TNSN05261A1 - Process for the preparation of n-substituted 2-cyanopyrrolidines - Google Patents

Process for the preparation of n-substituted 2-cyanopyrrolidines

Info

Publication number
TNSN05261A1
TNSN05261A1 TNP2005000261A TNSN05261A TNSN05261A1 TN SN05261 A1 TNSN05261 A1 TN SN05261A1 TN P2005000261 A TNP2005000261 A TN P2005000261A TN SN05261 A TNSN05261 A TN SN05261A TN SN05261 A1 TNSN05261 A1 TN SN05261A1
Authority
TN
Tunisia
Prior art keywords
reacting
preparation
resultant
compound
substituted
Prior art date
Application number
TNP2005000261A
Inventor
Frank Schafer
Gottfried Sedelmeier
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2004/003980 external-priority patent/WO2004092127A1/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TNSN05261A1 publication Critical patent/TNSN05261A1/en

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

The present invention relates to a process for the preparation of a N-(N'-substituted glycyl)-2-cyanopyrrolidine comprising at least (a) reacting, in the presence of dimethylformamide, a compound of formula (V) wherein, independently of each other, X1 and X3 are halogen; X2 is halogen, OH, O-C(=O)-CH2X3, -O-SO2-(C1-8)alkyl or -O-SO2-(aryl), with L-prolinamide, followed by (b) reacting the resultant compound without isolation with a dehydration agent, optionally followed by (c) reacting, in the presence of a base, the resultant compound without isolation with an appropriate amine and (d) recovering the resultant cornpound in free form or in acid addition salt form.
TNP2005000261A 2003-04-16 2005-10-14 Process for the preparation of n-substituted 2-cyanopyrrolidines TNSN05261A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0308854A GB0308854D0 (en) 2003-04-16 2003-04-16 Organic compounds
PCT/EP2004/003980 WO2004092127A1 (en) 2003-04-16 2004-04-15 Process for the preparation of n-substituted 2-cyanopyrrolidines

Publications (1)

Publication Number Publication Date
TNSN05261A1 true TNSN05261A1 (en) 2007-07-10

Family

ID=9956928

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2005000261A TNSN05261A1 (en) 2003-04-16 2005-10-14 Process for the preparation of n-substituted 2-cyanopyrrolidines

Country Status (4)

Country Link
CN (2) CN1774420B (en)
GB (1) GB0308854D0 (en)
TN (1) TNSN05261A1 (en)
ZA (1) ZA200507396B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0900638A2 (en) * 2009-10-07 2011-05-30 Egyt Gyogyszervegyeszeti Gyar Adducts of inorganic salts basea on vildaelitpin applicable for preparation of pharmaceutical compositions
CN103641761A (en) * 2013-11-22 2014-03-19 沈阳化工大学 Vildagliptin preparation method
CN104744334A (en) * 2015-03-25 2015-07-01 合肥创新医药技术有限公司 Preparation method for vildagliptin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW492957B (en) * 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
CO5150173A1 (en) * 1998-12-10 2002-04-29 Novartis Ag COMPOUNDS N- (REPLACED GLYCLE) -2-DIPEPTIDYL-IV PEPTIDASE INHIBITING CYANOPIRROLIDINS (DPP-IV) WHICH ARE EFFECTIVE IN THE TREATMENT OF CONDITIONS MEDIATED BY DPP-IV INHIBITION
US6380398B2 (en) * 2000-01-04 2002-04-30 Novo Nordisk A/S Therapeutically active and selective heterocyclic compounds that are inhibitors of the enzyme DPP-IV

Also Published As

Publication number Publication date
GB0308854D0 (en) 2003-05-21
ZA200507396B (en) 2007-02-28
CN101037409A (en) 2007-09-19
CN1774420A (en) 2006-05-17
CN101037409B (en) 2013-03-27
CN1774420B (en) 2012-05-30

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