JP2003507438A - オリゴアルギニン部分を使用する上皮組織を横切るおよび上皮組織内への薬物送達の増強 - Google Patents
オリゴアルギニン部分を使用する上皮組織を横切るおよび上皮組織内への薬物送達の増強Info
- Publication number
- JP2003507438A JP2003507438A JP2001518092A JP2001518092A JP2003507438A JP 2003507438 A JP2003507438 A JP 2003507438A JP 2001518092 A JP2001518092 A JP 2001518092A JP 2001518092 A JP2001518092 A JP 2001518092A JP 2003507438 A JP2003507438 A JP 2003507438A
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- delivery
- compound
- group
- arginine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
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- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
- A61K47/557—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells the modifying agent being biotin
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- A61K47/665—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells the pre-targeting system, clearing therapy or rescue therapy involving biotin-(strept) avidin systems
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- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- C—CHEMISTRY; METALLURGY
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Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
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- Immunology (AREA)
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- Genetics & Genomics (AREA)
- Pain & Pain Management (AREA)
- Biochemistry (AREA)
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- Dermatology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15051099P | 1999-08-24 | 1999-08-24 | |
| US60/150,510 | 1999-08-24 | ||
| PCT/US2000/023440 WO2001013957A2 (en) | 1999-08-24 | 2000-08-24 | Enhancing drug delivery across and into epithelial tissues using oligo arginine moieties |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003507438A true JP2003507438A (ja) | 2003-02-25 |
| JP2003507438A5 JP2003507438A5 (enExample) | 2007-10-11 |
Family
ID=22534881
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001518092A Pending JP2003507438A (ja) | 1999-08-24 | 2000-08-24 | オリゴアルギニン部分を使用する上皮組織を横切るおよび上皮組織内への薬物送達の増強 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US6593292B1 (enExample) |
| EP (2) | EP1210121A2 (enExample) |
| JP (1) | JP2003507438A (enExample) |
| AU (1) | AU769315B2 (enExample) |
| CA (1) | CA2381425A1 (enExample) |
| MX (1) | MXPA02001857A (enExample) |
| WO (1) | WO2001013957A2 (enExample) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007504151A (ja) * | 2003-08-25 | 2007-03-01 | ナステック ファーマスーティカル カンパニー インク. | 核酸および安定二本鎖rna導入用ナノ粒子 |
| JP2008510795A (ja) * | 2004-08-26 | 2008-04-10 | アッパラオ・サティアム | 新規バイオ開裂性リンカー |
| WO2013031833A1 (ja) * | 2011-08-31 | 2013-03-07 | 国立大学法人岡山大学 | 細胞導入ペプチドと皮膚導入促進剤とを組み合わせた皮膚導入システムおよび美白剤 |
| JP2013527224A (ja) * | 2010-06-01 | 2013-06-27 | ガイストリヒ・ファーマ・アクチェンゲゼルシャフト | 経口薬物療法のための方法および組成物 |
| JP2014012680A (ja) * | 2006-12-29 | 2014-01-23 | Revance Therapeutics Inc | 逆配列hiv−tatポリペプチドを用いる輸送分子 |
| JP2015096513A (ja) * | 2008-10-17 | 2015-05-21 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 癌の阻害剤としてのmuc−1細胞質ドメインペプチド |
| JP2017519840A (ja) * | 2014-06-27 | 2017-07-20 | ポステック・アカデミー‐インダストリー・ファウンデーションPostech Academy‐Industry Foundation | カチオン性分子輸送体およびアニオン性生物活性材料を含有する皮膚浸透用組成物 |
Families Citing this family (223)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20010055581A1 (en) | 1994-03-18 | 2001-12-27 | Lawrence Tamarkin | Composition and method for delivery of biologically-active factors |
| US7229841B2 (en) * | 2001-04-30 | 2007-06-12 | Cytimmune Sciences, Inc. | Colloidal metal compositions and methods |
| US6919076B1 (en) | 1998-01-20 | 2005-07-19 | Pericor Science, Inc. | Conjugates of agents and transglutaminase substrate linking molecules |
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| JP2015096513A (ja) * | 2008-10-17 | 2015-05-21 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | 癌の阻害剤としてのmuc−1細胞質ドメインペプチド |
| US9546201B2 (en) | 2008-10-17 | 2017-01-17 | Dana-Farber Cancer Institute, Inc. | MUC-1 cytoplasmic domain peptides as inhibitors of cancer |
| JP2013527224A (ja) * | 2010-06-01 | 2013-06-27 | ガイストリヒ・ファーマ・アクチェンゲゼルシャフト | 経口薬物療法のための方法および組成物 |
| WO2013031833A1 (ja) * | 2011-08-31 | 2013-03-07 | 国立大学法人岡山大学 | 細胞導入ペプチドと皮膚導入促進剤とを組み合わせた皮膚導入システムおよび美白剤 |
| JPWO2013031833A1 (ja) * | 2011-08-31 | 2015-03-23 | 国立大学法人 岡山大学 | 細胞導入ペプチドと皮膚導入促進剤とを組み合わせた皮膚導入システムおよび美白剤 |
| JP2017519840A (ja) * | 2014-06-27 | 2017-07-20 | ポステック・アカデミー‐インダストリー・ファウンデーションPostech Academy‐Industry Foundation | カチオン性分子輸送体およびアニオン性生物活性材料を含有する皮膚浸透用組成物 |
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| AU6939400A (en) | 2001-03-19 |
| WO2001013957A2 (en) | 2001-03-01 |
| EP2269654A3 (en) | 2011-04-13 |
| EP2269654A2 (en) | 2011-01-05 |
| WO2001013957A3 (en) | 2001-10-04 |
| MXPA02001857A (es) | 2003-07-14 |
| CA2381425A1 (en) | 2001-03-01 |
| AU769315B2 (en) | 2004-01-22 |
| US6759387B2 (en) | 2004-07-06 |
| US6593292B1 (en) | 2003-07-15 |
| EP1210121A2 (en) | 2002-06-05 |
| US20030083256A1 (en) | 2003-05-01 |
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