CY1113387T1 - Υδατοδιαλυτα συμπλοκα σιδηρου υδατανθρακα, η παρασκευη αυτων και φαρμακα, τα οποια περιεχουν αυτα - Google Patents

Υδατοδιαλυτα συμπλοκα σιδηρου υδατανθρακα, η παρασκευη αυτων και φαρμακα, τα οποια περιεχουν αυτα

Info

Publication number
CY1113387T1
CY1113387T1 CY20121100585T CY121100585T CY1113387T1 CY 1113387 T1 CY1113387 T1 CY 1113387T1 CY 20121100585 T CY20121100585 T CY 20121100585T CY 121100585 T CY121100585 T CY 121100585T CY 1113387 T1 CY1113387 T1 CY 1113387T1
Authority
CY
Cyprus
Prior art keywords
medicines
contain
preparation
water solutions
iron carbon
Prior art date
Application number
CY20121100585T
Other languages
English (en)
Inventor
Peter Otto Geisser
Erik Philipp
Walter Richle
Original Assignee
Vifor (International) Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=32102937&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1113387(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Vifor (International) Ag filed Critical Vifor (International) Ag
Publication of CY1113387T1 publication Critical patent/CY1113387T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/18—Oxidised starch
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B30/00—Preparation of starch, degraded or non-chemically modified starch, amylose, or amylopectin
    • C08B30/12—Degraded, destructured or non-chemically modified starch, e.g. mechanically, enzymatically or by irradiation; Bleaching of starch
    • C08B30/18—Dextrin, e.g. yellow canari, white dextrin, amylodextrin or maltodextrin; Methods of depolymerisation, e.g. by irradiation or mechanically
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/295—Iron group metal compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/718—Starch or degraded starch, e.g. amylose, amylopectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B31/00—Preparation of derivatives of starch
    • C08B31/18—Oxidised starch
    • C08B31/185—Derivatives of oxidised starch, e.g. crosslinked oxidised starch
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)

Abstract

Σύμπλοκα σιδήρου(ΙΙΙ)-υδατάνθρακα με βάση τα προϊόντα οξείδωσης μαλτοδεξτρινών, όπου τα σύμπλοκα σιδήρου(ΙΙΙ)-υδατάνθρακα έχουν ένα μεσοσταθμικό μοριακό βάρος Μw 80kDa έως 400kDa, ειδικότερα για τη χρήση ως φαρμάκων για τη θεραπευτική αγωγή αναιμιών έλλειψης σιδήρου, κατά προτίμηση δια παρεντερικής χορήγησης, καθώς επίσης υδατικά διαλύματα αυτών.
CY20121100585T 2002-10-23 2012-06-29 Υδατοδιαλυτα συμπλοκα σιδηρου υδατανθρακα, η παρασκευη αυτων και φαρμακα, τα οποια περιεχουν αυτα CY1113387T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10249552A DE10249552A1 (de) 2002-10-23 2002-10-23 Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
EP10194332A EP2287204B1 (de) 2002-10-23 2003-10-20 Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
CY1113387T1 true CY1113387T1 (el) 2016-06-22

Family

ID=32102937

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20111100589T CY1112680T1 (el) 2002-10-23 2011-06-21 Υδατοδιαλυτα συμπλοκα σιδηρου υδατανθρακα, παρασκευη αυτων και φαρμακα τα οποια περιεχουν αυτα
CY20121100585T CY1113387T1 (el) 2002-10-23 2012-06-29 Υδατοδιαλυτα συμπλοκα σιδηρου υδατανθρακα, η παρασκευη αυτων και φαρμακα, τα οποια περιεχουν αυτα

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20111100589T CY1112680T1 (el) 2002-10-23 2011-06-21 Υδατοδιαλυτα συμπλοκα σιδηρου υδατανθρακα, παρασκευη αυτων και φαρμακα τα οποια περιεχουν αυτα

Country Status (30)

Country Link
US (11) US7612109B2 (el)
EP (2) EP2287204B1 (el)
JP (2) JP4777653B2 (el)
KR (1) KR100992178B1 (el)
CN (1) CN100480275C (el)
AR (1) AR041472A1 (el)
AT (1) ATE507246T1 (el)
AU (1) AU2003278111C1 (el)
BR (2) BRPI0318840B8 (el)
CA (1) CA2493806C (el)
CY (2) CY1112680T1 (el)
DE (2) DE10249552A1 (el)
DK (2) DK2287204T3 (el)
ES (2) ES2364136T3 (el)
HK (2) HK1081976A1 (el)
IL (1) IL166747A (el)
JO (3) JO3286B1 (el)
MX (1) MXPA05004300A (el)
MY (1) MY134394A (el)
NO (2) NO333008B1 (el)
NZ (1) NZ539243A (el)
PE (1) PE20040571A1 (el)
PT (2) PT2287204E (el)
RU (1) RU2303039C2 (el)
SA (1) SA03240447B1 (el)
SI (2) SI1554315T1 (el)
TW (1) TWI265028B (el)
UY (1) UY28033A1 (el)
WO (1) WO2004037865A1 (el)
ZA (1) ZA200504174B (el)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6757848B2 (en) 2001-06-19 2004-06-29 Hewlett-Packard Development Company, L.P. Recovery of user data from partially incorrect data set in tape data storage system
DE10249552A1 (de) * 2002-10-23 2004-05-13 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
DE102004031181A1 (de) * 2004-06-28 2006-01-19 Vifor (International) Ag Phosphatadsorbens
US8722101B2 (en) * 2005-02-09 2014-05-13 Vifor (International) Ag Use of iron(III) complex compounds
ITMO20050056A1 (it) 2005-03-15 2006-09-16 Biofer Spa Processo per la preparazione di complessi del ferro trivalente con zuccheri mono-, di- e polisaccaridi.
EP1757299A1 (de) * 2005-08-25 2007-02-28 Vifor (International) Ag Eisen(III)-Komplexverbindungen zur Behandlung von Eisenmangel-Zuständen bei Patienten mit chronisch-entzündlicher Darmerkrankung
EP1790356A1 (de) * 2005-11-24 2007-05-30 Vifor (International) Ag Präparat, umfassend Eisen(III)-Komplexverbindungen und redoxaktive Substanz(en)
KR101905340B1 (ko) 2006-01-06 2018-10-05 루이트폴드 파머수티컬스, 인코퍼레이티드 철을 투여하기 위한 방법 및 조성물
AU2016205002C1 (en) * 2006-01-06 2020-09-24 Vifor (International) Ag Methods and compositions for administration of iron
AU2013206429B2 (en) * 2006-01-06 2016-04-28 Vifor (International) Ag Methods and compositions for administration of iron
EP1941869A1 (en) * 2007-01-04 2008-07-09 Vifor (International) Ag Multicompartment bag for storage of iron preparations
EP1947120A1 (de) * 2007-01-19 2008-07-23 Vifor (International) Ag Eisen-Kohlenhydrat-Komplex-Verbindungen
CA2676146C (en) * 2007-02-06 2016-08-09 Medical Research Council Ligand modified poly oxo-hydroxy metal ion materials, their uses and processes for their preparation
EP1997833A1 (de) 2007-05-29 2008-12-03 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydratderivat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
HUE030866T2 (en) 2009-03-25 2017-06-28 Pharmacosmos Holding As Stable iron-oligosaccharide compound
US20120214986A1 (en) * 2009-11-04 2012-08-23 Symed Labs Limited Process for the preparation of iron (iii) carboxymaltose complex
RU2589710C2 (ru) 2010-03-23 2016-07-10 Вифор (Интернациональ) Аг Комплексные соединения железа(iii) для лечения и профилактики симптомов железодефицита и железодефицитной анемии
WO2012104204A1 (en) 2011-01-31 2012-08-09 Vifor (International) Ag Iron-carbohydrate complex compounds for the intravenous therapy of malaria
US9370202B2 (en) 2013-03-15 2016-06-21 LG Bionano, LLC Encapsulated metal ion nanoclusters
US9384629B2 (en) 2014-03-31 2016-07-05 Fresh Idea Global Limited Automated money laundering detection, notification, and reporting techniques implemented at casino gaming networks
WO2015198304A1 (en) 2014-06-22 2015-12-30 Dexcel Pharma Technologies Ltd. Pharmaceutical compositions comprising ferric citrate and methods for the production thereof
EP2997968A1 (en) 2014-09-22 2016-03-23 Ioulia Tseti Iron (III) hydroxide complexes with activated glucose syrups and process for preparing same
CN104402984B (zh) * 2014-11-11 2018-09-07 武汉科福新药有限责任公司 一种高载铁量的蛋白琥珀酸铁的制备方法
WO2016151367A1 (en) * 2015-03-23 2016-09-29 Suven Life Sciences Limited Preparation of water soluble trivalent iron carbohydrate complexes
WO2016181195A1 (en) * 2015-05-08 2016-11-17 Suven Life Sciences Limited Improved process for water soluble iron carbohydrate complexes
WO2016196274A1 (en) * 2015-05-29 2016-12-08 Luitpold Pharmaceuticals, Inc. Compositions and methods for treatment of fibromyalgia
CN105125578B (zh) * 2015-07-29 2018-05-11 南京生命能科技开发有限公司 一种具有高溶解速度的糖-铁复合物及其制备方法
CN105125577B (zh) * 2015-07-29 2018-05-18 南京生命能科技开发有限公司 一种稳定的糖-铁复合物及其制备方法
US10258647B2 (en) 2015-09-01 2019-04-16 Particle Dynamics International, Llc Iron-polysaccharide complexes and methods for the preparation thereof
GB201517893D0 (en) 2015-10-09 2015-11-25 Medical Res Council Methods for producing carboxylate ligand modified ferric iron hydroxide colloids
CN105520955B (zh) * 2015-12-21 2018-05-11 南京生命能科技开发有限公司 一种羧基麦芽糖铁药用组合物及其制备方法
CN108129582A (zh) * 2016-12-01 2018-06-08 江苏奥赛康药业股份有限公司 一种铁碳水化合物复合物的制备方法
EP3339329A1 (en) 2016-12-22 2018-06-27 LEK Pharmaceuticals d.d. Selective oxidation of maltodextrin and its use in the preparation of water-soluble iron (iii) carboxymaltose complexes
AU2018328052B2 (en) 2017-09-11 2024-02-29 Pharmacosmos Holding A/S Iron complex compounds for therapeutic use
WO2019193608A1 (en) * 2018-04-05 2019-10-10 Msn Laboratories Private Limited, R&D Center Improved process for the preparation of iron (iii) carboxymaltose
CN108498539A (zh) * 2018-05-03 2018-09-07 东营天东制药有限公司 一种水溶性铁剂复合体原料药的制备方法
BR112021008142A2 (pt) 2018-10-29 2021-08-03 Pharmacosmos Holding A/S tratamento de deficiência de ferro com carboximaltose férrica
WO2020127928A1 (en) 2018-12-21 2020-06-25 Vifor (International) Ag Ferric carboxymaltose in the treatment of heart failure and in the treatment of congestion in heart failure
CN110218267B (zh) * 2019-07-04 2020-08-07 汉邦环宇多糖生物科技（河源）有限公司 一种右旋糖酐铁的制备方法及用途
US11447513B2 (en) * 2020-02-12 2022-09-20 Rk Pharma Inc. Purification process of ferric carboxymaltose
GB202005054D0 (en) 2020-04-06 2020-05-20 Nemysis Ltd Carboxylate Ligand Modified Ferric Iron Hydroxide Compositions for Use in the Treatment or Prevention of Iron Deficiency Associated with Liver Diseases
TWI784646B (zh) 2021-07-29 2022-11-21 台耀化學股份有限公司 製備羧基麥芽糖鐵的方法
WO2023041957A1 (en) * 2021-09-16 2023-03-23 Virchow Biotech Private Limited Efficient process for the synthesis of iron (iii) carbohydrate complexes
WO2024069644A1 (en) * 2022-09-30 2024-04-04 West Bengal Chemical Industries Limited A pharmaceutically acceptable ferric carboxymaltose and preparation thereof

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE370194C (de) 1923-02-28 Therese Rocksch Geb Laschet Elektrolytisches Zinnbad zur Darstellung schwammfreier Zinnkristalle
CA623411A (en) 1961-07-04 Muller Arthur Process for the manufacture of iron-polyisomaltose complex for therapeutical purposes
US1129307A (en) * 1914-12-26 1915-02-23 Howard L Marsh Process of forming compounds of iron and carbohydrates.
GB199951A (en) 1922-07-07 1923-07-05 William Swann Improvements in or relating to clamps or fastening devices for the brake chains of perambulators, and the like
DE461370C (de) 1925-06-13 1928-06-21 Chem Fab Vormals Sandoz Verfahren zur Herstellung von Monocarbonsaeuren aus Aldosen
GB289280A (en) 1927-06-17 1928-04-26 Chem Fab Vormals Sandoz Process for the oxidation of aldoses
GB335965A (en) 1929-06-05 1930-10-06 Ig Farbenindustrie Ag Process for the manufacture of complex iron compounds
US2807610A (en) 1952-02-15 1957-09-24 Baker Chem Co J T Hydrogenated dextran
GB748024A (en) 1953-02-27 1956-04-18 Benger S Ltd Improved therapeutic preparations of iron
GB828404A (en) * 1958-05-07 1960-02-17 Chugai Pharmaceutical Co Ltd A process for preparing divalent or trivalent metallic salts of glucuronic acid
GB879441A (en) 1959-05-25 1961-10-11 Crookes Lab Ltd Improved injectable iron preparations
US3065138A (en) 1959-10-09 1962-11-20 Warren Teed Products Company Therapeutic preparations of elemental iron
GB928238A (en) 1960-01-14 1963-06-12 Diamond Lab Inc Methods of preparing therapeutic preparations of iron
US3100202A (en) 1960-06-17 1963-08-06 Muller Arthur Process for preparing an iron hydroxide polyisomaltose complex and the resulting product
US3086009A (en) * 1960-07-19 1963-04-16 Diamond Lab Inc Process for preparing a water soluble hydrolyzed starch-ferric iron complex
GB978485A (en) 1960-10-26 1964-12-23 Astra Apotekarnes Kem Fab Iron preparations for intramuscular injection
GB928236A (en) 1960-11-22 1963-06-12 Atomic Energy Authority Uk Improvements in or relating to organic liquid moderated and cooled nuclear reactors
US3151107A (en) 1960-12-22 1964-09-29 Central Pharmacal Company Water-soluble iron complexes of carboxymethyl dextran
US3076798A (en) * 1961-02-23 1963-02-05 Hausmann Lab Ltd Process for preparing a ferric hydroxide polymaltose complex
GB985206A (en) 1961-12-20 1965-03-03 Hausmann Ag Labor Improvements in or relating to therapeutic iron preparation
ES282099A1 (es) 1962-11-02 1963-01-01 Rocador Sa Procedimiento para la preparación de un complejo de óxido de hierro y ácidos dextránicos
BE652508A (el) * 1963-08-30
FR1451203A (fr) * 1964-01-31 1966-01-07 Rocador Sa Procédé pour la fabrication d'un complexe d'oxyde ferrique et de polysaccharide
DE1617463A1 (de) * 1965-11-20 1971-04-08 Bayer Ag Verfahren zur Herstellung von injizierbaren kolloidalen Eisenzubereitungen
US3639588A (en) 1966-10-22 1972-02-01 Fisons Pharmaceuticals Ltd Pharmaceutical compositions containing ferric hydroxide complexed with dextran or dextrin heptonic acids
GB1183940A (en) 1966-10-22 1970-03-11 Fisons Pharmaceuticals Ltd Ferric Hydroxide Complexes
SE322866B (el) * 1966-12-15 1970-04-20 Astra Ab
GB1200902A (en) * 1967-05-13 1970-08-05 Fisons Pharmaceuticals Ltd Iron-dextran complexes
GB1199951A (en) 1967-05-13 1970-07-22 Fisons Pharmaceuticals Ltd Modified Dextran and Derivatives Thereof
US3395229A (en) 1967-07-03 1968-07-30 Mattox And Moore Inc Process and product for combatting iron deficiency anemia in suckling pigs
AT279048B (de) * 1967-07-04 1970-02-25 Pharmazeutische Fabrik Montavit Gmbh Verfahren zur Herstellung neuer, löslicher und stabiler organischer Eisen(III)-Komplexverbindungen und Injektionslösungen davon
GB1258566A (el) 1968-07-12 1971-12-30
US3908004A (en) * 1970-05-20 1975-09-23 C L Basingstoke Limited Process for making injectable iron compositions for treating iron-deficiency anemia
US3821192A (en) 1971-08-18 1974-06-28 Central Pharmacal Co Process for preparing an iron-saccharide complex
SE359447B (el) 1971-10-06 1973-09-03 Astra Laekemedel Ab
US3928581A (en) 1972-09-13 1975-12-23 Astra Laekemedel Ab Certain polymer-iron complexes for treatment of iron deficiency
US3969395A (en) 1972-10-04 1976-07-13 Astra Lakemedel Aktiebolag Polymers of hydroxy carboxylic acid and a polyhydric alcohol
US3965133A (en) 1972-10-04 1976-06-22 Astra Lakemedel Aktiebolag Polymer
US4056672A (en) 1973-03-22 1977-11-01 Astra Lakemedel Aktiebolag Polymer prepared by cyanhydrin method
JPS6039681B2 (ja) 1976-01-01 1985-09-07 日本臓器製薬株式会社 デキストリン・クエン酸・第二鉄多核複合体及び該複合体を含有する非経口用鉄剤
US4180567A (en) * 1977-09-02 1979-12-25 Pharmachem Corporation Iron preparations and methods of making and administering the same
US4370476A (en) 1979-07-17 1983-01-25 Usher Thomas C Dextran polycarboxylic acids, ferric hydroxide complexes
DE3026868C2 (de) * 1980-07-16 1986-03-13 Laboratorien Hausmann AG, St. Gallen Verfahren zur Herstellung von Eisen(III)hydroxid-Dextran-Komplexen und sie enthaltende pharmazeutische sterile wäßrige Lösung
US4335116A (en) 1980-10-07 1982-06-15 University Patents, Inc. Mineral-containing therapeutic compositions
EP0051707A1 (en) 1980-11-12 1982-05-19 Thomas Clemens Usher Dextran polycarboxylic acids, ferric hydroxide complexes thereof, pharmaceutical compositions containing them and methods for their manufacture
DE3114699A1 (de) 1981-04-10 1982-10-28 Siemens AG, 1000 Berlin und 8000 München Vorrichtung zum messen der roentgenroehrenhochspannung
HU187167B (en) 1982-10-15 1985-11-28 Richter Gedeon Vegyeszet Process for producing pharmaceutical solution of new type polynuclear iron/iii/ mixed complex activity
CS245379B1 (cs) 1983-12-12 1986-09-18 Karel Capek Způsob výroby komplexů sacharózy s biogenními prvky
US4788281A (en) * 1984-01-04 1988-11-29 Tosoni Anthony L Dextran hexonic acid derivative, ferric hydroxide complex and method manufacture thereof
US5746999A (en) * 1984-11-23 1998-05-05 Schering Aktiengesellschaft Magnetic particles for diagnostic purposes
DE3443251C2 (de) * 1984-11-23 1998-03-12 Schering Ag Eisenoxid-Komplexe für die NMR-Diagnostik, diese Verbindungen enthaltende diagnostische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
US4640837A (en) 1985-10-15 1987-02-03 General Foods Corporation Coating composition for microwave cooking
US5102652A (en) 1986-07-03 1992-04-07 Advanced Magnetics Inc. Low molecular weight carbohydrates as additives to stabilize metal oxide compositions
US5160726A (en) * 1990-02-15 1992-11-03 Advanced Magnetics Inc. Filter sterilization for production of colloidal, superparamagnetic MR contrast agents
JP2858752B2 (ja) 1987-04-10 1999-02-17 オーソ・フアーマシユーチカル・コーポレーシヨン 正常な哺乳動物のヘマトクリツト値の増大方法
GB8902894D0 (en) 1989-02-09 1989-03-30 Fisons Plc Compositions
JP2726520B2 (ja) 1989-10-20 1998-03-11 名糖産業株式会社 有機磁性複合体
DK0427349T3 (da) 1989-11-10 1995-11-20 Tno Fremgangsmåde til fremstilling af polydicarboxysaccharider, og erstatninger for phosphater i detergenter baseret på polydicarboxsaccharider
ATE161546T1 (de) 1991-06-11 1998-01-15 Meito Sangyo Kk Oxidierte zusammensetzung, enthaltend ein wasserlösliches carboxypolysaccharid und magnetisches eisenoxid
TW293036B (el) 1992-11-27 1996-12-11 Takeda Pharm Industry Co Ltd
EP0634174A1 (en) 1993-07-13 1995-01-18 Takeda Chemical Industries, Ltd. Antianemic composition for veterinary use
NL194919C (nl) 1993-09-07 2003-07-04 Tno Werkwijze voor het oxideren van koolhydraten.
FR2720398B1 (fr) * 1994-05-26 1996-07-05 Commissariat Energie Atomique Complexes de métaux trivalents avec un polyol tel que le cis-inositol, utilisables à des fins médicales et leur procédé de préparation.
GB9514090D0 (en) * 1995-07-11 1995-09-13 Cerestar Holding Bv Non-catalysed oxidation of maltodextrin with an oxygen containing oxidant
US5624668A (en) * 1995-09-29 1997-04-29 Luitpold Pharmaceuticals, Inc. Iron dextran formulations
WO1997017377A1 (en) 1995-11-09 1997-05-15 Abbott Laboratories Process for making crystalline iron dextran
FR2742755B1 (fr) * 1995-12-21 1998-02-20 Roquette Freres Procede perfectionne d'oxydation des sucres
US5756715A (en) 1996-11-08 1998-05-26 Abbott Laboratories Process for making crystalline iron dextran
CA2195283C (en) 1997-01-16 2008-07-22 Thomas C. Usher Process for manufacturing iron dextran using ultrafiltration
IT1291289B1 (it) 1997-04-30 1999-01-07 Derivati Organici Lab Complessi costituiti da fe(iii) un composto poliidrossilato e ovalbumina
DK172860B1 (da) 1998-03-25 1999-08-16 Pharmacosmos Holding As Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman
DE19833548A1 (de) 1998-07-25 2000-02-03 Messer Griesheim Gmbh Überkritische Fluorierung
US6587550B2 (en) 1998-09-02 2003-07-01 Michael O. Council Method and apparatus for enabling a fee to be charged to a party initiating an electronic mail communication when the party is not on an authorization list associated with the party to whom the communication is directed
DK173138B1 (da) 1998-11-20 2000-02-07 Pharmacosmos Holding As Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma
US6599498B1 (en) 1999-04-09 2003-07-29 Advanced Magnetics, Inc. Heat stable colloidal iron oxides coated with reduced carbohydrates and carbohdrate derivatives
US7871597B2 (en) 1999-04-09 2011-01-18 Amag Pharmaceuticals, Inc. Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
US6703499B1 (en) 1999-04-29 2004-03-09 Polydex Pharmaceuticals Ltd. Process of making carboxylated dextran
US6521247B1 (en) 1999-08-13 2003-02-18 Warner Chilcott Laboratories Ireland Limited Dual iron containing nutritional supplement
US6495177B1 (en) 1999-08-13 2002-12-17 Warner Chilcott Laboratories Ireland Limited Orally dissolvable nutritional supplement
AT500063A1 (de) 1999-11-23 2005-10-15 Sandoz Ag Beschichtete tablettenkerne
US20020119174A1 (en) 2000-07-26 2002-08-29 Gardlik John Michael Compositions useful for regulating hair growth containing metal complexes of oxidized carbohydrates
CN1473265B (zh) * 2000-11-02 2011-10-12 色品先进技术股份有限公司 生产纯化的补血铁-糖复合物的方法及产品的生产
US6929954B2 (en) * 2000-11-02 2005-08-16 Chromaceutical Advanced Technologies, Inc. Method for producing purified hematinic iron-saccharidic complex and product produced
CN1353194A (zh) * 2000-11-02 2002-06-12 杨敏 生产20%右旋糖酐铁的方法
EP1719495A3 (en) 2000-11-02 2007-05-02 Chromaceutical Advanced Technologies, Inc. Method for producing purified hematinic iron-saccharidic complex and product produced
DK1363951T3 (da) 2000-12-07 2007-03-12 Ad Zdravlje Farmaceutsko Hemij Polynukleært jern(III)kompleks med pullulanoligomerer, fremgangsmåde til dens opnåelse og farmaceutiske præparater på basis af komplekset
JP2002260951A (ja) 2000-12-28 2002-09-13 Denso Corp 積層型誘電素子及びその製造方法，並びに電極用ペースト材料
DE60307249T2 (de) 2002-04-09 2007-03-15 Pharmacosmos Holding A/S Eisen-dextrin verbindung zur behandlung von anämien durch eisenmangel
RS110504A (en) 2002-06-21 2007-02-05 University Of Pittsburgh Of The Commonwealth System Of Higher Education, Pharmaceutical use of nitric oxide, heme oxygenase-1 and products of heme degradation
BR0215853A (pt) 2002-08-26 2005-06-21 Luitpold Pharm Inc Testes de bioequivalência para formulações contendo ferro
US7169359B2 (en) * 2002-08-26 2007-01-30 Luitpold Pharmaceuticals, Inc. Bioequivalence test for iron-containing formulations
DE10249552A1 (de) 2002-10-23 2004-05-13 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
US6960571B2 (en) 2003-03-14 2005-11-01 Luitpold Pharmaceuticals, Inc. Methods and compositions for administration of iron for the treatment of restless leg syndrome
US20060116349A1 (en) * 2003-03-14 2006-06-01 Luitpold Pharmaceuticals, Inc. Methods and compositions for administration of iron for the treatment of restless leg syndrome
US7964568B2 (en) * 2003-05-30 2011-06-21 Chromaceutical Advanced Technologies, Inc. Synthesis of high molecular weight iron-saccharidic complexes
US8614204B2 (en) 2003-06-06 2013-12-24 Fibrogen, Inc. Enhanced erythropoiesis and iron metabolism
EP1680082A1 (en) 2003-10-31 2006-07-19 ALZA Corporation Compositions and dosage forms for enhanced absorption of metformin
US20060134227A1 (en) 2004-12-22 2006-06-22 Bortz Jonathan D Compositions including iron
US8722101B2 (en) 2005-02-09 2014-05-13 Vifor (International) Ag Use of iron(III) complex compounds
US7815621B2 (en) * 2005-07-07 2010-10-19 Eisai R & D Management Co. Ltd. Recovery system
EP1757299A1 (de) 2005-08-25 2007-02-28 Vifor (International) Ag Eisen(III)-Komplexverbindungen zur Behandlung von Eisenmangel-Zuständen bei Patienten mit chronisch-entzündlicher Darmerkrankung
US7660481B2 (en) 2005-11-17 2010-02-09 Vital Images, Inc. Image enhancement using anisotropic noise filtering
EP1790356A1 (de) * 2005-11-24 2007-05-30 Vifor (International) Ag Präparat, umfassend Eisen(III)-Komplexverbindungen und redoxaktive Substanz(en)
KR101905340B1 (ko) 2006-01-06 2018-10-05 루이트폴드 파머수티컬스, 인코퍼레이티드 철을 투여하기 위한 방법 및 조성물
US8071542B2 (en) 2007-01-29 2011-12-06 Chyna, LLC Use of ferritin to treat iron deficiency disorders
US8778878B2 (en) 2007-01-29 2014-07-15 Chyna, LLC Use of ferritin to treat iron disorders
EP1997833A1 (de) * 2007-05-29 2008-12-03 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydratderivat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
US20120214986A1 (en) 2009-11-04 2012-08-23 Symed Labs Limited Process for the preparation of iron (iii) carboxymaltose complex
BRPI0904979A2 (pt) 2009-12-04 2011-07-19 Braskem Sa processo para produção de olefinas, olefina, poliolefina, e, uso da poliolefina
WO2012145392A2 (en) 2011-04-18 2012-10-26 Curators Of The University Of Missouri Saccharide conjugates
US8772101B2 (en) 2012-11-08 2014-07-08 Globalfoundries Inc. Methods of forming replacement gate structures on semiconductor devices and the resulting device
WO2016151367A1 (en) 2015-03-23 2016-09-29 Suven Life Sciences Limited Preparation of water soluble trivalent iron carbohydrate complexes
WO2016181195A1 (en) 2015-05-08 2016-11-17 Suven Life Sciences Limited Improved process for water soluble iron carbohydrate complexes
EP3339329A1 (en) 2016-12-22 2018-06-27 LEK Pharmaceuticals d.d. Selective oxidation of maltodextrin and its use in the preparation of water-soluble iron (iii) carboxymaltose complexes

Also Published As

Publication number Publication date
MXPA05004300A (es) 2005-11-23
TWI265028B (en) 2006-11-01
US20190263939A1 (en) 2019-08-29
JOP20180046B1 (ar) 2022-09-15
TW200420289A (en) 2004-10-16
CA2493806C (en) 2014-02-11
AU2003278111B2 (en) 2009-05-28
HK1081976A1 (en) 2006-05-26
SI1554315T1 (sl) 2011-09-30
US11590097B2 (en) 2023-02-28
US20120316133A1 (en) 2012-12-13
US20210115163A1 (en) 2021-04-22
NZ539243A (en) 2007-05-31
ZA200504174B (en) 2006-04-26
EP2287204B1 (de) 2012-05-30
DE10249552A1 (de) 2004-05-13
US11123321B2 (en) 2021-09-21
NO20052410L (no) 2005-07-18
JP2006505638A (ja) 2006-02-16
EP2287204A1 (de) 2011-02-23
UY28033A1 (es) 2004-06-30
SA03240447B1 (ar) 2008-09-14
AU2003278111C1 (en) 2010-12-02
PT2287204E (pt) 2012-07-18
HK1149574A1 (en) 2011-10-07
AU2003278111B8 (en) 2009-06-04
KR100992178B1 (ko) 2010-11-05
BRPI0318840B1 (pt) 2021-02-02
US20100099647A1 (en) 2010-04-22
US20220387371A1 (en) 2022-12-08
RU2303039C2 (ru) 2007-07-20
BR0315452A (pt) 2005-08-23
NO20052410D0 (no) 2005-05-13
US20140371169A1 (en) 2014-12-18
CA2493806A1 (en) 2004-05-06
EP1554315B1 (de) 2011-04-27
NO335770B1 (no) 2015-02-09
PT1554315E (pt) 2011-06-30
CN100480275C (zh) 2009-04-22
PE20040571A1 (es) 2004-10-01
AR041472A1 (es) 2005-05-18
JOP20110173B1 (ar) 2021-08-17
US20210054105A1 (en) 2021-02-25
BRPI0315452B1 (pt) 2015-12-01
NO20110654L (no) 2005-07-18
JP2011052226A (ja) 2011-03-17
US20130203698A1 (en) 2013-08-08
DK1554315T3 (da) 2011-07-04
ES2385788T3 (es) 2012-07-31
US20190276563A1 (en) 2019-09-12
DK2287204T3 (da) 2012-07-23
US20060205691A1 (en) 2006-09-14
WO2004037865A1 (de) 2004-05-06
CY1112680T1 (el) 2016-02-10
US7612109B2 (en) 2009-11-03
DE50313653D1 (de) 2011-06-09
US11291645B2 (en) 2022-04-05
US9376505B2 (en) 2016-06-28
SI2287204T1 (sl) 2012-09-28
JO3286B1 (ar) 2018-09-16
ES2364136T3 (es) 2011-08-25
BRPI0315452B8 (pt) 2021-05-25
CN1705682A (zh) 2005-12-07
JP4777653B2 (ja) 2011-09-21
BRPI0318840B8 (pt) 2021-05-25
EP1554315A1 (de) 2005-07-20
US10519252B2 (en) 2019-12-31
NO333008B1 (no) 2013-02-18
IL166747A (en) 2010-11-30
IL166747A0 (en) 2006-01-15
ATE507246T1 (de) 2011-05-15
US20160215071A1 (en) 2016-07-28
JOP20180046A1 (ar) 2019-01-30
MY134394A (en) 2007-12-31
KR20050070014A (ko) 2005-07-05
AU2003278111A1 (en) 2004-05-13
JP5289413B2 (ja) 2013-09-11
RU2005115455A (ru) 2005-12-10

Similar Documents

Publication Publication Date Title
CY1113387T1 (el) Υδατοδιαλυτα συμπλοκα σιδηρου υδατανθρακα, η παρασκευη αυτων και φαρμακα, τα οποια περιεχουν αυτα
CY1108770T1 (el) Νεα παραγωγα του ινδολιου και χρηση τους ως φαρμακων
CY1108279T1 (el) 17α-ΑΛΚΥΛΟ-17β-ΟΞΥ-ΟΙΣΤΡΑΤΡΙΕΝΙΑ ΚΑΙ ΕΝΔΙΑΜΕΣΑ ΠΡΟΪΟΝΤΑ ΓΙΑ ΤΗΝ ΠΑΡΑΓΩΓΗ ΑΥΤΩΝ, Η ΧΡΗΣΗ ΤΩΝ 17α-ΑΛΚΥΛΟ-17β-ΟΞΥ-ΟΙΣΤΡΑΤΡΙΕΝΙΩΝ ΓΙΑ ΤΗΝ ΠΑΡΑΓΩΓΗ ΦΑΡΜΑΚΕΥΤΙΚΩΝ ΜΕΣΩΝ ΚΑΘΩΣ ΚΑΙ ΦΑΡΜΑΚΕΥΤΙΚΑ ΠΑΡΑΣΚΕΥΑΣΜΑΤΑ
DE60131177D1 (de) Abbaubare polyacetal-polymere
CY1108085T1 (el) Υποκατεστημενα παραγωγα 1,3-διφαινυλπροπ-2-εν-1-ονης παρασκευη και χρησης αυτων
MA32394B1 (fr) Composes pegyles d'insuline lispro
DE69507702T2 (de) Semisynthetisch taxal derivate mit antitumor wirkung
DK1061900T3 (da) Dermale præparater
HK1079207A1 (en) Benzimidazole derivatives and their use as prodrugs of proton pump inhibitor
PA8528401A1 (es) Derivados de quinolina y quinazolina
CY1114535T1 (el) Ρετινοειδη παραγωγα με αντιαγγειογονικες, αντιογκικες και προαποπτωτικες δραστικοτητες
CY1107272T1 (el) Παραγωγο διαρυλ σουλφιδιου, αλας προσθηκης εξ αυτου και ανοσοκατασταλτικο
DE60219677D1 (de) Wasserlösliche polymerkonjugate von retinoesäure
CY1106390T1 (el) Στepεα θepμοδιαμορφωσιμη φαρμακευτικη συνθεση για την ελεγχομενη απελευθερωση της ιβαβραδινης
DK1161228T3 (da) Præparat omfattende isoquercetin og ascorbinsyre i en sustained release-form
WO2001066601A8 (en) Clathrate complexes formed by hyaluronic acid derivatives and use thereof as pharmaceuticals
CY1107349T1 (el) Αλφα-κετογλουταρικα ενεργα συστατικα και σκευασματα που τα περιεχουν
BRPI0013924B8 (pt) soluções farmacêuticas de levosimendano
ATE319729T1 (de) 9a-azalide mit entzündungshemmender wirkung
AR022588A1 (es) Derivados de mevinolina
CY1106617T1 (el) Φαρμακευτικη συνθεση περιλαμβανουσα συμπλοκο ψευδαργυρου-υαλουρονικου για τη θεραπεια σκληρυνσης κατα πλακας
DE60227244D1 (de) Erythropoietin reduziert die chemotherapiebedingte in-vivo-toxizität
BR0307448A (pt) Preparação liofilizada compreendendo imunocitocinas
PT1102594E (pt) Utilizacao de cloreto de sodio para reduzir a toxicidade gastrointestinal de derivados de camptotecina
UA84418C2 (ru) Производные гуанидина с антимикробным действием на основе диамина