DE19643790A1 - Benzoxazol-Derivat - Google Patents

Benzoxazol-Derivat

Info

Publication number
DE19643790A1
DE19643790A1 DE19643790A DE19643790A DE19643790A1 DE 19643790 A1 DE19643790 A1 DE 19643790A1 DE 19643790 A DE19643790 A DE 19643790A DE 19643790 A DE19643790 A DE 19643790A DE 19643790 A1 DE19643790 A1 DE 19643790A1
Authority
DE
Germany
Prior art keywords
formula
compound
acid
salts
physiologically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19643790A
Other languages
German (de)
English (en)
Inventor
Helmut Dr Pruecher
Rudolf Dr Gottschlich
Joachim Dr Leibrock
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Patent GmbH
Original Assignee
Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Priority to DE19643790A priority Critical patent/DE19643790A1/de
Priority to CZ991479A priority patent/CZ147999A3/cs
Priority to EP97912162A priority patent/EP0938485A1/de
Priority to SK536-99A priority patent/SK53699A3/sk
Priority to CA002270359A priority patent/CA2270359A1/en
Priority to PL97332771A priority patent/PL332771A1/xx
Priority to HU9904547A priority patent/HUP9904547A3/hu
Priority to CN97199279A priority patent/CN1235604A/zh
Priority to KR1019990703727A priority patent/KR20000052876A/ko
Priority to PCT/EP1997/005590 priority patent/WO1998018793A1/de
Priority to JP10519971A priority patent/JP2001502713A/ja
Priority to AU49465/97A priority patent/AU4946597A/en
Priority to BR9712577-6A priority patent/BR9712577A/pt
Priority to ZA9709725A priority patent/ZA979725B/xx
Priority to ARP970105012A priority patent/AR008512A1/es
Publication of DE19643790A1 publication Critical patent/DE19643790A1/de
Priority to NO992063A priority patent/NO992063D0/no
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE19643790A 1996-10-30 1996-10-30 Benzoxazol-Derivat Withdrawn DE19643790A1 (de)

Priority Applications (16)

Application Number Priority Date Filing Date Title
DE19643790A DE19643790A1 (de) 1996-10-30 1996-10-30 Benzoxazol-Derivat
CN97199279A CN1235604A (zh) 1996-10-30 1997-10-10 对氨基酸受体结合位点具有亲和性的苯并噁唑衍生物
JP10519971A JP2001502713A (ja) 1996-10-30 1997-10-10 アミノ酸受容体の結合部位に対するアフィニティーを有するベンゾアキソゾール誘導体
SK536-99A SK53699A3 (en) 1996-10-30 1997-10-10 6-{3-[4-(fluorobenzyle)-piperidine-1-yl]-propionyl}-3h- -benzoxazole-2-one, method for its preparation, its use and pharmaceutical composition containing the same
CA002270359A CA2270359A1 (en) 1996-10-30 1997-10-10 Benzoaxozole derivative
PL97332771A PL332771A1 (en) 1996-10-30 1997-10-10 Derivatives of benzoxazoles exhibiting affinity to bonding locations of amino acid receptors
HU9904547A HUP9904547A3 (en) 1996-10-30 1997-10-10 Benzoxazole derivative with an affinity to binding sites of amino acid receptors and pharmaceutical compositions containing the same
CZ991479A CZ147999A3 (cs) 1996-10-30 1997-10-10 6-{3-[4-(4-Fluorbenzyl)piperidin-1-yl]propionyl}-3H-benzoxazol-2-on, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje
KR1019990703727A KR20000052876A (ko) 1996-10-30 1997-10-10 아미노산 수용체의 결합 부위에 친화력을 갖는 벤족사졸 유도체
PCT/EP1997/005590 WO1998018793A1 (de) 1996-10-30 1997-10-10 Benzoxazolderivat mit affinität zu bindungsstellen von aminosäurerezeptoren
EP97912162A EP0938485A1 (de) 1996-10-30 1997-10-10 Benzoxazolderivat mit affinität zu bindungsstellen von aminosäurerezeptoren
AU49465/97A AU4946597A (en) 1996-10-30 1997-10-10 Benzoxazole derivative with an affinity to binding sites of amino acid receptor
BR9712577-6A BR9712577A (pt) 1996-10-30 1997-10-10 Derivado de benzoxazola
ZA9709725A ZA979725B (en) 1996-10-30 1997-10-29 Benzoaxozole derivative.
ARP970105012A AR008512A1 (es) 1996-10-30 1997-10-29 Derivado de benzoxazol, procedimiento para su preparacion, su empleo para preparar un medicamento, preparacion farmaceutica que lo contiene y unprocedimiento para obtener esta preparacion farmaceutica.
NO992063A NO992063D0 (no) 1996-10-30 1999-04-29 Benzoksazolderivat med affinitet til bindingssteder pÕ aminosyrereseptorer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19643790A DE19643790A1 (de) 1996-10-30 1996-10-30 Benzoxazol-Derivat

Publications (1)

Publication Number Publication Date
DE19643790A1 true DE19643790A1 (de) 1998-05-07

Family

ID=7809592

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19643790A Withdrawn DE19643790A1 (de) 1996-10-30 1996-10-30 Benzoxazol-Derivat

Country Status (16)

Country Link
EP (1) EP0938485A1 (ko)
JP (1) JP2001502713A (ko)
KR (1) KR20000052876A (ko)
CN (1) CN1235604A (ko)
AR (1) AR008512A1 (ko)
AU (1) AU4946597A (ko)
BR (1) BR9712577A (ko)
CA (1) CA2270359A1 (ko)
CZ (1) CZ147999A3 (ko)
DE (1) DE19643790A1 (ko)
HU (1) HUP9904547A3 (ko)
NO (1) NO992063D0 (ko)
PL (1) PL332771A1 (ko)
SK (1) SK53699A3 (ko)
WO (1) WO1998018793A1 (ko)
ZA (1) ZA979725B (ko)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048891A1 (de) * 1998-03-20 1999-09-30 Merck Patent Gmbh 1-(3 -heteroarylpropyl- oder -prop -2-enyl) -4-benzylpiperidine als nmda-rezeptor-antagonisten
WO2002085352A1 (de) * 2001-04-25 2002-10-31 Merck Patent Gmbh Nmda-antagonisten und nmda-agonisten zur behandlung von suchterkrankungen

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9725541D0 (en) * 1997-12-02 1998-02-04 Pharmacia & Upjohn Spa Amino-benzothiazole derivatives
PE20000728A1 (es) 1998-06-26 2000-08-21 Cocensys Inc Heterociclos 4-bencil piperidina alquilsulfoxido y su uso como antagonistas receptores subtipo-selectivo nmda
US6476041B1 (en) * 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
CZ2004233A3 (cs) 2001-07-24 2004-12-15 Richter Gedeon Vegyészeti Gyár Rt. Nové amidové sloučeniny karboxylové kyseliny
DE102007047737A1 (de) 2007-10-05 2009-04-30 Merck Patent Gmbh Piperidin- und Piperazinderivate
DE102009049211A1 (de) 2009-10-13 2011-04-28 Merck Patent Gmbh Sulfoxide
KR20140097132A (ko) 2011-11-22 2014-08-06 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 허혈성 손상을 치료하기 위한 시스테아민 및/또는 시스타민

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0709384T3 (da) * 1994-10-31 1999-08-23 Merck Patent Gmbh Benzylpiperidinderivater med høj affinitet til aminosyrereceptorers bindingssteder

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999048891A1 (de) * 1998-03-20 1999-09-30 Merck Patent Gmbh 1-(3 -heteroarylpropyl- oder -prop -2-enyl) -4-benzylpiperidine als nmda-rezeptor-antagonisten
US6548516B1 (en) 1998-03-20 2003-04-15 Merck Patent Gmbh 1-(3-heteroarylpropyl- or -prop-2-enyl)-4-benzylpiperidines used as NMDA receptor antagonists
WO2002085352A1 (de) * 2001-04-25 2002-10-31 Merck Patent Gmbh Nmda-antagonisten und nmda-agonisten zur behandlung von suchterkrankungen

Also Published As

Publication number Publication date
KR20000052876A (ko) 2000-08-25
CZ147999A3 (cs) 1999-08-11
AU4946597A (en) 1998-05-22
HUP9904547A3 (en) 2001-01-29
HUP9904547A2 (hu) 2000-12-28
EP0938485A1 (de) 1999-09-01
AR008512A1 (es) 2000-01-19
ZA979725B (en) 1998-05-22
PL332771A1 (en) 1999-10-11
NO992063L (no) 1999-04-29
WO1998018793A1 (de) 1998-05-07
SK53699A3 (en) 2000-03-13
CN1235604A (zh) 1999-11-17
CA2270359A1 (en) 1998-05-07
BR9712577A (pt) 1999-10-19
JP2001502713A (ja) 2001-02-27
NO992063D0 (no) 1999-04-29

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Legal Events

Date Code Title Description
8139 Disposal/non-payment of the annual fee