JP2003518038A - 流動床噴霧乾燥によるナノ粒子製造方法 - Google Patents

流動床噴霧乾燥によるナノ粒子製造方法

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Publication number
JP2003518038A
JP2003518038A JP2001546416A JP2001546416A JP2003518038A JP 2003518038 A JP2003518038 A JP 2003518038A JP 2001546416 A JP2001546416 A JP 2001546416A JP 2001546416 A JP2001546416 A JP 2001546416A JP 2003518038 A JP2003518038 A JP 2003518038A
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JP
Japan
Prior art keywords
compound
particles
agents
excipient
agent
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Withdrawn
Application number
JP2001546416A
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English (en)
Japanese (ja)
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JP2003518038A5 (https=
Inventor
ニコラス， ジェイ カークホフ，
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Publication of JP2003518038A publication Critical patent/JP2003518038A/ja
Publication of JP2003518038A5 publication Critical patent/JP2003518038A5/ja
Withdrawn legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2001546416A 1999-12-20 2000-12-19 流動床噴霧乾燥によるナノ粒子製造方法 Withdrawn JP2003518038A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17257399P 1999-12-20 1999-12-20
US60/172,573 1999-12-20
PCT/US2000/034606 WO2001045677A1 (en) 1999-12-20 2000-12-19 Process for producing nanometer particles by fluid bed spray-drying

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009270841A Division JP2010090132A (ja) 1999-12-20 2009-11-27 流動床噴霧乾燥によるナノ粒子製造方法

Publications (2)

Publication Number Publication Date
JP2003518038A true JP2003518038A (ja) 2003-06-03
JP2003518038A5 JP2003518038A5 (https=) 2009-03-19

Family

ID=22628280

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2001546416A Withdrawn JP2003518038A (ja) 1999-12-20 2000-12-19 流動床噴霧乾燥によるナノ粒子製造方法
JP2009270841A Pending JP2010090132A (ja) 1999-12-20 2009-11-27 流動床噴霧乾燥によるナノ粒子製造方法
JP2012004371A Pending JP2012102135A (ja) 1999-12-20 2012-01-12 流動床噴霧乾燥によるナノ粒子製造方法

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2009270841A Pending JP2010090132A (ja) 1999-12-20 2009-11-27 流動床噴霧乾燥によるナノ粒子製造方法
JP2012004371A Pending JP2012102135A (ja) 1999-12-20 2012-01-12 流動床噴霧乾燥によるナノ粒子製造方法

Country Status (10)

Country Link
US (1) US7078057B2 (https=)
EP (1) EP1239844B1 (https=)
JP (3) JP2003518038A (https=)
AT (1) ATE297196T1 (https=)
AU (2) AU778931B2 (https=)
CA (1) CA2395129C (https=)
DE (1) DE60020732T2 (https=)
ES (1) ES2240222T3 (https=)
MX (1) MXPA02006079A (https=)
WO (2) WO2001045674A1 (https=)

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JP2002143725A (ja) * 2000-09-05 2002-05-21 Roche Vitamins Ag 中空の円筒を使って液体を霧状にする装置
WO2006038552A1 (ja) * 2004-10-01 2006-04-13 Eisai R & D Management Co., Ltd. 微粒子含有組成物およびその製造方法
JP2007508237A (ja) * 2003-07-02 2007-04-05 ティエンジン タスリー ファーマシューティカル カンパニー リミテッド チャイナ マトリクスアジュバントおよびそれらとともに調製される滴丸
JP2007530692A (ja) * 2004-04-01 2007-11-01 テバ ファーマシューティカル インダストリーズ リミティド ６−メルカプトプリンの改良された製剤
JP2007297348A (ja) * 2006-05-02 2007-11-15 Daito Kk エバスチンを含有する錠剤
WO2007132852A1 (ja) * 2006-05-15 2007-11-22 Ebara Corporation 難水溶性医薬
WO2007132828A1 (ja) 2006-05-15 2007-11-22 Osaka University 薬効成分ナノ粒子分散液の製造方法
JP2009524582A (ja) * 2005-11-28 2009-07-02 マリナス ファーマシューティカルズ ガナキソロン製剤、およびその作製方法、およびその使用
JP2009537633A (ja) * 2006-05-21 2009-10-29 ニコラス， ジェイ． カークホフ， 噴霧乾燥によるナノ粒子の製造方法
JP2010090132A (ja) * 1999-12-20 2010-04-22 Nicholas J Kerkhof 流動床噴霧乾燥によるナノ粒子製造方法
JP2010535498A (ja) * 2007-08-06 2010-11-25 コリア フード リサーチ インスティテュート 植物精油を含有するナノエマルジョンおよびナノ粒子ならびにそれらの製造方法
JP2011136334A (ja) * 2003-07-31 2011-07-14 Delavau Llc 炭酸カルシウム顆粒
JP2012501305A (ja) * 2008-09-01 2012-01-19 イオタ・ナノソリューションズ・リミテッド 医薬組成物に関連する改善
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US10828308B2 (en) 2015-10-16 2020-11-10 Hadasit Medical Research Services And Development Ltd. Treatment of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis with delayed-release 6-mercaptopurine

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US20030211162A1 (en) 2003-11-13
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ATE297196T1 (de) 2005-06-15
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