JP2003519228A5 - - Google Patents
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- Publication number
- JP2003519228A5 JP2003519228A5 JP2001550222A JP2001550222A JP2003519228A5 JP 2003519228 A5 JP2003519228 A5 JP 2003519228A5 JP 2001550222 A JP2001550222 A JP 2001550222A JP 2001550222 A JP2001550222 A JP 2001550222A JP 2003519228 A5 JP2003519228 A5 JP 2003519228A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound according
- general formula
- lower alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 21
- 150000003839 salts Chemical class 0.000 description 21
- 239000011780 sodium chloride Substances 0.000 description 21
- 0 CC(C(C)(CC1*(*)*)CN1C(NCc1c(*)c(I)c(C(*)=O)c(*)c1*)=C)IC* Chemical compound CC(C(C)(CC1*(*)*)CN1C(NCc1c(*)c(I)c(C(*)=O)c(*)c1*)=C)IC* 0.000 description 10
- 125000000217 alkyl group Chemical group 0.000 description 8
- 229910052760 oxygen Inorganic materials 0.000 description 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 6
- 239000008194 pharmaceutical composition Substances 0.000 description 6
- 229910052717 sulfur Inorganic materials 0.000 description 6
- 239000000203 mixture Substances 0.000 description 4
- 206010018987 Haemorrhage Diseases 0.000 description 3
- 206010029446 Nocturia Diseases 0.000 description 3
- 206010046543 Urinary incontinence Diseases 0.000 description 3
- 230000000740 bleeding Effects 0.000 description 3
- 231100000319 bleeding Toxicity 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 3
- 208000003450 Neurogenic Diabetes Insipidus Diseases 0.000 description 2
- -1 OBn Chemical group 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 2
- 201000010064 diabetes insipidus Diseases 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 201000005119 neurohypophyseal diabetes insipidus Diseases 0.000 description 2
- 208000008967 Enuresis Diseases 0.000 description 1
- 208000005346 Nocturnal Enuresis Diseases 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 150000001538 azepines Chemical class 0.000 description 1
- 125000002619 bicyclic group Chemical group 0.000 description 1
- QKIUAMUSENSFQQ-UHFFFAOYSA-N dimethylazanide Chemical compound C[N-]C QKIUAMUSENSFQQ-UHFFFAOYSA-N 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0000079.4 | 2000-01-05 | ||
GBGB0000079.4A GB0000079D0 (en) | 2000-01-05 | 2000-01-05 | Novel antidiuretic agents |
PCT/GB2001/000023 WO2001049682A1 (en) | 2000-01-05 | 2001-01-04 | Condensed azepines as vasopressin agonists |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005366100A Division JP3813629B2 (ja) | 2000-01-05 | 2005-12-20 | バソプレッシン・アゴニストとしての縮合アゼピン |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2003519228A JP2003519228A (ja) | 2003-06-17 |
JP2003519228A5 true JP2003519228A5 (US20070167479A1-20070719-C00034.png) | 2006-02-23 |
JP3869723B2 JP3869723B2 (ja) | 2007-01-17 |
Family
ID=9883168
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2001550222A Expired - Fee Related JP3869723B2 (ja) | 2000-01-05 | 2001-01-04 | バソプレッシン・アゴニストとしての縮合アゼピン |
JP2005366100A Expired - Fee Related JP3813629B2 (ja) | 2000-01-05 | 2005-12-20 | バソプレッシン・アゴニストとしての縮合アゼピン |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005366100A Expired - Fee Related JP3813629B2 (ja) | 2000-01-05 | 2005-12-20 | バソプレッシン・アゴニストとしての縮合アゼピン |
Country Status (34)
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7138393B2 (en) | 1998-07-24 | 2006-11-21 | Wyeth | Biologically active vasopressin agonist metabolites |
GB0000079D0 (en) * | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
SI1268418T1 (sl) * | 2000-03-27 | 2006-10-31 | Applied Research Systems | Farmacevtsko aktivni pirolidinski derivati kot bax-inhibitorji |
DE60120940T2 (de) * | 2000-03-27 | 2007-01-25 | Applied Research Systems Ars Holding N.V. | Pyrrolidin-derivate verwendbar als bax-inhibitoren |
GB0015601D0 (en) | 2000-06-26 | 2000-08-16 | Ferring Bv | Novel antidiuretic agents |
GB0115515D0 (en) * | 2001-06-25 | 2001-08-15 | Ferring Bv | Oxytocin agonisys |
GB0210397D0 (en) * | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
DK1619185T3 (da) | 2003-04-28 | 2011-07-18 | Astellas Pharma Inc | 4,4-difluor-1,2,3,4-tetrahydro-5H-1-benzazepinderivat eller salt deraf |
DK1530967T3 (da) * | 2003-11-13 | 2006-07-03 | Ferring Bv | Blisterpakning og dertil hörende fast dosisform |
EP1813603A1 (en) * | 2004-11-17 | 2007-08-01 | Kissei Pharmaceutical Co., Ltd. | Aromatic amide derivatives, medicinal compositions containing the same, medical uses of both |
EP1867639A1 (en) * | 2005-03-25 | 2007-12-19 | Kissei Pharmaceutical Co., Ltd. | Urea derivative, medicinal composition containing the same, and medicinal use of these |
WO2007052517A1 (ja) * | 2005-10-31 | 2007-05-10 | Sumitomo Chemical Company, Limited | ヒドロキシ-2-ピロリジンカルボキシアミド化合物の製法 |
JP5220611B2 (ja) * | 2006-09-25 | 2013-06-26 | キッセイ薬品工業株式会社 | 1,4−ベンゾジアゼピン誘導体、それを含有する医薬組成物およびそれらの医薬用途 |
WO2008141081A1 (en) * | 2007-05-10 | 2008-11-20 | Amr Technology, Inc. | Aryl- and heteroaryl-substituted tetrahydrobenzo-1,4-diazepines and use thereof to block reuptake of norepinephrine, dopamine, and serotonin |
AU2008283929B2 (en) | 2007-08-06 | 2013-10-10 | Serenity Pharmaceuticals, Llc | Methods and devices for desmopressin drug delivery |
US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
EP2712622B1 (en) * | 2008-05-21 | 2016-07-13 | Ferring B.V. | Orodispersible desmopressin for increasing initial period of sleep undisturbed by nocturia |
GB201005623D0 (en) * | 2010-04-01 | 2010-05-19 | Vantia Ltd | New polymorph |
GB201105537D0 (en) | 2011-03-31 | 2011-05-18 | Vantia Ltd | New process |
WO2020154581A1 (en) | 2019-01-24 | 2020-07-30 | Assia Chemical Industries Ltd | Solid state forms of fedovapagon-salicyclic acid co-crystal |
Family Cites Families (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3960886A (en) | 1968-07-03 | 1976-06-01 | Sterling Drug Inc. | Substituted N-arylanilines |
CA1047490A (en) | 1973-04-18 | 1979-01-30 | Friedrich Karrer | Ethers |
CH599752A5 (US20070167479A1-20070719-C00034.png) | 1973-04-18 | 1978-05-31 | Ciba Geigy Ag | |
DE2355454A1 (de) | 1973-11-07 | 1976-10-07 | Paul Geisslinger | Lochmaschine |
EP0186817B1 (en) | 1984-12-10 | 1989-08-02 | Nissan Chemical Industries Ltd. | 3(2h)pyridazinone, process for its preparation and anti-allergic agent containing it |
ES2089033T3 (es) | 1989-10-20 | 1996-10-01 | Otsuka Pharma Co Ltd | Compuestos benzoheterociclicos. |
US5753677A (en) | 1989-10-20 | 1998-05-19 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds |
CA2066104C (en) | 1991-04-19 | 2003-05-27 | Hidenori Ogawa | Benzazepine derivatives as vasopressin antagonists |
JPH05320135A (ja) * | 1992-05-19 | 1993-12-03 | Yamanouchi Pharmaceut Co Ltd | テトラヒドロベンズアゼピン誘導体 |
AU657431B2 (en) | 1992-08-20 | 1995-03-09 | Otsuka Pharmaceutical Co., Ltd. | Benzoheterocyclic compounds as oxytocin and vasopressin antagonists |
TW270927B (US20070167479A1-20070719-C00034.png) * | 1992-10-16 | 1996-02-21 | Otsuka Pharma Co Ltd | |
WO1994012476A1 (en) * | 1992-11-25 | 1994-06-09 | Yamanouchi Pharmaceutical Co., Ltd. | Benzanilide derivative |
AU6219994A (en) * | 1993-03-11 | 1994-09-26 | Yamanouchi Pharmaceutical Co., Ltd. | Compound with vasopressin antagonism |
GB9307527D0 (en) | 1993-04-13 | 1993-06-02 | Fujisawa Pharmaceutical Co | New venzamide derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same |
US5843952A (en) | 1993-07-29 | 1998-12-01 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
US5968930A (en) | 1993-07-29 | 1999-10-19 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
US5516774A (en) | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
US5760031A (en) | 1993-07-29 | 1998-06-02 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
FI1215U1 (fi) * | 1993-12-03 | 1994-02-21 | Valmet Paper Machinery Inc | Anlaeggning i samband med styrningen av en vira |
AU690980B2 (en) * | 1994-05-06 | 1998-05-07 | Koninklijke Philips Electronics N.V. | Microwave transmission system |
ES2199251T3 (es) | 1994-06-15 | 2004-02-16 | Otsuka Pharmaceutical Company, Limited | Derivados benzoheterociclicos utilizables como moduladores de vasopresina o de oxitocina. |
JP2926335B2 (ja) * | 1997-06-13 | 1999-07-28 | 大塚製薬株式会社 | 医薬組成物 |
DE69826677T2 (de) * | 1997-07-30 | 2005-02-10 | Wyeth | Trizyclische Vasopressin-Agonisten |
JP4338305B2 (ja) * | 1997-07-30 | 2009-10-07 | ワイス | 三環系バソプレシンアゴニスト |
EP1119568B1 (en) | 1998-10-09 | 2004-02-18 | Janssen Pharmaceutica N.V. | 4,5-dihydro-isoxazole derivatives and their pharmaceutical use |
GB2355454A (en) | 1999-10-20 | 2001-04-25 | Ferring Bv | Antidiuretic agents |
GB0000079D0 (en) | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
GB0015601D0 (en) | 2000-06-26 | 2000-08-16 | Ferring Bv | Novel antidiuretic agents |
DE10033337A1 (de) | 2000-07-08 | 2002-01-17 | Boehringer Ingelheim Pharma | Biphenylcarbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel |
GB0120051D0 (en) | 2001-08-16 | 2001-10-10 | Ferring Bv | Oxytocin agonists |
GB0224557D0 (en) | 2002-10-22 | 2002-11-27 | Glaxo Group Ltd | Novel compounds |
EP1449844A1 (en) | 2003-02-14 | 2004-08-25 | Ferring B.V. | benzamide derivatives as oxytocin agonists and vasopressin antagonists |
EP1627876A1 (en) | 2004-08-20 | 2006-02-22 | Ferring B.V. | Heterocyclic condensed compounds useful as antidiuretic agents |
US7341963B2 (en) * | 2005-05-17 | 2008-03-11 | Milliken & Company | Non-woven material with barrier skin |
-
2000
- 2000-01-05 GB GBGB0000079.4A patent/GB0000079D0/en not_active Ceased
-
2001
- 2001-01-04 RU RU2002120798/04A patent/RU2259367C2/ru not_active IP Right Cessation
- 2001-01-04 WO PCT/GB2001/000023 patent/WO2001049682A1/en active IP Right Grant
- 2001-01-04 PT PT01900169T patent/PT1248784E/pt unknown
- 2001-01-04 AU AU23846/01A patent/AU777538B2/en not_active Ceased
- 2001-01-04 DK DK01900169T patent/DK1248784T3/da active
- 2001-01-04 MY MYPI20010027A patent/MY140467A/en unknown
- 2001-01-04 PL PL355808A patent/PL211341B1/pl unknown
- 2001-01-04 US US10/130,749 patent/US7074781B2/en not_active Expired - Lifetime
- 2001-01-04 NZ NZ518803A patent/NZ518803A/xx not_active IP Right Cessation
- 2001-01-04 CN CNB018031323A patent/CN1183129C/zh not_active Expired - Fee Related
- 2001-01-04 AT AT01900169T patent/ATE366730T1/de active
- 2001-01-04 HU HU0203917A patent/HU229937B1/hu not_active IP Right Cessation
- 2001-01-04 BR BRPI0107414-8A patent/BR0107414B1/pt not_active IP Right Cessation
- 2001-01-04 KR KR1020027006382A patent/KR100605466B1/ko active IP Right Grant
- 2001-01-04 EE EEP200200367A patent/EE200200367A/xx unknown
- 2001-01-04 JP JP2001550222A patent/JP3869723B2/ja not_active Expired - Fee Related
- 2001-01-04 SK SK911-2002A patent/SK287005B6/sk not_active IP Right Cessation
- 2001-01-04 UY UY26521A patent/UY26521A1/es not_active IP Right Cessation
- 2001-01-04 DE DE60129298T patent/DE60129298T2/de not_active Expired - Lifetime
- 2001-01-04 CA CA2396277A patent/CA2396277C/en not_active Expired - Lifetime
- 2001-01-04 ES ES01900169T patent/ES2288923T3/es not_active Expired - Lifetime
- 2001-01-04 IL IL14952801A patent/IL149528A0/xx active IP Right Grant
- 2001-01-04 CZ CZ20022305A patent/CZ303444B6/cs not_active IP Right Cessation
- 2001-01-04 AR ARP010100035A patent/AR035327A1/es active IP Right Grant
- 2001-01-04 EP EP01900169A patent/EP1248784B1/en not_active Expired - Lifetime
- 2001-01-04 MX MXPA02006546A patent/MXPA02006546A/es active IP Right Grant
- 2001-01-04 SI SI200130766T patent/SI1248784T1/sl unknown
- 2001-04-01 UA UA2002075517A patent/UA73152C2/uk unknown
-
2002
- 2002-05-31 HR HR20020481A patent/HRP20020481B1/xx not_active IP Right Cessation
- 2002-06-27 NO NO20023137A patent/NO322571B1/no not_active IP Right Cessation
- 2002-06-27 ZA ZA200205180A patent/ZA200205180B/en unknown
- 2002-11-26 HK HK02108525.5A patent/HK1046910B/zh not_active IP Right Cessation
-
2005
- 2005-12-20 JP JP2005366100A patent/JP3813629B2/ja not_active Expired - Fee Related
-
2006
- 2006-03-09 US US11/370,861 patent/US7560454B2/en not_active Expired - Fee Related
-
2007
- 2007-10-04 CY CY20071101261T patent/CY1108034T1/el unknown
-
2008
- 2008-06-23 US US12/213,651 patent/US20080261951A1/en not_active Abandoned