JP2002504694A - 試薬を吸引し分配する（ａｓｐｉｒａｔｉｎｇａｎｄｄｉｓｐｅｎｓｉｎｇ）システムと方法 - Google Patents
試薬を吸引し分配する（ａｓｐｉｒａｔｉｎｇａｎｄｄｉｓｐｅｎｓｉｎｇ）システムと方法Info
- Publication number
- JP2002504694A JP2002504694A JP2000533222A JP2000533222A JP2002504694A JP 2002504694 A JP2002504694 A JP 2002504694A JP 2000533222 A JP2000533222 A JP 2000533222A JP 2000533222 A JP2000533222 A JP 2000533222A JP 2002504694 A JP2002504694 A JP 2002504694A
- Authority
- JP
- Japan
- Prior art keywords
- probe
- reagent
- vial
- dispensing
- hole
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
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- 238000004140 cleaning Methods 0.000 claims description 38
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- 239000012530 fluid Substances 0.000 claims description 20
- 239000011534 wash buffer Substances 0.000 claims description 17
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- 238000005406 washing Methods 0.000 abstract description 52
- 238000010926 purge Methods 0.000 description 13
- 238000010186 staining Methods 0.000 description 8
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- PIVBPZFQXKMHBD-UHFFFAOYSA-N 1,2,3-trichloro-5-(2,5-dichlorophenyl)benzene Chemical compound ClC1=CC=C(Cl)C(C=2C=C(Cl)C(Cl)=C(Cl)C=2)=C1 PIVBPZFQXKMHBD-UHFFFAOYSA-N 0.000 description 6
- 230000008569 process Effects 0.000 description 6
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- 230000001744 histochemical effect Effects 0.000 description 5
- 229910052751 metal Inorganic materials 0.000 description 5
- 239000002184 metal Substances 0.000 description 5
- 238000012544 monitoring process Methods 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 239000004809 Teflon Substances 0.000 description 4
- 229920006362 Teflon® Polymers 0.000 description 4
- 238000010586 diagram Methods 0.000 description 4
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- 238000003745 diagnosis Methods 0.000 description 3
- 238000001704 evaporation Methods 0.000 description 3
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- 229910001220 stainless steel Inorganic materials 0.000 description 3
- 239000010935 stainless steel Substances 0.000 description 3
- 239000002699 waste material Substances 0.000 description 3
- WZUVPPKBWHMQCE-UHFFFAOYSA-N Haematoxylin Chemical compound C12=CC(O)=C(O)C=C2CC2(O)C1C1=CC=C(O)C(O)=C1OC2 WZUVPPKBWHMQCE-UHFFFAOYSA-N 0.000 description 2
- 241001510071 Pyrrhocoridae Species 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
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- 230000009977 dual effect Effects 0.000 description 2
- 239000000975 dye Substances 0.000 description 2
- 230000002255 enzymatic effect Effects 0.000 description 2
- YQGOJNYOYNNSMM-UHFFFAOYSA-N eosin Chemical compound [Na+].OC(=O)C1=CC=CC=C1C1=C2C=C(Br)C(=O)C(Br)=C2OC2=C(Br)C(O)=C(Br)C=C21 YQGOJNYOYNNSMM-UHFFFAOYSA-N 0.000 description 2
- 238000011532 immunohistochemical staining Methods 0.000 description 2
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- 239000004065 semiconductor Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000007910 cell fusion Effects 0.000 description 1
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- 239000003795 chemical substances by application Substances 0.000 description 1
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- 238000001914 filtration Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 231100000767 hemotoxin Toxicity 0.000 description 1
- 230000002055 immunohistochemical effect Effects 0.000 description 1
- 238000007901 in situ hybridization Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
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- 239000013610 patient sample Substances 0.000 description 1
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- 239000012859 tissue stain Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1002—Reagent dispensers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
- G01N1/312—Apparatus therefor for samples mounted on planar substrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/36—Embedding or analogous mounting of samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/30—Staining; Impregnating ; Fixation; Dehydration; Multistep processes for preparing samples of tissue, cell or nucleic acid material and the like for analysis
- G01N1/31—Apparatus therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1079—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices with means for piercing stoppers or septums
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Microscoopes, Condenser (AREA)
- Devices For Use In Laboratory Experiments (AREA)
- Laminated Bodies (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7619898P | 1998-02-27 | 1998-02-27 | |
| US60/076,198 | 1998-02-27 | ||
| PCT/US1999/004379 WO1999043434A1 (en) | 1998-02-27 | 1999-02-26 | System and method of aspirating and dispensing reagent |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009120016A Division JP4505538B2 (ja) | 1998-02-27 | 2009-05-18 | 試薬を吸引し分配するシステムと方法 |
| JP2009282843A Division JP4505547B2 (ja) | 1998-02-27 | 2009-12-14 | 試薬を吸引し分配するシステムと方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2002504694A true JP2002504694A (ja) | 2002-02-12 |
| JP2002504694A5 JP2002504694A5 (enExample) | 2006-04-20 |
Family
ID=22130540
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000533730A Expired - Lifetime JP3847559B2 (ja) | 1998-02-27 | 1999-02-26 | 独立スライド加熱器を有する自動化分子病理学装置 |
| JP2000533222A Pending JP2002504694A (ja) | 1998-02-27 | 1999-02-26 | 試薬を吸引し分配する（ａｓｐｉｒａｔｉｎｇａｎｄｄｉｓｐｅｎｓｉｎｇ）システムと方法 |
| JP2006190677A Expired - Lifetime JP4091960B2 (ja) | 1998-02-27 | 2006-07-11 | 顕微鏡スライド加熱システム |
| JP2009120016A Expired - Lifetime JP4505538B2 (ja) | 1998-02-27 | 2009-05-18 | 試薬を吸引し分配するシステムと方法 |
| JP2009282843A Expired - Lifetime JP4505547B2 (ja) | 1998-02-27 | 2009-12-14 | 試薬を吸引し分配するシステムと方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000533730A Expired - Lifetime JP3847559B2 (ja) | 1998-02-27 | 1999-02-26 | 独立スライド加熱器を有する自動化分子病理学装置 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006190677A Expired - Lifetime JP4091960B2 (ja) | 1998-02-27 | 2006-07-11 | 顕微鏡スライド加熱システム |
| JP2009120016A Expired - Lifetime JP4505538B2 (ja) | 1998-02-27 | 2009-05-18 | 試薬を吸引し分配するシステムと方法 |
| JP2009282843A Expired - Lifetime JP4505547B2 (ja) | 1998-02-27 | 2009-12-14 | 試薬を吸引し分配するシステムと方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6296809B1 (enExample) |
| EP (3) | EP2284543A3 (enExample) |
| JP (5) | JP3847559B2 (enExample) |
| CN (1) | CN100403008C (enExample) |
| AT (1) | ATE489613T1 (enExample) |
| AU (3) | AU763354B2 (enExample) |
| CA (2) | CA2321836C (enExample) |
| DE (1) | DE69942975D1 (enExample) |
| ES (1) | ES2354598T3 (enExample) |
| WO (2) | WO1999044030A1 (enExample) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007526479A (ja) * | 2004-03-02 | 2007-09-13 | ダコ デンマーク アクティーゼルスカブ | 生物学的染色装置のための試薬送達システム、分配デバイスおよび容器 |
| JP2016505136A (ja) * | 2012-12-26 | 2016-02-18 | ベンタナ メディカル システムズ， インコーポレイテッド | 試薬を準備する標本処理システムおよび方法 |
| US9989448B2 (en) | 2012-12-26 | 2018-06-05 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for holding slides |
| US10746752B2 (en) | 2009-11-13 | 2020-08-18 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| US11274998B2 (en) | 2012-12-26 | 2022-03-15 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for holding slides |
Families Citing this family (244)
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| US20040191128A1 (en) * | 1992-05-11 | 2004-09-30 | Cytologix Corporation | Slide stainer with heating |
| US6180061B1 (en) | 1992-05-11 | 2001-01-30 | Cytologix Corporation | Moving platform slide stainer with heating elements |
| US6735531B2 (en) | 1996-10-07 | 2004-05-11 | Lab Vision Corporation | Method and apparatus for automatic tissue staining |
| JP3750772B2 (ja) * | 1998-01-27 | 2006-03-01 | 富士写真フイルム株式会社 | 生化学分析装置 |
| GB9803684D0 (en) * | 1998-02-24 | 1998-04-15 | Genevac Ltd | Method and apparatus for controlling temperature during evaporation of samples |
| US6582962B1 (en) * | 1998-02-27 | 2003-06-24 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US6183693B1 (en) * | 1998-02-27 | 2001-02-06 | Cytologix Corporation | Random access slide stainer with independent slide heating regulation |
| US7396508B1 (en) | 2000-07-12 | 2008-07-08 | Ventana Medical Systems, Inc. | Automated molecular pathology apparatus having independent slide heaters |
| US7188001B2 (en) * | 1998-03-23 | 2007-03-06 | Cepheid | System and method for temperature control |
| US6495106B1 (en) * | 1998-03-24 | 2002-12-17 | Biogenex Laboratories | Automated staining apparatus |
| US6620620B1 (en) * | 1998-04-27 | 2003-09-16 | Era Systems, Inc. | Micro liquid evaporator |
| US6855552B2 (en) * | 1998-09-03 | 2005-02-15 | Ventana Medical Systems | Automated immunohistochemical and in situ hybridization assay formulations |
| US7550298B2 (en) * | 1998-09-03 | 2009-06-23 | Ventana Medical Systems, Inc. | Automated immunohistochemical and in situ hybridization assay formulations |
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| US7897106B2 (en) | 1999-07-08 | 2011-03-01 | Lee Angros | Situ heat induced antigen recovery and staining apparatus and method |
| EP1208378B9 (en) | 1999-07-08 | 2014-12-10 | Lee H. Angros | Antigen recovery and/or staining apparatus and method |
| US7951612B2 (en) * | 1999-07-08 | 2011-05-31 | Lee H. Angros | In situ heat induced antigen recovery and staining apparatus and method |
| US8298485B2 (en) * | 1999-07-08 | 2012-10-30 | Lee H. Angros | In situ heat induced antigen recovery and staining apparatus and method |
| JP2003510571A (ja) * | 1999-09-24 | 2003-03-18 | ジョナサン コヘン | 組織試料中の分子標的の臨床的有用性を評価するための高処理量システム |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007526479A (ja) * | 2004-03-02 | 2007-09-13 | ダコ デンマーク アクティーゼルスカブ | 生物学的染色装置のための試薬送達システム、分配デバイスおよび容器 |
| US10746752B2 (en) | 2009-11-13 | 2020-08-18 | Ventana Medical Systems, Inc. | Opposables and automated specimen processing systems with opposables |
| JP2016505136A (ja) * | 2012-12-26 | 2016-02-18 | ベンタナ メディカル システムズ， インコーポレイテッド | 試薬を準備する標本処理システムおよび方法 |
| US9989448B2 (en) | 2012-12-26 | 2018-06-05 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for holding slides |
| US11274998B2 (en) | 2012-12-26 | 2022-03-15 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for holding slides |
| US12104994B2 (en) | 2012-12-26 | 2024-10-01 | Ventana Medical Systems, Inc. | Specimen processing systems and methods for holding slides |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2320750C (en) | 2004-08-24 |
| DE69942975D1 (de) | 2011-01-05 |
| EP1056541B1 (en) | 2017-10-25 |
| JP4505547B2 (ja) | 2010-07-21 |
| ATE489613T1 (de) | 2010-12-15 |
| AU763354B2 (en) | 2003-07-17 |
| US6296809B1 (en) | 2001-10-02 |
| EP1073892B1 (en) | 2010-11-24 |
| JP2010091579A (ja) | 2010-04-22 |
| CN100403008C (zh) | 2008-07-16 |
| CA2321836A1 (en) | 1999-09-02 |
| JP2006304806A (ja) | 2006-11-09 |
| CA2321836C (en) | 2004-09-28 |
| JP2009216714A (ja) | 2009-09-24 |
| EP1073892A1 (en) | 2001-02-07 |
| JP4505538B2 (ja) | 2010-07-21 |
| AU2879699A (en) | 1999-09-15 |
| EP1073892A4 (en) | 2005-10-12 |
| CN1297529A (zh) | 2001-05-30 |
| JP4091960B2 (ja) | 2008-05-28 |
| EP2284543A2 (en) | 2011-02-16 |
| ES2354598T3 (es) | 2011-03-16 |
| AU2003255169A1 (en) | 2003-11-13 |
| AU2883499A (en) | 1999-09-15 |
| CA2320750A1 (en) | 1999-09-02 |
| EP2284543A3 (en) | 2015-05-27 |
| JP3847559B2 (ja) | 2006-11-22 |
| EP1056541A1 (en) | 2000-12-06 |
| JP2002505089A (ja) | 2002-02-19 |
| WO1999044030A1 (en) | 1999-09-02 |
| WO1999044030A9 (en) | 1999-12-16 |
| EP1056541A4 (en) | 2005-11-30 |
| WO1999043434A1 (en) | 1999-09-02 |
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