AR042467A1 - Compuestos de 5h-pirrolo[2,1-c][1,4]benzodiazepina agonistas de vasopresina biologicamente activos - Google Patents

Compuestos de 5h-pirrolo[2,1-c][1,4]benzodiazepina agonistas de vasopresina biologicamente activos

Info

Publication number
AR042467A1
AR042467A1 ARP030104629A ARP030104629A AR042467A1 AR 042467 A1 AR042467 A1 AR 042467A1 AR P030104629 A ARP030104629 A AR P030104629A AR P030104629 A ARP030104629 A AR P030104629A AR 042467 A1 AR042467 A1 AR 042467A1
Authority
AR
Argentina
Prior art keywords
alkylene
group
cycloalkylene
compounds
heteroaryl
Prior art date
Application number
ARP030104629A
Other languages
English (en)
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR042467A1 publication Critical patent/AR042467A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Abstract

La presente se refiere a compuestos de la fórmula (1) donde W representa ya sea un O unido por doble enlace o bien dos H unidos por simple enlace; R1 es seleccionado del grupo formado por R, R3-X-R2-, R3-S(O)-, R3-S(O)2-, -SO3R4, -S(O)2N(R )2, y D-glucuronidato, cuando W es H. O R1 es seleccionado del grupo formado por H, alquilo, cicloalquilo, arilo, arilalquilo, heteroarilo, y heteroarilalquilo, cuando W es O; R2 es seleccionado del grupo que consiste de alquileno, cicloalquileno, alquilen-X-alquileno, alquilen-X-cicloalquileno, cicloalquilen-X-alquileno, y cicloalquilen-X-cicloalquileno; R3 es seleccionado del grupo que consiste de alquilo, arilo, heteroarilo, cicloalquilo, alquenilo, cicloalquenilo, alquinilo, alquenil-X-alquileno, cicl9oalquenil-X-alquileno, y perfluoroalquilo; R4 es seleccionado del grupo que consiste de H y R3; R3 es independientemente seleccionado del grupo que consiste de H, alquilo, alquenilo, alquinilo, ciclo-alquilo, cicloalquenilo, monofluoroalquilo, perfluoroalquilo, arilo, arilalquilo, heteroarilo, heteroarilalquilo, hidroxialquilo (C1-6), alcoxialquilo, alquiltioalquilo, acilo, alcoxicarbonilo, -C(O)NH2, alquilaminocarbonilo, dialquilaminocarbonilo, alquilaminalquilo, y dialquilaminalquilo, y cuando dos grupos R se encuentran unidos al mismo átomo estos dos grupos juntos pueden formar un grupo alquileno; X es seleccionado del grupo que consiste de O, -NR-, -S(O)m-, -C(O)-, -OC(O)-, -C(O)O-, -NRC(O)-, y -C(O)NR-; y m es un entero seleccionado de 0, 1, y 2, y los racematos, enantiómeros, y las sales farmacéuticamente aceptables de lo mismo, un proceso para su fabricación y las formulaciones farmacéuticas que contienen a dichos compuestos las cuales son útiles como agentes anti-acuareticos en el tratamiento de la enuresis urinaria nocturna, la emergencia urinaria nocturna, y/o condiciones similares.
ARP030104629A 2002-12-16 2003-12-15 Compuestos de 5h-pirrolo[2,1-c][1,4]benzodiazepina agonistas de vasopresina biologicamente activos AR042467A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10/320,761 US7138393B2 (en) 1998-07-24 2002-12-16 Biologically active vasopressin agonist metabolites

Publications (1)

Publication Number Publication Date
AR042467A1 true AR042467A1 (es) 2005-06-22

Family

ID=32710746

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030104629A AR042467A1 (es) 2002-12-16 2003-12-15 Compuestos de 5h-pirrolo[2,1-c][1,4]benzodiazepina agonistas de vasopresina biologicamente activos

Country Status (15)

Country Link
US (1) US7138393B2 (es)
EP (1) EP1572694B1 (es)
JP (1) JP2006514956A (es)
CN (1) CN1745083A (es)
AR (1) AR042467A1 (es)
AT (1) ATE410428T1 (es)
AU (1) AU2003297127A1 (es)
BR (1) BR0317383A (es)
CA (1) CA2508764A1 (es)
DE (1) DE60324018D1 (es)
DK (1) DK1572694T3 (es)
ES (1) ES2312859T3 (es)
MX (1) MXPA05006241A (es)
TW (1) TW200413355A (es)
WO (1) WO2004060894A1 (es)

Families Citing this family (13)

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Publication number Priority date Publication date Assignee Title
GB0210397D0 (en) * 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
RU2472539C2 (ru) 2007-08-06 2013-01-20 Аллерган, Инк. Способы и устройства для доставки препарата десмопрессина
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
PT3085381T (pt) * 2008-05-21 2018-05-18 Ferring Bv Desmopressina orodispersível para aumentar o período inicial de sono não perturbado pela noctúria
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
MX2011005119A (es) * 2008-11-18 2011-05-30 Hoffmann La Roche Alquilciclohexileteres de dihidrotetraazabenzoazulenos.
US9532959B2 (en) 2010-07-08 2017-01-03 Wellesley Pharmaceuticals, Llc Pharmaceutical formulation for reducing frequency of urination and method of use thereof
US10010514B2 (en) 2010-07-08 2018-07-03 Wellesley Pharmaceuticals, Llc Pharmaceutical formulation for reducing frequency of urination and method of use thereof
US10278925B2 (en) 2012-01-04 2019-05-07 Wellesley Pharmaceuticals, Llc Delayed-release formulations, methods of making and use thereof
US10105330B2 (en) 2012-01-04 2018-10-23 Wellesley Pharmaceuticals, Llc Extended, delayed and immediate release formulation method of manufacturing and use thereof
AU2012363788B2 (en) * 2012-01-04 2017-03-09 Wellesley Pharmaceuticals, Llc Delayed-release formulation for reducing the frequency of urination and method of use thereof
KR20180025993A (ko) * 2012-01-04 2018-03-09 웰즐리 파마슈티컬스 엘엘씨 배뇨 빈도를 감소시키기 위한 연장-방출형 제제 및 이의 사용 방법
US10105328B2 (en) 2014-06-06 2018-10-23 Wellesley Pharmaceuticals, Llc Composition for reducing frequency of urination, method of making and use thereof

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DE1251767B (de) 1964-02-28 1968-04-18 Dr Karl Thomae Gesellschaft mit beschrankter Haftung Biberach/Riß Verfahren zur Herstellung von neuen m 6 Stellung substituierten 5 6 Dihydro-5oxo HH pyrido[2,3-b] [l,5]benzodiazepinen
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Also Published As

Publication number Publication date
US20030134845A1 (en) 2003-07-17
ES2312859T3 (es) 2009-03-01
CA2508764A1 (en) 2004-07-22
MXPA05006241A (es) 2005-08-19
EP1572694A1 (en) 2005-09-14
EP1572694B1 (en) 2008-10-08
TW200413355A (en) 2004-08-01
JP2006514956A (ja) 2006-05-18
BR0317383A (pt) 2005-11-16
ATE410428T1 (de) 2008-10-15
CN1745083A (zh) 2006-03-08
DE60324018D1 (de) 2008-11-20
US7138393B2 (en) 2006-11-21
DK1572694T3 (da) 2009-02-02
AU2003297127A1 (en) 2004-07-29
WO2004060894A1 (en) 2004-07-22

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