BR9712577A - Derivado de benzoxazola - Google Patents

Derivado de benzoxazola

Info

Publication number
BR9712577A
BR9712577A BR9712577-6A BR9712577A BR9712577A BR 9712577 A BR9712577 A BR 9712577A BR 9712577 A BR9712577 A BR 9712577A BR 9712577 A BR9712577 A BR 9712577A
Authority
BR
Brazil
Prior art keywords
disease
benzoxazole derivative
benzoxazola
alznheimer
cerebovascular
Prior art date
Application number
BR9712577-6A
Other languages
English (en)
Inventor
Helmut Pruecher
Rudolf Gottschlich
Joachim Leibrock
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9712577A publication Critical patent/BR9712577A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

patente de Invenção:<B>"DERIVADO DE BENZOXAZOLA"<D>. O composto 6-{3-[4-(4-flúor benzil) piperidin-1-il] propionil} 3H- benzoxazol-2-ona da fórmula I: e sais fisiologicamente aceitáveis do mesmo, podem ser empregados como antagonistas de aminoácidos excitatórios para o tratamento de distúrbios neurodegenerativos incluindo doenças cerebovasculares, epilepsia, esquizofrenia, doença de Alznheimer, doença de Parkinson, doença de Huntington, isquemias cerebrais, infartos, ou psicoses.
BR9712577-6A 1996-10-30 1997-10-10 Derivado de benzoxazola BR9712577A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19643790A DE19643790A1 (de) 1996-10-30 1996-10-30 Benzoxazol-Derivat
PCT/EP1997/005590 WO1998018793A1 (de) 1996-10-30 1997-10-10 Benzoxazolderivat mit affinität zu bindungsstellen von aminosäurerezeptoren

Publications (1)

Publication Number Publication Date
BR9712577A true BR9712577A (pt) 1999-10-19

Family

ID=7809592

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9712577-6A BR9712577A (pt) 1996-10-30 1997-10-10 Derivado de benzoxazola

Country Status (16)

Country Link
EP (1) EP0938485A1 (pt)
JP (1) JP2001502713A (pt)
KR (1) KR20000052876A (pt)
CN (1) CN1235604A (pt)
AR (1) AR008512A1 (pt)
AU (1) AU4946597A (pt)
BR (1) BR9712577A (pt)
CA (1) CA2270359A1 (pt)
CZ (1) CZ147999A3 (pt)
DE (1) DE19643790A1 (pt)
HU (1) HUP9904547A3 (pt)
NO (1) NO992063L (pt)
PL (1) PL332771A1 (pt)
SK (1) SK53699A3 (pt)
WO (1) WO1998018793A1 (pt)
ZA (1) ZA979725B (pt)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9725541D0 (en) * 1997-12-02 1998-02-04 Pharmacia & Upjohn Spa Amino-benzothiazole derivatives
DE19812331A1 (de) * 1998-03-20 1999-09-23 Merck Patent Gmbh Piperidinderivate
PE20000728A1 (es) 1998-06-26 2000-08-21 Cocensys Inc Heterociclos 4-bencil piperidina alquilsulfoxido y su uso como antagonistas receptores subtipo-selectivo nmda
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
EP1674087A1 (en) 2000-10-02 2006-06-28 Pfizer Products Inc. Prophylactic use of n-methyl-d-aspartate (NMDA) antagonists
DE10120159A1 (de) * 2001-04-25 2002-10-31 Merck Patent Gmbh NMDA-Antagonisten und NMDA-Agonisten zur Behandlung von Suchterkrankungen
SI1409477T1 (sl) 2001-07-24 2009-02-28 Richter Gedeon Nyrt Derivati piperidina kot antagonisti nmda-receptorjev
DE102007047737A1 (de) * 2007-10-05 2009-04-30 Merck Patent Gmbh Piperidin- und Piperazinderivate
DE102009049211A1 (de) 2009-10-13 2011-04-28 Merck Patent Gmbh Sulfoxide
CN103974698A (zh) 2011-11-22 2014-08-06 加利福尼亚大学董事会 用于治疗缺血性损伤的半胱胺和/或胱胺

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0709384T3 (da) * 1994-10-31 1999-08-23 Merck Patent Gmbh Benzylpiperidinderivater med høj affinitet til aminosyrereceptorers bindingssteder

Also Published As

Publication number Publication date
SK53699A3 (en) 2000-03-13
ZA979725B (en) 1998-05-22
EP0938485A1 (de) 1999-09-01
PL332771A1 (en) 1999-10-11
CN1235604A (zh) 1999-11-17
NO992063D0 (no) 1999-04-29
JP2001502713A (ja) 2001-02-27
CZ147999A3 (cs) 1999-08-11
HUP9904547A3 (en) 2001-01-29
CA2270359A1 (en) 1998-05-07
AR008512A1 (es) 2000-01-19
KR20000052876A (ko) 2000-08-25
WO1998018793A1 (de) 1998-05-07
HUP9904547A2 (hu) 2000-12-28
DE19643790A1 (de) 1998-05-07
NO992063L (no) 1999-04-29
AU4946597A (en) 1998-05-22

Similar Documents

Publication Publication Date Title
ECSP055719A (es) Compuestos de tiazol para el tratamiento de trastornos neurodegenerativos
CY1107401T1 (el) Παραγωγα βενζοθειαζολιου πα την θεραπευτικη αντιμετωπιση της νοσου alzheimer και της νοσου parkinson
DE50313528D1 (de) Substituierte indole und deren verwendung als 5ht-wiederaufnahme inhibitoren und als 5ht liganden
BR9712577A (pt) Derivado de benzoxazola
HK1074046A1 (en) Ccr1 antagonists for the treatment of i.a. demyelinating inflammatory disease
NO20064726L (no) Imidazolforbindelser for behandling av neurodegenerative forstyrrelser
ES2162257T3 (es) N-aminoalquildibenzofurancarboxamidas como ligandos especificos del subtipo de receptor de la dopamina.
ATE355374T1 (de) Therapeutische agentien und methoden ihrer verwendung zur behandlung von amyloidogenen erkrankungen
CY1108514T1 (el) Παραγωγα 1-φαινυλαλκανεκαρβοξυλικου οξεος για τη θεραπεια νευρογενων ασθενειων
DE60216830D1 (de) Pharmazeutische Zusammensetzungen zur Behandlung von Störungen des ZNS oder anderen Erkrankungen
NO20004668L (no) 1-(3-heteroarylpropyl- eller -prop-2-enyl)-4- benzylpiperidiner anvendt som NMDA-reseptorantagonister
DE602005023963D1 (de) Weitere heteropolycyclische verbindungen und deren verwendung als antagonisten des metabotropen glutamatrezeptors
CY1106645T1 (el) Παραγωγα 1,2,4 τριαμινοβενζολης χρησιμα για τη θεραπευτικη αντιμετωπιση διαταραχων του κεντρικου νευρικου συστηματος
ATE398618T1 (de) Pharmazeutische zusammensetzungen zur behandlung von zns und anderen krankheiten
MXPA03010843A (es) Uso de derivados con azetidinona en el tratamiento de enfermedad de alzheimer.
ATE253918T1 (de) Verwendung von hymenialdisin und dessen derivaten zur herstellung therapeutischer mittel
EA200401114A2 (ru) Замещённые гидроксиэтиламины
BR0309486A (pt) Composto ou um seu sal farmaceuticamente aceitável, composição farmacêutica, e, método para o tratamento de uma condição associada com um excesso de taquicininas
DE69809827D1 (de) Chinolinische Sulfid-Derivate als NMDA Rezeptor-Antagonisten und Verfahren zu ihrer Herstellung
EA200701181A1 (ru) Лекарственные средства, предназначенные для лечения или предупреждения фиброзных заболеваний
BR0206495A (pt) Tratamento de distúrbios de cns empregando antagonistas de oxidase de d-aminoácido e oxidase de d-aspartato
IL169889A0 (en) Methods for diagnosis and monitoring of neurological disease by detection of an encephalotoxin
ES2157565T3 (es) N-azacicloalquilalquildibenzotiofenocarboxamidas: ligandos especificos de un subtipo de receptor de la dopamina.
ATE526981T1 (de) Verwendung von vegf 165 und homologen zur behandlung von neurologischen störungen
AR029428A1 (es) DERIVADOS DE FENIL--PIPERIDINA, TETRAHIDROPIRIDINA,-PIPERAZINA,-AZEPAN,-TETRAHIDRO-1H-AZEPINA Y DIAZEPAN SUSTITUIDOS, UNA COMPOSICIoN FARMACEUTICA Y EL USO DE LOS MISMOS PARA LA MANUFACTURA DE UNA PREPARACION FARMACEUTICA

Legal Events

Date Code Title Description
FA10 Dismissal: dismissal - article 33 of industrial property law
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]