IT1254401B - Formulazioni galeniche contenenti ciclosporina. - Google Patents
Formulazioni galeniche contenenti ciclosporina.Info
- Publication number
- IT1254401B IT1254401B ITRM920476A ITRM920476A IT1254401B IT 1254401 B IT1254401 B IT 1254401B IT RM920476 A ITRM920476 A IT RM920476A IT RM920476 A ITRM920476 A IT RM920476A IT 1254401 B IT1254401 B IT 1254401B
- Authority
- IT
- Italy
- Prior art keywords
- cyclosporine
- formulations containing
- mono
- galenic formulations
- mixture
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 6
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 3
- 108010036949 Cyclosporine Proteins 0.000 title abstract 3
- 229960001265 ciclosporin Drugs 0.000 title abstract 3
- 229930182912 cyclosporin Natural products 0.000 title abstract 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- 238000009472 formulation Methods 0.000 abstract 2
- 150000003626 triacylglycerols Chemical class 0.000 abstract 2
- 239000002285 corn oil Substances 0.000 abstract 1
- 235000005687 corn oil Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
- C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
- C11C3/04—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils
- C11C3/06—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils with glycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Nanotechnology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dispersion Chemistry (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Transplantation (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Fats And Perfumes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Confectionery (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB919113872A GB9113872D0 (en) | 1991-06-27 | 1991-06-27 | Improvements in or relating to organic compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM920476A0 ITRM920476A0 (it) | 1992-06-23 |
| ITRM920476A1 ITRM920476A1 (it) | 1993-12-23 |
| IT1254401B true IT1254401B (it) | 1995-09-14 |
Family
ID=10697415
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ITRM920476A IT1254401B (it) | 1991-06-27 | 1992-06-23 | Formulazioni galeniche contenenti ciclosporina. |
Country Status (38)
| Country | Link |
|---|---|
| EP (2) | EP0953630B1 (OSRAM) |
| JP (2) | JP2653958B2 (OSRAM) |
| KR (3) | KR0131064B1 (OSRAM) |
| CN (1) | CN1077798C (OSRAM) |
| AT (1) | AT403436B (OSRAM) |
| AU (1) | AU659460B2 (OSRAM) |
| CA (2) | CA2175842C (OSRAM) |
| CH (2) | CH684163A5 (OSRAM) |
| CY (1) | CY1906A (OSRAM) |
| CZ (1) | CZ281790B6 (OSRAM) |
| DE (3) | DE4244930C2 (OSRAM) |
| DK (2) | DK0953630T3 (OSRAM) |
| EE (1) | EE03108B1 (OSRAM) |
| ES (2) | ES2227921T3 (OSRAM) |
| FI (2) | FI109454B (OSRAM) |
| FR (2) | FR2678169B1 (OSRAM) |
| GB (2) | GB9113872D0 (OSRAM) |
| GR (1) | GR3032366T3 (OSRAM) |
| HK (2) | HK57196A (OSRAM) |
| HU (1) | HU216792B (OSRAM) |
| IE (1) | IE73662B1 (OSRAM) |
| IL (3) | IL102310A (OSRAM) |
| IT (1) | IT1254401B (OSRAM) |
| LU (1) | LU88138A1 (OSRAM) |
| MX (1) | MX9203236A (OSRAM) |
| MY (1) | MY109512A (OSRAM) |
| NO (2) | NO303964B1 (OSRAM) |
| NZ (1) | NZ243309A (OSRAM) |
| PH (1) | PH30337A (OSRAM) |
| PT (2) | PT539319E (OSRAM) |
| RO (2) | RO111021B1 (OSRAM) |
| RU (1) | RU2143919C1 (OSRAM) |
| SA (1) | SA92130213B1 (OSRAM) |
| SK (1) | SK278759B6 (OSRAM) |
| TW (1) | TW267943B (OSRAM) |
| UA (1) | UA35559C2 (OSRAM) |
| UY (1) | UY23864A1 (OSRAM) |
| ZA (1) | ZA924719B (OSRAM) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9113872D0 (en) * | 1991-06-27 | 1991-08-14 | Sandoz Ag | Improvements in or relating to organic compounds |
| EP1142568A1 (en) | 1992-09-25 | 2001-10-10 | Novartis AG | Pharmaceutical compositions containing cyclosporins |
| NZ247516A (en) * | 1993-04-28 | 1995-02-24 | Bernard Charles Sherman | Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant |
| CH686761A5 (de) | 1993-05-27 | 1996-06-28 | Sandoz Ag | Galenische Formulierungen. |
| GB2278780B (en) * | 1993-05-27 | 1998-10-14 | Sandoz Ltd | Macrolide formulations |
| AT408520B (de) * | 1993-05-27 | 2001-12-27 | Novartis Erfind Verwalt Gmbh | Galenische formulierungen |
| DE4322826A1 (de) * | 1993-07-08 | 1995-01-12 | Galenik Labor Freiburg Gmbh | Pharmazeutisches Präparat |
| ES2308955T5 (es) | 1993-09-28 | 2012-04-03 | R.P. Scherer Gmbh | Fabricación de cápsulas de gelatina blanda |
| DE4340781C3 (de) * | 1993-11-30 | 2000-01-27 | Novartis Ag | Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung |
| WO1995022343A1 (en) * | 1994-02-17 | 1995-08-24 | Shiseido Company, Ltd. | Cyclosporin-containing emulsion composition |
| US5891846A (en) * | 1994-02-17 | 1999-04-06 | Shiseido Company, Ltd. | Cyclosporin-containing emulsion composition |
| NZ270145A (en) * | 1994-03-01 | 1996-08-27 | Lilly Co Eli | Non-aqueous pharmaceutical formulation for oral administration comprising water-insoluble active agent, fatty acid solubilising agent, an oil and a surface active agent |
| GB9405304D0 (en) * | 1994-03-16 | 1994-04-27 | Scherer Ltd R P | Delivery systems for hydrophobic drugs |
| ATE181568T1 (de) * | 1994-03-31 | 1999-07-15 | Loders Croklaan Bv | Öle mit niedrigem gehalt an gesättigter fettsäure |
| IL129547A (en) | 1994-10-26 | 2001-01-11 | Novartis Ag | Pharmaceutical compositions comprising a macrolide and an acid |
| GB2308545B (en) * | 1994-10-26 | 1999-06-02 | Novartis Ag | Pharmaceutical microemulsion preconcentrates |
| SK164796A3 (en) | 1994-11-03 | 1997-06-04 | Dresden Arzneimittel | Novel cyclosporine preparation forms for oral administration of and process for producing them |
| HU215966B (hu) * | 1994-11-21 | 1999-07-28 | BIOGAL Gyógyszergyár Rt. | Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum |
| JPH11505258A (ja) * | 1995-05-17 | 1999-05-18 | セダーシナイ メディカル センター | 小腸における消化および吸収を改善させる脂肪酸を含む組成物 |
| US6861053B1 (en) | 1999-08-11 | 2005-03-01 | Cedars-Sinai Medical Center | Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth |
| WO1996036330A2 (en) * | 1995-05-17 | 1996-11-21 | Cedars-Sinai Medical Center | Compositions containing fatty acids for improving digestion and absorption in the small intestine |
| US7048906B2 (en) | 1995-05-17 | 2006-05-23 | Cedars-Sinai Medical Center | Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions |
| US6008228A (en) * | 1995-06-06 | 1999-12-28 | Hoffman-La Roche Inc. | Pharmaceutical compositions containing proteinase inhibitors |
| US6696413B2 (en) * | 1995-06-16 | 2004-02-24 | Hexal Ag | Pharmaceutical preparation with cyclosporin A |
| SE504582C2 (sv) * | 1995-07-06 | 1997-03-10 | Gs Dev Ab | Cyklosporinkomposition baserad på en L2-fas |
| DE19544507B4 (de) | 1995-11-29 | 2007-11-15 | Novartis Ag | Cyclosporin enthaltende Präparate |
| US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
| CN1104258C (zh) * | 1996-05-29 | 2003-04-02 | 周德和 | 用于环孢霉素a的赋形剂 |
| US5958876A (en) * | 1996-06-19 | 1999-09-28 | Novartis Ag | Cyclosporin-containing pharmaceutical compositions |
| BR9713811A (pt) * | 1996-06-19 | 2004-03-02 | Novartis Ag | Preparações de cápsula macia contendo ciclosporina |
| KR980008239A (ko) * | 1996-07-26 | 1998-04-30 | 김충환 | 사이클로스포린-함유 약학적 조성물 |
| FR2752732B1 (fr) * | 1996-08-28 | 1998-11-20 | Pf Medicament | Forme galenique a liberation prolongee de milnacipran |
| US6517860B1 (en) | 1996-12-31 | 2003-02-11 | Quadrant Holdings Cambridge, Ltd. | Methods and compositions for improved bioavailability of bioactive agents for mucosal delivery |
| CA2284000C (en) * | 1997-03-12 | 2012-01-03 | Abbott Laboratories | Hydrophilic binary systems for the administration of cyclosporine |
| NZ314702A (en) * | 1997-04-29 | 1998-07-28 | Bernard Charles Sherman | Pharmaceutical composition comprising a cyclosporin in a solvent system of acetylated monoglycerides and a surfactant and optionally a hydrophilic solvent |
| AR012627A1 (es) | 1997-04-29 | 2000-11-08 | Sherman Bernard Charles | Pre-concentrado de emulsion que comprende una ciclosporina y monoglicerido acetilado |
| GB2326337A (en) * | 1997-06-20 | 1998-12-23 | Phares Pharma Holland | Homogeneous lipid compositions for drug delivery |
| ES2174462T3 (es) * | 1997-07-29 | 2002-11-01 | Upjohn Co | Formulacion autoestimulante para compuestos lipofilos. |
| DK0989851T3 (da) | 1997-07-29 | 2003-01-27 | Upjohn Co | Selvemulgerende formulering indeholdende sure lipofile forbindelser |
| PT999826E (pt) * | 1997-07-29 | 2004-09-30 | Upjohn Co | Formulacao auto-emulsionante para compostos lipofilos |
| US20030220234A1 (en) | 1998-11-02 | 2003-11-27 | Selvaraj Naicker | Deuterated cyclosporine analogs and their use as immunodulating agents |
| JP2001520170A (ja) | 1997-10-16 | 2001-10-30 | ボード・オヴ・リージェンツ，ザ・ユニヴァーシティ・オヴ・テキサス・システム | Ｎｆ−ａｔ３機能に関連した心肥大動物モデルと治療法 |
| AU1508899A (en) * | 1997-12-02 | 1999-06-16 | Chong Kun Dang Corporation | Pharmaceutical composition comprising cyclosporin solid-state microemulsion |
| ATE497384T1 (de) | 1997-12-10 | 2011-02-15 | Cyclosporine Therapeutics Ltd | Omega-3 fettsäure enthaltende pharmazeutische zusammensetzungen |
| ID25908A (id) * | 1998-03-06 | 2000-11-09 | Novartis Ag | Prakonsentrat-prakonsentrat emulsi yang mengandung siklosporin atau makrolida |
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| DK0982035T3 (da) * | 1998-08-18 | 2004-06-28 | Panacea Biotec Ltd | Cyclosporinpræparater |
| US6638522B1 (en) * | 1998-12-11 | 2003-10-28 | Pharmasolutions, Inc. | Microemulsion concentrate composition of cyclosporin |
| JP2002534370A (ja) | 1998-12-30 | 2002-10-15 | デクセル リミテッド | サイクロスポリンを送達するための分散可能な濃縮物 |
| GB9903547D0 (en) | 1999-02-16 | 1999-04-07 | Novartis Ag | Organic compounds |
| CN1167462C (zh) * | 1999-03-09 | 2004-09-22 | 杭州华东医药集团生物工程研究所有限公司 | 一种含环孢素的药物组合物 |
| US6956048B2 (en) | 1999-03-31 | 2005-10-18 | Pharmacia & Upjohn Company | Pharmaceutical emulsions for retroviral protease inhibitors |
| WO2001032143A1 (en) * | 1999-11-02 | 2001-05-10 | Cipla Ltd. | A pharmaceutical composition for the administration of water-insoluble pharmaceutically active substances and a process for preparation thereof |
| US7732404B2 (en) | 1999-12-30 | 2010-06-08 | Dexcel Ltd | Pro-nanodispersion for the delivery of cyclosporin |
| GB0008785D0 (en) | 2000-04-10 | 2000-05-31 | Novartis Ag | Organic compounds |
| GB0019118D0 (en) * | 2000-08-03 | 2000-09-27 | Danisco | Solid phase glycerolysis |
| DE60123849T2 (de) | 2000-08-08 | 2007-05-24 | Kao Corp. | Öl-/fett-zusammensetzung |
| US7115565B2 (en) | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| AR033711A1 (es) * | 2001-05-09 | 2004-01-07 | Novartis Ag | Composiciones farmaceuticas |
| US7060672B2 (en) | 2001-10-19 | 2006-06-13 | Isotechnika, Inc. | Cyclosporin analog formulations |
| CN100334106C (zh) | 2001-10-19 | 2007-08-29 | 伊索泰克尼卡股份有限公司 | 环孢菌素类似物的合成 |
| KR100441167B1 (ko) * | 2001-12-27 | 2004-07-21 | 씨제이 주식회사 | 마이크로에멀젼 예비 농축액 조성물 |
| KR100525234B1 (ko) * | 2003-02-19 | 2005-10-28 | 한국유나이티드제약 주식회사 | 사이클로스포린 함유 연질캅셀제 및 그 제조방법 |
| GT200500310A (es) | 2004-11-19 | 2006-06-19 | Compuestos organicos | |
| GB0504950D0 (en) | 2005-03-10 | 2005-04-20 | Novartis Ag | Organic compositions |
| JP4889262B2 (ja) * | 2005-08-19 | 2012-03-07 | 理研ビタミン株式会社 | 脂溶性薬剤組成物 |
| MD3347G2 (ro) * | 2006-12-26 | 2008-01-31 | Институт Сельскохозяйственной Техники "Mecagro" | Procedeu de obţinere a esterilor metilici din ulei de rapiţă |
| ITPD20070049A1 (it) * | 2007-02-14 | 2008-08-15 | Sila S R L | Prodotto a base di acido linoleico coniugato e processo per la sua fabbricazione |
| EP2380564B1 (en) | 2007-04-04 | 2014-10-22 | Sigmoid Pharma Limited | An oral pharmaceutical composition |
| CN101199836B (zh) * | 2007-11-07 | 2011-03-30 | 安徽省药物研究所 | 一种阶段释放型环孢素a固体微乳制剂及其微乳固化方法 |
| CN105213318A (zh) | 2009-05-18 | 2016-01-06 | 希格默伊德药业有限公司 | 包含油滴的组合物 |
| CN102573802A (zh) | 2009-08-12 | 2012-07-11 | 希格默伊德药业有限公司 | 包含聚合物基质和油相的免疫调节组合物 |
| GB201020032D0 (en) | 2010-11-25 | 2011-01-12 | Sigmoid Pharma Ltd | Composition |
| JO3337B1 (ar) * | 2010-12-13 | 2019-03-13 | Debiopharm Sa | تركيبات صيدلية تشمل أليسبوريفير |
| FR2971941B1 (fr) | 2011-02-24 | 2013-08-02 | Physica Pharma | Compositions pharmaceutiques administrables par voie cutanee et destinees au traitement local de la dermatite atopique canine |
| GB201304662D0 (en) | 2013-03-14 | 2013-05-01 | Sigmoid Pharma Ltd | Compositions |
| DK3215127T3 (da) | 2014-11-07 | 2021-02-01 | Sublimity Therapeutics Ltd | Sammensætninger omfattende cyclosporin |
| WO2020050182A1 (ja) * | 2018-09-06 | 2020-03-12 | 株式会社カマタ | カプセル充填用液状組成物及びカプセル剤 |
| EP3886813B1 (en) * | 2018-11-26 | 2023-03-22 | Hepion Pharmaceuticals, Inc. | Pharmaceutical formulations of cyclosporine analogs |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1274354A (fr) * | 1956-03-10 | 1961-10-27 | Agents tensio-actifs obtenus à partir de triglycérides et polyéthylène glycol | |
| FR2344283A1 (fr) * | 1976-03-17 | 1977-10-14 | Gattefosse Ets Sa | Nouveau melange de glycerides utile comme nutriment lipidique |
| FI65914C (fi) * | 1978-03-07 | 1984-08-10 | Sandoz Ag | Foerfarande foer framstaellning av farmaceutiska kompositionerinnehaollande cyklosporin a |
| CH641356A5 (en) * | 1979-02-27 | 1984-02-29 | Sandoz Ag | Pharmaceutical compositions containing cyclosporin |
| PH19156A (en) * | 1982-02-01 | 1986-01-15 | Sandoz Ltd | Dihydrocyclosporin d in the treatment of multiple sclerosis |
| GB8903804D0 (en) * | 1989-02-20 | 1989-04-05 | Sandoz Ltd | Improvements in or relating to organic compounds |
| DE3444893A1 (de) * | 1984-12-08 | 1986-06-12 | Henkel KGaA, 4000 Düsseldorf | Verfahren zur herstellung von fettsaeuremethylestern |
| JPS62201591A (ja) * | 1986-02-28 | 1987-09-05 | Shoichi Shimizu | 油脂のグリセロリシス法 |
| JP2632010B2 (ja) * | 1988-01-29 | 1997-07-16 | 三共株式会社 | シクロスポリン製剤 |
| CH679119A5 (OSRAM) * | 1988-05-13 | 1991-12-31 | Sandoz Ag | |
| HU201567B (en) * | 1988-07-21 | 1990-11-28 | Gyogyszerkutato Intezet | Process for production of intravenous medical compositions containing cyclosphorin |
| KR0148748B1 (ko) * | 1988-09-16 | 1998-08-17 | 장 크라메르, 한스 루돌프 하우스 | 사이클로스포린을 함유하는 약학조성물 |
| GB8823621D0 (en) * | 1988-10-07 | 1988-11-16 | Madhok R | Compositions containing cyclosporins |
| JPH0738771B2 (ja) * | 1989-01-17 | 1995-05-01 | 花王株式会社 | 液状食用油組成物 |
| GB2230440B (en) * | 1989-02-09 | 1993-05-19 | Sandoz Ltd | Novel cyclosporin galenic forms |
| AU6785490A (en) * | 1989-12-18 | 1991-06-20 | Kraft General Foods, Inc. | Low-saturate edible oils and transesterification methods for production thereof |
| GB9113872D0 (en) * | 1991-06-27 | 1991-08-14 | Sandoz Ag | Improvements in or relating to organic compounds |
-
1991
- 1991-06-27 GB GB919113872A patent/GB9113872D0/en active Pending
-
1992
- 1992-06-12 HU HU9201975A patent/HU216792B/hu unknown
- 1992-06-15 DE DE4244930A patent/DE4244930C2/de not_active Expired - Lifetime
- 1992-06-15 DE DE4244986A patent/DE4244986B4/de not_active Expired - Lifetime
- 1992-06-15 DE DE4219526A patent/DE4219526C2/de not_active Expired - Lifetime
- 1992-06-23 IT ITRM920476A patent/IT1254401B/it active
- 1992-06-23 ES ES99106122T patent/ES2227921T3/es not_active Expired - Lifetime
- 1992-06-23 EP EP99106122A patent/EP0953630B1/en not_active Expired - Lifetime
- 1992-06-23 EP EP92810479A patent/EP0539319B1/en not_active Expired - Lifetime
- 1992-06-23 PT PT92810479T patent/PT539319E/pt unknown
- 1992-06-23 CH CH1971/92A patent/CH684163A5/de not_active IP Right Cessation
- 1992-06-23 ES ES92810479T patent/ES2142818T3/es not_active Expired - Lifetime
- 1992-06-23 PT PT99106122T patent/PT953630E/pt unknown
- 1992-06-23 DK DK99106122T patent/DK0953630T3/da active
- 1992-06-23 DK DK92810479T patent/DK0539319T3/da active
- 1992-06-23 CH CH296/94A patent/CH685764A5/de not_active IP Right Cessation
- 1992-06-24 GB GB9213393A patent/GB2257359B/en not_active Expired - Lifetime
- 1992-06-24 CY CY190692A patent/CY1906A/en unknown
- 1992-06-24 FR FR9207856A patent/FR2678169B1/fr not_active Expired - Lifetime
- 1992-06-24 MX MX9203236A patent/MX9203236A/es unknown
- 1992-06-25 IL IL102310A patent/IL102310A/xx not_active IP Right Cessation
- 1992-06-25 AT AT0129892A patent/AT403436B/de not_active IP Right Cessation
- 1992-06-25 MY MYPI92001199A patent/MY109512A/en unknown
- 1992-06-25 PH PH44558A patent/PH30337A/en unknown
- 1992-06-25 NZ NZ243309A patent/NZ243309A/en not_active IP Right Cessation
- 1992-06-25 NO NO922506A patent/NO303964B1/no not_active IP Right Cessation
- 1992-06-25 ZA ZA924719A patent/ZA924719B/xx unknown
- 1992-06-25 IL IL11854692A patent/IL118546A/en not_active IP Right Cessation
- 1992-06-25 FI FI922958A patent/FI109454B/fi not_active IP Right Cessation
- 1992-06-25 CZ CS921977A patent/CZ281790B6/cs not_active IP Right Cessation
- 1992-06-25 SK SK1977-92A patent/SK278759B6/sk not_active IP Right Cessation
- 1992-06-25 LU LU88138A patent/LU88138A1/fr unknown
- 1992-06-25 AU AU18527/92A patent/AU659460B2/en not_active Expired
- 1992-06-26 RU SU5052126/A patent/RU2143919C1/ru active
- 1992-06-26 RO RO92-0868A patent/RO111021B1/ro unknown
- 1992-06-26 CA CA002175842A patent/CA2175842C/en not_active Expired - Lifetime
- 1992-06-26 CA CA002072509A patent/CA2072509C/en not_active Expired - Lifetime
- 1992-06-26 KR KR1019920011198A patent/KR0131064B1/ko not_active Expired - Lifetime
- 1992-06-26 JP JP4168946A patent/JP2653958B2/ja not_active Expired - Lifetime
- 1992-06-29 TW TW081105112A patent/TW267943B/zh not_active IP Right Cessation
- 1992-07-01 IE IE922082A patent/IE73662B1/en not_active IP Right Cessation
- 1992-10-31 SA SA92130213A patent/SA92130213B1/ar unknown
-
1993
- 1993-01-01 CN CN93100563A patent/CN1077798C/zh not_active Expired - Lifetime
- 1993-02-01 FR FR9301141A patent/FR2685706A1/fr active Granted
- 1993-06-18 UA UA93003147A patent/UA35559C2/uk unknown
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1994
- 1994-11-09 EE EE9400190A patent/EE03108B1/xx unknown
- 1994-11-30 UY UY23864A patent/UY23864A1/es not_active IP Right Cessation
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1995
- 1995-06-14 RO RO95-01142A patent/RO111110B1/ro unknown
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1996
- 1996-04-03 FI FI961513A patent/FI116199B/fi not_active IP Right Cessation
- 1996-04-03 HK HK57196A patent/HK57196A/xx not_active IP Right Cessation
- 1996-06-03 IL IL11854696A patent/IL118546A0/xx unknown
- 1996-08-22 HK HK157696A patent/HK157696A/xx not_active IP Right Cessation
- 1996-09-12 JP JP24170596A patent/JP3420897B2/ja not_active Expired - Lifetime
- 1996-10-15 NO NO19964382A patent/NO325267B1/no not_active IP Right Cessation
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1997
- 1997-06-20 KR KR1019970026005A patent/KR100231385B1/ko not_active Expired - Lifetime
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1998
- 1998-09-22 KR KR1019980039160A patent/KR100231384B1/ko not_active Expired - Lifetime
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2000
- 2000-01-14 GR GR20000400064T patent/GR3032366T3/el unknown
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