AU2003239472A1 - Synthesis of benzonitriles and benzimidates - Google Patents

Synthesis of benzonitriles and benzimidates

Info

Publication number
AU2003239472A1
AU2003239472A1 AU2003239472A AU2003239472A AU2003239472A1 AU 2003239472 A1 AU2003239472 A1 AU 2003239472A1 AU 2003239472 A AU2003239472 A AU 2003239472A AU 2003239472 A AU2003239472 A AU 2003239472A AU 2003239472 A1 AU2003239472 A1 AU 2003239472A1
Authority
AU
Australia
Prior art keywords
cysteine
synthesis
peptidal
preparing
amino acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003239472A
Other languages
English (en)
Inventor
Joseph Cherian
Mukund S. Chorghade
Mukund K. Gurjar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genzyme Corp
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of AU2003239472A1 publication Critical patent/AU2003239472A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/53—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/04—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers
    • C07C257/08—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines without replacement of the other oxygen atom of the carboxyl group, e.g. imino-ethers having carbon atoms of imino-carboxyl groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C07C319/06—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols from sulfides, hydropolysulfides or polysulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/02—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols
    • C07C319/12—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of thiols by reactions not involving the formation of mercapto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/12—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24—Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AU2003239472A 2002-05-15 2003-05-15 Synthesis of benzonitriles and benzimidates Abandoned AU2003239472A1 (en)

Applications Claiming Priority (25)

Application Number Priority Date Filing Date Title
US38101702P 2002-05-15 2002-05-15
US38101302P 2002-05-15 2002-05-15
US38090302P 2002-05-15 2002-05-15
US38090902P 2002-05-15 2002-05-15
US38091002P 2002-05-15 2002-05-15
US38102102P 2002-05-15 2002-05-15
US38088002P 2002-05-15 2002-05-15
US38089402P 2002-05-15 2002-05-15
US38089502P 2002-05-15 2002-05-15
US38087802P 2002-05-15 2002-05-15
US38101202P 2002-05-15 2002-05-15
US60/380,903 2002-05-15
US60/381,012 2002-05-15
US60/380,894 2002-05-15
US60/381,013 2002-05-15
US60/380,895 2002-05-15
US60/380,909 2002-05-15
US60/381,017 2002-05-15
US60/380,878 2002-05-15
US60/380,910 2002-05-15
US60/380,880 2002-05-15
US60/381,021 2002-05-15
US39283302P 2002-06-27 2002-06-27
US60/392,833 2002-06-27
PCT/US2003/015339 WO2003097582A2 (en) 2002-05-15 2003-05-15 Synthesis of benzonitriles and benzimidates

Publications (1)

Publication Number Publication Date
AU2003239472A1 true AU2003239472A1 (en) 2003-12-02

Family

ID=29554649

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2003247374A Abandoned AU2003247374A1 (en) 2002-05-15 2003-05-15 Synthesis of 2-alkylcysteines, 2-(hydroxylated phenyl)-4-alkylthiazoline-4-carboxylic acids and derivatives thereof
AU2003239472A Abandoned AU2003239472A1 (en) 2002-05-15 2003-05-15 Synthesis of benzonitriles and benzimidates

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AU2003247374A Abandoned AU2003247374A1 (en) 2002-05-15 2003-05-15 Synthesis of 2-alkylcysteines, 2-(hydroxylated phenyl)-4-alkylthiazoline-4-carboxylic acids and derivatives thereof

Country Status (6)

Country Link
US (17) US7115769B2 (enExample)
EP (2) EP1529037B1 (enExample)
JP (3) JP2005538950A (enExample)
AT (1) ATE415387T1 (enExample)
AU (2) AU2003247374A1 (enExample)
WO (2) WO2003097622A2 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT500490A1 (de) * 2001-10-16 2006-01-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte
US20080086494A1 (en) * 2006-09-11 2008-04-10 Apple Computer, Inc. Transfer and synchronization of media data
WO2003097622A2 (en) * 2002-05-15 2003-11-27 Genzyme Corporation Synthesis of 2-alkylcysteines, 2-(hydroxylated phenyl)-4-alkylthiazoline-4-carboxylic acids and derivatives thereof
US7394410B1 (en) * 2004-02-13 2008-07-01 Samplify Systems, Inc. Enhanced data converters using compression and decompression
US7432086B2 (en) 2004-07-22 2008-10-07 Mitsubishi Gas Chemical Company, Inc. L-amino acid amide asymmetric hydrolase and DNA encoding the same
DE102005054362A1 (de) 2004-12-01 2006-06-08 Degussa Ag Verfahren zur Herstellung von Amino- oder Hydroxybenzonitrilen
US7790720B2 (en) 2005-03-31 2010-09-07 Ucb Pharma, S.A. Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses
JP4173909B1 (ja) 2005-04-28 2008-10-29 ファイザー・リミテッド アミノ酸誘導体
JP2006312614A (ja) * 2005-05-09 2006-11-16 Ajinomoto Co Inc チアゾリン化合物および光学活性α−アルキルシステインの製造方法
US7947837B2 (en) * 2006-10-25 2011-05-24 Polyera Corporation Organic semiconductor materials and methods of preparing and use thereof
US7799934B2 (en) * 2007-06-29 2010-09-21 University Of South Florida Enantioselective ring-opening of aziridines
CN102143928A (zh) * 2008-09-05 2011-08-03 马克斯普朗克科学促进协会 利用两个连续的结晶步骤对化合物形成的手性体系进行对映体拆分的方法
US8765817B1 (en) 2008-12-03 2014-07-01 Arrowhead Center, Inc. Selective inhibitors of EG5 motors and methods of use
US8349899B1 (en) 2008-12-03 2013-01-08 Arrowhead Center, Inc. Selective inhibitors of EG5 motors and methods of use
EP3300717B1 (en) 2009-06-29 2020-09-23 Inolex Investment Corporation Non-petrochemically derived cationic emulsifiers that are neutralized amino acid esters and related compositions and methods
US9279022B1 (en) 2014-09-08 2016-03-08 Sirrus, Inc. Solution polymers including one or more 1,1-disubstituted alkene compounds, solution polymerization methods, and polymer compositions
US10414839B2 (en) 2010-10-20 2019-09-17 Sirrus, Inc. Polymers including a methylene beta-ketoester and products formed therefrom
KR20140092225A (ko) * 2010-10-20 2014-07-23 바이오포믹스, 인크. 불순물이 실질적으로 없는 메틸렌 말로네이트의 합성
US9249265B1 (en) 2014-09-08 2016-02-02 Sirrus, Inc. Emulsion polymers including one or more 1,1-disubstituted alkene compounds, emulsion methods, and polymer compositions
US9828324B2 (en) 2010-10-20 2017-11-28 Sirrus, Inc. Methylene beta-diketone monomers, methods for making methylene beta-diketone monomers, polymerizable compositions and products formed therefrom
CA2853079A1 (en) 2011-10-19 2013-05-10 Bioformix Inc. Methylene beta-ketoester monomers, methods for making methylene beta-ketoester monomers, polymerizable compositions and products formed therefrom
CN102775399A (zh) * 2011-12-27 2012-11-14 盛世泰科生物医药技术(苏州)有限公司 arylhydrocarbon受体(AHR)的内源性配体,2-(1’H3’-吲哚羰基)噻唑-4-羧酸甲酯的合成新方法
CA2869112A1 (en) 2012-03-30 2013-10-03 Bioformix Inc. Composite and laminate articles and polymerizable systems for producing the same
CA2869115A1 (en) 2012-03-30 2013-10-03 Bioformix Inc. Ink and coating formulations and polymerizable systems for producing the same
WO2013149165A1 (en) 2012-03-30 2013-10-03 Bioformix Inc. Methods for activating polymerizable compositions, polymerizable systems, and products formed thereby
WO2013181600A2 (en) 2012-06-01 2013-12-05 Bioformix Inc. Optical material and articles formed therefrom
WO2014078689A1 (en) 2012-11-16 2014-05-22 Bioformix Inc. Plastics bonding systems and methods
CN105164797B (zh) 2012-11-30 2019-04-19 瑟拉斯公司 用于电子应用的复合组合物
CN105008321A (zh) 2013-01-11 2015-10-28 瑟拉斯公司 经过双(羟甲基)丙二酸酯的途径获得亚甲基丙二酸酯的方法
US9315597B2 (en) 2014-09-08 2016-04-19 Sirrus, Inc. Compositions containing 1,1-disubstituted alkene compounds for preparing polymers having enhanced glass transition temperatures
US9416091B1 (en) 2015-02-04 2016-08-16 Sirrus, Inc. Catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US10501400B2 (en) 2015-02-04 2019-12-10 Sirrus, Inc. Heterogeneous catalytic transesterification of ester compounds with groups reactive under transesterification conditions
US9334430B1 (en) 2015-05-29 2016-05-10 Sirrus, Inc. Encapsulated polymerization initiators, polymerization systems and methods using the same
US9217098B1 (en) 2015-06-01 2015-12-22 Sirrus, Inc. Electroinitiated polymerization of compositions having a 1,1-disubstituted alkene compound
US9518001B1 (en) 2016-05-13 2016-12-13 Sirrus, Inc. High purity 1,1-dicarbonyl substituted-1-alkenes and methods for their preparation
US9617377B1 (en) 2016-06-03 2017-04-11 Sirrus, Inc. Polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes
US10428177B2 (en) 2016-06-03 2019-10-01 Sirrus, Inc. Water absorbing or water soluble polymers, intermediate compounds, and methods thereof
US10196481B2 (en) 2016-06-03 2019-02-05 Sirrus, Inc. Polymer and other compounds functionalized with terminal 1,1-disubstituted alkene monomer(s) and methods thereof
US9567475B1 (en) 2016-06-03 2017-02-14 Sirrus, Inc. Coatings containing polyester macromers containing 1,1-dicarbonyl-substituted 1 alkenes

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2062210A5 (enExample) 1969-09-17 1971-06-25 Godo Shusei Kk
DE2020866A1 (de) 1970-04-29 1971-11-18 Basf Ag Verfahren zur Herstellung von Hydroxy- und Aminobenzonitrilen
DE3002989A1 (de) 1980-01-29 1981-07-30 Hoechst Ag, 6000 Frankfurt Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels
DE3170401D1 (en) 1980-07-28 1985-06-13 Ciba Geigy Ag Triazoline derivatives and processes for their preparation
GB9126832D0 (en) 1991-12-18 1992-02-19 Sandoz Ltd Separation process
AU5602594A (en) 1992-11-16 1994-06-08 University Of Florida Research Foundation, Inc. 2-(pyrid-2'-yl)-2-thiazoline-4(s)-carboxylic acid derivatives
US5840739A (en) 1992-11-16 1998-11-24 University Of Florida Research Foundation, Inc. Thiazoline acid derivatives
JPH08512281A (ja) * 1993-02-26 1996-12-24 メレル ダウ ファーマス−ティカルズ インコーポレイテッド アデノシンａ▲下１▼受容体拮抗剤としてのキサンチン誘導体類
US5554753A (en) 1993-08-25 1996-09-10 Indiana University Foundation Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis
US5859001A (en) * 1996-01-11 1999-01-12 University Of Florida Research Foundation, Inc. Neuroprotective effects of polycyclic phenolic compounds
US6197833B1 (en) * 1995-07-24 2001-03-06 Apollo Biopharmaceutics, Inc. Neuroprotective effects of polycyclic phenolic compounds
US6319914B1 (en) * 1993-11-05 2001-11-20 Apollo Biopharmaceuticals, Inc. Cytoprotective effect of polycyclic phenolic compounds
US5554601A (en) * 1993-11-05 1996-09-10 University Of Florida Methods for neuroprotection
US6350739B1 (en) * 1999-08-11 2002-02-26 University Of Florida Resarch Foundation, Inc. Methods of prevention and treatment of ischemic damage
US5877169A (en) * 1993-11-05 1999-03-02 University Of Florida Research Foundation, Inc. Methods of treatment of ischemic damage
US5665890A (en) 1995-03-14 1997-09-09 President And Fellows Of Harvard College Stereoselective ring opening reactions
US6383233B1 (en) 1996-03-10 2002-05-07 Reuter Chemicscher Apparatebau Kg Separation process
WO1998031381A1 (en) * 1997-01-16 1998-07-23 University Of Florida Research Foundation, Incorporated Compositions to enhance the cytoprotective effects of polycyclic phenolic compounds through the synergistic interaction with anti-oxidants
JP2001515776A (ja) * 1997-09-06 2001-09-25 ロイター・ヒェーミシェ・アパラーテバウ・コマンディート・ゲゼルシャフト 分離法
US6172088B1 (en) * 1997-11-24 2001-01-09 University Of Florida Research Foundation, Inc. Testosterone compounds and use for the protection of neurons
US6407281B1 (en) * 1998-01-13 2002-06-18 Kaneka Corporation Process for producing optically active cysteine derivatives
US5929252A (en) * 1998-06-15 1999-07-27 The Scripps Research Institute Aziridination of olefins
US6765109B1 (en) * 1998-06-29 2004-07-20 Roche Colorado Corporation Preparation of S-aryl-cysteine and its derivatives
JP2002519410A (ja) 1998-07-03 2002-07-02 リューコサイト インク 置換された窒素及びイオウの脂環式化合物、およびその合成法
US6083966A (en) 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
US6159983A (en) 1998-09-18 2000-12-12 University Of Florida Method and composition for treatment of inflammatory bowel disease
NZ526880A (en) 1998-09-21 2005-05-27 Univ Florida Antimalarial agents
EP1120407B1 (en) * 1998-10-09 2013-02-20 Ajinomoto Co., Inc. Cystine derivatives
US6339078B1 (en) * 1999-07-20 2002-01-15 University Of Florida Research Foundation, Inc. Methods of prevention and treatment of ischemic damage
US6326365B1 (en) * 1999-07-20 2001-12-04 Apollo Biopharmaceutics, Inc. Methods of prevention and treatment of ischemic damage
DE20000122U1 (de) * 2000-01-05 2000-04-20 ABT Advanced Bioanalytical Technology GmbH & Co KG, 01454 Radeberg Mobiles Handgerät mit wiederverwendbarem Biosensor
HK1054392B (zh) 2000-01-14 2005-11-18 H‧隆德贝克有限公司 製備5-氰基2-苯並[c]呋喃酮的方法
AT500490A1 (de) 2001-10-16 2006-01-15 Dsm Fine Chem Austria Gmbh Verfahren zur herstellung von substituierten thiazolinen und deren zwischenprodukte
WO2003097622A2 (en) * 2002-05-15 2003-11-27 Genzyme Corporation Synthesis of 2-alkylcysteines, 2-(hydroxylated phenyl)-4-alkylthiazoline-4-carboxylic acids and derivatives thereof
ITVR20020062A1 (it) * 2002-06-03 2003-12-03 Andrea Pretto Preparazione estemporanea di periossiacidi organici stabili nel tempo

Also Published As

Publication number Publication date
US20030236434A1 (en) 2003-12-25
AU2003247374A8 (en) 2003-12-02
US7285670B2 (en) 2007-10-23
US6903220B2 (en) 2005-06-07
ATE415387T1 (de) 2008-12-15
EP1529037A2 (en) 2005-05-11
US6982335B2 (en) 2006-01-03
JP2005525427A (ja) 2005-08-25
US20040082796A1 (en) 2004-04-29
US20030236435A1 (en) 2003-12-25
US7285676B2 (en) 2007-10-23
US20030225287A1 (en) 2003-12-04
US7576234B2 (en) 2009-08-18
US20030220504A1 (en) 2003-11-27
US6875882B2 (en) 2005-04-05
WO2003097622A2 (en) 2003-11-27
US20040006224A1 (en) 2004-01-08
AU2003247374A1 (en) 2003-12-02
US20030236404A1 (en) 2003-12-25
WO2003097582A3 (en) 2004-02-12
US7002036B2 (en) 2006-02-21
US20030229231A1 (en) 2003-12-11
US6875883B2 (en) 2005-04-05
EP1506162A2 (en) 2005-02-16
WO2003097582A2 (en) 2003-11-27
US20050209462A1 (en) 2005-09-22
US20060281926A1 (en) 2006-12-14
US7115769B2 (en) 2006-10-03
JP2007001986A (ja) 2007-01-11
WO2003097622A3 (en) 2004-04-08
US6794515B2 (en) 2004-09-21
JP4414331B2 (ja) 2010-02-10
US20060217561A1 (en) 2006-09-28
US6846958B2 (en) 2005-01-25
US20060069265A1 (en) 2006-03-30
EP1529037B1 (en) 2009-07-15
US20040002613A1 (en) 2004-01-01
JP2005538950A (ja) 2005-12-22
US20040024224A1 (en) 2004-02-05
US20060142586A1 (en) 2006-06-29
US20060167267A1 (en) 2006-07-27
US6861532B2 (en) 2005-03-01
US6878828B2 (en) 2005-04-12
EP1506162B1 (en) 2008-11-26
US7038073B2 (en) 2006-05-02
US7294718B2 (en) 2007-11-13
US20030236426A1 (en) 2003-12-25

Similar Documents

Publication Publication Date Title
AU2003239472A1 (en) Synthesis of benzonitriles and benzimidates
EP1312601A4 (en) CARBOXYLENE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICAMENTS CONTAINING THEM AS AN ACTIVE SUBSTANCE
PT1196414E (pt) Pro-farmacos de inibidores carbamato de impdh
SI1767535T1 (sl) Sinteza epotilonov njihovih intermediatov analogov in uporaba le teh
EE04911B1 (et) Ühend ja farmatseutiline kompositsioon proteaasi inhibiitoritena, nende kasutamine ning meetod selle ühendi valmistamiseks
TR200401739T4 (tr) Persikuinnin, üretimi ve ilaç olarak kullanımı için bir işlem
AU9419601A (en) Nitrogenous five-membered ring compounds
ZA200704236B (en) An oral preparation having improved bioavailability
TW200507831A (en) Combination comprising s-[2-([[1-(2-ethylbutyl)cyclohexyl] carbonyl]amino)phenyl]2-methylpropanethioate and an HMG CoA reductase inhibitor
MXPA04000357A (es) COMPUESTO QUE CONTIENE AMIDA Y TIENE UNA MEJOR SOLUBILIDAD, Y MeTODO PARA MEJORAR LA SOLUBILIDAD DE UN COMPUESTO QUE CONTIENE AMIDA.
AU9093901A (en) Creatine ester pronutrient compounds and formulations
AU6117598A (en) Compounds
WO2003004457A3 (en) Preparation process for atorvastatin and intermediates
BR0104188A (pt) Processo para a preparação fermentativa de l-aminoácidos não proteinogênicos
DK1421946T3 (da) Et farmaceutisk præparat til behandling af HIV-infektion
IL153830A0 (en) A PROCESS FOR THE PREPARATION OF alpha' CHLOROKETONES
DE602004031129D1 (de) Verfahren zur herstellung von quetiapin
DE60040592D1 (de) Verfahren zur herstellung von alpha-aminoketonen
ATE281522T1 (de) Sentrin-spezifische menschliche protease senp1
TR200000672T2 (tr) Epoksit aramaddeleri hazırlamak için bir işlem.
HU0102118D0 (en) Process for chloromethylation
DE60308663D1 (de) Verwendung eines neuen mittels zur verhütung von infektionen
TW200505872A (en) Hepatitis C virus inhibitors
NO20020328L (no) Fremgangsmåte for fremstilling av 4-cyano-2-aminometyltiazol
TW200509941A (en) Pharmaceutical solution composition

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase