ES2157565T3 - N-azacicloalquilalquildibenzotiofenocarboxamidas: ligandos especificos de un subtipo de receptor de la dopamina. - Google Patents

N-azacicloalquilalquildibenzotiofenocarboxamidas: ligandos especificos de un subtipo de receptor de la dopamina.

Info

Publication number
ES2157565T3
ES2157565T3 ES97916178T ES97916178T ES2157565T3 ES 2157565 T3 ES2157565 T3 ES 2157565T3 ES 97916178 T ES97916178 T ES 97916178T ES 97916178 T ES97916178 T ES 97916178T ES 2157565 T3 ES2157565 T3 ES 2157565T3
Authority
ES
Spain
Prior art keywords
alkyl
disorders
compounds
subtipe
azacicloalquilalquildibenzotiofenocarboxamidas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97916178T
Other languages
English (en)
Inventor
Jun Yuan
Xi Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Application granted granted Critical
Publication of ES2157565T3 publication Critical patent/ES2157565T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/76—Dibenzothiophenes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • C08G73/1003—Preparatory processes
    • C08G73/1007—Preparatory processes from tetracarboxylic acids or derivatives and diamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • C08G73/1003—Preparatory processes
    • C08G73/1007—Preparatory processes from tetracarboxylic acids or derivatives and diamines
    • C08G73/101—Preparatory processes from tetracarboxylic acids or derivatives and diamines containing chain terminating or branching agents
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/02—Details
    • H05K1/03—Use of materials for the substrate
    • H05K1/0313—Organic insulating material
    • H05K1/032—Organic insulating material consisting of one material
    • H05K1/0346—Organic insulating material consisting of one material containing N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

LA INVENCION SE REFIERE A COMPUESTOS DE FORMULA (I) O A LAS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES DE LOS MISMOS. EN DICHA FORMULA R1, R2, R3, R4 SON IGUALES O DISTINTOS Y REPRESENTAN HIDROGENO, ALQUILO C1-C6 , HALOGENO, HIDROXILO, AMINO, CIANO, NITRO, TRIFLUOROMETILO, TRIFLUOROMETOXI, ALCOXI C1-C6 , ALCOXI, O2 CR'', - NHCOR'', COR'', - SO M R'', DONDE R'' ES ALQUILO C1-C6 Y M ES 0, 1 O 2; O R1, R2, R3, R4 REPRESENTAN INDEPENDIENTEMENTE - CONR''R'''', O N R''R'''', DONDE R'' Y R'''' REPRESENTAN INDEPENDIENTEMENTE HIDROGENO O ALQUILO C1-C6; R5 ES HIDROGENO O ALQUILO C1-C6; Y R REPRESENTA UN GRUPO AMINOALQUILO. DICHOS COMPUESTOS SON UTILES PARA EL TRATAMIENTO DE ALTERACIONES AFECTIVAS COMO LA ESQUIZOFRENIA, DEPRESION, ENFERMEDAD DE ALZHEIMER, ALTERACIONES MOTRICES COMO EL PARKINSONISMO Y LA DISTONIA, Y OTRAS ALTERACIONES QUE RESPONDEN AL BLOQUEO DOPAMINERGICO, COMO EL ABUSO DE SUSTANCIAS Y ALTERACIONES COMPULSIVAS OBSESIVAS. ADEMAS, LOS COMPUESTOS DE LA INVENCION PUEDEN SER UTILES PARA EL TRATAMIENTO DE LOS EFECTOS SECUNDARIOS EXTRAPIRAMIDALES ASOCIADOS CON EL USO DE AGENTES NEUROLEPTICOS CONVENCIONALES.
ES97916178T 1996-03-21 1997-03-21 N-azacicloalquilalquildibenzotiofenocarboxamidas: ligandos especificos de un subtipo de receptor de la dopamina. Expired - Lifetime ES2157565T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/619,429 US5763609A (en) 1996-03-21 1996-03-21 Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands

Publications (1)

Publication Number Publication Date
ES2157565T3 true ES2157565T3 (es) 2001-08-16

Family

ID=24481895

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97916178T Expired - Lifetime ES2157565T3 (es) 1996-03-21 1997-03-21 N-azacicloalquilalquildibenzotiofenocarboxamidas: ligandos especificos de un subtipo de receptor de la dopamina.

Country Status (7)

Country Link
US (5) US5763609A (es)
EP (1) EP0888332B1 (es)
AT (1) ATE201676T1 (es)
AU (1) AU2342397A (es)
DE (1) DE69705035T2 (es)
ES (1) ES2157565T3 (es)
WO (1) WO1997034889A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763609A (en) * 1996-03-21 1998-06-09 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands
WO1998025915A1 (fr) * 1996-12-12 1998-06-18 Shionogi & Co., Ltd. Derives d'amide d'acide benzenecarboxylique condenses heterocycliques et antagonistes pgd2 renfermant ces derives
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
US6022307A (en) * 1998-07-14 2000-02-08 American Cyanamid Company Substituted dibenzothiophenes having antiangiogenic activity
EA200100428A1 (ru) 1998-10-08 2001-10-22 Смитклайн Бичам Плс Производные тетрагидробензазепина, полезные в качестве модуляторов допаминовых d3 рецепторов (антипсихотические агенты)
US6751604B2 (en) * 1999-01-06 2004-06-15 Hewlett-Packard Development Company, L.P. Method of displaying temporal and storage media relationships of file names protected on removable storage media
WO2001009117A1 (en) * 1999-07-29 2001-02-08 Allellix Neuroscience Inc. Tricyclic compounds as glycine transport inhibitors
DE10133927A1 (de) * 2001-07-12 2003-01-23 Bayer Ag Benzodioxinothiophene, deren Herstellung und Verwendung
HUP0103987A3 (en) * 2001-09-28 2004-11-29 Richter Gedeon Vegyeszet Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates
HUP0103986A2 (hu) * 2001-09-28 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. Új karbonsavamid szerkezetet tartalmazó piperidinil vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
AR039280A1 (es) * 2002-04-11 2005-02-16 Smithkline Beecham Corp Compuesto de aminotiofeno y su uso para preparar una composicion farmaceutica
WO2004037805A1 (en) * 2002-10-23 2004-05-06 Glenmark Pharmaceuticals Ltd. Novel tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them
EP1704648A2 (en) * 2003-12-30 2006-09-27 Anthony Whelan Broadband data services over vehicle power lines
HUP0500170A3 (en) 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
CA2690789C (en) 2007-06-15 2014-08-05 Amy Hauck Newman 4-phenylpiperazine derivatives with functionalized linkers as dopamine d3 receptor selective ligands and methods of use
US11299476B2 (en) 2016-03-14 2022-04-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof
CA3111785A1 (en) 2018-09-11 2020-03-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine d3 receptor selective antagonists/partial agonists and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3952014A (en) * 1969-08-18 1976-04-20 Richardson-Merrell Inc. Bis-basic esters and amides of dibenzothiophene
US4146624A (en) * 1970-09-14 1979-03-27 Richardson-Merrell Inc. Method of treating viruses with bis-basic ketones of dibenzofuran
US4334078A (en) * 1976-03-24 1982-06-08 Hoffmann-La Roche Inc. Dibenzothiophenes
US4448990A (en) * 1982-11-16 1984-05-15 Eli Lilly And Company Hydroxyaminotetralincarboxamides
US5254552A (en) 1988-05-24 1993-10-19 American Home Products Corporation Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity
SE9201138D0 (sv) 1992-04-09 1992-04-09 Astra Ab Novel phthalimidoalkylpiperazines
US5395835A (en) * 1994-03-24 1995-03-07 Warner-Lambert Company Naphthalamides as central nervous system agents
US5659033A (en) * 1995-09-13 1997-08-19 Neurogen Corporation N-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands
US5763609A (en) * 1996-03-21 1998-06-09 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands
US5703235A (en) * 1996-03-21 1997-12-30 Neurogen Corporation N-Aminoalkyl-2-anthracenecarboxamides; new dopamine receptor subtype specific ligands

Also Published As

Publication number Publication date
DE69705035D1 (de) 2001-07-05
US5929246A (en) 1999-07-27
AU2342397A (en) 1997-10-10
US6429312B2 (en) 2002-08-06
EP0888332B1 (en) 2001-05-30
US5763609A (en) 1998-06-09
US20010044461A1 (en) 2001-11-22
US6040459A (en) 2000-03-21
DE69705035T2 (de) 2002-02-14
ATE201676T1 (de) 2001-06-15
WO1997034889A1 (en) 1997-09-25
US6221869B1 (en) 2001-04-24
EP0888332A1 (en) 1999-01-07

Similar Documents

Publication Publication Date Title
ES2162257T3 (es) N-aminoalquildibenzofurancarboxamidas como ligandos especificos del subtipo de receptor de la dopamina.
ES2157565T3 (es) N-azacicloalquilalquildibenzotiofenocarboxamidas: ligandos especificos de un subtipo de receptor de la dopamina.
ATE369848T1 (de) Verwendung von d-serine oder d-alanine zur behandlung von schizophrenie
ATE168007T1 (de) Zur behandlung von erkrankungen des zentralnervensystems verwendbare benzimidazole
BR0007424A (pt) Composto, composição farmacêutica, método para o tratamento de depressão em um paciente necessitando do mesmo, e, processo para a preparação de um composto
GEP20022676B (en) 4-Phenyl-Pyridine Derivatives, Method for Their Production and Their Use for Treatment of Disorders Caused by Antagonist of NK-1 Receptors
ATE219068T1 (de) Naphtylamides als zentralnervensystemmittel
ATE396174T1 (de) Hydroxyalkylaminderivate als beta-secretase- inhibitoren und deren verwendung zur behandlung der alzheimerschen krankheit oder ähnlicher krankheiten
MXPA04005847A (es) Compuestos derivados de 4-sulfuro/sulfoxido/sulfonil-1h-pirazolilo, para uso en enfermedades asociadas con el receptor 5-ht2c.
NZ516599A (en) 2-arylimino-2,3-dihydrothiazoles, and their use thereof as somatostatin receptor ligands
NO180632C (no) 1,3-substituerte cykloalkener og cykloalkaner som sentralnervesystem-midler
BR0315837A (pt) Derivados de amida de ácido heteroaril-hexanóico como agentes imunomoduladores
DK0432648T3 (da) Isatinderivater, deres fremstilling og anvendelse
GR3024187T3 (en) Tetrahydrocyclopent[b]indole methanamines and related compounds, a process for their preparation and their use as medicaments.
DE69822937D1 (de) Indolmorphinan-derivate und medikamente zur behandlung/mittel zur vorbeugung von cerebralen störungen
AU2459897A (en) Novel n-aminoalkyl-1-biphenylenyl-2-carboxamides; new dopamine receptor subtype specific ligands
BR9906719A (pt) "n-óxidos de compostos heterocìclicos com atividade inibidora de tnf e de pde-iv"
DE69827706D1 (de) 5-(Heteroaryl)alkyl)-3-oxo-pyrido(1,2-a)benzimidazol-4-carboxamid (PBI) Derivate zur Behandlung von Störungen des zentralen Nervensystems

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 888332

Country of ref document: ES