JP2001522828A5 - - Google Patents
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- Publication number
- JP2001522828A5 JP2001522828A5 JP2000520407A JP2000520407A JP2001522828A5 JP 2001522828 A5 JP2001522828 A5 JP 2001522828A5 JP 2000520407 A JP2000520407 A JP 2000520407A JP 2000520407 A JP2000520407 A JP 2000520407A JP 2001522828 A5 JP2001522828 A5 JP 2001522828A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- alcohol
- oxa
- contacting
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- -1 p-toluenesulfonyl Chemical group 0.000 description 14
- 238000000034 method Methods 0.000 description 11
- 150000001412 amines Chemical class 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 7
- 238000004519 manufacturing process Methods 0.000 description 6
- 239000002253 acid Substances 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 150000002924 oxiranes Chemical class 0.000 description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 4
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical group CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
- 239000011260 aqueous acid Substances 0.000 description 3
- 239000011541 reaction mixture Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 2
- HBBGRARXTFLTSG-UHFFFAOYSA-N Lithium ion Chemical compound [Li+] HBBGRARXTFLTSG-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 229940006487 lithium cation Drugs 0.000 description 2
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical group C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- ZCPJBHYNOFIAPJ-AENDTGMFSA-N (2s)-1-amino-3-chloropropan-2-ol;hydrochloride Chemical compound Cl.NC[C@H](O)CCl ZCPJBHYNOFIAPJ-AENDTGMFSA-N 0.000 description 1
- 0 *=CN(*([N+](c1ccccc11)[O-])[N+]1[O-])N Chemical compound *=CN(*([N+](c1ccccc11)[O-])[N+]1[O-])N 0.000 description 1
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical compound O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 description 1
- KBRVYEPWGIQEOF-SSDOTTSWSA-N 2-[(2s)-3-chloro-2-hydroxypropyl]isoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(C[C@@H](CCl)O)C(=O)C2=C1 KBRVYEPWGIQEOF-SSDOTTSWSA-N 0.000 description 1
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 description 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 description 1
- MHABMANUFPZXEB-UHFFFAOYSA-N O-demethyl-aloesaponarin I Natural products O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=C(O)C(C(O)=O)=C2C MHABMANUFPZXEB-UHFFFAOYSA-N 0.000 description 1
- 150000008065 acid anhydrides Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 235000011114 ammonium hydroxide Nutrition 0.000 description 1
- NXSHODVXBOPCHO-UHFFFAOYSA-N benzene-1,2-dicarboxamide;potassium Chemical compound [K].NC(=O)C1=CC=CC=C1C(N)=O NXSHODVXBOPCHO-UHFFFAOYSA-N 0.000 description 1
- 150000001768 cations Chemical class 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- XWJZCAOMAPZUFS-RXMQYKEDSA-N n-[(2s)-3-chloro-2-hydroxypropyl]acetamide Chemical compound CC(=O)NC[C@H](O)CCl XWJZCAOMAPZUFS-RXMQYKEDSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- AFEQENGXSMURHA-UHFFFAOYSA-N oxiran-2-ylmethanamine Chemical compound NCC1CO1 AFEQENGXSMURHA-UHFFFAOYSA-N 0.000 description 1
- 125000005270 trialkylamine group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6473897P | 1997-11-07 | 1997-11-07 | |
| US60/064,738 | 1997-11-07 | ||
| PCT/US1998/020934 WO1999024393A1 (en) | 1997-11-07 | 1998-10-13 | Process to produce oxazolidinones |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001522828A JP2001522828A (ja) | 2001-11-20 |
| JP2001522828A5 true JP2001522828A5 (enExample) | 2006-01-05 |
Family
ID=22057971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000520407A Withdrawn JP2001522828A (ja) | 1997-11-07 | 1998-10-13 | オキサゾリジノンの製法 |
Country Status (28)
| Country | Link |
|---|---|
| US (8) | US6107519A (enExample) |
| EP (2) | EP1772453A1 (enExample) |
| JP (1) | JP2001522828A (enExample) |
| KR (2) | KR100619639B1 (enExample) |
| CN (2) | CN101353313A (enExample) |
| AT (1) | ATE359994T1 (enExample) |
| AU (1) | AU748128B2 (enExample) |
| BG (1) | BG64794B1 (enExample) |
| BR (1) | BR9813187A (enExample) |
| CA (2) | CA2304100A1 (enExample) |
| CY (1) | CY1106611T1 (enExample) |
| CZ (1) | CZ20001613A3 (enExample) |
| DE (1) | DE69837615T2 (enExample) |
| DK (1) | DK1028940T3 (enExample) |
| EE (1) | EE04370B1 (enExample) |
| ES (1) | ES2284216T3 (enExample) |
| HU (1) | HUP0004388A3 (enExample) |
| IL (2) | IL135912A (enExample) |
| IS (2) | IS5431A (enExample) |
| NO (2) | NO20002373D0 (enExample) |
| NZ (1) | NZ504372A (enExample) |
| PL (1) | PL199355B1 (enExample) |
| PT (1) | PT1028940E (enExample) |
| RU (1) | RU2205822C2 (enExample) |
| SK (1) | SK286569B6 (enExample) |
| TR (1) | TR200001199T2 (enExample) |
| TW (2) | TW555752B (enExample) |
| WO (1) | WO1999024393A1 (enExample) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1082323A2 (en) | 1998-06-05 | 2001-03-14 | AstraZeneca UK Limited | Oxazolidinone derivatives, process for their preparation and pharmaceutical compositions containing them |
| GB9928568D0 (en) | 1999-12-03 | 2000-02-02 | Zeneca Ltd | Chemical compounds |
| AR027261A1 (es) * | 2000-02-02 | 2003-03-19 | Upjohn Co | Linezolid forma cristalina ii |
| US6444813B2 (en) | 2000-02-02 | 2002-09-03 | Pharmacia & Upjohn Company | Linezolid-crystal form II |
| MY127336A (en) | 2000-03-22 | 2006-11-30 | Upjohn Co | Container for linezolid iv solution |
| US6514529B2 (en) | 2000-03-22 | 2003-02-04 | Pharmacia & Upjohn Company | Oxazolidinone tablet formulation |
| GB0009803D0 (en) * | 2000-04-25 | 2000-06-07 | Astrazeneca Ab | Chemical compounds |
| DE60112581T2 (de) | 2000-06-30 | 2006-06-01 | Pharmacia & Upjohn Co. Llc, Kalamazoo | Zusammensetzungen zur Behandlung bakterieller Infektionen, welche ein Oxazolidinonderivat, Sulbactam und Ampicillin enthalten |
| PE20020300A1 (es) | 2000-08-22 | 2002-05-10 | Pharmacia Corp | Composicion de solucion de un farmaco antibiotico a base de oxazolidinona con mejoramiento de la carga de farmaco |
| ATE321024T1 (de) * | 2000-10-17 | 2006-04-15 | Pharmacia & Upjohn Co Llc | Verfahren zur herstellung von oxazolidinonverbindungen |
| ATE374463T1 (de) * | 2001-04-20 | 2007-10-15 | Pharmacia & Upjohn Co Llc | Verfahren zur herstellung von oxazolidinonen |
| JP2005521690A (ja) | 2002-02-22 | 2005-07-21 | ファルマシア・コーポレーション | ゴム系を含む眼科用製剤 |
| ATE315562T1 (de) * | 2002-09-25 | 2006-02-15 | Daiso Co Ltd | Verfahren zur herstellung von glycidylphthalimid |
| ES2803516T3 (es) | 2003-10-16 | 2021-01-27 | Symed Labs Ltd | Una forma cristalina de linezolid |
| US7186844B2 (en) * | 2004-01-13 | 2007-03-06 | Mitsubishi Gas Chemical Co., Inc. | Method for producing cyclic carbamate ester |
| ES2294494T3 (es) | 2004-04-19 | 2008-04-01 | Symed Labs Limited | Un nuevo procedimiento para la preparacion de linezolid y compuestos relacionados. |
| EP1768967B1 (en) | 2004-07-20 | 2009-04-22 | Symed Labs Limited | Novel intermediates for linezolid and related compounds |
| SE0402200D0 (sv) * | 2004-09-13 | 2004-09-13 | Astrazeneca Ab | New process II |
| AU2007235635A1 (en) * | 2006-04-07 | 2007-10-18 | Pfizer Products Inc. | Process for preparing linezolid |
| JP5451611B2 (ja) * | 2007-07-26 | 2014-03-26 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | １１β−ヒドロキシステロイドデヒドロゲナーゼ１のサイクリックインヒビター |
| EP2033960A3 (en) | 2007-09-04 | 2009-04-29 | Dipharma Francis S.r.l. | Linezolid crystalline hydrate form and linezolid salts |
| ITMI20072359A1 (it) | 2007-12-18 | 2009-06-19 | Dipharma Francis Srl | Procedimento per la preparazione di derivati ossazolidinonici |
| EP2163547A1 (en) | 2008-09-16 | 2010-03-17 | Unión Químico Farmacéutica, S.A. (UQUIFA) | Process for the preparation of an oxazolidinone antibacterial agent and intermediates thereof |
| CN101774978B (zh) | 2009-01-13 | 2011-09-21 | 联化科技股份有限公司 | 一种利奈唑胺的制备方法及其中间体 |
| WO2011077310A1 (en) | 2009-12-26 | 2011-06-30 | Alembic Limited | Process for the preparation of linezolid |
| US20110232588A1 (en) * | 2010-03-26 | 2011-09-29 | Msp Corporation | Integrated system for vapor generation and thin film deposition |
| CN103025730A (zh) | 2010-04-30 | 2013-04-03 | 印第安纳大学研究及科技有限公司 | 制备利奈唑胺的方法 |
| EP2690100A1 (en) | 2010-08-11 | 2014-01-29 | Synhton B.V. | Process for making linezolid |
| WO2012019632A1 (en) | 2010-08-11 | 2012-02-16 | Synthon B.V. | Process for making linezolid |
| US20130296569A1 (en) | 2010-11-03 | 2013-11-07 | Vijaykumar Jagdishwar Patil | Process for the preparation of phosphoric acid mono-(1--4-methoxymethyl-piperidin-4-yl) ester |
| EP2593440A1 (en) | 2011-02-24 | 2013-05-22 | Lee Pharma Limited | Anhydrous linezolid crystalline form-ii |
| CN102731336B (zh) * | 2011-04-12 | 2014-05-07 | 浙江医药股份有限公司新昌制药厂 | 利奈唑胺中间体及合成利奈唑胺的方法 |
| CN102731341A (zh) * | 2011-04-13 | 2012-10-17 | 上海医药工业研究院 | 用于制备利奈唑胺的中间体及其制备方法 |
| CN102267955A (zh) * | 2011-06-02 | 2011-12-07 | 山东鲁抗医药股份有限公司 | 一种利奈唑胺的制备方法 |
| WO2013072923A1 (en) | 2011-09-19 | 2013-05-23 | Cadila Healthcare Limited | Process for the preparation of crystalline linezolid |
| WO2013111048A1 (en) | 2012-01-24 | 2013-08-01 | Jubilant Life Sciences Limited | Improved process for the preparation of stable crystalline form-i of linezolid, substantially free of residual solvent |
| CN103254148B (zh) * | 2012-02-15 | 2016-04-13 | 浙江海正药业股份有限公司 | 利奈唑胺中间体的制备方法 |
| EP2838897A1 (en) | 2012-04-16 | 2015-02-25 | Ranbaxy Laboratories Limited | Process for the preparation of rivaroxaban and intermediates thereof |
| EP2855465A1 (en) | 2012-05-24 | 2015-04-08 | Ranbaxy Laboratories Limited | Process for the preparation of rivaroxaban |
| CN103626712B (zh) * | 2012-08-23 | 2016-06-01 | 重庆药友制药有限责任公司 | 一种用于制备利奈唑胺的中间体及其制备方法 |
| ES2603252T3 (es) | 2012-11-09 | 2017-02-24 | Synthon Bv | Proceso para preparar linezolid |
| WO2014141067A2 (en) | 2013-03-14 | 2014-09-18 | Benova Labs Pvt Limited | Process for the preparation of oxazolidinone derivatives |
| CN103483294B (zh) * | 2013-08-12 | 2015-01-28 | 四川大学 | 3-氨基-2-丙醇乙酰胺类化合物的盐、其制备方法和用途 |
| WO2015068121A1 (en) | 2013-11-06 | 2015-05-14 | Unimark Remedies Ltd. | Process for preparation of crystalline form i of linezolid and its compositions |
| WO2015173664A1 (en) | 2014-05-14 | 2015-11-19 | Wockhardt Limited | Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide |
| WO2016150937A1 (en) | 2015-03-25 | 2016-09-29 | Lonza Ltd | Method for preparation of thiophenecarbonyl chlorides |
| KR101880881B1 (ko) | 2015-11-04 | 2018-07-20 | 론자 리미티드 | 옥살릴 클로라이드를 사용하는 티오펜-2-카보닐 클로라이드의 제조 방법 |
| US9643939B1 (en) | 2016-04-18 | 2017-05-09 | Optimus Drugs Private Limited | Process for the preparation of linezolid |
| EP3250568A4 (en) | 2016-04-21 | 2018-08-01 | Optimus Drugs Pvt Ltd | An improved process for the preparation of linezolid |
| USRE47606E1 (en) | 2016-04-21 | 2019-09-17 | Optimus Drugs Private Limited | Process for the preparation of linezolid |
| CN108440382B (zh) * | 2018-04-03 | 2020-02-21 | 浙江永太科技股份有限公司 | 一种s-n-缩水甘油邻苯二甲酰亚胺的制备方法 |
| CN111574384B (zh) * | 2020-06-12 | 2021-03-16 | 上海馨远医药科技有限公司 | 一种手性1-氨基-2-丙醇的制备方法 |
| CN116789557A (zh) * | 2023-05-31 | 2023-09-22 | 迪嘉药业集团股份有限公司 | 一种(s)-1-氨基-3-氯-2-丙醇盐酸盐的合成方法 |
| CN118290358A (zh) * | 2024-03-06 | 2024-07-05 | 江苏医药职业学院 | 一种制备利奈唑胺关键中间体(s)-5-((苄基氨基)甲基)噁唑烷-2-酮的方法 |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2432905A (en) * | 1943-01-04 | 1947-12-16 | Lilly Co Eli | N-substituted phthalimides and their synthesis |
| GB1180089A (en) * | 1967-10-20 | 1970-02-04 | Delalande Sa | Acetylenic Derivatives of 2-Oxazolidinones and processes of preparation |
| FR2356422A1 (fr) * | 1976-03-01 | 1978-01-27 | Delalande Sa | Nouveaux hydroxymethyl-5 oxazolidinone-2, leur procede de preparation et leur application en therapeutique |
| ES469020A1 (es) * | 1977-05-10 | 1979-09-01 | Kali Chemie Pharma Gmbh | Procedimiento para la preparacion de nuevos 1-acil-2-hidroxi-1,3-diaminopropanos |
| DE2720915C2 (de) * | 1977-05-10 | 1986-04-17 | Kali-Chemie Pharma Gmbh, 3000 Hannover | N↓1↓-Acyl-2-hydroxy-1,3-diaminopropane und Arzneimittel mit diesen Verbindungen als Wirkstoff |
| LU80081A1 (fr) * | 1977-08-26 | 1979-05-15 | Delalande Sa | Nouvelles hydroxymethyl-5 oxazolidinones-2,leur procede de preparation et leur application therapeutique |
| JPS55133357A (en) * | 1979-04-02 | 1980-10-17 | Seitetsu Kagaku Co Ltd | Preparation of 1-cyano-2-hydroxy-3-phthalimidopropane |
| US4340606A (en) * | 1980-10-23 | 1982-07-20 | E. I. Du Pont De Nemours And Company | 3-(p-Alkylsulfonylphenyl)oxazolidinone derivatives as antibacterial agents |
| FR2500450A1 (fr) * | 1981-02-25 | 1982-08-27 | Delalande Sa | Nouveaux derives aminomethyl-5 oxazolidiniques, leur procede de preparation et leur application en therapeutique |
| US4461773A (en) * | 1982-09-15 | 1984-07-24 | E. I. Dupont De Nemours And Company | P-Oxooxazolidinylbenzene compounds as antibacterial agents |
| US4948801A (en) * | 1988-07-29 | 1990-08-14 | E. I. Du Pont De Nemours And Company | Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents |
| US5225565A (en) * | 1988-09-15 | 1993-07-06 | The Upjohn Company | Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones |
| US5182403A (en) * | 1988-09-15 | 1993-01-26 | The Upjohn Company | Substituted 3(5'indazolyl) oxazolidin-2-ones |
| US5164510A (en) * | 1988-09-15 | 1992-11-17 | The Upjohn Company | 5'Indolinyl-5β-amidomethyloxazolidin-2-ones |
| US5182296A (en) * | 1989-10-26 | 1993-01-26 | Tanabe Seiyaky Co., Ltd. | Naphthyloxazolidone derivatives |
| US5231188A (en) * | 1989-11-17 | 1993-07-27 | The Upjohn Company | Tricyclic [6.5.51]-fused oxazolidinone antibacterial agents |
| FR2678271B1 (fr) * | 1991-06-27 | 1995-01-13 | Synthelabo | Derives de pyrimidine-4-carboxamide, leur preparation et leur application en therapeutique. |
| EP0610265B1 (en) * | 1991-11-01 | 1996-12-27 | PHARMACIA & UPJOHN COMPANY | Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents |
| SK283420B6 (sk) * | 1992-05-08 | 2003-07-01 | Pharmacia & Upjohn Company | Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny |
| AU5404394A (en) * | 1992-10-15 | 1994-05-09 | Duke University | Antifouling coating composition and method |
| DE69316240T2 (de) * | 1992-12-08 | 1998-05-20 | Upjohn Co | Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel |
| US5608110A (en) | 1993-06-15 | 1997-03-04 | Bracco International B.V. | Heteroatom-bearing ligands and metal complexes thereof |
| MY115155A (en) * | 1993-09-09 | 2003-04-30 | Upjohn Co | Substituted oxazine and thiazine oxazolidinone antimicrobials. |
| US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
| FR2735475B1 (fr) * | 1995-06-13 | 1997-07-11 | Synthelabo | Derives de n-((1,4-diazabicyclo(2.2.2)oct-2-yl)methyl) benzamide, leur preparation et leur application en therapeutique |
| DE19604223A1 (de) * | 1996-02-06 | 1997-08-07 | Bayer Ag | Neue substituierte Oxazolidinone |
-
1998
- 1998-10-13 NZ NZ504372A patent/NZ504372A/xx unknown
- 1998-10-13 ES ES98953258T patent/ES2284216T3/es not_active Expired - Lifetime
- 1998-10-13 DE DE69837615T patent/DE69837615T2/de not_active Expired - Fee Related
- 1998-10-13 AT AT98953258T patent/ATE359994T1/de not_active IP Right Cessation
- 1998-10-13 CA CA002304100A patent/CA2304100A1/en not_active Abandoned
- 1998-10-13 CN CNA2008100872739A patent/CN101353313A/zh active Pending
- 1998-10-13 CZ CZ20001613A patent/CZ20001613A3/cs unknown
- 1998-10-13 EP EP07100547A patent/EP1772453A1/en not_active Withdrawn
- 1998-10-13 SK SK619-2000A patent/SK286569B6/sk unknown
- 1998-10-13 PT PT98953258T patent/PT1028940E/pt unknown
- 1998-10-13 DK DK98953258T patent/DK1028940T3/da active
- 1998-10-13 AU AU10672/99A patent/AU748128B2/en not_active Ceased
- 1998-10-13 PL PL340657A patent/PL199355B1/pl not_active IP Right Cessation
- 1998-10-13 CA CA002634657A patent/CA2634657A1/en not_active Abandoned
- 1998-10-13 BR BR9813187-7A patent/BR9813187A/pt not_active Application Discontinuation
- 1998-10-13 US US09/170,776 patent/US6107519A/en not_active Expired - Fee Related
- 1998-10-13 HU HU0004388A patent/HUP0004388A3/hu unknown
- 1998-10-13 CN CNB988100193A patent/CN100387581C/zh not_active Expired - Fee Related
- 1998-10-13 RU RU2000114835/04A patent/RU2205822C2/ru not_active IP Right Cessation
- 1998-10-13 WO PCT/US1998/020934 patent/WO1999024393A1/en not_active Ceased
- 1998-10-13 IL IL13591298A patent/IL135912A/en not_active IP Right Cessation
- 1998-10-13 KR KR1020057020639A patent/KR100619639B1/ko not_active Expired - Fee Related
- 1998-10-13 TR TR2000/01199T patent/TR200001199T2/xx unknown
- 1998-10-13 EP EP98953258A patent/EP1028940B1/en not_active Expired - Lifetime
- 1998-10-13 JP JP2000520407A patent/JP2001522828A/ja not_active Withdrawn
- 1998-10-13 KR KR1020007004932A patent/KR100580408B1/ko not_active Expired - Fee Related
- 1998-10-13 EE EEP200000210A patent/EE04370B1/xx not_active IP Right Cessation
- 1998-10-19 TW TW087117213A patent/TW555752B/zh active
- 1998-10-19 TW TW092112352A patent/TWI250155B/zh not_active IP Right Cessation
-
2000
- 2000-04-06 IS IS5431A patent/IS5431A/is unknown
- 2000-04-10 US US09/546,357 patent/US6362334B1/en not_active Expired - Fee Related
- 2000-04-25 BG BG104377A patent/BG64794B1/bg unknown
- 2000-05-05 NO NO20002373A patent/NO20002373D0/no not_active Application Discontinuation
-
2001
- 2001-08-09 US US09/927,007 patent/US6410788B1/en not_active Expired - Fee Related
-
2002
- 2002-01-15 US US10/047,705 patent/US6492555B2/en not_active Expired - Fee Related
- 2002-10-16 US US10/271,861 patent/US6563003B2/en not_active Expired - Fee Related
-
2003
- 2003-01-28 US US10/352,533 patent/US6613944B2/en not_active Expired - Fee Related
- 2003-04-24 US US10/422,334 patent/US6740754B2/en not_active Expired - Fee Related
- 2003-06-27 US US10/607,697 patent/US6716980B2/en not_active Expired - Fee Related
-
2004
- 2004-01-06 IL IL159740A patent/IL159740A/en not_active IP Right Cessation
-
2007
- 2007-05-21 CY CY20071100686T patent/CY1106611T1/el unknown
-
2008
- 2008-07-29 IS IS8754A patent/IS8754A/is unknown
- 2008-10-30 NO NO20084605A patent/NO20084605L/no not_active Application Discontinuation
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