JP2003506426A5 - - Google Patents
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- Publication number
- JP2003506426A5 JP2003506426A5 JP2001515283A JP2001515283A JP2003506426A5 JP 2003506426 A5 JP2003506426 A5 JP 2003506426A5 JP 2001515283 A JP2001515283 A JP 2001515283A JP 2001515283 A JP2001515283 A JP 2001515283A JP 2003506426 A5 JP2003506426 A5 JP 2003506426A5
- Authority
- JP
- Japan
- Prior art keywords
- corresponding hydrochloride
- dimethylamine
- ylmethyl
- group
- hydrochloride
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 90
- 150000001875 compounds Chemical class 0.000 description 22
- -1 acetamidyl group Chemical group 0.000 description 15
- 125000003118 aryl group Chemical group 0.000 description 15
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 11
- 238000000034 method Methods 0.000 description 11
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 description 10
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 7
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 6
- 229910052801 chlorine Inorganic materials 0.000 description 6
- 229910052736 halogen Inorganic materials 0.000 description 6
- 150000002367 halogens Chemical class 0.000 description 6
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 208000002193 Pain Diseases 0.000 description 5
- 229910052794 bromium Inorganic materials 0.000 description 5
- 238000006555 catalytic reaction Methods 0.000 description 5
- 238000007796 conventional method Methods 0.000 description 5
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 description 5
- 230000036407 pain Effects 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 239000013543 active substance Substances 0.000 description 4
- 125000001931 aliphatic group Chemical group 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 229910052731 fluorine Inorganic materials 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 229910052763 palladium Inorganic materials 0.000 description 4
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 3
- PDXBFKSMNSEDCE-UHFFFAOYSA-N 1-[2-(1h-indol-5-yl)phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=C(NC=C2)C2=C1 PDXBFKSMNSEDCE-UHFFFAOYSA-N 0.000 description 3
- ZSEWWHJKGCHKPU-UHFFFAOYSA-N 1-[3-[2-[2-(dimethylamino)ethyl]phenyl]phenyl]ethanone Chemical compound CN(C)CCC1=CC=CC=C1C1=CC=CC(C(C)=O)=C1 ZSEWWHJKGCHKPU-UHFFFAOYSA-N 0.000 description 3
- FAZQQEZPBSDIHS-UHFFFAOYSA-N 2,6-dichloro-4-[2-[(dimethylamino)methyl]phenyl]aniline Chemical compound CN(C)CC1=CC=CC=C1C1=CC(Cl)=C(N)C(Cl)=C1 FAZQQEZPBSDIHS-UHFFFAOYSA-N 0.000 description 3
- VIQLLOSQHKNCDO-UHFFFAOYSA-N 2-[2-[(dimethylamino)methyl]phenyl]-4-(trifluoromethoxy)aniline Chemical compound CN(C)CC1=CC=CC=C1C1=CC(OC(F)(F)F)=CC=C1N VIQLLOSQHKNCDO-UHFFFAOYSA-N 0.000 description 3
- RZYZVPIOXYSUBY-UHFFFAOYSA-N 2-amino-5-[2-[(dimethylamino)methyl]phenyl]phenol Chemical compound CN(C)CC1=CC=CC=C1C1=CC=C(N)C(O)=C1 RZYZVPIOXYSUBY-UHFFFAOYSA-N 0.000 description 3
- 239000004215 Carbon black (E152) Substances 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 3
- 125000002947 alkylene group Chemical group 0.000 description 3
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- 125000000000 cycloalkoxy group Chemical group 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 229930195733 hydrocarbon Natural products 0.000 description 3
- 150000002430 hydrocarbons Chemical class 0.000 description 3
- 229910052739 hydrogen Inorganic materials 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- GWBXJEYJOFJIDE-UHFFFAOYSA-N n,n-dimethyl-1-[2-(4-methylsulfonylphenyl)phenyl]methanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=C(S(C)(=O)=O)C=C1 GWBXJEYJOFJIDE-UHFFFAOYSA-N 0.000 description 3
- HMOUTLUBEOLWPI-UHFFFAOYSA-N n,n-dimethyl-1-[2-[4-nitro-3-(trifluoromethyl)phenyl]phenyl]methanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 HMOUTLUBEOLWPI-UHFFFAOYSA-N 0.000 description 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- SPSIQJQHKXSAKX-UHFFFAOYSA-N n-[2-[2-[(dimethylamino)methyl]phenyl]-4-(trifluoromethoxy)phenyl]acetamide Chemical compound CN(C)CC1=CC=CC=C1C1=CC(OC(F)(F)F)=CC=C1NC(C)=O SPSIQJQHKXSAKX-UHFFFAOYSA-N 0.000 description 3
- FDPZLVPLMIXVAX-UHFFFAOYSA-N n-[4-[2-[(dimethylamino)methyl]phenyl]-2-(trifluoromethoxy)phenyl]acetamide Chemical compound CN(C)CC1=CC=CC=C1C1=CC=C(NC(C)=O)C(OC(F)(F)F)=C1 FDPZLVPLMIXVAX-UHFFFAOYSA-N 0.000 description 3
- 125000001624 naphthyl group Chemical group 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 229910052723 transition metal Inorganic materials 0.000 description 3
- 150000003624 transition metals Chemical class 0.000 description 3
- UKSZBOKPHAQOMP-SVLSSHOZSA-N (1e,4e)-1,5-diphenylpenta-1,4-dien-3-one;palladium Chemical compound [Pd].C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1.C=1C=CC=CC=1\C=C\C(=O)\C=C\C1=CC=CC=C1 UKSZBOKPHAQOMP-SVLSSHOZSA-N 0.000 description 2
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 description 2
- SNIFFGBBEWKUBK-UHFFFAOYSA-N 1-[2-(2,3-difluorophenyl)phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=CC(F)=C1F SNIFFGBBEWKUBK-UHFFFAOYSA-N 0.000 description 2
- MJOBAQLOUXHZMY-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=C(Cl)C=C1Cl MJOBAQLOUXHZMY-UHFFFAOYSA-N 0.000 description 2
- KJJFSSKZRIADGY-UHFFFAOYSA-N 1-[2-(2,5-difluorophenyl)phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC(F)=CC=C1F KJJFSSKZRIADGY-UHFFFAOYSA-N 0.000 description 2
- HDAZXBAXHBHAKY-UHFFFAOYSA-N 1-[2-(2,5-dimethoxyphenyl)phenyl]-n,n-dimethylmethanamine Chemical compound COC1=CC=C(OC)C(C=2C(=CC=CC=2)CN(C)C)=C1 HDAZXBAXHBHAKY-UHFFFAOYSA-N 0.000 description 2
- XHRRKQAJVXMETQ-UHFFFAOYSA-N 1-[2-(2-fluorophenyl)phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=CC=C1F XHRRKQAJVXMETQ-UHFFFAOYSA-N 0.000 description 2
- NGBLJEJJDVRALS-UHFFFAOYSA-N 1-[2-(2-methoxyphenyl)phenyl]-n,n-dimethylmethanamine Chemical compound COC1=CC=CC=C1C1=CC=CC=C1CN(C)C NGBLJEJJDVRALS-UHFFFAOYSA-N 0.000 description 2
- OTRMKSUBIQNHCR-UHFFFAOYSA-N 1-[2-(3,4-dichlorophenyl)phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=C(Cl)C(Cl)=C1 OTRMKSUBIQNHCR-UHFFFAOYSA-N 0.000 description 2
- RIOGUJGOLAUMTE-UHFFFAOYSA-N 1-[2-(3,4-difluorophenyl)phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=C(F)C(F)=C1 RIOGUJGOLAUMTE-UHFFFAOYSA-N 0.000 description 2
- KTWXEUKXOLJXMB-UHFFFAOYSA-N 1-[2-(3,5-dichlorophenyl)phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC(Cl)=CC(Cl)=C1 KTWXEUKXOLJXMB-UHFFFAOYSA-N 0.000 description 2
- PPHDOJRHRRTMIU-UHFFFAOYSA-N 1-[2-(3-chloro-4-fluorophenyl)phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=C(F)C(Cl)=C1 PPHDOJRHRRTMIU-UHFFFAOYSA-N 0.000 description 2
- GERRSWMXAXUWPR-UHFFFAOYSA-N 1-[2-(3-chlorophenyl)phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=CC(Cl)=C1 GERRSWMXAXUWPR-UHFFFAOYSA-N 0.000 description 2
- FAVQYIOENLBFBX-UHFFFAOYSA-N 1-[2-(3-fluorophenyl)phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=CC(F)=C1 FAVQYIOENLBFBX-UHFFFAOYSA-N 0.000 description 2
- RBLPHFRSGBIGTA-UHFFFAOYSA-N 1-[2-(3-methoxyphenyl)phenyl]-n,n-dimethylmethanamine Chemical compound COC1=CC=CC(C=2C(=CC=CC=2)CN(C)C)=C1 RBLPHFRSGBIGTA-UHFFFAOYSA-N 0.000 description 2
- SUOYYQRYHPEYLQ-UHFFFAOYSA-N 1-[2-(4-chloro-3-methoxyphenyl)phenyl]-n,n-dimethylmethanamine Chemical compound C1=C(Cl)C(OC)=CC(C=2C(=CC=CC=2)CN(C)C)=C1 SUOYYQRYHPEYLQ-UHFFFAOYSA-N 0.000 description 2
- HNAYTOFGCJTVGH-UHFFFAOYSA-N 1-[2-(4-chlorophenyl)phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=C(Cl)C=C1 HNAYTOFGCJTVGH-UHFFFAOYSA-N 0.000 description 2
- SBFNZQDDWACYDX-UHFFFAOYSA-N 1-[2-(4-fluorophenyl)phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=C(F)C=C1 SBFNZQDDWACYDX-UHFFFAOYSA-N 0.000 description 2
- OYNHUQIKBDRNEA-UHFFFAOYSA-N 1-[2-[3-(difluoromethyl)phenyl]phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=CC(C(F)F)=C1 OYNHUQIKBDRNEA-UHFFFAOYSA-N 0.000 description 2
- KPHPPVMJRZLUTJ-UHFFFAOYSA-N 1-[2-[4-fluoro-3-(trifluoromethyl)phenyl]phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC=C(F)C(C(F)(F)F)=C1 KPHPPVMJRZLUTJ-UHFFFAOYSA-N 0.000 description 2
- PFPFBJNHLYMTGR-UHFFFAOYSA-N 2-[2-(3-methoxyphenyl)phenyl]-n,n-dimethylethanamine Chemical compound COC1=CC=CC(C=2C(=CC=CC=2)CCN(C)C)=C1 PFPFBJNHLYMTGR-UHFFFAOYSA-N 0.000 description 2
- QXVPQVPPQAGMRL-UHFFFAOYSA-N 2-[2-(4-chloro-3-methoxyphenyl)phenyl]-n,n-dimethylethanamine Chemical compound C1=C(Cl)C(OC)=CC(C=2C(=CC=CC=2)CCN(C)C)=C1 QXVPQVPPQAGMRL-UHFFFAOYSA-N 0.000 description 2
- GLQGKRDYDYKALF-UHFFFAOYSA-N 2-[2-[(dimethylamino)methyl]phenyl]benzaldehyde;hydrochloride Chemical compound Cl.CN(C)CC1=CC=CC=C1C1=CC=CC=C1C=O GLQGKRDYDYKALF-UHFFFAOYSA-N 0.000 description 2
- YCLCBIXTKVEJJY-UHFFFAOYSA-N 2-chloro-5-[2-[(dimethylamino)methyl]phenyl]phenol Chemical compound CN(C)CC1=CC=CC=C1C1=CC=C(Cl)C(O)=C1 YCLCBIXTKVEJJY-UHFFFAOYSA-N 0.000 description 2
- OZMWAZUMBANJDD-UHFFFAOYSA-N 2-chloro-5-[2-[2-(dimethylamino)ethyl]phenyl]phenol Chemical compound CN(C)CCC1=CC=CC=C1C1=CC=C(Cl)C(O)=C1 OZMWAZUMBANJDD-UHFFFAOYSA-N 0.000 description 2
- XYQDZLIZLSPCLF-UHFFFAOYSA-N 3-[2-[(dimethylamino)methyl]phenyl]benzaldehyde Chemical compound CN(C)CC1=CC=CC=C1C1=CC=CC(C=O)=C1 XYQDZLIZLSPCLF-UHFFFAOYSA-N 0.000 description 2
- SJNQGAJHCYNNCI-UHFFFAOYSA-N 3-[2-[(dimethylamino)methyl]phenyl]phenol Chemical compound CN(C)CC1=CC=CC=C1C1=CC=CC(O)=C1 SJNQGAJHCYNNCI-UHFFFAOYSA-N 0.000 description 2
- VWYRCIJMCZVEJI-UHFFFAOYSA-N 3-[2-[2-(dimethylamino)ethyl]phenyl]phenol Chemical compound CN(C)CCC1=CC=CC=C1C1=CC=CC(O)=C1 VWYRCIJMCZVEJI-UHFFFAOYSA-N 0.000 description 2
- 208000007848 Alcoholism Diseases 0.000 description 2
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 2
- 208000024172 Cardiovascular disease Diseases 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 206010013654 Drug abuse Diseases 0.000 description 2
- 208000007882 Gastritis Diseases 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 206010046543 Urinary incontinence Diseases 0.000 description 2
- 206010001584 alcohol abuse Diseases 0.000 description 2
- 208000025746 alcohol use disease Diseases 0.000 description 2
- 239000003638 chemical reducing agent Substances 0.000 description 2
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 206010015037 epilepsy Diseases 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 229910052740 iodine Inorganic materials 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- OGXXAIADAKFPHK-UHFFFAOYSA-N n,n-dimethyl-1-(2-phenylphenyl)methanamine;hydrochloride Chemical compound Cl.CN(C)CC1=CC=CC=C1C1=CC=CC=C1 OGXXAIADAKFPHK-UHFFFAOYSA-N 0.000 description 2
- RZSDQDMYAIKVCF-UHFFFAOYSA-N n,n-dimethyl-1-[2-(3-propan-2-yloxyphenyl)phenyl]methanamine Chemical compound CC(C)OC1=CC=CC(C=2C(=CC=CC=2)CN(C)C)=C1 RZSDQDMYAIKVCF-UHFFFAOYSA-N 0.000 description 2
- JTYYDDGYKKMUNY-UHFFFAOYSA-N n,n-dimethyl-2-[2-(3-propan-2-yloxyphenyl)phenyl]ethanamine Chemical compound CC(C)OC1=CC=CC(C=2C(=CC=CC=2)CCN(C)C)=C1 JTYYDDGYKKMUNY-UHFFFAOYSA-N 0.000 description 2
- MUJIDPITZJWBSW-UHFFFAOYSA-N palladium(2+) Chemical class [Pd+2] MUJIDPITZJWBSW-UHFFFAOYSA-N 0.000 description 2
- LXNAVEXFUKBNMK-UHFFFAOYSA-N palladium(II) acetate Substances [Pd].CC(O)=O.CC(O)=O LXNAVEXFUKBNMK-UHFFFAOYSA-N 0.000 description 2
- PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 description 2
- YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 2
- 208000020016 psychiatric disease Diseases 0.000 description 2
- 208000023504 respiratory system disease Diseases 0.000 description 2
- 208000011117 substance-related disease Diseases 0.000 description 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- FHVFEMXXFFTDPH-UHFFFAOYSA-N 1-[2-(3,5-difluorophenyl)phenyl]-n,n-dimethylmethanamine Chemical compound CN(C)CC1=CC=CC=C1C1=CC(F)=CC(F)=C1 FHVFEMXXFFTDPH-UHFFFAOYSA-N 0.000 description 1
- 125000003542 3-methylbutan-2-yl group Chemical group [H]C([H])([H])C([H])(*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- DBACJLCLFSETSR-UHFFFAOYSA-N 5-chloro-2-[2-[(dimethylamino)methyl]phenyl]benzonitrile Chemical compound CN(C)CC1=CC=CC=C1C1=CC=C(Cl)C=C1C#N DBACJLCLFSETSR-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 239000011260 aqueous acid Substances 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- YUCFVHQCAFKDQG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH] YUCFVHQCAFKDQG-UHFFFAOYSA-N 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- UWNADWZGEHDQAB-UHFFFAOYSA-N i-Pr2C2H4i-Pr2 Natural products CC(C)CCC(C)C UWNADWZGEHDQAB-UHFFFAOYSA-N 0.000 description 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000012280 lithium aluminium hydride Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- WRECIMRULFAWHA-UHFFFAOYSA-N trimethyl borate Chemical group COB(OC)OC WRECIMRULFAWHA-UHFFFAOYSA-N 0.000 description 1
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| DE19937537A DE19937537A1 (de) | 1999-08-09 | 1999-08-09 | Substituierte 2-Dialkylaminoalkylbiphenyl-Derivate |
| DE19937537.2 | 1999-08-09 | ||
| PCT/EP2000/007095 WO2001010816A2 (de) | 1999-08-09 | 2000-07-25 | Substituierte 2-dialkylaminoalkylbiphenyl-derivate |
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Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1253152B1 (en) * | 2000-02-02 | 2009-11-04 | Banyu Pharmaceutical Co., Ltd. | Method of converting functional group through halogen-metal exchange reaction |
| US7506197B2 (en) * | 2005-02-07 | 2009-03-17 | International Business Machines Corporation | Multi-directional fault detection system |
| CN100364966C (zh) * | 2005-04-14 | 2008-01-30 | 上海雅本化学有限公司 | 1－[2－氨基－1－(对甲氧苯基)乙基]环己醇甲酸盐的合成方法 |
| TW200823204A (en) * | 2006-10-17 | 2008-06-01 | Arena Pharm Inc | Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto |
| EP1997493A1 (en) * | 2007-05-28 | 2008-12-03 | Laboratorios del Dr. Esteve S.A. | Combination of a 5-HT7 receptor ligand and an opioid receptor ligand |
| UA98839C2 (en) * | 2008-02-01 | 2012-06-25 | Панмира Фармасьютикалз, Ллк. | N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors |
| WO2009099902A1 (en) * | 2008-02-01 | 2009-08-13 | Amira Pharmaceuticals, Inc. | N,n-disubstituted aminoalkylbiphenyl antagonists of prostaglandin d2 receptors |
| JP2011512359A (ja) * | 2008-02-14 | 2011-04-21 | アミラ ファーマシューティカルズ，インク． | プロスタグランジンｄ２受容体のアンタゴニストとしての環式ジアリールエーテル化合物 |
| WO2009108720A2 (en) * | 2008-02-25 | 2009-09-03 | Amira Pharmaceuticals, Inc. | Antagonists of prostaglandin d2 receptors |
| JP2011518130A (ja) * | 2008-04-02 | 2011-06-23 | アミラ ファーマシューティカルズ，インク． | プロスタグランジンｄ２受容体のアミノアルキルフェニルアンタゴニスト |
| MX2010014172A (es) * | 2008-07-03 | 2011-02-22 | Amira Pharmaceuticals Inc | Antagonistas de receptores de prostaglandina d2. |
| GB2463788B (en) * | 2008-09-29 | 2010-12-15 | Amira Pharmaceuticals Inc | Heteroaryl antagonists of prostaglandin D2 receptors |
| WO2010039977A2 (en) * | 2008-10-01 | 2010-04-08 | Amira Pharmaceuticals, Inc. | Heteroaryl antagonists of prostaglandin d2 receptors |
| WO2010042652A2 (en) | 2008-10-08 | 2010-04-15 | Amira Pharmaceuticals, Inc. | Heteroalkyl biphenyl antagonists of prostaglandin d2 receptors |
| US8383654B2 (en) | 2008-11-17 | 2013-02-26 | Panmira Pharmaceuticals, Llc | Heterocyclic antagonists of prostaglandin D2 receptors |
| US20100173313A1 (en) * | 2009-01-08 | 2010-07-08 | Amira Pharmaceuticals, Inc. | Biomarkers of inflammation |
| KR20120038544A (ko) | 2009-07-31 | 2012-04-23 | 판미라 파마슈티칼스, 엘엘씨 | Ｄｐ2 수용체 길항제의 안과용 약학 조성물 |
| SG10201404662YA (en) * | 2009-08-05 | 2014-10-30 | Panmira Pharmaceuticals Llc | Dp2 antagonist and uses thereof |
| AU2011203649A1 (en) | 2010-01-06 | 2012-06-14 | Brickell Biotech, Inc. | DP2 antagonist and uses thereof |
| DE102010055322A1 (de) | 2010-12-21 | 2012-06-21 | Christian-Albrechts-Universität Zu Kiel | Antibakteriell und antimykotisch wirkende Substanzen |
| US20120309796A1 (en) | 2011-06-06 | 2012-12-06 | Fariborz Firooznia | Benzocycloheptene acetic acids |
| CN103864624A (zh) * | 2014-03-05 | 2014-06-18 | 湖北大学 | 一种简单碱催化的n-烷基化高效制备仲胺的方法 |
| CN115636775B (zh) * | 2021-07-20 | 2024-02-06 | 晶美晟光电材料（南京）有限公司 | 一种含硫的联苯类液晶化合物的制备方法 |
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| US3443943A (en) * | 1967-07-24 | 1969-05-13 | Polaroid Corp | Photographic products and processes employing ring - closing 2 - equivalent silver halide developing agents |
| US4315926A (en) | 1979-12-26 | 1982-02-16 | Ciba-Geigy Corporation | Dibenz[c,e]azepines |
| US4473709A (en) * | 1980-07-14 | 1984-09-25 | Fmc Corporation | Pyrethroid intermediates and process |
| US5283241A (en) * | 1992-08-28 | 1994-02-01 | Merck & Co., Inc. | Benzo-fused lactams promote release of growth hormone |
| KR20000069075A (ko) * | 1996-11-22 | 2000-11-25 | 진 엠. 듀발 | Ｎ-(아릴/헤테로아릴/알킬아세틸)아미노산 아미드, 이들을 함유하는 제약 조성물, 및 이들 화합물을 사용하여 베타-아밀로이드 펩티드의 방출 및(또는) 합성의 억제 방법 |
| ZA985247B (en) * | 1997-06-19 | 1999-12-17 | Du Pont Merck Pharma | Guanidine mimics as factor Xa inhibitors. |
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1999
- 1999-08-09 DE DE19937537A patent/DE19937537A1/de not_active Withdrawn
-
2000
- 2000-07-25 AU AU64374/00A patent/AU778596B2/en not_active Ceased
- 2000-07-25 HK HK02107800.3A patent/HK1046400B/zh not_active IP Right Cessation
- 2000-07-25 SI SI200030909T patent/SI1202953T1/sl unknown
- 2000-07-25 CZ CZ20020492A patent/CZ302984B6/cs not_active IP Right Cessation
- 2000-07-25 DE DE50013404T patent/DE50013404D1/de not_active Expired - Lifetime
- 2000-07-25 CN CNB00813734XA patent/CN1245376C/zh not_active Expired - Fee Related
- 2000-07-25 MX MXPA02001372A patent/MXPA02001372A/es active IP Right Grant
- 2000-07-25 KR KR1020027001825A patent/KR100723816B1/ko not_active Expired - Fee Related
- 2000-07-25 CN CN200610004917A patent/CN100575334C/zh not_active Expired - Fee Related
- 2000-07-25 DK DK00951440T patent/DK1202953T3/da active
- 2000-07-25 CA CA2380857A patent/CA2380857C/en not_active Expired - Fee Related
- 2000-07-25 BR BR0013316-7A patent/BR0013316A/pt not_active IP Right Cessation
- 2000-07-25 AT AT00951440T patent/ATE338021T1/de active
- 2000-07-25 PT PT00951440T patent/PT1202953E/pt unknown
- 2000-07-25 JP JP2001515283A patent/JP5042422B2/ja not_active Expired - Fee Related
- 2000-07-25 HU HU0202075A patent/HUP0202075A3/hu unknown
- 2000-07-25 WO PCT/EP2000/007095 patent/WO2001010816A2/de not_active Ceased
- 2000-07-25 NZ NZ517364A patent/NZ517364A/en not_active IP Right Cessation
- 2000-07-25 SK SK203-2002A patent/SK287353B6/sk not_active IP Right Cessation
- 2000-07-25 EP EP00951440A patent/EP1202953B1/de not_active Expired - Lifetime
- 2000-07-25 RU RU2002105496/04A patent/RU2259349C2/ru not_active IP Right Cessation
- 2000-07-25 ES ES00951440T patent/ES2270861T3/es not_active Expired - Lifetime
- 2000-07-25 IL IL14805800A patent/IL148058A0/xx active IP Right Grant
- 2000-07-25 PL PL353876A patent/PL199880B1/pl not_active IP Right Cessation
- 2000-08-01 PE PE2000000759A patent/PE20010384A1/es not_active Application Discontinuation
- 2000-08-03 CO CO00058414A patent/CO5200790A1/es not_active Application Discontinuation
- 2000-08-04 AR ARP000104054A patent/AR025052A1/es active IP Right Grant
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2002
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- 2002-02-07 NO NO20020610A patent/NO327670B1/no not_active IP Right Cessation
- 2002-02-11 US US10/071,229 patent/US6710080B2/en not_active Expired - Fee Related
- 2002-03-07 ZA ZA200201917A patent/ZA200201917B/en unknown
-
2006
- 2006-09-27 CY CY20061101399T patent/CY1105387T1/el unknown
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