GB985206A - Improvements in or relating to therapeutic iron preparation - Google Patents

Improvements in or relating to therapeutic iron preparation

Info

Publication number
GB985206A
GB985206A GB4569061A GB4569061A GB985206A GB 985206 A GB985206 A GB 985206A GB 4569061 A GB4569061 A GB 4569061A GB 4569061 A GB4569061 A GB 4569061A GB 985206 A GB985206 A GB 985206A
Authority
GB
United Kingdom
Prior art keywords
iron
complex
polyisomaltose
hydroxide
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4569061A
Inventor
Arthur Muller
Theodor Bersin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorien Hausmann AG
Original Assignee
Laboratorien Hausmann AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DEL40581A external-priority patent/DE1196629B/en
Application filed by Laboratorien Hausmann AG filed Critical Laboratorien Hausmann AG
Priority to GB4569061A priority Critical patent/GB985206A/en
Publication of GB985206A publication Critical patent/GB985206A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran

Abstract

A polymeric g -ferric oxide-hydroxide of formula (g -FeOOH)n is said to be formed in the preparation of a ferric hydroxide-polyisomaltose complex. An aqueous solution of an alkali metal carbonate or bicarbonate is added to an aqueous solution of polyisomaltose and an iron salt at 15-25 DEG C., to give a pH of about 2.6. Alkali metal hydroxide is then added to form a suspension of pH 11 or more, and the suspension is heated to form a solution.ALSO:A ferric hydroxide-polyisomaltose (i.e. water-soluble dextran) complex comprises 2 mols. of iron per anhydroglucose unit. The complex, which contains about 33% of iron, is made by adding to an acidic solution of polyisomaltose and a water-soluble iron compound at 15 DEG to 25 DEG C., an aqueous solution of an alkali metal carbonate or bicarbonate, subsequently adding an alkali metal hydroxide, heating the resulting suspension to form a solution and neutralizing the solution. Specified iron compounds are ferric chloride, acetate, sulphate or nitrate. The solution of the complex may be neutralized, e.g. addition of acids or ion-exchange resins. Electrolytes may be removed by further addition of ion-exchange resins or by dialysis, and the complex may be isolated by precipitation with organic solvents or by evaporation of the solution. The viscosity of the polyisomaltose may be reduced, if necessary, by heating and subsequently cooling the acids olution of iron compound and polyisomaltose. Preferably, alkali metal carbonate or bicarbonate is added to give a pH of about 2.6, and alkali metal hydroxide to give a suspension of pH not less than 11. The suspension may be heated to e.g. 90-100 DEG C. The polysaccharide is said to complex with a polymeric g -ferric oxide-hydroxide (g -FeOOH)n (Division C1). The complex is non-colloidal, and has therapeutic properties (Division A5). Specifications 748,024, Canadian Specifications 623,411, 623,412 and U.S.A. Specification 2,885,393 are referred to.ALSO:A parenterally-injectable composition for the treatment of iron-deficiency anaemia contains an iron hydroxide-polyisomaltose (a water-soluble dextran) complex comprising 2 moles of iron per anhydroglucose unit and containing about 33% by weight of iron. Specification 748,024 is referred to.
GB4569061A 1961-12-20 1961-12-20 Improvements in or relating to therapeutic iron preparation Expired GB985206A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB4569061A GB985206A (en) 1961-12-20 1961-12-20 Improvements in or relating to therapeutic iron preparation

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEL40581A DE1196629B (en) 1961-11-30 1961-11-30 Process for the production of nonionic, therapeutically usable ferric hydroxide-dextran complexes
GB4569061A GB985206A (en) 1961-12-20 1961-12-20 Improvements in or relating to therapeutic iron preparation

Publications (1)

Publication Number Publication Date
GB985206A true GB985206A (en) 1965-03-03

Family

ID=10438178

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4569061A Expired GB985206A (en) 1961-12-20 1961-12-20 Improvements in or relating to therapeutic iron preparation

Country Status (1)

Country Link
GB (1) GB985206A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11123321B2 (en) 2002-10-23 2021-09-21 Vifor (International) Ag Aqueous iron carbohydrate complexes, their production and medicaments containing them
US11344568B2 (en) 2006-01-06 2022-05-31 American Regent, Inc. Methods and compositions for administration of iron

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11123321B2 (en) 2002-10-23 2021-09-21 Vifor (International) Ag Aqueous iron carbohydrate complexes, their production and medicaments containing them
US11291645B2 (en) 2002-10-23 2022-04-05 Vifor (International) Ag Aqueous iron carbohydrate complexes, their production and medicaments containing them
US11344568B2 (en) 2006-01-06 2022-05-31 American Regent, Inc. Methods and compositions for administration of iron

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