ITMI20021861A1 - Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. - Google Patents
Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione.Info
- Publication number
- ITMI20021861A1 ITMI20021861A1 IT001861A ITMI20021861A ITMI20021861A1 IT MI20021861 A1 ITMI20021861 A1 IT MI20021861A1 IT 001861 A IT001861 A IT 001861A IT MI20021861 A ITMI20021861 A IT MI20021861A IT MI20021861 A1 ITMI20021861 A1 IT MI20021861A1
- Authority
- IT
- Italy
- Prior art keywords
- nitroxialkyl
- intermediates
- procedure
- preparation
- carboxylic acids
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 230000015572 biosynthetic process Effects 0.000 title 1
- 150000001735 carboxylic acids Chemical class 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 101150020251 NR13 gene Proteins 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/02—Preparation of esters of nitric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C203/00—Esters of nitric or nitrous acid
- C07C203/02—Esters of nitric acid
- C07C203/04—Esters of nitric acid having nitrate groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/26—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
- C07C271/28—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring to a carbon atom of a non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
- C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/10—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with ester groups or with a carbon-halogen bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
- C07C69/734—Ethers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001861A ITMI20021861A1 (it) | 2002-08-29 | 2002-08-29 | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
| JP2004532055A JP2005536559A (ja) | 2002-08-29 | 2003-08-06 | カルボン酸のニトロオキシアルキル置換エステルの製造法、その方法において有用な中間体およびその製造法 |
| DE60330152T DE60330152D1 (de) | 2002-08-29 | 2003-08-06 | Verfahren zur herstellung von nitrooxyderivaten von naproxen |
| RU2005104419/04A RU2315035C2 (ru) | 2002-08-29 | 2003-08-06 | Способ получения нитрооксипроизводных напроксена |
| AU2003266261A AU2003266261A1 (en) | 2002-08-29 | 2003-08-06 | Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof |
| SI200331743T SI1532098T1 (sl) | 2002-08-29 | 2003-08-06 | Postopek za pripravo nitrooksi derivatov naproksena |
| US10/522,986 US7723382B2 (en) | 2002-08-29 | 2003-08-06 | Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof |
| NZ537993A NZ537993A (en) | 2002-08-29 | 2003-08-06 | Process for preparing nitrooxyderivatives of naproxen |
| CNB038206056A CN1326830C (zh) | 2002-08-29 | 2003-08-06 | 制备萘普生的硝基氧基衍生物的方法 |
| PCT/EP2003/008700 WO2004020385A1 (en) | 2002-08-29 | 2003-08-06 | Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof |
| AT03747879T ATE449060T1 (de) | 2002-08-29 | 2003-08-06 | Verfahren zur herstellung von nitrooxyderivaten von naproxen |
| PT03747879T PT1532098E (pt) | 2002-08-29 | 2003-08-06 | Processo para a preparação de derivados nitrooxilados do naproxeno |
| EP03790866A EP1537070A1 (en) | 2002-08-29 | 2003-08-06 | Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof |
| EP03747879A EP1532098B1 (en) | 2002-08-29 | 2003-08-06 | Process for preparing nitrooxyderivatives of naproxen |
| AU2003266966A AU2003266966B2 (en) | 2002-08-29 | 2003-08-06 | Process for preparing nitrooxyderivatives of naproxen |
| CA2497187A CA2497187C (en) | 2002-08-29 | 2003-08-06 | Process for preparing nitrooxyderivatives of naproxen |
| KR1020057003509A KR101100064B1 (ko) | 2002-08-29 | 2003-08-06 | 나프록센의 니트로옥시유도체 제조방법 |
| PCT/EP2003/008698 WO2004020384A1 (en) | 2002-08-29 | 2003-08-06 | Process for preparing nitrooxyderivatives of naproxen |
| US10/523,722 US7199258B2 (en) | 2002-08-29 | 2003-08-06 | Process for preparing nitrooxyderivatives of naproxen |
| ES03747879T ES2335656T3 (es) | 2002-08-29 | 2003-08-06 | Proceso para preparar nitrooxiderivados de naproxeno. |
| JP2004532054A JP4528123B2 (ja) | 2002-08-29 | 2003-08-06 | ナプロキセンのニトロオキシ誘導体の製造法 |
| DK03747879.9T DK1532098T3 (da) | 2002-08-29 | 2003-08-06 | Fremgangsmåde til fremstilling af nitrooxyderivater af naproxen |
| ZA200500890A ZA200500890B (en) | 2002-08-29 | 2005-01-31 | Process for preparing nitrooxyderivatives of naproxen. |
| IL16658705A IL166587A0 (en) | 2002-08-29 | 2005-01-31 | Process for preparing nitrooxyderivatives of napr oxen |
| CY20101100132T CY1109769T1 (el) | 2002-08-29 | 2010-02-10 | Μεθοδος παρασκευης νιτροοξυ παραγωγων τησναπροξενης |
| US12/750,381 US20100217028A1 (en) | 2002-08-29 | 2010-03-30 | Process for preparing nitrooxyalkyl substituted esters of carboxylic acids, intermediates useful in said process and preparation thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT001861A ITMI20021861A1 (it) | 2002-08-29 | 2002-08-29 | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ITMI20021861A1 true ITMI20021861A1 (it) | 2004-02-29 |
Family
ID=31972201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT001861A ITMI20021861A1 (it) | 2002-08-29 | 2002-08-29 | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
Country Status (20)
| Country | Link |
|---|---|
| US (3) | US7723382B2 (https=) |
| EP (2) | EP1532098B1 (https=) |
| JP (2) | JP4528123B2 (https=) |
| KR (1) | KR101100064B1 (https=) |
| CN (1) | CN1326830C (https=) |
| AT (1) | ATE449060T1 (https=) |
| AU (2) | AU2003266966B2 (https=) |
| CA (1) | CA2497187C (https=) |
| CY (1) | CY1109769T1 (https=) |
| DE (1) | DE60330152D1 (https=) |
| DK (1) | DK1532098T3 (https=) |
| ES (1) | ES2335656T3 (https=) |
| IL (1) | IL166587A0 (https=) |
| IT (1) | ITMI20021861A1 (https=) |
| NZ (1) | NZ537993A (https=) |
| PT (1) | PT1532098E (https=) |
| RU (1) | RU2315035C2 (https=) |
| SI (1) | SI1532098T1 (https=) |
| WO (2) | WO2004020385A1 (https=) |
| ZA (1) | ZA200500890B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2491127A1 (en) | 2002-07-03 | 2004-01-15 | Nitromed, Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| ITMI20021861A1 (it) * | 2002-08-29 | 2004-02-29 | Nicox Sa | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
| JP2008521770A (ja) * | 2004-11-25 | 2008-06-26 | ニコックス エス エイ | ハロゲノアルキルナイトレートの製造方法 |
| WO2009149053A2 (en) * | 2008-06-02 | 2009-12-10 | Dr. Reddy's Laboratories Ltd. | Naproxcinod process and solid dispersion |
| ITRM20080325A1 (it) * | 2008-06-20 | 2009-12-21 | Nicox Sa | Metodo per purificare 4-(nitroosi)butil(2s)-2-(6-metossi-2-naftil) propanoato |
| US8062653B2 (en) | 2009-02-18 | 2011-11-22 | Bezwada Biomedical, Llc | Controlled release of nitric oxide and drugs from functionalized macromers and oligomers |
| CN101885684B (zh) * | 2010-07-01 | 2013-10-30 | 南京中医药大学 | 带有一氧化氮供体的芳香酸前体药物及其制备方法和其应用 |
| TWI417276B (zh) * | 2011-03-01 | 2013-12-01 | Everlight Chem Ind Corp | ２-（ｓ）-（６-甲氧基-２-萘基）-丙酸之酸酐衍生物、其製法暨及其用途 |
| CA2897571C (en) | 2013-01-21 | 2018-12-18 | Apparao Satyam | Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group |
| MX2021004581A (es) * | 2018-10-25 | 2021-06-15 | Dsm Ip Assets Bv | Composiciones acuosas que comprenden omega nitrooxi-1-alcanoles. |
| CN111333560B (zh) * | 2020-04-13 | 2024-01-23 | 合肥工业大学 | 一种制备螺环β-内酰胺的方法 |
| CN112321420A (zh) * | 2020-11-03 | 2021-02-05 | 浙江海翔川南药业有限公司 | 一种萘普生杂质及其制备方法 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5279359A (en) * | 1975-12-26 | 1977-07-04 | Hitachi Ltd | Cleaning material arrestor |
| US5057427A (en) * | 1988-04-07 | 1991-10-15 | Sepracor, Inc. | Method for resolution of stereoisomers |
| JPH05279359A (ja) | 1992-02-06 | 1993-10-26 | Kawaken Fine Chem Co Ltd | アポビンカミン酸エステルの製造方法 |
| JPH05247015A (ja) * | 1992-03-05 | 1993-09-24 | Nippon Iyakuhin Kogyo Kk | 新規ピペラジン誘導体 |
| DE69412109T2 (de) | 1993-10-06 | 1999-01-21 | Nicox S.A., Paris | Salzetersaüreester mit entzündungshemmender und/oder schmerzlindernder wirkung und verfahren zu deren herstellung |
| SI0759899T1 (en) | 1994-05-10 | 1999-12-31 | Nicox S.A. | Nitro compounds and their compositions having anti-inflammatory, analgesic and anti-thrombotic acitivities |
| IT1276071B1 (it) * | 1995-10-31 | 1997-10-24 | Nicox Ltd | Compositi ad attivita' anti-infiammatoria |
| CA2262788A1 (en) * | 1996-08-16 | 1998-02-26 | Gustavo Enrique Aldoma | Non-ulcerogenic analgesic/anti-inflammatory clonixin derivative |
| IT1288123B1 (it) * | 1996-09-04 | 1998-09-10 | Nicox Sa | Uso di nitroderivati per l'incontinenza urinaria |
| FR2757159B1 (fr) | 1996-12-12 | 1999-12-17 | Hoechst Marion Roussel Inc | Nouveaux derives nitres analgesiques, anti-inflammatoires et anti-thrombotiques, leur procede de preparation, leur application comme medicaments |
| IT1311924B1 (it) * | 1999-04-13 | 2002-03-20 | Nicox Sa | Composti farmaceutici. |
| IT1313596B1 (it) | 1999-08-04 | 2002-09-09 | Nicox Sa | Processo per la preparazione di nitrossialchil esteri del naproxene |
| IT1314184B1 (it) * | 1999-08-12 | 2002-12-06 | Nicox Sa | Composizioni farmaceutiche per la terapia di condizioni di stressossidativo |
| US6429223B1 (en) * | 2000-06-23 | 2002-08-06 | Medinox, Inc. | Modified forms of pharmacologically active agents and uses therefor |
| ITMI20010985A1 (it) * | 2001-05-15 | 2002-11-15 | Nicox Sa | Farmaci per il morbo di alzheimer |
| ITMI20011307A1 (it) * | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per l'epilessia |
| ITMI20011308A1 (it) * | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per il dolore cronico |
| WO2003045896A1 (en) * | 2001-11-27 | 2003-06-05 | Astrazeneca Ab | New process |
| WO2003103602A2 (en) * | 2002-06-11 | 2003-12-18 | Nitromed, Inc. | Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| CA2491127A1 (en) * | 2002-07-03 | 2004-01-15 | Nitromed, Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| ITMI20021861A1 (it) * | 2002-08-29 | 2004-02-29 | Nicox Sa | Procedimento di sintesi di nitrossialchilesteri di acidi carbossilici, intermedi impiegabili in detto procedimento e loro preparazione. |
| US7199947B2 (en) * | 2004-12-28 | 2007-04-03 | Motorola Inc. | Miniature digital camera lens |
-
2002
- 2002-08-29 IT IT001861A patent/ITMI20021861A1/it unknown
-
2003
- 2003-08-06 AU AU2003266966A patent/AU2003266966B2/en not_active Ceased
- 2003-08-06 DE DE60330152T patent/DE60330152D1/de not_active Expired - Lifetime
- 2003-08-06 AU AU2003266261A patent/AU2003266261A1/en not_active Abandoned
- 2003-08-06 WO PCT/EP2003/008700 patent/WO2004020385A1/en not_active Ceased
- 2003-08-06 WO PCT/EP2003/008698 patent/WO2004020384A1/en not_active Ceased
- 2003-08-06 NZ NZ537993A patent/NZ537993A/en not_active IP Right Cessation
- 2003-08-06 CN CNB038206056A patent/CN1326830C/zh not_active Expired - Fee Related
- 2003-08-06 ES ES03747879T patent/ES2335656T3/es not_active Expired - Lifetime
- 2003-08-06 PT PT03747879T patent/PT1532098E/pt unknown
- 2003-08-06 EP EP03747879A patent/EP1532098B1/en not_active Expired - Lifetime
- 2003-08-06 US US10/522,986 patent/US7723382B2/en not_active Expired - Fee Related
- 2003-08-06 US US10/523,722 patent/US7199258B2/en not_active Expired - Fee Related
- 2003-08-06 RU RU2005104419/04A patent/RU2315035C2/ru not_active IP Right Cessation
- 2003-08-06 SI SI200331743T patent/SI1532098T1/sl unknown
- 2003-08-06 EP EP03790866A patent/EP1537070A1/en not_active Withdrawn
- 2003-08-06 CA CA2497187A patent/CA2497187C/en not_active Expired - Fee Related
- 2003-08-06 KR KR1020057003509A patent/KR101100064B1/ko not_active Expired - Fee Related
- 2003-08-06 JP JP2004532054A patent/JP4528123B2/ja not_active Expired - Fee Related
- 2003-08-06 DK DK03747879.9T patent/DK1532098T3/da active
- 2003-08-06 JP JP2004532055A patent/JP2005536559A/ja not_active Ceased
- 2003-08-06 AT AT03747879T patent/ATE449060T1/de active
-
2005
- 2005-01-31 ZA ZA200500890A patent/ZA200500890B/xx unknown
- 2005-01-31 IL IL16658705A patent/IL166587A0/xx not_active IP Right Cessation
-
2010
- 2010-02-10 CY CY20101100132T patent/CY1109769T1/el unknown
- 2010-03-30 US US12/750,381 patent/US20100217028A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1109769T1 (el) | Μεθοδος παρασκευης νιτροοξυ παραγωγων τησναπροξενης | |
| GB0220581D0 (en) | Organic Compound | |
| EA200501061A1 (ru) | N-(1-бензил-2-оксо-2-(1-пиперазинил)этил)-1-пиперидинкарбоксамидные производные и родственные соединения в качестве cgrp-антагонистов для лечения головных болей | |
| IL164487A0 (en) | 3-Heteroaryl substituted 5-methyloxymethyl isoxazolines used as herbicides | |
| NO20090327L (no) | Nye forbindelser 384 | |
| DK344882A (da) | Fremgangsmaade til fremstilling af substituerede 2-carbamimidoyl-1-carbadethiapen-2-em-carboxylsyrer | |
| ES2007543A6 (es) | Procedimiento de preparacion de 1,4-dihidropiridinas. | |
| PT73791A (en) | Process for preparing 2-carbamimidoyl-6-substituted-1- -carbadethiapen-2-em-3-carboxylic acids | |
| EA200000792A3 (ru) | Новые пиридиновые соединения, способ их получения и содержащие их фармацевтические композиции | |
| TW200510299A (en) | Organic compounds | |
| HRPK20050567B3 (hr) | Perindopril | |
| WO2008051875A3 (en) | Adamantylurea compounds as soluble epoxide hydrolase inhibitors | |
| WO2021016220A3 (en) | Synthesis of substituted furans | |
| AU2001250356A1 (en) | Method for the production of spirocyclic tetronic acid derivatives | |
| IL153830A0 (en) | A PROCESS FOR THE PREPARATION OF alpha' CHLOROKETONES | |
| DK0643061T3 (da) | Nye cephalosporin-antibitotika | |
| WO2001081298A3 (en) | Cyclic carboxylic acids as integrin antagonists | |
| EA200500716A1 (ru) | Новые соединения 2,3-дигидро-4-(1h)-пиридона, способ их получения и фармацевтические композиции, которые их содержат | |
| RU95113420A (ru) | Способы получения 1,3-оксазолидин-5-карбоновой кислоты | |
| DK1406865T3 (da) | Ravsyrederivater | |
| NO20020561L (no) | Fremgangsmåte for fremstilling av syrer via alfa-klorepoksi- estere | |
| BR0311504A (pt) | Processo para a preparação de um ácido dicarboxìlico | |
| WO2002030874A3 (en) | Aliphatic, cyclic amino carboxylic acids as integrin antagonists | |
| JPS6445350A (en) | Production of n-substituted-l-amino acid derivative | |
| TH78315A (th) | Cgrp แอนตะกอนิสต์ที่ได้รับการคัดเลือก, กระบวนการในการเตรียมสารดังกล่าว และการใช้สารดังกล่าวในรูปของสารผสมทางเภสัชกรรม |