JP2020506192A5 - - Google Patents
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- Publication number
- JP2020506192A5 JP2020506192A5 JP2019541718A JP2019541718A JP2020506192A5 JP 2020506192 A5 JP2020506192 A5 JP 2020506192A5 JP 2019541718 A JP2019541718 A JP 2019541718A JP 2019541718 A JP2019541718 A JP 2019541718A JP 2020506192 A5 JP2020506192 A5 JP 2020506192A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- och
- optionally substituted
- hydrogen
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims 15
- -1 hydroxy Cyclohexyl Chemical group 0.000 claims 9
- 125000001424 substituent group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 125000000131 cyclopropyloxy group Chemical group C1(CC1)O* 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- CUJPFPXNDSIBPG-UHFFFAOYSA-N 1,3-propanediyl Chemical group [CH2]C[CH2] CUJPFPXNDSIBPG-UHFFFAOYSA-N 0.000 claims 1
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- KZHUULABPNPTEO-UHFFFAOYSA-N 2-methoxy-2-phenylacetamide Chemical class COC(C(N)=O)C1=CC=CC=C1 KZHUULABPNPTEO-UHFFFAOYSA-N 0.000 claims 1
- WOGXHNJBKGZMHV-UHFFFAOYSA-N 2-methoxypropanamide Chemical compound COC(C)C(N)=O WOGXHNJBKGZMHV-UHFFFAOYSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004603 benzisoxazolyl group Chemical group O1N=C(C2=C1C=CC=C2)* 0.000 claims 1
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 claims 1
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 1
- 125000001153 fluoro group Chemical group F* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 claims 1
- 206010022000 influenza Diseases 0.000 claims 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 claims 1
- LCEDQNDDFOCWGG-UHFFFAOYSA-N morpholine-4-carbaldehyde Chemical compound O=CN1CCOCC1 LCEDQNDDFOCWGG-UHFFFAOYSA-N 0.000 claims 1
- 125000001715 oxadiazolyl group Chemical group 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 125000003831 tetrazolyl group Chemical group 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
- ITMCEJHCFYSIIV-UHFFFAOYSA-M triflate Chemical compound [O-]S(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-M 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762453673P | 2017-02-02 | 2017-02-02 | |
| US62/453,673 | 2017-02-02 | ||
| EP17156448.7 | 2017-02-16 | ||
| EP17156448 | 2017-02-16 | ||
| PCT/EP2018/052537 WO2018141854A1 (en) | 2017-02-02 | 2018-02-01 | Piperazine derivatives for influenza virus inhibition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020506192A JP2020506192A (ja) | 2020-02-27 |
| JP2020506192A5 true JP2020506192A5 (https=) | 2021-03-11 |
Family
ID=61192896
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019541718A Pending JP2020506192A (ja) | 2017-02-02 | 2018-02-01 | インフルエンザウイルスを阻害するためのピペラジン誘導体 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US11040963B2 (https=) |
| EP (1) | EP3577107A1 (https=) |
| JP (1) | JP2020506192A (https=) |
| AU (1) | AU2018216954B2 (https=) |
| CA (1) | CA3052353A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10452480B2 (en) | 2017-05-25 | 2019-10-22 | Micron Technology, Inc. | Memory device with dynamic processing level calibration |
| US10140040B1 (en) | 2017-05-25 | 2018-11-27 | Micron Technology, Inc. | Memory device with dynamic program-verify voltage calibration |
| US10664194B2 (en) | 2018-05-16 | 2020-05-26 | Micron Technology, Inc. | Memory system with dynamic calibration using a variable adjustment mechanism |
| US10990466B2 (en) | 2018-06-20 | 2021-04-27 | Micron Technology, Inc. | Memory sub-system with dynamic calibration using component-based function(s) |
| US11188416B2 (en) | 2018-07-12 | 2021-11-30 | Micron Technology, Inc. | Enhanced block management for a memory sub-system |
| US11113129B2 (en) | 2018-07-13 | 2021-09-07 | Micron Technology, Inc. | Real time block failure analysis for a memory sub-system |
| US10936246B2 (en) | 2018-10-10 | 2021-03-02 | Micron Technology, Inc. | Dynamic background scan optimization in a memory sub-system |
| KR20230026522A (ko) * | 2019-12-20 | 2023-02-24 | 란도스 바이오파마, 인크. | 란티오닌 c-유사 단백질 2 리간드, 이로 제조된 세포, 및 이를 사용하는 치료법 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5656642A (en) * | 1993-04-07 | 1997-08-12 | Otsuka Pharmaceutical Co., Ltd. | Peripheral vasodilating agent containing piperidine derivative as active ingredient |
| US6984652B2 (en) * | 2003-09-05 | 2006-01-10 | Warner-Lambert Company Llc | Gyrase inhibitors |
| EP2450377A1 (en) | 2006-09-07 | 2012-05-09 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza virus H5N1 and uses thereof |
| WO2009117444A1 (en) * | 2008-03-17 | 2009-09-24 | Northeastern University | Inhibitors of fatty acid amide hydrolase and monoacylglycerol lipase for modulation of cannabinoid receptors |
| SG178106A1 (en) | 2009-08-05 | 2012-03-29 | Versitech Ltd | Antiviral compounds and methods of making and using thereof |
| JP5902172B2 (ja) * | 2010-09-08 | 2016-04-13 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 広範囲のインフルエンザ抗ウイルス薬としての新規ピペラジン類似体 |
| KR101369584B1 (ko) | 2011-04-19 | 2014-03-06 | 일양약품주식회사 | 페닐-이속사졸 유도체 및 그의 제조방법 |
| US8961978B2 (en) | 2011-07-14 | 2015-02-24 | Crucell Holland B.V. | Human binding molecules capable of neutralizing influenza A viruses of phylogenetic group 1 and phylogenetic group 2 and influenza B viruses |
-
2018
- 2018-02-01 EP EP18704480.5A patent/EP3577107A1/en not_active Withdrawn
- 2018-02-01 AU AU2018216954A patent/AU2018216954B2/en not_active Ceased
- 2018-02-01 JP JP2019541718A patent/JP2020506192A/ja active Pending
- 2018-02-01 CA CA3052353A patent/CA3052353A1/en active Pending
- 2018-02-01 US US16/483,283 patent/US11040963B2/en not_active Expired - Fee Related
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