RU2259349C2 - Замещенные производные 2-диалкиламиноалкилбифенила - Google Patents

Замещенные производные 2-диалкиламиноалкилбифенила Download PDF

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RU2259349C2
RU2259349C2 RU2002105496/04A RU2002105496A RU2259349C2 RU 2259349 C2 RU2259349 C2 RU 2259349C2 RU 2002105496/04 A RU2002105496/04 A RU 2002105496/04A RU 2002105496 A RU2002105496 A RU 2002105496A RU 2259349 C2 RU2259349 C2 RU 2259349C2
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Russia
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corresponding hydrochloride
dimethylamine
ylmethyl
alkyl
hydrochloride
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RU2002105496/04A
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Russian (ru)
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RU2002105496A (ru
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Бернд ЗУНДЕРМАНН (DE)
Бернд ЗУНДЕРМАНН
Бабетте-Ивонне КЁГЕЛЬ (DE)
Бабетте-Ивонне КЁГЕЛЬ
Хельмут БУШМАНН (DE)
Хельмут БУШМАНН
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Грюненталь Гмбх
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    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
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    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
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    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/50—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/52—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
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    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
    • C07C217/60—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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    • C07C223/00—Compounds containing amino and —CHO groups bound to the same carbon skeleton
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    • C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
    • C07C225/02—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C225/14—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated
    • C07C225/16—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
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    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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    • C07C317/00—Sulfones; Sulfoxides
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    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
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    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
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  • Chemical & Material Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Addiction (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Furan Compounds (AREA)
  • Indole Compounds (AREA)
RU2002105496/04A 1999-08-09 2000-07-25 Замещенные производные 2-диалкиламиноалкилбифенила RU2259349C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19937537.2 1999-08-09
DE19937537A DE19937537A1 (de) 1999-08-09 1999-08-09 Substituierte 2-Dialkylaminoalkylbiphenyl-Derivate

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RU2002105496A RU2002105496A (ru) 2003-12-20
RU2259349C2 true RU2259349C2 (ru) 2005-08-27

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US (1) US6710080B2 (enExample)
EP (1) EP1202953B1 (enExample)
JP (1) JP5042422B2 (enExample)
KR (1) KR100723816B1 (enExample)
CN (2) CN1245376C (enExample)
AR (1) AR025052A1 (enExample)
AT (1) ATE338021T1 (enExample)
AU (1) AU778596B2 (enExample)
BR (1) BR0013316A (enExample)
CA (1) CA2380857C (enExample)
CO (1) CO5200790A1 (enExample)
CY (1) CY1105387T1 (enExample)
CZ (1) CZ302984B6 (enExample)
DE (2) DE19937537A1 (enExample)
DK (1) DK1202953T3 (enExample)
ES (1) ES2270861T3 (enExample)
HK (1) HK1046400B (enExample)
HU (1) HUP0202075A3 (enExample)
IL (2) IL148058A0 (enExample)
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NO (1) NO327670B1 (enExample)
NZ (1) NZ517364A (enExample)
PE (1) PE20010384A1 (enExample)
PL (1) PL199880B1 (enExample)
PT (1) PT1202953E (enExample)
RU (1) RU2259349C2 (enExample)
SI (1) SI1202953T1 (enExample)
SK (1) SK287353B6 (enExample)
WO (1) WO2001010816A2 (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
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RU2814636C1 (ru) * 2020-09-11 2024-03-04 Бейджинг Хунхуэй Медитек Ко., Лтд Способ получения водорастворимых производных магнолола и производных хонокиола и их интермедиатов, и родственных моногидрокси-защищенных интермедиатов

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001057046A1 (en) * 2000-02-02 2001-08-09 Banyu Pharmaceutical Co., Ltd. Method of converting functional group through halogen-metal exchange reaction
US7506197B2 (en) * 2005-02-07 2009-03-17 International Business Machines Corporation Multi-directional fault detection system
CN100364966C (zh) * 2005-04-14 2008-01-30 上海雅本化学有限公司 1－[2－氨基－1－(对甲氧苯基)乙基]环己醇甲酸盐的合成方法
TW200823204A (en) * 2006-10-17 2008-06-01 Arena Pharm Inc Biphenyl sulfonyl and phenyl-heteroaryl sulfonyl modulators of the histamine H3-receptor useful for the treatment of disorders related thereto
EP1997493A1 (en) * 2007-05-28 2008-12-03 Laboratorios del Dr. Esteve S.A. Combination of a 5-HT7 receptor ligand and an opioid receptor ligand
JP5491416B2 (ja) 2008-02-01 2014-05-14 パンミラ ファーマシューティカルズ，エルエルシー． プロスタグランジンｄ２受容体のｎ，ｎ−２置換アミノアルキルビフェニルアンタゴニスト
EP2245002A4 (en) * 2008-02-01 2011-08-17 Amira Pharmaceuticals Inc AMINOALKYLBIPHENYL ANTAGONISTS N, N 'DISUBSTITUTED FROM D2 RECEPTORS OF PROSTAGLANDIN
US8242145B2 (en) * 2008-02-14 2012-08-14 Panmira Pharmaceuticals, Llc Cyclic diaryl ether compounds as antagonists of prostaglandin D2 receptors
EP2245022A4 (en) * 2008-02-25 2012-02-22 Panmira Pharmaceuticals Llc ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
EP2268611A2 (en) * 2008-04-02 2011-01-05 Amira Pharmaceuticals, Inc. Aminoalkylphenyl antagonists of prostaglandin d2 receptors
TWI403319B (zh) * 2008-07-03 2013-08-01 Panmira Pharmaceuticals Llc 前列腺素ｄ2受體之雜烷基拮抗劑
GB2463788B (en) * 2008-09-29 2010-12-15 Amira Pharmaceuticals Inc Heteroaryl antagonists of prostaglandin D2 receptors
WO2010039977A2 (en) * 2008-10-01 2010-04-08 Amira Pharmaceuticals, Inc. Heteroaryl antagonists of prostaglandin d2 receptors
US8524748B2 (en) 2008-10-08 2013-09-03 Panmira Pharmaceuticals, Llc Heteroalkyl biphenyl antagonists of prostaglandin D2 receptors
US8383654B2 (en) 2008-11-17 2013-02-26 Panmira Pharmaceuticals, Llc Heterocyclic antagonists of prostaglandin D2 receptors
US20100173313A1 (en) * 2009-01-08 2010-07-08 Amira Pharmaceuticals, Inc. Biomarkers of inflammation
KR20120038544A (ko) 2009-07-31 2012-04-23 판미라 파마슈티칼스, 엘엘씨 Ｄｐ2 수용체 길항제의 안과용 약학 조성물
SG178252A1 (en) 2009-08-05 2012-03-29 Panmira Pharmaceuticals Llc Dp2 antagonist and uses thereof
PH12012501349A1 (en) 2010-01-06 2013-01-14 Panmira Pharmaceuticals Llc Dp2 antagonist and uses thereof
DE102010055322A1 (de) 2010-12-21 2012-06-21 Christian-Albrechts-Universität Zu Kiel Antibakteriell und antimykotisch wirkende Substanzen
US20120309796A1 (en) 2011-06-06 2012-12-06 Fariborz Firooznia Benzocycloheptene acetic acids
CN103864624A (zh) * 2014-03-05 2014-06-18 湖北大学 一种简单碱催化的n-烷基化高效制备仲胺的方法
CN115636775B (zh) * 2021-07-20 2024-02-06 晶美晟光电材料（南京）有限公司 一种含硫的联苯类液晶化合物的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3443943A (en) * 1967-07-24 1969-05-13 Polaroid Corp Photographic products and processes employing ring - closing 2 - equivalent silver halide developing agents
US4473709A (en) * 1980-07-14 1984-09-25 Fmc Corporation Pyrethroid intermediates and process

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4315926A (en) 1979-12-26 1982-02-16 Ciba-Geigy Corporation Dibenz[c,e]azepines
US5283241A (en) * 1992-08-28 1994-02-01 Merck & Co., Inc. Benzo-fused lactams promote release of growth hormone
EP0946499B1 (en) * 1996-11-22 2005-06-01 Elan Pharmaceuticals, Inc. N-(aryl/heteroaryl/alkylacetyl) amino acid amides, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
ZA985247B (en) * 1997-06-19 1999-12-17 Du Pont Merck Pharma Guanidine mimics as factor Xa inhibitors.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3443943A (en) * 1967-07-24 1969-05-13 Polaroid Corp Photographic products and processes employing ring - closing 2 - equivalent silver halide developing agents
US4473709A (en) * 1980-07-14 1984-09-25 Fmc Corporation Pyrethroid intermediates and process

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A.MISIORNY ET AL.: "Chemistry and CNS-effect of 2-aminomethyl-2'-hydroxybiphenyls and 2-aminomethyl-2'-3'-dihydroxybiphenyls", ACTA PHARMACEUTICA SUECICA., 1977, v.14, p.105-112. SHIGERU KOBAYASHI ET AL.:"Syntheses of Apogalanthamine analogs as alpha-adrenergic blocking agents", CHEMICAL AND PHARMACEUTICAL BULLETIN., 1977, v.25, p.3312-3323. SHIGERU KOBAYASHI ET AL., "The constitution of Apogalanthamine", J. of THE CHEMICAL SOIETY., 1957, p.638-645. MOSHE WETZBERG ET AL.: "Syntheses and chemistry of some dibenz(c,e)azepines.", J. of ORGANIC CHEMISTRY., 1987, v.52, №4, р.529-536. P.W. JEFFS ET AL.:"Biosyntheses of mesembrine and related alkaloids.", J. of THE AMERICAN CHEMICAL SOCIETY., 1971, v. 93, №15,р.3752-3758. KEVIN E. CULLEN ET AL.:"Reactions of diene-conjugated 1,3-dipolar intermediates.", J. of THE CHEMICAL SOCIETY PERKIN TRANSACTIONS 1993, №23, р.2961-2967. CHEMICAL ABSTRACTS, 1976, v.84, №9, abstracts №58806t. ROBERT J. DE VITA AT AL.: "A potent, orally bioavailable benzazepi *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2814636C1 (ru) * 2020-09-11 2024-03-04 Бейджинг Хунхуэй Медитек Ко., Лтд Способ получения водорастворимых производных магнолола и производных хонокиола и их интермедиатов, и родственных моногидрокси-защищенных интермедиатов

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