治療するための医薬組成物であって、
該腫瘍の治療が、該腫瘍を該医薬組成物と接触させ、それを約650〜約750nmの波長を有する光に暴露することによって行われることを特徴とする医薬組成物
【請求項5】 請求項2に記載の化合物を含む、腫瘍を治療するための医薬組成物であって、
該腫瘍の治療が、該腫瘍を該医薬組成物と接触させ、それを約650〜約750nmの波長を有する光に暴露することによって行われることを特徴とする医薬組成物
【請求項6】 請求項3に記載の化合物を含む、腫瘍を治療するための医薬組成物であって、
該腫瘍の治療が、該腫瘍を該医薬組成物と接触させ、それを約650〜約750nmの波長を有する光に暴露することによって行われることを特徴とする医薬組成物
【請求項7】 該光が約695〜約710nmの波長を有する、請求項4に記載の医薬組成物
【請求項8】 該光が約695〜約710nmの波長を有する、請求項5に記載の医薬組成物
【請求項9】 該光が約695〜約710nmの波長を有する、請求項6に記載の医薬組成物
JP2000555901A 1998-06-22 1999-03-05 N−置換イミド環を有するクロリンのアルキルエーテル類似体 Pending JP2002518502A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/102,394 US5952366A (en) 1996-03-08 1998-06-22 Alkyl ether analogs of chlorins having an N-substituted imide ring
US09/102,394 1998-06-22
PCT/US1999/004924 WO1999067249A1 (en) 1998-06-22 1999-03-05 Alkyl ether analogs of chlorins having an n-substituted imide ring

Publications (2)

Publication Number Publication Date
JP2002518502A JP2002518502A (ja) 2002-06-25
JP2002518502A5 true JP2002518502A5 (ja) 2006-03-02

Family

ID=22289615

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000555901A Pending JP2002518502A (ja) 1998-06-22 1999-03-05 N−置換イミド環を有するクロリンのアルキルエーテル類似体

Country Status (5)

Country Link
US (1) US5952366A (ja)
EP (1) EP1090006A4 (ja)
JP (1) JP2002518502A (ja)
CA (1) CA2335514C (ja)
WO (1) WO1999067249A1 (ja)

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Publication number Priority date Publication date Assignee Title
USRE38994E1 (en) 1988-07-20 2006-02-28 Health Research, Inc. Pyropheophorbides conjugates and their use in photodynamic therapy
USRE39094E1 (en) 1988-07-20 2006-05-09 Health Research, Inc. Pyropheophorbides and their use in photodynamic therapy
WO2000041725A2 (en) * 1999-01-15 2000-07-20 Light Sciences Corporation Therapeutic compositions for metabolic bone disorders or bone metastases
US20030114434A1 (en) * 1999-08-31 2003-06-19 James Chen Extended duration light activated cancer therapy
US7097826B2 (en) 1999-12-23 2006-08-29 Health Research, Inc. Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US7078014B2 (en) * 1999-12-23 2006-07-18 Health Research, Inc. Method for using chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US6534040B2 (en) 1999-12-23 2003-03-18 Health Research, Inc. Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US7897140B2 (en) 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
EP1267935A2 (en) * 2000-01-12 2003-01-02 Light Sciences Corporation Novel treatment for eye disease
US6624187B1 (en) 2000-06-12 2003-09-23 Health Research, Inc. Long wave length absorbing bacteriochlorin alkyl ether analogs
US6849607B2 (en) * 2001-05-09 2005-02-01 Health Research, Inc. Galectin recognized photosensitizers for photodynamic therapy
WO2004002476A2 (en) * 2002-06-27 2004-01-08 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
US7053210B2 (en) * 2002-07-02 2006-05-30 Health Research, Inc. Efficient synthesis of pyropheophorbide a and its derivatives
US7057100B2 (en) * 2003-06-26 2006-06-06 The J.C. Robinson Seed Co. Inbred corn line W23129
US20100256136A1 (en) * 2006-07-10 2010-10-07 Pandey Ravindra K Method for Enhancing Pdt Efficacy Using a Tyrosine Kinase Inhibitor
US20110092961A1 (en) * 2008-08-13 2011-04-21 Searete Llc Artificial cells
US10960013B2 (en) 2016-03-04 2021-03-30 East Carolina University J-series prostaglandin-ethanolamides as novel therapeutics for skin and/or oral disorders
WO2018035281A1 (en) 2016-08-17 2018-02-22 North Carolina State University Northern-southern route to synthesis of bacteriochlorins
US10836774B2 (en) 2016-11-30 2020-11-17 North Carolina State University Methods for making bacteriochlorin macrocycles comprising an annulated isocyclic ring and related compounds
EP4265257A1 (en) 2017-09-01 2023-10-25 East Carolina University Combination of a j-series prostaglandin-ethanolamide and a checkpoint inhibitor for use in treating cancer
CA3138403A1 (en) 2019-05-20 2020-11-26 Christopher J. MACNEVIN Narrow emission dyes, compositions comprising same, and methods for making and using same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5002962A (en) * 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
US5591847A (en) * 1994-05-23 1997-01-07 Health Research, Inc. Long wavelength absorbing photosensitizers related to purpurin-18, bacteriopurpurin-18 and related compounds with imide linkages
US5770730A (en) * 1996-03-08 1998-06-23 Health Research, Inc. Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer

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