DE69705035D1 - N-Azacycloalkylalkyldibenzothiophencarboxamide: spezifische Liganden für Dopaminrezeptorsubtypen - Google Patents

N-Azacycloalkylalkyldibenzothiophencarboxamide: spezifische Liganden für Dopaminrezeptorsubtypen

Info

Publication number
DE69705035D1
DE69705035D1 DE69705035T DE69705035T DE69705035D1 DE 69705035 D1 DE69705035 D1 DE 69705035D1 DE 69705035 T DE69705035 T DE 69705035T DE 69705035 T DE69705035 T DE 69705035T DE 69705035 D1 DE69705035 D1 DE 69705035D1
Authority
DE
Germany
Prior art keywords
alkyl
disorders
compounds
azacycloalkylalkyldibenzothiophencarboxamide
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69705035T
Other languages
English (en)
Other versions
DE69705035T2 (de
Inventor
Jun Yuan
Xi Chen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Application granted granted Critical
Publication of DE69705035D1 publication Critical patent/DE69705035D1/de
Publication of DE69705035T2 publication Critical patent/DE69705035T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00—Layered products comprising a layer of metal
    • B32B15/04—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B15/08—Layered products comprising a layer of metal comprising metal as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/76—Dibenzothiophenes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • C08G73/1003—Preparatory processes
    • C08G73/1007—Preparatory processes from tetracarboxylic acids or derivatives and diamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
    • C08G73/1003—Preparatory processes
    • C08G73/1007—Preparatory processes from tetracarboxylic acids or derivatives and diamines
    • C08G73/101—Preparatory processes from tetracarboxylic acids or derivatives and diamines containing chain terminating or branching agents
    • H—ELECTRICITY
    • H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
    • H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
    • H05K1/00—Printed circuits
    • H05K1/02—Details
    • H05K1/03—Use of materials for the substrate
    • H05K1/0313—Organic insulating material
    • H05K1/032—Organic insulating material consisting of one material
    • H05K1/0346—Organic insulating material consisting of one material containing N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
DE69705035T 1996-03-21 1997-03-21 N-Azacycloalkylalkyldibenzothiophencarboxamide: spezifische Liganden für Dopaminrezeptorsubtypen Expired - Fee Related DE69705035T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/619,429 US5763609A (en) 1996-03-21 1996-03-21 Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands
PCT/US1997/004661 WO1997034889A1 (en) 1996-03-21 1997-03-21 N-aminoalkyldibenzothiophenecarboxamides; dopamine receptor subtype specific ligands

Publications (2)

Publication Number Publication Date
DE69705035D1 true DE69705035D1 (de) 2001-07-05
DE69705035T2 DE69705035T2 (de) 2002-02-14

Family

ID=24481895

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69705035T Expired - Fee Related DE69705035T2 (de) 1996-03-21 1997-03-21 N-Azacycloalkylalkyldibenzothiophencarboxamide: spezifische Liganden für Dopaminrezeptorsubtypen

Country Status (7)

Country Link
US (5) US5763609A (de)
EP (1) EP0888332B1 (de)
AT (1) ATE201676T1 (de)
AU (1) AU2342397A (de)
DE (1) DE69705035T2 (de)
ES (1) ES2157565T3 (de)
WO (1) WO1997034889A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5763609A (en) * 1996-03-21 1998-06-09 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands
ATE295360T1 (de) * 1996-12-12 2005-05-15 Shionogi & Co Kondensierte heterocyclische benzolcarbonsäureamid-derivate und diese enthaltende pgd2 antagonisten
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
US6022307A (en) * 1998-07-14 2000-02-08 American Cyanamid Company Substituted dibenzothiophenes having antiangiogenic activity
HUP0104280A3 (en) 1998-10-08 2002-07-29 Smithkline Beecham Plc Tetrahydrobenzazepine derivatives useful as modulators of dopamine d3 receptors, process for their preparation, medicaments containing them
US6751604B2 (en) * 1999-01-06 2004-06-15 Hewlett-Packard Development Company, L.P. Method of displaying temporal and storage media relationships of file names protected on removable storage media
WO2001009117A1 (en) * 1999-07-29 2001-02-08 Allellix Neuroscience Inc. Tricyclic compounds as glycine transport inhibitors
DE10133927A1 (de) * 2001-07-12 2003-01-23 Bayer Ag Benzodioxinothiophene, deren Herstellung und Verwendung
HUP0103986A2 (hu) * 2001-09-28 2003-06-28 Richter Gedeon Vegyészeti Gyár Rt. Új karbonsavamid szerkezetet tartalmazó piperidinil vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
HUP0103987A3 (en) * 2001-09-28 2004-11-29 Richter Gedeon Vegyeszet Phenylpiperazinylalkyl carboxylic acid amid derivatives, process for their preparation, pharmaceutical compositions containing them and their intermediates
TW200403991A (en) * 2002-04-11 2004-03-16 Smithkline Beecham Corp NF-κb inhibitors
JP2006506379A (ja) * 2002-10-23 2006-02-23 グレンマーク・ファーマシューティカルズ・リミテッド 炎症性およびアレルギー性疾患の治療に有用な新規三環式化合物：その調製方法およびそれらを含む医薬組成物
WO2005065228A2 (en) * 2003-12-30 2005-07-21 Anthony Whelan Broadband data services over vehicle power lines
HUP0500170A3 (en) 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
US8748608B2 (en) 2007-06-15 2014-06-10 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services 4-phenylpiperazine derivatives with functionalized linkers as dopamine D3 receptor selective ligands and methods of use
US11299476B2 (en) 2016-03-14 2022-04-12 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine D3 receptor selective antagonists/partial agonists; method of making; and use thereof
WO2020055725A1 (en) 2018-09-11 2020-03-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Dopamine d3 receptor selective antagonists/partial agonists and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3952014A (en) * 1969-08-18 1976-04-20 Richardson-Merrell Inc. Bis-basic esters and amides of dibenzothiophene
US4146624A (en) * 1970-09-14 1979-03-27 Richardson-Merrell Inc. Method of treating viruses with bis-basic ketones of dibenzofuran
US4334078A (en) * 1976-03-24 1982-06-08 Hoffmann-La Roche Inc. Dibenzothiophenes
US4448990A (en) * 1982-11-16 1984-05-15 Eli Lilly And Company Hydroxyaminotetralincarboxamides
US5254552A (en) 1988-05-24 1993-10-19 American Home Products Corporation Aryl-and heteroaryl piperazinyl carboxamides having central nervous system activity
SE9201138D0 (sv) 1992-04-09 1992-04-09 Astra Ab Novel phthalimidoalkylpiperazines
US5395835A (en) * 1994-03-24 1995-03-07 Warner-Lambert Company Naphthalamides as central nervous system agents
US5659033A (en) * 1995-09-13 1997-08-19 Neurogen Corporation N-aminoalkylfluorenecarboxamides; a new class of dopamine receptor subtype specific ligands
US5763609A (en) 1996-03-21 1998-06-09 Neurogen Corporation Certain pyrrolo pyridine-3-carboxamides; a new class of gaba brain receptor ligands
US5703235A (en) * 1996-03-21 1997-12-30 Neurogen Corporation N-Aminoalkyl-2-anthracenecarboxamides; new dopamine receptor subtype specific ligands

Also Published As

Publication number Publication date
US5763609A (en) 1998-06-09
DE69705035T2 (de) 2002-02-14
EP0888332B1 (de) 2001-05-30
AU2342397A (en) 1997-10-10
WO1997034889A1 (en) 1997-09-25
ATE201676T1 (de) 2001-06-15
US5929246A (en) 1999-07-27
US20010044461A1 (en) 2001-11-22
EP0888332A1 (de) 1999-01-07
US6429312B2 (en) 2002-08-06
US6221869B1 (en) 2001-04-24
ES2157565T3 (es) 2001-08-16
US6040459A (en) 2000-03-21

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee