CA2270359A1 - Benzoaxozole derivative - Google Patents

Benzoaxozole derivative Download PDF

Info

Publication number
CA2270359A1
CA2270359A1 CA002270359A CA2270359A CA2270359A1 CA 2270359 A1 CA2270359 A1 CA 2270359A1 CA 002270359 A CA002270359 A CA 002270359A CA 2270359 A CA2270359 A CA 2270359A CA 2270359 A1 CA2270359 A1 CA 2270359A1
Authority
CA
Canada
Prior art keywords
formula
compound
acid
disease
physiologically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002270359A
Other languages
English (en)
French (fr)
Inventor
Helmut Prucher
Rudolf Gottschlich
Joachim Leibrock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2270359A1 publication Critical patent/CA2270359A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002270359A 1996-10-30 1997-10-10 Benzoaxozole derivative Abandoned CA2270359A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19643790.3 1996-10-30
DE19643790A DE19643790A1 (de) 1996-10-30 1996-10-30 Benzoxazol-Derivat
PCT/EP1997/005590 WO1998018793A1 (de) 1996-10-30 1997-10-10 Benzoxazolderivat mit affinität zu bindungsstellen von aminosäurerezeptoren

Publications (1)

Publication Number Publication Date
CA2270359A1 true CA2270359A1 (en) 1998-05-07

Family

ID=7809592

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002270359A Abandoned CA2270359A1 (en) 1996-10-30 1997-10-10 Benzoaxozole derivative

Country Status (16)

Country Link
EP (1) EP0938485A1 (ko)
JP (1) JP2001502713A (ko)
KR (1) KR20000052876A (ko)
CN (1) CN1235604A (ko)
AR (1) AR008512A1 (ko)
AU (1) AU4946597A (ko)
BR (1) BR9712577A (ko)
CA (1) CA2270359A1 (ko)
CZ (1) CZ147999A3 (ko)
DE (1) DE19643790A1 (ko)
HU (1) HUP9904547A3 (ko)
NO (1) NO992063L (ko)
PL (1) PL332771A1 (ko)
SK (1) SK53699A3 (ko)
WO (1) WO1998018793A1 (ko)
ZA (1) ZA979725B (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284774B1 (en) 1998-06-26 2001-09-04 Warner-Lambert Company 4-Benzyl piperidine alkylsulfoxide heterocycles and their use as subtype-selective NMDA receptor antagonists

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9725541D0 (en) * 1997-12-02 1998-02-04 Pharmacia & Upjohn Spa Amino-benzothiazole derivatives
DE19812331A1 (de) * 1998-03-20 1999-09-23 Merck Patent Gmbh Piperidinderivate
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
DE10120159A1 (de) * 2001-04-25 2002-10-31 Merck Patent Gmbh NMDA-Antagonisten und NMDA-Agonisten zur Behandlung von Suchterkrankungen
ATE408611T1 (de) 2001-07-24 2008-10-15 Richter Gedeon Nyrt Piperidine als nmda-rezeptorantagonisten
DE102007047737A1 (de) * 2007-10-05 2009-04-30 Merck Patent Gmbh Piperidin- und Piperazinderivate
DE102009049211A1 (de) 2009-10-13 2011-04-28 Merck Patent Gmbh Sulfoxide
SG11201402472QA (en) 2011-11-22 2014-06-27 Univ California Cysteamine and/or cystamine for treating ischemic injury

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE174915T1 (de) * 1994-10-31 1999-01-15 Merck Patent Gmbh Benzylpiperidinderivate mit hoher affinität zu bindungsstellen von aminosäure-rezeptoren

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6284774B1 (en) 1998-06-26 2001-09-04 Warner-Lambert Company 4-Benzyl piperidine alkylsulfoxide heterocycles and their use as subtype-selective NMDA receptor antagonists

Also Published As

Publication number Publication date
WO1998018793A1 (de) 1998-05-07
JP2001502713A (ja) 2001-02-27
HUP9904547A3 (en) 2001-01-29
NO992063D0 (no) 1999-04-29
PL332771A1 (en) 1999-10-11
AU4946597A (en) 1998-05-22
CZ147999A3 (cs) 1999-08-11
SK53699A3 (en) 2000-03-13
HUP9904547A2 (hu) 2000-12-28
ZA979725B (en) 1998-05-22
NO992063L (no) 1999-04-29
AR008512A1 (es) 2000-01-19
CN1235604A (zh) 1999-11-17
EP0938485A1 (de) 1999-09-01
DE19643790A1 (de) 1998-05-07
BR9712577A (pt) 1999-10-19
KR20000052876A (ko) 2000-08-25

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Legal Events

Date Code Title Description
FZDE Discontinued