JP2005525427A5 - - Google Patents
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- Publication number
- JP2005525427A5 JP2005525427A5 JP2004505315A JP2004505315A JP2005525427A5 JP 2005525427 A5 JP2005525427 A5 JP 2005525427A5 JP 2004505315 A JP2004505315 A JP 2004505315A JP 2004505315 A JP2004505315 A JP 2004505315A JP 2005525427 A5 JP2005525427 A5 JP 2005525427A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- represented
- forming
- formula
- structural formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 13
- UIAFKZKHHVMJGS-UHFFFAOYSA-N 2,4-dihydroxybenzoic acid Chemical compound OC(=O)C1=CC=C(O)C=C1O UIAFKZKHHVMJGS-UHFFFAOYSA-N 0.000 claims 10
- JFDZBHWFFUWGJE-UHFFFAOYSA-N benzenecarbonitrile Natural products N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 7
- ZXTHWIZHGLNEPG-UHFFFAOYSA-N 2-phenyl-4,5-dihydro-1,3-oxazole Chemical class O1CCN=C1C1=CC=CC=C1 ZXTHWIZHGLNEPG-UHFFFAOYSA-N 0.000 claims 6
- XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 claims 6
- 150000008359 benzonitriles Chemical class 0.000 claims 5
- 229940114055 beta-resorcylic acid Drugs 0.000 claims 5
- JFZAJWBGISKERI-UHFFFAOYSA-N 2,4-dihydroxybenzonitrile Chemical compound OC1=CC=C(C#N)C(O)=C1 JFZAJWBGISKERI-UHFFFAOYSA-N 0.000 claims 3
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 3
- 239000005711 Benzoic acid Substances 0.000 claims 3
- 230000009435 amidation Effects 0.000 claims 3
- 238000007112 amidation reaction Methods 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 235000010233 benzoic acid Nutrition 0.000 claims 3
- 150000001558 benzoic acid derivatives Chemical class 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000006239 protecting group Chemical group 0.000 claims 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- NZBONMFLYFGTAC-SCSAIBSYSA-N (2s)-2-amino-2-methyl-3-sulfanylpropanoic acid Chemical compound SC[C@](N)(C)C(O)=O NZBONMFLYFGTAC-SCSAIBSYSA-N 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- OVHDZBAFUMEXCX-UHFFFAOYSA-N benzyl 4-methylbenzenesulfonate Chemical compound C1=CC(C)=CC=C1S(=O)(=O)OCC1=CC=CC=C1 OVHDZBAFUMEXCX-UHFFFAOYSA-N 0.000 claims 1
- -1 benzyl halide Chemical class 0.000 claims 1
- 230000008878 coupling Effects 0.000 claims 1
- 238000010168 coupling process Methods 0.000 claims 1
- 238000005859 coupling reaction Methods 0.000 claims 1
- 125000001033 ether group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38087802P | 2002-05-15 | 2002-05-15 | |
| US38088002P | 2002-05-15 | 2002-05-15 | |
| US38090902P | 2002-05-15 | 2002-05-15 | |
| US38091002P | 2002-05-15 | 2002-05-15 | |
| US38090302P | 2002-05-15 | 2002-05-15 | |
| US38101202P | 2002-05-15 | 2002-05-15 | |
| US38102102P | 2002-05-15 | 2002-05-15 | |
| US38101702P | 2002-05-15 | 2002-05-15 | |
| US38089402P | 2002-05-15 | 2002-05-15 | |
| US38089502P | 2002-05-15 | 2002-05-15 | |
| US38101302P | 2002-05-15 | 2002-05-15 | |
| US39283302P | 2002-06-27 | 2002-06-27 | |
| PCT/US2003/015339 WO2003097582A2 (en) | 2002-05-15 | 2003-05-15 | Synthesis of benzonitriles and benzimidates |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005525427A JP2005525427A (ja) | 2005-08-25 |
| JP2005525427A5 true JP2005525427A5 (enExample) | 2006-06-29 |
| JP4414331B2 JP4414331B2 (ja) | 2010-02-10 |
Family
ID=29554649
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004505355A Pending JP2005538950A (ja) | 2002-05-15 | 2003-05-15 | ２−アルキルシステイン、２−（ヒドロキシル化フェニル）−４−アルキルチアゾリン−４−カルボン酸およびそれらの誘導体の合成 |
| JP2004505315A Expired - Fee Related JP4414331B2 (ja) | 2002-05-15 | 2003-05-15 | ベンゾニトリルおよびベンズイミデートの合成 |
| JP2006231196A Pending JP2007001986A (ja) | 2002-05-15 | 2006-08-28 | ２−アルキルシステイン、２−（ヒドロキシル化フェニル）−４−アルキルチアゾリン−４−カルボン酸およびそれらの誘導体の合成 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004505355A Pending JP2005538950A (ja) | 2002-05-15 | 2003-05-15 | ２−アルキルシステイン、２−（ヒドロキシル化フェニル）−４−アルキルチアゾリン−４−カルボン酸およびそれらの誘導体の合成 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006231196A Pending JP2007001986A (ja) | 2002-05-15 | 2006-08-28 | ２−アルキルシステイン、２−（ヒドロキシル化フェニル）−４−アルキルチアゾリン−４−カルボン酸およびそれらの誘導体の合成 |
Country Status (6)
| Country | Link |
|---|---|
| US (17) | US7038073B2 (enExample) |
| EP (2) | EP1506162B1 (enExample) |
| JP (3) | JP2005538950A (enExample) |
| AT (1) | ATE415387T1 (enExample) |
| AU (2) | AU2003247374A1 (enExample) |
| WO (2) | WO2003097582A2 (enExample) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT500490A1 (de) * | 2001-10-16 | 2006-01-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte |
| US20080086494A1 (en) * | 2006-09-11 | 2008-04-10 | Apple Computer, Inc. | Transfer and synchronization of media data |
| ATE415387T1 (de) | 2002-05-15 | 2008-12-15 | Genzyme Corp | Verfahren zur herstellung von benzonitrilen und benzimidosäure-derivaten |
| US7394410B1 (en) * | 2004-02-13 | 2008-07-01 | Samplify Systems, Inc. | Enhanced data converters using compression and decompression |
| EP1770166B1 (en) * | 2004-07-22 | 2010-09-08 | Mitsubishi Gas Chemical Company, Inc. | L-amino acid amide asymmetric hydrolase and dna encoding the same |
| DE102005054362A1 (de) | 2004-12-01 | 2006-06-08 | Degussa Ag | Verfahren zur Herstellung von Amino- oder Hydroxybenzonitrilen |
| EP1866293A1 (en) * | 2005-03-31 | 2007-12-19 | UCB Pharma, S.A. | Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses |
| CN101166524B (zh) | 2005-04-28 | 2010-12-22 | 辉瑞有限公司 | 氨基酸衍生物 |
| JP2006312614A (ja) * | 2005-05-09 | 2006-11-16 | Ajinomoto Co Inc | チアゾリン化合物および光学活性α−アルキルシステインの製造方法 |
| EP2089398A2 (en) * | 2006-10-25 | 2009-08-19 | Polyera Corporation | Organic semiconductor materials and methods of preparing and use thereof |
| WO2009005775A2 (en) * | 2007-06-29 | 2009-01-08 | University Of South Florida | Enantioselective ring-opening of aziridines |
| US8992783B2 (en) | 2008-09-05 | 2015-03-31 | Max-Planck-Gessellschaft zur förderung der Wissenschaften e.V. | Process for enantioseparation of chiral systems with compound formation using two subsequent crystallization steps |
| US8765817B1 (en) | 2008-12-03 | 2014-07-01 | Arrowhead Center, Inc. | Selective inhibitors of EG5 motors and methods of use |
| US8349899B1 (en) | 2008-12-03 | 2013-01-08 | Arrowhead Center, Inc. | Selective inhibitors of EG5 motors and methods of use |
| AU2010266495B2 (en) * | 2009-06-29 | 2013-10-03 | Inolex Investment Corporation | Non-petrochemically derived cationic emulsifiers that are neutralized amino acid esters and related compositions and methods |
| US9249265B1 (en) | 2014-09-08 | 2016-02-02 | Sirrus, Inc. | Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions |
| US9828324B2 (en) | 2010-10-20 | 2017-11-28 | Sirrus, Inc. | Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom |
| US8884051B2 (en) * | 2010-10-20 | 2014-11-11 | Bioformix Inc. | Synthesis of methylene malonates using rapid recovery in the presence of a heat transfer agent |
| US10414839B2 (en) | 2010-10-20 | 2019-09-17 | Sirrus, Inc. | Polymers including a methylene beta-ketoester and products formed therefrom |
| US9279022B1 (en) | 2014-09-08 | 2016-03-08 | Sirrus, Inc. | Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions |
| MX360462B (es) | 2011-10-19 | 2018-11-05 | Sirrus Inc | Monomeros de metileno beta-dicetona, procedimientos de preparacion de monomeros de metileno beta-dicetona, composiciones polimerizables y productos formados a partir de ellos. |
| CN102775399A (zh) * | 2011-12-27 | 2012-11-14 | 盛世泰科生物医药技术(苏州)有限公司 | arylhydrocarbon受体(AHR)的内源性配体,2-(1’H3’-吲哚羰基)噻唑-4-羧酸甲酯的合成新方法 |
| EP2831124B1 (en) | 2012-03-30 | 2016-10-05 | Sirrus, Inc. | Composite and laminate articles and polymerizable systems for producing the same |
| EP2831125B1 (en) | 2012-03-30 | 2016-10-05 | Sirrus, Inc. | Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby |
| WO2013149173A1 (en) | 2012-03-30 | 2013-10-03 | Bioformix Inc. | Ink and coating formulations and polymerizable systems for producing the same |
| US10047192B2 (en) | 2012-06-01 | 2018-08-14 | Sirrus, Inc. | Optical material and articles formed therefrom |
| CN105008438B (zh) | 2012-11-16 | 2019-10-22 | 拜奥福米克斯公司 | 塑料粘结体系及方法 |
| WO2014085570A1 (en) | 2012-11-30 | 2014-06-05 | Bioformix, Inc. | Composite compositions for electronics applications |
| CN110204441A (zh) | 2013-01-11 | 2019-09-06 | 瑟拉斯公司 | 经过双(羟甲基)丙二酸酯的途径获得亚甲基丙二酸酯的方法 |
| US9416091B1 (en) | 2015-02-04 | 2016-08-16 | Sirrus, Inc. | Catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
| US9315597B2 (en) | 2014-09-08 | 2016-04-19 | Sirrus, Inc. | Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures |
| US10501400B2 (en) | 2015-02-04 | 2019-12-10 | Sirrus, Inc. | Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions |
| US9334430B1 (en) | 2015-05-29 | 2016-05-10 | Sirrus, Inc. | Encapsulated polymerization initiators, polymerization systems and methods using the same |
| US9217098B1 (en) | 2015-06-01 | 2015-12-22 | Sirrus, Inc. | Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound |
| US9518001B1 (en) | 2016-05-13 | 2016-12-13 | Sirrus, Inc. | High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation |
| US10428177B2 (en) | 2016-06-03 | 2019-10-01 | Sirrus, Inc. | Water absorbing or water soluble polymers, intermediate compounds, and methods thereof |
| US10196481B2 (en) | 2016-06-03 | 2019-02-05 | Sirrus, Inc. | Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof |
| US9567475B1 (en) | 2016-06-03 | 2017-02-14 | Sirrus, Inc. | Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
| US9617377B1 (en) | 2016-06-03 | 2017-04-11 | Sirrus, Inc. | Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2062210A5 (enExample) | 1969-09-17 | 1971-06-25 | Godo Shusei Kk | |
| DE2020866A1 (de) | 1970-04-29 | 1971-11-18 | Basf Ag | Verfahren zur Herstellung von Hydroxy- und Aminobenzonitrilen |
| DE3002989A1 (de) | 1980-01-29 | 1981-07-30 | Hoechst Ag, 6000 Frankfurt | Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels |
| EP0045281B1 (de) | 1980-07-28 | 1985-05-08 | Ciba-Geigy Ag | Thiazolinderivate und Verfahren zu ihrer Herstellung |
| GB9126832D0 (en) * | 1991-12-18 | 1992-02-19 | Sandoz Ltd | Separation process |
| US5840739A (en) | 1992-11-16 | 1998-11-24 | University Of Florida Research Foundation, Inc. | Thiazoline acid derivatives |
| AU5602594A (en) | 1992-11-16 | 1994-06-08 | University Of Florida Research Foundation, Inc. | 2-(pyrid-2'-yl)-2-thiazoline-4(s)-carboxylic acid derivatives |
| HUT72677A (en) * | 1993-02-26 | 1996-05-28 | Merrell Dow Pharma | Xanthine derivatives as adenosine a1 receptor antagonists |
| US5554753A (en) | 1993-08-25 | 1996-09-10 | Indiana University Foundation | Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis |
| US6197833B1 (en) * | 1995-07-24 | 2001-03-06 | Apollo Biopharmaceutics, Inc. | Neuroprotective effects of polycyclic phenolic compounds |
| US5877169A (en) * | 1993-11-05 | 1999-03-02 | University Of Florida Research Foundation, Inc. | Methods of treatment of ischemic damage |
| US5554601A (en) * | 1993-11-05 | 1996-09-10 | University Of Florida | Methods for neuroprotection |
| US6319914B1 (en) * | 1993-11-05 | 2001-11-20 | Apollo Biopharmaceuticals, Inc. | Cytoprotective effect of polycyclic phenolic compounds |
| US5859001A (en) * | 1996-01-11 | 1999-01-12 | University Of Florida Research Foundation, Inc. | Neuroprotective effects of polycyclic phenolic compounds |
| US6350739B1 (en) * | 1999-08-11 | 2002-02-26 | University Of Florida Resarch Foundation, Inc. | Methods of prevention and treatment of ischemic damage |
| US5665890A (en) * | 1995-03-14 | 1997-09-09 | President And Fellows Of Harvard College | Stereoselective ring opening reactions |
| US6383233B1 (en) * | 1996-03-10 | 2002-05-07 | Reuter Chemicscher Apparatebau Kg | Separation process |
| ES2217538T3 (es) * | 1997-01-16 | 2004-11-01 | University Of Florida Research Foundation, Inc. | Composiciones para mejorar los efectos citoprotectores de compuestos fenolicos policiclicos mediante la interaccion sinergica con antioxidantes. |
| WO1999012623A1 (en) | 1997-09-06 | 1999-03-18 | Reuter Chemische Apparatebau Kg | Separation process |
| US6172088B1 (en) * | 1997-11-24 | 2001-01-09 | University Of Florida Research Foundation, Inc. | Testosterone compounds and use for the protection of neurons |
| WO1999036399A1 (en) * | 1998-01-13 | 1999-07-22 | Kaneka Corporation | Process for producing optically active cysteine derivatives |
| US5929252A (en) * | 1998-06-15 | 1999-07-27 | The Scripps Research Institute | Aziridination of olefins |
| US6765109B1 (en) * | 1998-06-29 | 2004-07-20 | Roche Colorado Corporation | Preparation of S-aryl-cysteine and its derivatives |
| EP1115702A4 (en) | 1998-07-03 | 2002-04-17 | Millennium Pharm Inc | ALICYCLIC COMPOUNDS SUBSTITUTED BY NITROGEN AND SULFUR AND METHOD FOR THEIR PRODUCTION |
| US6083966A (en) * | 1998-08-31 | 2000-07-04 | University Of Florida | Thiazoline acid derivatives |
| US6159983A (en) | 1998-09-18 | 2000-12-12 | University Of Florida | Method and composition for treatment of inflammatory bowel disease |
| NZ526880A (en) | 1998-09-21 | 2005-05-27 | Univ Florida | Antimalarial agents |
| CA2346700A1 (en) * | 1998-10-09 | 2000-04-20 | Ajinomoto Co., Inc. | Cysteine derivatives |
| US6326365B1 (en) * | 1999-07-20 | 2001-12-04 | Apollo Biopharmaceutics, Inc. | Methods of prevention and treatment of ischemic damage |
| US6339078B1 (en) * | 1999-07-20 | 2002-01-15 | University Of Florida Research Foundation, Inc. | Methods of prevention and treatment of ischemic damage |
| DE20000122U1 (de) * | 2000-01-05 | 2000-04-20 | ABT Advanced Bioanalytical Technology GmbH & Co KG, 01454 Radeberg | Mobiles Handgerät mit wiederverwendbarem Biosensor |
| KR100660802B1 (ko) * | 2000-01-14 | 2006-12-26 | 하. 룬트벡 아크티에 셀스카브 | 5-시아노프탈리드의 제조 방법 |
| AT500490A1 (de) | 2001-10-16 | 2006-01-15 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte |
| ATE415387T1 (de) | 2002-05-15 | 2008-12-15 | Genzyme Corp | Verfahren zur herstellung von benzonitrilen und benzimidosäure-derivaten |
| ITVR20020062A1 (it) * | 2002-06-03 | 2003-12-03 | Andrea Pretto | Preparazione estemporanea di periossiacidi organici stabili nel tempo |
-
2003
- 2003-05-15 AT AT03734040T patent/ATE415387T1/de not_active IP Right Cessation
- 2003-05-15 JP JP2004505355A patent/JP2005538950A/ja active Pending
- 2003-05-15 US US10/439,265 patent/US7038073B2/en not_active Expired - Lifetime
- 2003-05-15 WO PCT/US2003/015339 patent/WO2003097582A2/en not_active Ceased
- 2003-05-15 JP JP2004505315A patent/JP4414331B2/ja not_active Expired - Fee Related
- 2003-05-15 US US10/438,770 patent/US7002036B2/en not_active Expired - Fee Related
- 2003-05-15 US US10/439,341 patent/US6875882B2/en not_active Expired - Lifetime
- 2003-05-15 WO PCT/US2003/015553 patent/WO2003097622A2/en not_active Ceased
- 2003-05-15 AU AU2003247374A patent/AU2003247374A1/en not_active Abandoned
- 2003-05-15 US US10/439,263 patent/US6982335B2/en not_active Expired - Lifetime
- 2003-05-15 EP EP03734040A patent/EP1506162B1/en not_active Expired - Lifetime
- 2003-05-15 EP EP03753073A patent/EP1529037B1/en not_active Expired - Lifetime
- 2003-05-15 US US10/438,745 patent/US6861532B2/en not_active Expired - Lifetime
- 2003-05-15 US US10/439,313 patent/US6903220B2/en not_active Expired - Lifetime
- 2003-05-15 US US10/439,342 patent/US6846958B2/en not_active Expired - Lifetime
- 2003-05-15 US US10/439,282 patent/US6878828B2/en not_active Expired - Lifetime
- 2003-05-15 AU AU2003239472A patent/AU2003239472A1/en not_active Abandoned
- 2003-05-15 US US10/438,744 patent/US6794515B2/en not_active Expired - Lifetime
- 2003-05-15 US US10/439,286 patent/US6875883B2/en not_active Expired - Lifetime
- 2003-05-15 US US10/438,757 patent/US7115769B2/en not_active Expired - Lifetime
-
2004
- 2004-12-09 US US11/008,084 patent/US7294718B2/en not_active Expired - Lifetime
-
2005
- 2005-03-21 US US11/085,824 patent/US7285676B2/en not_active Expired - Lifetime
- 2005-10-03 US US11/242,640 patent/US7285670B2/en not_active Expired - Lifetime
- 2005-11-28 US US11/287,891 patent/US20060142586A1/en not_active Abandoned
- 2005-12-16 US US11/305,305 patent/US7576234B2/en not_active Expired - Fee Related
-
2006
- 2006-08-23 US US11/508,679 patent/US20060281926A1/en not_active Abandoned
- 2006-08-28 JP JP2006231196A patent/JP2007001986A/ja active Pending
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