NO992063L - Benzoksazolderivat med affinitet til bindingssteder pÕ aminosyrereseptorer - Google Patents

Benzoksazolderivat med affinitet til bindingssteder pÕ aminosyrereseptorer

Info

Publication number
NO992063L
NO992063L NO992063A NO992063A NO992063L NO 992063 L NO992063 L NO 992063L NO 992063 A NO992063 A NO 992063A NO 992063 A NO992063 A NO 992063A NO 992063 L NO992063 L NO 992063L
Authority
NO
Norway
Prior art keywords
amino acid
affinity
binding sites
acid receptors
benzoxazole derivative
Prior art date
Application number
NO992063A
Other languages
English (en)
Other versions
NO992063D0 (no
Inventor
Cher Helmut Pr
Rudolf Gottschlich
Joachim Leibrock
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of NO992063D0 publication Critical patent/NO992063D0/no
Publication of NO992063L publication Critical patent/NO992063L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Forbindelsen 6-{3-[4-(4- fluorbenzyl)-piperidin-1-yl]- prop±onyl}-3H-benzoksazol-2-on med formel (I) samt dens fysiologisk akseptable salter kan anvendes som eksitatoriske aminosyreantagonister for bekjempelse av neurodegenerative sykdommer, særlig cerebrovaskulære sykdommer, epilepsi, schizofreni, Alzheimers, Parkinsons hhv. Huntingtons sykdom, cerebrale iskemier, infarkt eller psykoser.
NO992063A 1996-10-30 1999-04-29 Benzoksazolderivat med affinitet til bindingssteder pÕ aminosyrereseptorer NO992063L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19643790A DE19643790A1 (de) 1996-10-30 1996-10-30 Benzoxazol-Derivat
PCT/EP1997/005590 WO1998018793A1 (de) 1996-10-30 1997-10-10 Benzoxazolderivat mit affinität zu bindungsstellen von aminosäurerezeptoren

Publications (2)

Publication Number Publication Date
NO992063D0 NO992063D0 (no) 1999-04-29
NO992063L true NO992063L (no) 1999-04-29

Family

ID=7809592

Family Applications (1)

Application Number Title Priority Date Filing Date
NO992063A NO992063L (no) 1996-10-30 1999-04-29 Benzoksazolderivat med affinitet til bindingssteder pÕ aminosyrereseptorer

Country Status (16)

Country Link
EP (1) EP0938485A1 (no)
JP (1) JP2001502713A (no)
KR (1) KR20000052876A (no)
CN (1) CN1235604A (no)
AR (1) AR008512A1 (no)
AU (1) AU4946597A (no)
BR (1) BR9712577A (no)
CA (1) CA2270359A1 (no)
CZ (1) CZ147999A3 (no)
DE (1) DE19643790A1 (no)
HU (1) HUP9904547A3 (no)
NO (1) NO992063L (no)
PL (1) PL332771A1 (no)
SK (1) SK53699A3 (no)
WO (1) WO1998018793A1 (no)
ZA (1) ZA979725B (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9725541D0 (en) * 1997-12-02 1998-02-04 Pharmacia & Upjohn Spa Amino-benzothiazole derivatives
DE19812331A1 (de) 1998-03-20 1999-09-23 Merck Patent Gmbh Piperidinderivate
PE20000728A1 (es) 1998-06-26 2000-08-21 Cocensys Inc Heterociclos 4-bencil piperidina alquilsulfoxido y su uso como antagonistas receptores subtipo-selectivo nmda
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
DE10120159A1 (de) * 2001-04-25 2002-10-31 Merck Patent Gmbh NMDA-Antagonisten und NMDA-Agonisten zur Behandlung von Suchterkrankungen
EP1409477B1 (en) 2001-07-24 2008-09-17 Richter Gedeon NYRT Piperidine derivatives as nmda receptor antagonists
DE102007047737A1 (de) * 2007-10-05 2009-04-30 Merck Patent Gmbh Piperidin- und Piperazinderivate
DE102009049211A1 (de) 2009-10-13 2011-04-28 Merck Patent Gmbh Sulfoxide
MX2014004469A (es) 2011-11-22 2014-08-01 Univ California Metodos y composiciones para tratar inflamacion y lesion isquemica.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2128629T3 (es) * 1994-10-31 1999-05-16 Merck Patent Gmbh Derivados de bencilpiperidina con afinidad elevada a puntos de enlace de receptores de aminoacidos.

Also Published As

Publication number Publication date
NO992063D0 (no) 1999-04-29
HUP9904547A2 (hu) 2000-12-28
EP0938485A1 (de) 1999-09-01
AR008512A1 (es) 2000-01-19
AU4946597A (en) 1998-05-22
WO1998018793A1 (de) 1998-05-07
JP2001502713A (ja) 2001-02-27
PL332771A1 (en) 1999-10-11
CA2270359A1 (en) 1998-05-07
SK53699A3 (en) 2000-03-13
BR9712577A (pt) 1999-10-19
KR20000052876A (ko) 2000-08-25
HUP9904547A3 (en) 2001-01-29
ZA979725B (en) 1998-05-22
DE19643790A1 (de) 1998-05-07
CZ147999A3 (cs) 1999-08-11
CN1235604A (zh) 1999-11-17

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Legal Events

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