JP2006514956A5 - - Google Patents
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- Publication number
- JP2006514956A5 JP2006514956A5 JP2004565510A JP2004565510A JP2006514956A5 JP 2006514956 A5 JP2006514956 A5 JP 2006514956A5 JP 2004565510 A JP2004565510 A JP 2004565510A JP 2004565510 A JP2004565510 A JP 2004565510A JP 2006514956 A5 JP2006514956 A5 JP 2006514956A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- alkylene
- group
- cycloalkylene
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 12
- -1 monofluoroalkyl Chemical group 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 150000002431 hydrogen Chemical group 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- VKIODPSRTWIKKR-UHFFFAOYSA-N [2-chloro-4-[3-(hydroxymethyl)pyrazol-1-yl]phenyl]-(6,11-dihydropyrrolo[2,1-c][1,4]benzodiazepin-5-yl)methanone Chemical compound N1=C(CO)C=CN1C(C=C1Cl)=CC=C1C(=O)N1C2=CC=CC=C2CN2C=CC=C2C1 VKIODPSRTWIKKR-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000003710 aryl alkyl group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 125000005010 perfluoroalkyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 208000008967 Enuresis Diseases 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000006350 alkyl thio alkyl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 239000003638 chemical reducing agent Substances 0.000 claims 1
- 125000002993 cycloalkylene group Chemical group 0.000 claims 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 206010029446 nocturia Diseases 0.000 claims 1
- 208000005346 nocturnal enuresis Diseases 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/320,761 US7138393B2 (en) | 1998-07-24 | 2002-12-16 | Biologically active vasopressin agonist metabolites |
| PCT/US2003/039897 WO2004060894A1 (en) | 2002-12-16 | 2003-12-16 | Pyrrolo`2,1-c!`1,4! benzodiazepines as vasopressin agonists |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2006514956A JP2006514956A (ja) | 2006-05-18 |
| JP2006514956A5 true JP2006514956A5 (enExample) | 2008-03-27 |
Family
ID=32710746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004565510A Pending JP2006514956A (ja) | 2002-12-16 | 2003-12-16 | バソプレッシンアゴニストとしてのピロロ［２，１−ｃ］［１，４］ベンゾジアゼピン |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7138393B2 (enExample) |
| EP (1) | EP1572694B1 (enExample) |
| JP (1) | JP2006514956A (enExample) |
| CN (1) | CN1745083A (enExample) |
| AR (1) | AR042467A1 (enExample) |
| AT (1) | ATE410428T1 (enExample) |
| AU (1) | AU2003297127A1 (enExample) |
| BR (1) | BR0317383A (enExample) |
| CA (1) | CA2508764A1 (enExample) |
| DE (1) | DE60324018D1 (enExample) |
| DK (1) | DK1572694T3 (enExample) |
| ES (1) | ES2312859T3 (enExample) |
| MX (1) | MXPA05006241A (enExample) |
| TW (1) | TW200413355A (enExample) |
| WO (1) | WO2004060894A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0210397D0 (en) * | 2002-05-07 | 2002-06-12 | Ferring Bv | Pharmaceutical formulations |
| CN101801452B (zh) | 2007-08-06 | 2014-10-22 | 阿勒根公司 | 用于去氨加压素药物给送的设备 |
| US20100286045A1 (en) | 2008-05-21 | 2010-11-11 | Bjarke Mirner Klein | Methods comprising desmopressin |
| US11963995B2 (en) | 2008-05-21 | 2024-04-23 | Ferring B.V. | Methods comprising desmopressin |
| LT3225249T (lt) | 2008-05-21 | 2019-01-10 | Ferring B.V. | Burnoje disperguojamas desmopresinas, skirtas pirminio miego periodo, nepertraukiamo nikturija, pailginimui |
| MX2011005119A (es) * | 2008-11-18 | 2011-05-30 | Hoffmann La Roche | Alquilciclohexileteres de dihidrotetraazabenzoazulenos. |
| US10010514B2 (en) | 2010-07-08 | 2018-07-03 | Wellesley Pharmaceuticals, Llc | Pharmaceutical formulation for reducing frequency of urination and method of use thereof |
| US9532959B2 (en) | 2010-07-08 | 2017-01-03 | Wellesley Pharmaceuticals, Llc | Pharmaceutical formulation for reducing frequency of urination and method of use thereof |
| US10105330B2 (en) | 2012-01-04 | 2018-10-23 | Wellesley Pharmaceuticals, Llc | Extended, delayed and immediate release formulation method of manufacturing and use thereof |
| WO2013103389A1 (en) * | 2012-01-04 | 2013-07-11 | Wellesley Pharmaceuticals, Llc | Delayed-release formulation for reducing the frequency of urination and method of use thereof |
| US10278925B2 (en) | 2012-01-04 | 2019-05-07 | Wellesley Pharmaceuticals, Llc | Delayed-release formulations, methods of making and use thereof |
| MX2014008283A (es) * | 2012-01-04 | 2015-03-03 | Wellesley Pharmaceutical Llc | Formulacion de liberacion prolongada para reducir la frecuencia de orinar y metodos de uso de esta. |
| US10105328B2 (en) | 2014-06-06 | 2018-10-23 | Wellesley Pharmaceuticals, Llc | Composition for reducing frequency of urination, method of making and use thereof |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1251767B (de) | 1964-02-28 | 1968-04-18 | Dr Karl Thomae Gesellschaft mit beschrankter Haftung Biberach/Riß | Verfahren zur Herstellung von neuen m 6 Stellung substituierten 5 6 Dihydro-5oxo HH pyrido[2,3-b] [l,5]benzodiazepinen |
| US4680298A (en) | 1983-05-31 | 1987-07-14 | Schering Corporation | Tricyclic anti-allergy and use as anti-inflammatory agents |
| US4766108A (en) | 1986-12-04 | 1988-08-23 | Smith Kline Beckman Corporation | Tyr-Arg-vasopressin antagonists |
| US5055448A (en) | 1987-06-25 | 1991-10-08 | Medical College Of Ohio | Linear derivatives of arginine vasopressin antagonists |
| US4839355A (en) | 1987-09-09 | 1989-06-13 | Sterling Drug Inc. | Tricyclic-pyridinylquinoline compounds, their preparation and use |
| US5070187A (en) | 1989-11-03 | 1991-12-03 | Trustees Of Boston University | Pharmacologically effective antagonists of arginine-vasopressin |
| CA2048003A1 (en) | 1990-08-21 | 1992-02-22 | Serge Burner | Tricyclic pyridone derivatives |
| US5516774A (en) | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
| US5512563A (en) | 1993-07-29 | 1996-04-30 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5420270A (en) | 1993-10-07 | 1995-05-30 | G. D. Searle & Co. | Aryl substituted dibenzoxazepine compounds, pharmaceutical compositions and methods of use |
| ES2284741T3 (es) | 1994-06-15 | 2007-11-16 | Otsuka Pharmaceutical Company, Limited | Derivados de benzoheterociclicos utilizados como moduladores de vasoprsinao de oxitocina. |
| JPH0881460A (ja) | 1994-09-08 | 1996-03-26 | Yamanouchi Pharmaceut Co Ltd | 新規なテトラヒドロベンゾジアゼピン誘導体又はその塩 |
| US5536718A (en) | 1995-01-17 | 1996-07-16 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| AR002459A1 (es) | 1995-01-17 | 1998-03-25 | American Cyanamid Co | Antagonistas de vasopresina de benzacepina triciclicos, una composicion farmaceutica que los contiene, un metodo para tratar enfermedades y unprocedimiento para su preparacion. |
| US5521173A (en) | 1995-01-17 | 1996-05-28 | American Home Products Corporation | Tricyclic benzazepine vasopressin antagonists |
| TW359669B (en) | 1995-12-15 | 1999-06-01 | Otsuka Pharma Co Ltd | Benzazepine derivatives |
| US5880122A (en) | 1996-11-01 | 1999-03-09 | American Home Products Corporation | 3-Carboxamide derivatives of 5H-pyrrolo 2,1-c! 1,4!-benzodiazepines |
| AU727654B2 (en) | 1997-06-13 | 2000-12-21 | Yamanouchi Pharmaceutical Co., Ltd. | Tricyclic pyrazole derivative |
| EP1000062B1 (en) | 1997-07-30 | 2004-09-22 | Wyeth | Tricyclic vasopressin agonists |
| US6194407B1 (en) | 1997-07-30 | 2001-02-27 | American Home Products Corporation | Tricyclic pyrido vasopressin agonists |
| US6297234B1 (en) | 1999-02-04 | 2001-10-02 | American Home Products Corporation | Arylthiophene vasopressin agonists |
| JP2002536378A (ja) | 1999-02-04 | 2002-10-29 | ワイス | ピロロベンゾジアゼピンカルボキシアミドバソプレシンアゴニスト |
| MXPA02003190A (es) | 1999-09-27 | 2002-09-30 | American Cyanamid Co | Formulacion para portadores farmaceuticos. |
| CN1391476A (zh) | 1999-09-27 | 2003-01-15 | 美国氰胺公司 | 血管升压素激动剂制剂和方法 |
| GB0000079D0 (en) | 2000-01-05 | 2000-02-23 | Ferring Bv | Novel antidiuretic agents |
| GB0015601D0 (en) | 2000-06-26 | 2000-08-16 | Ferring Bv | Novel antidiuretic agents |
-
2002
- 2002-12-16 US US10/320,761 patent/US7138393B2/en not_active Expired - Fee Related
-
2003
- 2003-12-09 TW TW092134683A patent/TW200413355A/zh unknown
- 2003-12-15 AR ARP030104629A patent/AR042467A1/es not_active Application Discontinuation
- 2003-12-16 DK DK03814820T patent/DK1572694T3/da active
- 2003-12-16 ES ES03814820T patent/ES2312859T3/es not_active Expired - Lifetime
- 2003-12-16 JP JP2004565510A patent/JP2006514956A/ja active Pending
- 2003-12-16 BR BR0317383-6A patent/BR0317383A/pt not_active IP Right Cessation
- 2003-12-16 EP EP03814820A patent/EP1572694B1/en not_active Expired - Lifetime
- 2003-12-16 CA CA002508764A patent/CA2508764A1/en not_active Abandoned
- 2003-12-16 WO PCT/US2003/039897 patent/WO2004060894A1/en not_active Ceased
- 2003-12-16 CN CNA2003801095935A patent/CN1745083A/zh active Pending
- 2003-12-16 MX MXPA05006241A patent/MXPA05006241A/es active IP Right Grant
- 2003-12-16 DE DE60324018T patent/DE60324018D1/de not_active Expired - Lifetime
- 2003-12-16 AU AU2003297127A patent/AU2003297127A1/en not_active Withdrawn
- 2003-12-16 AT AT03814820T patent/ATE410428T1/de not_active IP Right Cessation
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