JOP20180046B1 - متراكبات قابلة للذوبان في الماء من حديد وكربوهيدرات، إنتاجها وأدوية تحتوي عليها - Google Patents

متراكبات قابلة للذوبان في الماء من حديد وكربوهيدرات، إنتاجها وأدوية تحتوي عليها

Info

Publication number
JOP20180046B1
JOP20180046B1 JOP/2018/0046A JOP20180046A JOP20180046B1 JO P20180046 B1 JOP20180046 B1 JO P20180046B1 JO P20180046 A JOP20180046 A JO P20180046A JO P20180046 B1 JOP20180046 B1 JO P20180046B1
Authority
JO
Jordan
Prior art keywords
complexes
production
water
soluble iron
medicaments containing
Prior art date
Application number
JOP/2018/0046A
Other languages
English (en)
Inventor
Philipp Erik
Geisser Peter
Richle Walter
Original Assignee
Vifor Int Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32102937&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JOP20180046(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vifor Int Ag filed Critical Vifor Int Ag
Publication of JOP20180046A1 publication Critical patent/JOP20180046A1/ar
Application granted granted Critical
Publication of JOP20180046B1 publication Critical patent/JOP20180046B1/ar

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B30/00Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
    • C08B30/12Degraded, destructured or non-chemically modified starch, e.g. mechanically, enzymatically or by irradiation; Bleaching of starch
    • C08B30/18Dextrin, e.g. yellow canari, white dextrin, amylodextrin or maltodextrin; Methods of depolymerisation, e.g. by irradiation or mechanically
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00Preparation of derivatives of starch
    • C08B31/18Oxidised starch
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/718Starch or degraded starch, e.g. amylose, amylopectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/24Heavy metals; Compounds thereof
    • A61K33/26Iron; Compounds thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00Preparation of derivatives of starch
    • C08B31/18Oxidised starch
    • C08B31/185Derivatives of oxidised starch, e.g. crosslinked oxidised starch
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • A61K31/295Iron group metal compounds
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)

Abstract

يتعلق الاختراع الراهن بمتراكب قابل للذوبان في الماء من حديد وكربوهيدرات يمكن الحصول عليه من محلول مائي لملح الحديد (III) ومحلول مائي للمنتج الناتج عن أكسدة مركب مالتودكسترون واحد أو أكثر له مكافئ دكستروز يتراوح من 5 إلى 22 باستخدام محلول هيبوكلوريت مائي عند درجة حموضة تتراوح من 8.5 إلى 12, ويتعلق الاختراع الراهن بعملية لإنتاجه وبدواء لمعالجة حالات مرضية ناشئة عن نقص الحديد.
JOP/2018/0046A 2002-10-23 2018-05-02 متراكبات قابلة للذوبان في الماء من حديد وكربوهيدرات، إنتاجها وأدوية تحتوي عليها JOP20180046B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10249552A DE10249552A1 (de) 2002-10-23 2002-10-23 Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel

Publications (2)

Publication Number Publication Date
JOP20180046A1 JOP20180046A1 (ar) 2019-01-30
JOP20180046B1 true JOP20180046B1 (ar) 2022-09-15

Family

ID=32102937

Family Applications (3)

Application Number Title Priority Date Filing Date
JOP/2003/0130A JO3286B1 (ar) 2002-10-23 2003-10-02 متراكبات مائية من حديد و كربوهيدرات,انتاجها و ادوية تحتوي عليها
JOP/2011/0173A JOP20110173B1 (ar) 2002-10-23 2011-05-26 متراكبات قابلة للذوبان في الماء من حديد وكربوهيدرات، إنتاجها وأدوية تحتوي عليها
JOP/2018/0046A JOP20180046B1 (ar) 2002-10-23 2018-05-02 متراكبات قابلة للذوبان في الماء من حديد وكربوهيدرات، إنتاجها وأدوية تحتوي عليها

Family Applications Before (2)

Application Number Title Priority Date Filing Date
JOP/2003/0130A JO3286B1 (ar) 2002-10-23 2003-10-02 متراكبات مائية من حديد و كربوهيدرات,انتاجها و ادوية تحتوي عليها
JOP/2011/0173A JOP20110173B1 (ar) 2002-10-23 2011-05-26 متراكبات قابلة للذوبان في الماء من حديد وكربوهيدرات، إنتاجها وأدوية تحتوي عليها

Country Status (30)

Country Link
US (11) US7612109B2 (ar)
EP (2) EP1554315B1 (ar)
JP (2) JP4777653B2 (ar)
KR (1) KR100992178B1 (ar)
CN (1) CN100480275C (ar)
AR (1) AR041472A1 (ar)
AT (1) ATE507246T1 (ar)
AU (1) AU2003278111C1 (ar)
BR (2) BRPI0318840B8 (ar)
CA (1) CA2493806C (ar)
CY (2) CY1112680T1 (ar)
DE (2) DE10249552A1 (ar)
DK (2) DK1554315T3 (ar)
ES (2) ES2364136T3 (ar)
HK (2) HK1081976A1 (ar)
IL (1) IL166747A (ar)
JO (3) JO3286B1 (ar)
MX (1) MXPA05004300A (ar)
MY (1) MY134394A (ar)
NO (2) NO333008B1 (ar)
NZ (1) NZ539243A (ar)
PE (1) PE20040571A1 (ar)
PT (2) PT1554315E (ar)
RU (1) RU2303039C2 (ar)
SA (1) SA03240447B1 (ar)
SI (2) SI2287204T1 (ar)
TW (1) TWI265028B (ar)
UY (1) UY28033A1 (ar)
WO (1) WO2004037865A1 (ar)
ZA (1) ZA200504174B (ar)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6757848B2 (en) 2001-06-19 2004-06-29 Hewlett-Packard Development Company, L.P. Recovery of user data from partially incorrect data set in tape data storage system
DE10249552A1 (de) 2002-10-23 2004-05-13 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
DE102004031181A1 (de) * 2004-06-28 2006-01-19 Vifor (International) Ag Phosphatadsorbens
UA88347C2 (ru) * 2005-02-09 2009-10-12 Вифор (Интернешенл) Аг Применение комплексных соединений железа (iii) с углеводами или их производными в изготовлении медикамента для улучшения иммунной защиты и/или мозговой функции у пациентов без анемии
ITMO20050056A1 (it) 2005-03-15 2006-09-16 Biofer Spa Processo per la preparazione di complessi del ferro trivalente con zuccheri mono-, di- e polisaccaridi.
EP1757299A1 (de) * 2005-08-25 2007-02-28 Vifor (International) Ag Eisen(III)-Komplexverbindungen zur Behandlung von Eisenmangel-Zuständen bei Patienten mit chronisch-entzündlicher Darmerkrankung
EP1790356A1 (de) * 2005-11-24 2007-05-30 Vifor (International) Ag Präparat, umfassend Eisen(III)-Komplexverbindungen und redoxaktive Substanz(en)
AU2013206429B2 (en) * 2006-01-06 2016-04-28 Vifor (International) Ag Methods and compositions for administration of iron
KR20140117678A (ko) 2006-01-06 2014-10-07 루이트폴드 파머수티컬스, 인코퍼레이티드 철을 투여하기 위한 방법 및 조성물
AU2016205002C1 (en) * 2006-01-06 2020-09-24 Vifor (International) Ag Methods and compositions for administration of iron
EP1941869A1 (en) * 2007-01-04 2008-07-09 Vifor (International) Ag Multicompartment bag for storage of iron preparations
EP1947120A1 (de) * 2007-01-19 2008-07-23 Vifor (International) Ag Eisen-Kohlenhydrat-Komplex-Verbindungen
AU2008212653B2 (en) * 2007-02-06 2012-05-24 United Kingdom Research And Innovation Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation
EP1997833A1 (de) * 2007-05-29 2008-12-03 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydratderivat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
EP3156075B1 (en) 2009-03-25 2020-10-14 Pharmacosmos Holding A/S An oligosaccharide and a process for preparation thereof
EP2496595A2 (en) * 2009-11-04 2012-09-12 Symed Labs Limited Process for the preparation of iron (iii) carboxymaltose complex
JP5648120B2 (ja) 2010-03-23 2015-01-07 ヴィフォール (インターナショナル) アクチェンゲゼルシャフトVifor (International) AG 鉄欠乏症および鉄欠乏性貧血の治療および予防用の鉄(iii)錯体化合物
WO2012104204A1 (en) 2011-01-31 2012-08-09 Vifor (International) Ag Iron-carbohydrate complex compounds for the intravenous therapy of malaria
US9370202B2 (en) 2013-03-15 2016-06-21 LG Bionano, LLC Encapsulated metal ion nanoclusters
US9384629B2 (en) 2014-03-31 2016-07-05 Fresh Idea Global Limited Automated money laundering detection, notification, and reporting techniques implemented at casino gaming networks
WO2015198304A1 (en) 2014-06-22 2015-12-30 Dexcel Pharma Technologies Ltd. Pharmaceutical compositions comprising ferric citrate and methods for the production thereof
EP2997968A1 (en) 2014-09-22 2016-03-23 Ioulia Tseti Iron (III) hydroxide complexes with activated glucose syrups and process for preparing same
CN104402984B (zh) * 2014-11-11 2018-09-07 武汉科福新药有限责任公司 一种高载铁量的蛋白琥珀酸铁的制备方法
EP3274372A1 (en) * 2015-03-23 2018-01-31 Suven Life Sciences Limited Preparation of water soluble trivalent iron carbohydrate complexes
WO2016181195A1 (en) * 2015-05-08 2016-11-17 Suven Life Sciences Limited Improved process for water soluble iron carbohydrate complexes
WO2016196274A1 (en) * 2015-05-29 2016-12-08 Luitpold Pharmaceuticals, Inc. Compositions and methods for treatment of fibromyalgia
CN105125577B (zh) * 2015-07-29 2018-05-18 南京生命能科技开发有限公司 一种稳定的糖-铁复合物及其制备方法
CN105125578B (zh) * 2015-07-29 2018-05-11 南京生命能科技开发有限公司 一种具有高溶解速度的糖-铁复合物及其制备方法
US10258647B2 (en) 2015-09-01 2019-04-16 Particle Dynamics International, Llc Iron-polysaccharide complexes and methods for the preparation thereof
GB201517893D0 (en) 2015-10-09 2015-11-25 Medical Res Council Methods for producing carboxylate ligand modified ferric iron hydroxide colloids
CN105520955B (zh) * 2015-12-21 2018-05-11 南京生命能科技开发有限公司 一种羧基麦芽糖铁药用组合物及其制备方法
CN108129582A (zh) * 2016-12-01 2018-06-08 江苏奥赛康药业股份有限公司 一种铁碳水化合物复合物的制备方法
EP3339329A1 (en) 2016-12-22 2018-06-27 LEK Pharmaceuticals d.d. Selective oxidation of maltodextrin and its use in the preparation of water-soluble iron (iii) carboxymaltose complexes
EP3681539A1 (en) 2017-09-11 2020-07-22 Pharmacosmos Holding A/S Iron complex compounds for therapeutic use
WO2019193608A1 (en) * 2018-04-05 2019-10-10 Msn Laboratories Private Limited, R&D Center Improved process for the preparation of iron (iii) carboxymaltose
CN108498539A (zh) * 2018-05-03 2018-09-07 东营天东制药有限公司 一种水溶性铁剂复合体原料药的制备方法
EP3873492A1 (en) 2018-10-29 2021-09-08 Pharmacosmos Holding A/s Treating iron deficiency with ferric carboxymaltose
WO2020127928A1 (en) 2018-12-21 2020-06-25 Vifor (International) Ag Ferric carboxymaltose in the treatment of heart failure and in the treatment of congestion in heart failure
CN110218267B (zh) * 2019-07-04 2020-08-07 汉邦环宇多糖生物科技(河源)有限公司 一种右旋糖酐铁的制备方法及用途
US11447513B2 (en) * 2020-02-12 2022-09-20 Rk Pharma Inc. Purification process of ferric carboxymaltose
GB202005054D0 (en) 2020-04-06 2020-05-20 Nemysis Ltd Carboxylate Ligand Modified Ferric Iron Hydroxide Compositions for Use in the Treatment or Prevention of Iron Deficiency Associated with Liver Diseases
TWI784646B (zh) 2021-07-29 2022-11-21 台耀化學股份有限公司 製備羧基麥芽糖鐵的方法
WO2023041957A1 (en) * 2021-09-16 2023-03-23 Virchow Biotech Private Limited Efficient process for the synthesis of iron (iii) carbohydrate complexes
WO2024069644A1 (en) * 2022-09-30 2024-04-04 West Bengal Chemical Industries Limited A pharmaceutically acceptable ferric carboxymaltose and preparation thereof

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA623411A (en) 1961-07-04 Muller Arthur Process for the manufacture of iron-polyisomaltose complex for therapeutical purposes
DE370194C (de) 1923-02-28 Therese Rocksch Geb Laschet Elektrolytisches Zinnbad zur Darstellung schwammfreier Zinnkristalle
US1129307A (en) * 1914-12-26 1915-02-23 Howard L Marsh Process of forming compounds of iron and carbohydrates.
GB199951A (en) 1922-07-07 1923-07-05 William Swann Improvements in or relating to clamps or fastening devices for the brake chains of perambulators, and the like
DE461370C (de) 1925-06-13 1928-06-21 Chem Fab Vormals Sandoz Verfahren zur Herstellung von Monocarbonsaeuren aus Aldosen
GB289280A (en) 1927-06-17 1928-04-26 Chem Fab Vormals Sandoz Process for the oxidation of aldoses
GB335965A (en) 1929-06-05 1930-10-06 Ig Farbenindustrie Ag Process for the manufacture of complex iron compounds
US2807610A (en) 1952-02-15 1957-09-24 Baker Chem Co J T Hydrogenated dextran
GB748024A (en) 1953-02-27 1956-04-18 Benger S Ltd Improved therapeutic preparations of iron
GB828404A (en) * 1958-05-07 1960-02-17 Chugai Pharmaceutical Co Ltd A process for preparing divalent or trivalent metallic salts of glucuronic acid
GB879441A (en) 1959-05-25 1961-10-11 Crookes Lab Ltd Improved injectable iron preparations
US3065138A (en) 1959-10-09 1962-11-20 Warren Teed Products Company Therapeutic preparations of elemental iron
GB928238A (en) 1960-01-14 1963-06-12 Diamond Lab Inc Methods of preparing therapeutic preparations of iron
US3100202A (en) 1960-06-17 1963-08-06 Muller Arthur Process for preparing an iron hydroxide polyisomaltose complex and the resulting product
US3086009A (en) * 1960-07-19 1963-04-16 Diamond Lab Inc Process for preparing a water soluble hydrolyzed starch-ferric iron complex
GB978485A (en) 1960-10-26 1964-12-23 Astra Apotekarnes Kem Fab Iron preparations for intramuscular injection
GB928236A (en) 1960-11-22 1963-06-12 Atomic Energy Authority Uk Improvements in or relating to organic liquid moderated and cooled nuclear reactors
US3151107A (en) 1960-12-22 1964-09-29 Central Pharmacal Company Water-soluble iron complexes of carboxymethyl dextran
US3076798A (en) * 1961-02-23 1963-02-05 Hausmann Lab Ltd Process for preparing a ferric hydroxide polymaltose complex
GB985206A (en) 1961-12-20 1965-03-03 Hausmann Ag Labor Improvements in or relating to therapeutic iron preparation
ES282099A1 (es) 1962-11-02 1963-01-01 Rocador Sa Procedimiento para la preparación de un complejo de óxido de hierro y ácidos dextránicos
BE652508A (ar) * 1963-08-30
FR1451203A (fr) * 1964-01-31 1966-01-07 Rocador Sa Procédé pour la fabrication d'un complexe d'oxyde ferrique et de polysaccharide
DE1617463A1 (de) * 1965-11-20 1971-04-08 Bayer Ag Verfahren zur Herstellung von injizierbaren kolloidalen Eisenzubereitungen
US3639588A (en) 1966-10-22 1972-02-01 Fisons Pharmaceuticals Ltd Pharmaceutical compositions containing ferric hydroxide complexed with dextran or dextrin heptonic acids
GB1183940A (en) 1966-10-22 1970-03-11 Fisons Pharmaceuticals Ltd Ferric Hydroxide Complexes
SE322866B (ar) * 1966-12-15 1970-04-20 Astra Ab
GB1200902A (en) * 1967-05-13 1970-08-05 Fisons Pharmaceuticals Ltd Iron-dextran complexes
GB1199951A (en) 1967-05-13 1970-07-22 Fisons Pharmaceuticals Ltd Modified Dextran and Derivatives Thereof
US3395229A (en) 1967-07-03 1968-07-30 Mattox And Moore Inc Process and product for combatting iron deficiency anemia in suckling pigs
AT279048B (de) * 1967-07-04 1970-02-25 Pharmazeutische Fabrik Montavit Gmbh Verfahren zur Herstellung neuer, löslicher und stabiler organischer Eisen(III)-Komplexverbindungen und Injektionslösungen davon
GB1258566A (ar) 1968-07-12 1971-12-30
US3908004A (en) * 1970-05-20 1975-09-23 C L Basingstoke Limited Process for making injectable iron compositions for treating iron-deficiency anemia
US3821192A (en) 1971-08-18 1974-06-28 Central Pharmacal Co Process for preparing an iron-saccharide complex
SE359447B (ar) 1971-10-06 1973-09-03 Astra Laekemedel Ab
US3928581A (en) 1972-09-13 1975-12-23 Astra Laekemedel Ab Certain polymer-iron complexes for treatment of iron deficiency
US3969395A (en) 1972-10-04 1976-07-13 Astra Lakemedel Aktiebolag Polymers of hydroxy carboxylic acid and a polyhydric alcohol
US3965133A (en) 1972-10-04 1976-06-22 Astra Lakemedel Aktiebolag Polymer
US4056672A (en) 1973-03-22 1977-11-01 Astra Lakemedel Aktiebolag Polymer prepared by cyanhydrin method
JPS6039681B2 (ja) 1976-01-01 1985-09-07 日本臓器製薬株式会社 デキストリン・クエン酸・第二鉄多核複合体及び該複合体を含有する非経口用鉄剤
US4180567A (en) * 1977-09-02 1979-12-25 Pharmachem Corporation Iron preparations and methods of making and administering the same
US4370476A (en) 1979-07-17 1983-01-25 Usher Thomas C Dextran polycarboxylic acids, ferric hydroxide complexes
DE3026868C2 (de) * 1980-07-16 1986-03-13 Laboratorien Hausmann AG, St. Gallen Verfahren zur Herstellung von Eisen(III)hydroxid-Dextran-Komplexen und sie enthaltende pharmazeutische sterile wäßrige Lösung
US4335116A (en) 1980-10-07 1982-06-15 University Patents, Inc. Mineral-containing therapeutic compositions
EP0051707A1 (en) 1980-11-12 1982-05-19 Thomas Clemens Usher Dextran polycarboxylic acids, ferric hydroxide complexes thereof, pharmaceutical compositions containing them and methods for their manufacture
DE3114699A1 (de) 1981-04-10 1982-10-28 Siemens AG, 1000 Berlin und 8000 München Vorrichtung zum messen der roentgenroehrenhochspannung
HU187167B (en) 1982-10-15 1985-11-28 Richter Gedeon Vegyeszet Process for producing pharmaceutical solution of new type polynuclear iron/iii/ mixed complex activity
CS245379B1 (cs) 1983-12-12 1986-09-18 Karel Capek Způsob výroby komplexů sacharózy s biogenními prvky
US4788281A (en) 1984-01-04 1988-11-29 Tosoni Anthony L Dextran hexonic acid derivative, ferric hydroxide complex and method manufacture thereof
US5746999A (en) * 1984-11-23 1998-05-05 Schering Aktiengesellschaft Magnetic particles for diagnostic purposes
DE3443251C2 (de) * 1984-11-23 1998-03-12 Schering Ag Eisenoxid-Komplexe für die NMR-Diagnostik, diese Verbindungen enthaltende diagnostische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
US4640837A (en) 1985-10-15 1987-02-03 General Foods Corporation Coating composition for microwave cooking
US5160726A (en) * 1990-02-15 1992-11-03 Advanced Magnetics Inc. Filter sterilization for production of colloidal, superparamagnetic MR contrast agents
US5102652A (en) 1986-07-03 1992-04-07 Advanced Magnetics Inc. Low molecular weight carbohydrates as additives to stabilize metal oxide compositions
NO881507D0 (no) 1987-04-10 1988-04-07 Ortho Pharma Corp Fremgangsmaate for forhoeyning av hematokritnivaaet til et normalt pattedyr.
GB8902894D0 (en) 1989-02-09 1989-03-30 Fisons Plc Compositions
JP2726520B2 (ja) 1989-10-20 1998-03-11 名糖産業株式会社 有機磁性複合体
DK0427349T3 (da) 1989-11-10 1995-11-20 Tno Fremgangsmåde til fremstilling af polydicarboxysaccharider, og erstatninger for phosphater i detergenter baseret på polydicarboxsaccharider
ATE161546T1 (de) 1991-06-11 1998-01-15 Meito Sangyo Kk Oxidierte zusammensetzung, enthaltend ein wasserlösliches carboxypolysaccharid und magnetisches eisenoxid
TW293036B (ar) 1992-11-27 1996-12-11 Takeda Pharm Industry Co Ltd
EP0634174A1 (en) 1993-07-13 1995-01-18 Takeda Chemical Industries, Ltd. Antianemic composition for veterinary use
NL194919C (nl) 1993-09-07 2003-07-04 Tno Werkwijze voor het oxideren van koolhydraten.
FR2720398B1 (fr) * 1994-05-26 1996-07-05 Commissariat Energie Atomique Complexes de métaux trivalents avec un polyol tel que le cis-inositol, utilisables à des fins médicales et leur procédé de préparation.
GB9514090D0 (en) 1995-07-11 1995-09-13 Cerestar Holding Bv Non-catalysed oxidation of maltodextrin with an oxygen containing oxidant
US5624668A (en) * 1995-09-29 1997-04-29 Luitpold Pharmaceuticals, Inc. Iron dextran formulations
ATE236196T1 (de) 1995-11-09 2003-04-15 Abbott Lab Verfahren zur herstellung eines kristallinen eisendextrans
FR2742755B1 (fr) * 1995-12-21 1998-02-20 Roquette Freres Procede perfectionne d'oxydation des sucres
US5756715A (en) 1996-11-08 1998-05-26 Abbott Laboratories Process for making crystalline iron dextran
CA2195283C (en) 1997-01-16 2008-07-22 Thomas C. Usher Process for manufacturing iron dextran using ultrafiltration
IT1291289B1 (it) 1997-04-30 1999-01-07 Derivati Organici Lab Complessi costituiti da fe(iii) un composto poliidrossilato e ovalbumina
DK172860B1 (da) 1998-03-25 1999-08-16 Pharmacosmos Holding As Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman
DE19833548A1 (de) 1998-07-25 2000-02-03 Messer Griesheim Gmbh Überkritische Fluorierung
US6587550B2 (en) 1998-09-02 2003-07-01 Michael O. Council Method and apparatus for enabling a fee to be charged to a party initiating an electronic mail communication when the party is not on an authorization list associated with the party to whom the communication is directed
DK173138B1 (da) 1998-11-20 2000-02-07 Pharmacosmos Holding As Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma
EP1169062B1 (en) 1999-04-09 2009-10-21 AMAG Pharmaceuticals, Inc. Heat stable coated colloidal iron oxides
US7871597B2 (en) 1999-04-09 2011-01-18 Amag Pharmaceuticals, Inc. Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
US6703499B1 (en) 1999-04-29 2004-03-09 Polydex Pharmaceuticals Ltd. Process of making carboxylated dextran
US6521247B1 (en) 1999-08-13 2003-02-18 Warner Chilcott Laboratories Ireland Limited Dual iron containing nutritional supplement
US6495177B1 (en) 1999-08-13 2002-12-17 Warner Chilcott Laboratories Ireland Limited Orally dissolvable nutritional supplement
AT500063A1 (de) 1999-11-23 2005-10-15 Sandoz Ag Beschichtete tablettenkerne
US20020119174A1 (en) 2000-07-26 2002-08-29 Gardlik John Michael Compositions useful for regulating hair growth containing metal complexes of oxidized carbohydrates
BR0115100A (pt) * 2000-11-02 2003-09-30 Chromaceutical Advanced Tech Métodos para monitorar um produto de complexo ferro-sacarìdico, para purificar uma composição, e para produzir uma composição hematìnica, complexo ferro-sacarìdico, e, complexo hematìnico reconstituìdo
US6929954B2 (en) * 2000-11-02 2005-08-16 Chromaceutical Advanced Technologies, Inc. Method for producing purified hematinic iron-saccharidic complex and product produced
EP1719496A3 (en) 2000-11-02 2007-05-16 Chromaceutical Advanced Technologies, Inc. Method for producing purified hematinic iron-saccharidic complex and product produced
CN1353194A (zh) * 2000-11-02 2002-06-12 杨敏 生产20%右旋糖酐铁的方法
WO2002046241A2 (en) 2000-12-07 2002-06-13 Ad 'zdravlje' Farmaceutsko - Hemijska Industrija, Centar Za Istrazivanje I Razvoj Polynuclear complex fe(iii) with pullulan oligomers, process of its obtaining, and pharmaceutical preparations on the basis of the complex
JP2002260951A (ja) 2000-12-28 2002-09-13 Denso Corp 積層型誘電素子及びその製造方法,並びに電極用ペースト材料
BR0308773A (pt) 2002-04-09 2005-02-09 Pharmacosmos Holding As Compostos de dextrina de ferro para tratamento de anemia por deficiência de ferro
WO2004000368A1 (en) 2002-06-21 2003-12-31 University Of Pittsburgh Of The Commonwealth System Of Higher Education Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
US7169359B2 (en) * 2002-08-26 2007-01-30 Luitpold Pharmaceuticals, Inc. Bioequivalence test for iron-containing formulations
DK1540338T3 (da) * 2002-08-26 2009-02-09 Vifor Int Ag Bioækvivalenstest for jernholdige formuleringer
DE10249552A1 (de) * 2002-10-23 2004-05-13 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
US20060116349A1 (en) * 2003-03-14 2006-06-01 Luitpold Pharmaceuticals, Inc. Methods and compositions for administration of iron for the treatment of restless leg syndrome
US6960571B2 (en) 2003-03-14 2005-11-01 Luitpold Pharmaceuticals, Inc. Methods and compositions for administration of iron for the treatment of restless leg syndrome
US7964568B2 (en) * 2003-05-30 2011-06-21 Chromaceutical Advanced Technologies, Inc. Synthesis of high molecular weight iron-saccharidic complexes
US8614204B2 (en) 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
KR20060109922A (ko) 2003-10-31 2006-10-23 알자 코포레이션 가바펜틴 및 프리가발린의 개선된 흡수를 위한 조성물 및제형
US20060134227A1 (en) 2004-12-22 2006-06-22 Bortz Jonathan D Compositions including iron
UA88347C2 (ru) 2005-02-09 2009-10-12 Вифор (Интернешенл) Аг Применение комплексных соединений железа (iii) с углеводами или их производными в изготовлении медикамента для улучшения иммунной защиты и/или мозговой функции у пациентов без анемии
US7815621B2 (en) * 2005-07-07 2010-10-19 Eisai R & D Management Co. Ltd. Recovery system
EP1757299A1 (de) 2005-08-25 2007-02-28 Vifor (International) Ag Eisen(III)-Komplexverbindungen zur Behandlung von Eisenmangel-Zuständen bei Patienten mit chronisch-entzündlicher Darmerkrankung
US7660481B2 (en) 2005-11-17 2010-02-09 Vital Images, Inc. Image enhancement using anisotropic noise filtering
EP1790356A1 (de) 2005-11-24 2007-05-30 Vifor (International) Ag Präparat, umfassend Eisen(III)-Komplexverbindungen und redoxaktive Substanz(en)
KR20140117678A (ko) 2006-01-06 2014-10-07 루이트폴드 파머수티컬스, 인코퍼레이티드 철을 투여하기 위한 방법 및 조성물
US8778878B2 (en) 2007-01-29 2014-07-15 Chyna, LLC Use of ferritin to treat iron disorders
US8071542B2 (en) 2007-01-29 2011-12-06 Chyna, LLC Use of ferritin to treat iron deficiency disorders
EP1997833A1 (de) * 2007-05-29 2008-12-03 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydratderivat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
EP2496595A2 (en) 2009-11-04 2012-09-12 Symed Labs Limited Process for the preparation of iron (iii) carboxymaltose complex
BRPI0904979A2 (pt) 2009-12-04 2011-07-19 Braskem Sa processo para produção de olefinas, olefina, poliolefina, e, uso da poliolefina
US9120838B2 (en) 2011-04-18 2015-09-01 Curators Of The University Of Missouri Saccharide conjugates
US8772101B2 (en) 2012-11-08 2014-07-08 Globalfoundries Inc. Methods of forming replacement gate structures on semiconductor devices and the resulting device
EP3274372A1 (en) 2015-03-23 2018-01-31 Suven Life Sciences Limited Preparation of water soluble trivalent iron carbohydrate complexes
WO2016181195A1 (en) 2015-05-08 2016-11-17 Suven Life Sciences Limited Improved process for water soluble iron carbohydrate complexes
EP3339329A1 (en) 2016-12-22 2018-06-27 LEK Pharmaceuticals d.d. Selective oxidation of maltodextrin and its use in the preparation of water-soluble iron (iii) carboxymaltose complexes

Also Published As

Publication number Publication date
US10519252B2 (en) 2019-12-31
NZ539243A (en) 2007-05-31
US20140371169A1 (en) 2014-12-18
US20190276563A1 (en) 2019-09-12
HK1081976A1 (en) 2006-05-26
US20130203698A1 (en) 2013-08-08
DE50313653D1 (de) 2011-06-09
EP1554315A1 (de) 2005-07-20
SA03240447B1 (ar) 2008-09-14
US11123321B2 (en) 2021-09-21
US11590097B2 (en) 2023-02-28
ES2385788T3 (es) 2012-07-31
MY134394A (en) 2007-12-31
BR0315452A (pt) 2005-08-23
BRPI0318840B8 (pt) 2021-05-25
US11291645B2 (en) 2022-04-05
JO3286B1 (ar) 2018-09-16
SI1554315T1 (sl) 2011-09-30
CY1113387T1 (el) 2016-06-22
IL166747A0 (en) 2006-01-15
MXPA05004300A (es) 2005-11-23
JP5289413B2 (ja) 2013-09-11
PE20040571A1 (es) 2004-10-01
KR100992178B1 (ko) 2010-11-05
CY1112680T1 (el) 2016-02-10
AU2003278111B2 (en) 2009-05-28
RU2303039C2 (ru) 2007-07-20
EP2287204B1 (de) 2012-05-30
US20100099647A1 (en) 2010-04-22
JOP20110173B1 (ar) 2021-08-17
WO2004037865A1 (de) 2004-05-06
JOP20180046A1 (ar) 2019-01-30
BRPI0318840B1 (pt) 2021-02-02
BRPI0315452B1 (pt) 2015-12-01
US20220387371A1 (en) 2022-12-08
NO335770B1 (no) 2015-02-09
RU2005115455A (ru) 2005-12-10
NO20110654L (no) 2005-07-18
CN100480275C (zh) 2009-04-22
EP1554315B1 (de) 2011-04-27
CA2493806C (en) 2014-02-11
DK2287204T3 (da) 2012-07-23
PT1554315E (pt) 2011-06-30
US20210115163A1 (en) 2021-04-22
NO20052410D0 (no) 2005-05-13
EP2287204A1 (de) 2011-02-23
AR041472A1 (es) 2005-05-18
US20210054105A1 (en) 2021-02-25
HK1149574A1 (en) 2011-10-07
UY28033A1 (es) 2004-06-30
DE10249552A1 (de) 2004-05-13
AU2003278111A1 (en) 2004-05-13
PT2287204E (pt) 2012-07-18
TWI265028B (en) 2006-11-01
US9376505B2 (en) 2016-06-28
CA2493806A1 (en) 2004-05-06
US7612109B2 (en) 2009-11-03
JP2011052226A (ja) 2011-03-17
JP4777653B2 (ja) 2011-09-21
NO20052410L (no) 2005-07-18
ATE507246T1 (de) 2011-05-15
NO333008B1 (no) 2013-02-18
SI2287204T1 (sl) 2012-09-28
US20120316133A1 (en) 2012-12-13
US20190263939A1 (en) 2019-08-29
BRPI0315452B8 (pt) 2021-05-25
US20160215071A1 (en) 2016-07-28
ZA200504174B (en) 2006-04-26
AU2003278111C1 (en) 2010-12-02
ES2364136T3 (es) 2011-08-25
JP2006505638A (ja) 2006-02-16
AU2003278111B8 (en) 2009-06-04
CN1705682A (zh) 2005-12-07
US20060205691A1 (en) 2006-09-14
DK1554315T3 (da) 2011-07-04
KR20050070014A (ko) 2005-07-05
TW200420289A (en) 2004-10-16
IL166747A (en) 2010-11-30

Similar Documents

Publication Publication Date Title
JOP20180046B1 (ar) متراكبات قابلة للذوبان في الماء من حديد وكربوهيدرات، إنتاجها وأدوية تحتوي عليها
TN2009000443A1 (en) Water-soluble iron-carbohydrate derivative complexes, the preparation thereof, and medicaments comprising them
YU91002A (sh) Derivati acilfenil-karbamida, postupak za njihovu proizvodnju i njihova primena kao leka
GR3030437T3 (en) Water-soluble nimesulide salt, and uses thereof for the treatment of inflammations
ES400886A1 (es) Procedimiento para la preparacion de una solucion para la activacion, especialmente de superficies no conductoras parala subsiguiente metalizacion quimica.
UA74346C2 (uk) Похідні амінодикарбонових кислот, їх застосування та лікарський засіб
DK1198411T3 (da) Kemisk sammensætning og fremgangsmåde
ITMO20050056A1 (it) Processo per la preparazione di complessi del ferro trivalente con zuccheri mono-, di- e polisaccaridi.
CA2537920A1 (en) Methods and compositions for treating subterranean zones utilizing delayed breaker compositions
GEP20053650B (en) Disinfectant Solution Based on Sodium Hypochlorite, and Process for Preparing It
HUP0202749A2 (hu) Levoszimendánt tartalmazó oldat formájú gyógyszerkészítmény
CA2384433A1 (en) Novel betulinic acid derivatives having antiangiogenic activity, processes for producing such derivatives and their use for treating tumor associated angiogenesis
AR000087A1 (es) Proceso.
WO2000063219A8 (en) Platinum complexes for the treatment of cancer
PL1466599T3 (pl) Stężone roztwory oksaliplatyny
HK1091146A1 (en) New use, pharmaceutical preparations as well as a process for their production
EE200200259A (et) Veeparendusagens
EE200100627A (et) Pressitud produktid mittepaakuvast soolast
MXPA03001874A (es) Metodo para remover proteina de articulos de caucho de latex sumergidos.
GR1004016B (el) Αναβραζοντα δισκια, που περιεχουν ως δραστικο συστατικο συμπλοκες ενωσεις σιδηρου, για την θεραπεια των σιδηροπενικων αναιμιων
TH69577A (th) สารเชิงซ้อนของเหล็กกับคาร์โบไฮเดรตในลักษณะเป็นน้ำการผลิตและผลิตภัณฑ์ยาที่มีสารนี้เป็นส่วนประกอบ
AU2002365628A1 (en) Method for producing coated bleach activator granules
TH114614B (th) สารเชิงซ้อนอนุพันธ์เหล็ก-คาร์โบไฮเดรตที่ละลายน้ำได้ การเตรียมของมัน และเวชภัณฑ์ที่ประกอบด้วยสารเชิงซ้อนเหล่านี้
UA34171A (uk) Спосіб одержання пігментного двоокису титану з ільменітових концентратів
HUP9902478A2 (hu) Vírusellenes gyógyszerkészítmények és eljárás azok előállítására