GB335965A - Process for the manufacture of complex iron compounds - Google Patents
Process for the manufacture of complex iron compoundsInfo
- Publication number
- GB335965A GB335965A GB1731129A GB1731129A GB335965A GB 335965 A GB335965 A GB 335965A GB 1731129 A GB1731129 A GB 1731129A GB 1731129 A GB1731129 A GB 1731129A GB 335965 A GB335965 A GB 335965A
- Authority
- GB
- United Kingdom
- Prior art keywords
- iron
- acid
- acids
- ferrous
- ferric
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002506 iron compounds Chemical class 0.000 title abstract 4
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 abstract 8
- 239000002253 acid Substances 0.000 abstract 8
- CWYNVVGOOAEACU-UHFFFAOYSA-N Fe2+ Chemical compound [Fe+2] CWYNVVGOOAEACU-UHFFFAOYSA-N 0.000 abstract 5
- LOUPRKONTZGTKE-WZBLMQSHSA-N Quinine Chemical compound C([C@H]([C@H](C1)C=C)C2)C[N@@]1[C@@H]2[C@H](O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-WZBLMQSHSA-N 0.000 abstract 4
- 150000007513 acids Chemical class 0.000 abstract 4
- 229910052742 iron Inorganic materials 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 230000003472 neutralizing effect Effects 0.000 abstract 3
- AFABGHUZZDYHJO-UHFFFAOYSA-N 2-Methylpentane Chemical compound CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 235000001258 Cinchona calisaya Nutrition 0.000 abstract 2
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 abstract 2
- OFBQJSOFQDEBGM-UHFFFAOYSA-N Pentane Chemical compound CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 abstract 2
- -1 aliphatic hydroxycarboxylic acids Chemical class 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 2
- LOUPRKONTZGTKE-UHFFFAOYSA-N cinchonine Natural products C1C(C(C2)C=C)CCN2C1C(O)C1=CC=NC2=CC=C(OC)C=C21 LOUPRKONTZGTKE-UHFFFAOYSA-N 0.000 abstract 2
- 229960004887 ferric hydroxide Drugs 0.000 abstract 2
- IEECXTSVVFWGSE-UHFFFAOYSA-M iron(3+);oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Fe+3] IEECXTSVVFWGSE-UHFFFAOYSA-M 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 229960000948 quinine Drugs 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- CGQJFTGLCACLRB-UHFFFAOYSA-N 2,2,3,3-tetrahydroxyhexanedioic acid Chemical class OC(=O)CCC(O)(O)C(O)(O)C(O)=O CGQJFTGLCACLRB-UHFFFAOYSA-N 0.000 abstract 1
- VGVLFMIJNWWPBR-UHFFFAOYSA-N 2,2,3-trihydroxypentanedioic acid Chemical class OC(=O)CC(O)C(O)(O)C(O)=O VGVLFMIJNWWPBR-UHFFFAOYSA-N 0.000 abstract 1
- BFSVOASYOCHEOV-UHFFFAOYSA-N 2-diethylaminoethanol Chemical compound CCN(CC)CCO BFSVOASYOCHEOV-UHFFFAOYSA-N 0.000 abstract 1
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical class [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 abstract 1
- DSLZVSRJTYRBFB-LLEIAEIESA-N D-glucaric acid Chemical compound OC(=O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O DSLZVSRJTYRBFB-LLEIAEIESA-N 0.000 abstract 1
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 abstract 1
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 abstract 1
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- OOIOHEBTXPTBBE-UHFFFAOYSA-N [Na].[Fe] Chemical compound [Na].[Fe] OOIOHEBTXPTBBE-UHFFFAOYSA-N 0.000 abstract 1
- GOKIPOOTKLLKDI-UHFFFAOYSA-N acetic acid;iron Chemical compound [Fe].CC(O)=O.CC(O)=O.CC(O)=O GOKIPOOTKLLKDI-UHFFFAOYSA-N 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- LUEHNHVFDCZTGL-UHFFFAOYSA-N but-2-ynoic acid Chemical compound CC#CC(O)=O LUEHNHVFDCZTGL-UHFFFAOYSA-N 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 abstract 1
- 229960001231 choline Drugs 0.000 abstract 1
- HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 235000008824 ferric saccharate Nutrition 0.000 abstract 1
- 235000012208 gluconic acid Nutrition 0.000 abstract 1
- 239000000174 gluconic acid Substances 0.000 abstract 1
- 229940097043 glucuronic acid Drugs 0.000 abstract 1
- 150000002505 iron Chemical class 0.000 abstract 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- BITYAPCSNKJESK-UHFFFAOYSA-N potassiosodium Chemical compound [Na].[K] BITYAPCSNKJESK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
- C07F15/025—Iron compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
335,965. Carpmael, A., (I. G. Farbenindustrie Akt.-Ges.). June 5, 1929. Complex iron compounds of aliphatic hydroxycarboxylic acids are prepared by treating a polyhydroxy mono- or poly-carboxylic acid of the pentane or hexane series or a salt thereof with iron or an iron compound, the reaction mixture being simultaneously or subsequently neutralized with a basic substance. Acids specified comprise pentonic acids (tetrahydroxy-monocarboxylic acids) such as hexane-tetrolic acid (2-methylpentane tetrolic acid), hexonic acids such as gluconic acid, trihydroxyglutaric acids, glucuronic acid, and tetrahydroxyadipic acids such as saccharic and mucic acids and their isomers. As basic substance may be used the alkalies and also nitrogenous bases such as ammonia, diethylamine, diethylaminoethanol, choline and quinine. The iron compound may comprise ferrous or ferric hydroxide or a corresponding water-soluble salt such as ferric acetate or ferric and ferrous chlorides. The preparation may be effected by dissolving iron in the acid and then neutralizing, or by mixing an aqueous solution of the acid or its salt with an aqueous solution of an iron salt and neutralizing, or by treating the acid or its salt with ferrous or ferric hydroxide and subsequently neutralizing. The iron may be present in the product in the proportion of one atom or iron to one molecule of acid or in such other proportions as 1 : 2, 2 : 1, and 3 : 1. The products, which can be isolated by precipitation or evaporation, are readily water-soluble and are useful therapeutically. Examples are given of the preparation of sodium ferrous and ferric gluconates, potassium-sodium ferrous and ferric saccharates, quinine potassium ferrous saccharate, and sodium iron mucate. Specification 326,231 is referred to.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1731129A GB335965A (en) | 1929-06-05 | 1929-06-05 | Process for the manufacture of complex iron compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1731129A GB335965A (en) | 1929-06-05 | 1929-06-05 | Process for the manufacture of complex iron compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB335965A true GB335965A (en) | 1930-10-06 |
Family
ID=10092943
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1731129A Expired GB335965A (en) | 1929-06-05 | 1929-06-05 | Process for the manufacture of complex iron compounds |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB335965A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2474989A (en) * | 1944-07-07 | 1949-07-05 | Hoffmann La Roche | Injectable iron preparation and process for the manufacture of same |
| US2943100A (en) * | 1956-01-23 | 1960-06-28 | Pfanstiehl Lab Inc | Chelation composition and method of making the same |
| CN109311837A (en) * | 2016-03-31 | 2019-02-05 | 英国神盾Tx股份有限公司 | Method for generating maltol Fe composition by ferrous hydroxide |
| US11123321B2 (en) | 2002-10-23 | 2021-09-21 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11344568B2 (en) | 2006-01-06 | 2022-05-31 | American Regent, Inc. | Methods and compositions for administration of iron |
-
1929
- 1929-06-05 GB GB1731129A patent/GB335965A/en not_active Expired
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2474989A (en) * | 1944-07-07 | 1949-07-05 | Hoffmann La Roche | Injectable iron preparation and process for the manufacture of same |
| US2943100A (en) * | 1956-01-23 | 1960-06-28 | Pfanstiehl Lab Inc | Chelation composition and method of making the same |
| US11123321B2 (en) | 2002-10-23 | 2021-09-21 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11291645B2 (en) | 2002-10-23 | 2022-04-05 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11590097B2 (en) | 2002-10-23 | 2023-02-28 | Vifor (International) Ag | Aqueous iron carbohydrate complexes, their production and medicaments containing them |
| US11344568B2 (en) | 2006-01-06 | 2022-05-31 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11364260B2 (en) | 2006-01-06 | 2022-06-21 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11406656B2 (en) | 2006-01-06 | 2022-08-09 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11433091B2 (en) | 2006-01-06 | 2022-09-06 | American Regent, Inc. | Methods and compositions for administration of iron |
| US11478502B2 (en) | 2006-01-06 | 2022-10-25 | American Regent, Inc. | Methods and compositions for administration of iron |
| CN109311837A (en) * | 2016-03-31 | 2019-02-05 | 英国神盾Tx股份有限公司 | Method for generating maltol Fe composition by ferrous hydroxide |
| CN109311837B (en) * | 2016-03-31 | 2022-09-30 | 英国神盾Tx股份有限公司 | Method for producing a maltoferric composition from ferrous hydroxide |
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