JP2001502713A - アミノ酸受容体の結合部位に対するアフィニティーを有するベンゾアキソゾール誘導体 - Google Patents

アミノ酸受容体の結合部位に対するアフィニティーを有するベンゾアキソゾール誘導体

Info

Publication number
JP2001502713A
JP2001502713A JP10519971A JP51997198A JP2001502713A JP 2001502713 A JP2001502713 A JP 2001502713A JP 10519971 A JP10519971 A JP 10519971A JP 51997198 A JP51997198 A JP 51997198A JP 2001502713 A JP2001502713 A JP 2001502713A
Authority
JP
Japan
Prior art keywords
formula
acid
compound
disease
physiologically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP10519971A
Other languages
English (en)
Japanese (ja)
Inventor
プルッヒャー，ヘルムート
ゴットシュリッヒ，ルドルフ
レイブロック，ヨアヒム
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of JP2001502713A publication Critical patent/JP2001502713A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP10519971A 1996-10-30 1997-10-10 アミノ酸受容体の結合部位に対するアフィニティーを有するベンゾアキソゾール誘導体 Pending JP2001502713A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19643790.3 1996-10-30
DE19643790A DE19643790A1 (de) 1996-10-30 1996-10-30 Benzoxazol-Derivat
PCT/EP1997/005590 WO1998018793A1 (de) 1996-10-30 1997-10-10 Benzoxazolderivat mit affinität zu bindungsstellen von aminosäurerezeptoren

Publications (1)

Publication Number Publication Date
JP2001502713A true JP2001502713A (ja) 2001-02-27

Family

ID=7809592

Family Applications (1)

Application Number Title Priority Date Filing Date
JP10519971A Pending JP2001502713A (ja) 1996-10-30 1997-10-10 アミノ酸受容体の結合部位に対するアフィニティーを有するベンゾアキソゾール誘導体

Country Status (16)

Country Link
EP (1) EP0938485A1 (ko)
JP (1) JP2001502713A (ko)
KR (1) KR20000052876A (ko)
CN (1) CN1235604A (ko)
AR (1) AR008512A1 (ko)
AU (1) AU4946597A (ko)
BR (1) BR9712577A (ko)
CA (1) CA2270359A1 (ko)
CZ (1) CZ147999A3 (ko)
DE (1) DE19643790A1 (ko)
HU (1) HUP9904547A3 (ko)
NO (1) NO992063D0 (ko)
PL (1) PL332771A1 (ko)
SK (1) SK53699A3 (ko)
WO (1) WO1998018793A1 (ko)
ZA (1) ZA979725B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010540579A (ja) * 2007-10-05 2010-12-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 腫瘍の治療のためのピペリジンおよびピペラジン誘導体

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9725541D0 (en) * 1997-12-02 1998-02-04 Pharmacia & Upjohn Spa Amino-benzothiazole derivatives
DE19812331A1 (de) 1998-03-20 1999-09-23 Merck Patent Gmbh Piperidinderivate
PE20000728A1 (es) 1998-06-26 2000-08-21 Cocensys Inc Heterociclos 4-bencil piperidina alquilsulfoxido y su uso como antagonistas receptores subtipo-selectivo nmda
US6476041B1 (en) * 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
DE10120159A1 (de) * 2001-04-25 2002-10-31 Merck Patent Gmbh NMDA-Antagonisten und NMDA-Agonisten zur Behandlung von Suchterkrankungen
CZ2004233A3 (cs) 2001-07-24 2004-12-15 Richter Gedeon Vegyészeti Gyár Rt. Nové amidové sloučeniny karboxylové kyseliny
DE102009049211A1 (de) 2009-10-13 2011-04-28 Merck Patent Gmbh Sulfoxide
KR20140097132A (ko) 2011-11-22 2014-08-06 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 허혈성 손상을 치료하기 위한 시스테아민 및/또는 시스타민

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0709384T3 (da) * 1994-10-31 1999-08-23 Merck Patent Gmbh Benzylpiperidinderivater med høj affinitet til aminosyrereceptorers bindingssteder

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010540579A (ja) * 2007-10-05 2010-12-24 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 腫瘍の治療のためのピペリジンおよびピペラジン誘導体
JP2014129427A (ja) * 2007-10-05 2014-07-10 Merck Patent Gmbh 腫瘍の治療のためのピペリジンおよびピペラジン誘導体

Also Published As

Publication number Publication date
KR20000052876A (ko) 2000-08-25
CZ147999A3 (cs) 1999-08-11
AU4946597A (en) 1998-05-22
HUP9904547A3 (en) 2001-01-29
HUP9904547A2 (hu) 2000-12-28
EP0938485A1 (de) 1999-09-01
AR008512A1 (es) 2000-01-19
DE19643790A1 (de) 1998-05-07
ZA979725B (en) 1998-05-22
PL332771A1 (en) 1999-10-11
NO992063L (no) 1999-04-29
WO1998018793A1 (de) 1998-05-07
SK53699A3 (en) 2000-03-13
CN1235604A (zh) 1999-11-17
CA2270359A1 (en) 1998-05-07
BR9712577A (pt) 1999-10-19
NO992063D0 (no) 1999-04-29

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