ES2101574T3 - Composicion administrable por via oral apta para formar una microemulsion. - Google Patents

Composicion administrable por via oral apta para formar una microemulsion.

Info

Publication number
ES2101574T3
ES2101574T3 ES94928928T ES94928928T ES2101574T3 ES 2101574 T3 ES2101574 T3 ES 2101574T3 ES 94928928 T ES94928928 T ES 94928928T ES 94928928 T ES94928928 T ES 94928928T ES 2101574 T3 ES2101574 T3 ES 2101574T3
Authority
ES
Spain
Prior art keywords
surfactant
esters
microemulsion
phase
hydrophilic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94928928T
Other languages
English (en)
Inventor
Nabil Farah
Joel Denis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gattefosse SA
Original Assignee
Gattefosse SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gattefosse SA filed Critical Gattefosse SA
Application granted granted Critical
Publication of ES2101574T3 publication Critical patent/ES2101574T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A61K8/068—Microemulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Abstract

COMPOSICION DE USO FARMACEUTICO O COSMETICO, APTO PARA FORMAR UNA MICROEMULSION, QUE COMPRENDE ALMENOS: UN ACTIVO, UNA FASE LIPOFILA CONSTITUIDA POR UNA MEZCLA DE GLICERIDOS Y DE ESTERES DE ACIDOS GRASOS; UN AGENTE TENSIOACTIVO (TA); UN AGENTE COTENSIOACTIVO (COTA); UNA FASE HIDROFILA , CARACTERIZADO :EN QUE LA FASE LIPOFILA ESTA CONSTITUIDA POR UNA MEZCLA DE GLICERIDOS POLIGLICOLIZADOS EN C8 A C18, PRESENTANDO UN EQUILIBRIO HIDROFILO-LIPOFILO (HLB) INFERIOR A 16 REPRESENTANDO ESTA FASE LIPOFILA DE 30 A 75% DEL PESO TOTAL DE LOS ESTERES OLEICOS DEL POLIGLICEROL, PRESENTANDO ESTE AGENTE TENSIOACTIVO UNA HLB INFERIOR A 16; EN QUE EL AGENTE COTENSIOACTIVO (COTA) ES ELEGIDO EN EL GRUPO QUE COMPRENDE LOS ESTERES LAURICOS DEL PROPILENO GLICOL, LOS ESTERES OLEICOS DEL POLIGLICOL Y EL ETIL DIGLICOL; EN QUE LA RELACION TA/COTA ESTA COMPRENDIA ENTRE 0.5 Y 6; Y ENQUE LA FASE HIDROFILA DE LA MICROEMULSION FINAL ES APORTADA TRAS LA INGESTION POR EL LIQUIDO FISIOLOGICO DEL MEDIO DIGESTIVO.
ES94928928T 1993-09-30 1994-09-29 Composicion administrable por via oral apta para formar una microemulsion. Expired - Lifetime ES2101574T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9311876A FR2710535B1 (fr) 1993-09-30 1993-09-30 Composition à usage pharmaceutique ou cosmétique apte à former une microémulsion.

Publications (1)

Publication Number Publication Date
ES2101574T3 true ES2101574T3 (es) 1997-07-01

Family

ID=9451565

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94928928T Expired - Lifetime ES2101574T3 (es) 1993-09-30 1994-09-29 Composicion administrable por via oral apta para formar una microemulsion.

Country Status (6)

Country Link
EP (1) EP0670715B1 (es)
AT (1) ATE152613T1 (es)
DE (1) DE69403057T2 (es)
ES (1) ES2101574T3 (es)
FR (1) FR2710535B1 (es)
WO (1) WO1995008983A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6312704B1 (en) * 1993-09-30 2001-11-06 Gattefosse, S.A. Orally administrable composition capable of providing enhanced bioavailability when ingested
FR2729307B1 (fr) * 1995-01-18 1997-04-18 Seppic Sa Utilisation d'esters d'acides gras ethoxyles comme composants auto-emulsionnables notamment utiles pour la preparation de produits de traitement phytosanitaires ou de medicaments a usage veterinaire ou humain
CA2313024C (en) 1997-12-10 2008-06-03 Severson, Mary L. Pharmaceutical compositions containing an omega-3 fatty acid oil
AU3843999A (en) * 1998-05-07 1999-11-23 Elan Corporation, Plc Solvent/cosolvent free microemulsion and emulsion preconcentrate drug delivery systems
FR2782006B1 (fr) 1998-08-07 2002-04-19 Gattefosse Ets Sa Composition a liberation prolongee apte a former une micro-emulsion
JP2000237284A (ja) * 1999-02-17 2000-09-05 Shionogi Qualicaps Kk 硬質カプセル製剤
GB9912476D0 (en) 1999-05-28 1999-07-28 Novartis Ag Organic compounds
FR2794023B1 (fr) * 1999-05-28 2003-04-25 Codif Internat Sa Composition cosmetique destinee a renforcer l'efficacite des principes actifs d'autres compositions cosmetiques
SE0000773D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
SE0000774D0 (sv) * 2000-03-08 2000-03-08 Astrazeneca Ab New formulation
KR100426346B1 (ko) * 2000-11-30 2004-04-08 한국화학연구원 자가미세유화형 약물전달시스템을 이용한 고지혈증치료용약제 조성물
US20040115161A1 (en) * 2001-03-29 2004-06-17 Keiichi Oyama Cosmetic emulsion preparation and agent for external use
FR2827770B1 (fr) * 2001-07-27 2005-08-19 Gattefosse Ets Sa Composition pharmaceutique a usage oral comprenant un principe actif susceptible de subir un important effet de premier passage intestinal
SE0102993D0 (sv) 2001-09-07 2001-09-07 Astrazeneca Ab New self emulsifying drug delivery system
SE0200154D0 (sv) * 2002-01-21 2002-01-21 Galenica Ab New process
PL1660047T3 (pl) 2003-08-13 2014-05-30 Biocon Ltd Formulacje dawek stałych mikrocząsteczek soli kwasów tłuszczowych do środków terapeutycznych
WO2005037251A1 (en) * 2003-10-17 2005-04-28 Amylin Pharmaceuticals, Inc. Self-emulsifying drug delivery systems for hydrophobic therapeutic compounds
WO2005037250A1 (en) * 2003-10-17 2005-04-28 Amylin Pharmaceuticals, Inc. Self emulsifying drug delivery systems for hydrophobic therapeutic compounds
PT1729797E (pt) * 2004-03-22 2008-12-17 Solvay Pharm Gmbh Composições farmacêuticas orais de produtos contendo lipase, em particular de pancreatina, contendo tensioactivos
FR2873585B1 (fr) * 2004-07-27 2006-11-17 Aventis Pharma Sa Nouvelles formulations galeniques de principes actifs
PL2278002T3 (pl) 2005-07-29 2017-12-29 Abbott Laboratories Gmbh Pankreatyna o zmniejszonej zawartości wirusowej
US11266607B2 (en) 2005-08-15 2022-03-08 AbbVie Pharmaceuticals GmbH Process for the manufacture and use of pancreatin micropellet cores
US9198871B2 (en) 2005-08-15 2015-12-01 Abbott Products Gmbh Delayed release pancreatin compositions
US10072256B2 (en) 2006-05-22 2018-09-11 Abbott Products Gmbh Process for separating and determining the viral load in a pancreatin sample
JP5501224B2 (ja) * 2007-05-25 2014-05-21 ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア 治療薬の経口投与のための製剤および関連する方法
WO2011050457A1 (en) 2009-10-26 2011-05-05 The University Of British Columbia Stabilized formulation for oral administration of therapeutic agents and related methods
DE102012019029A1 (de) 2012-09-27 2014-03-27 Alf Lamprecht Arzneiformulierungen zur oralen Gabe von therapeutischen Substanzen und Verfahren zur Herstellung
TR201704471T1 (tr) 2014-11-05 2018-04-24 Abbott Gmbh & Co Kg Pankreatin İhtiva Eden İyileştirilmiş Güvenlik Profiline Sahip Bileşimlerin Üretilmesi İçin Prosesler Ve Farmasötik Kullanıma Uygun Bileşimler
WO2016126970A1 (en) 2015-02-04 2016-08-11 Abbvie Inc. Pharmaceutical compositions and methods of use thereof to treat pancreatic enzyme insufficiency
FR3073415B1 (fr) 2017-11-10 2019-11-08 Gattefosse Sas Systeme auto-emulsionnable solide et son procede de fabrication par impression en 3 dimensions

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3406497A1 (de) * 1984-02-23 1985-09-05 Mueller Bernhard Willi Werner Hochdisperse pharmazeutische mehrkomponentensysteme und verfahren zu ihrer herstellung
US5314685A (en) * 1992-05-11 1994-05-24 Agouron Pharmaceuticals, Inc. Anhydrous formulations for administering lipophilic agents

Also Published As

Publication number Publication date
FR2710535B1 (fr) 1995-11-24
FR2710535A1 (fr) 1995-04-07
WO1995008983A1 (fr) 1995-04-06
EP0670715B1 (fr) 1997-05-07
ATE152613T1 (de) 1997-05-15
DE69403057D1 (de) 1997-06-12
EP0670715A1 (fr) 1995-09-13
DE69403057T2 (de) 1997-08-14

Similar Documents

Publication Publication Date Title
ES2101574T3 (es) Composicion administrable por via oral apta para formar una microemulsion.
US7988995B1 (en) Pharmaceutical compositions for lipophilic drugs
US6054136A (en) Orally administrable composition capable of providing enhanced bioavailability when ingested
US6312704B1 (en) Orally administrable composition capable of providing enhanced bioavailability when ingested
KR960016904A (ko) 사이클로스포린-함유 연질캅셀제 조성물
IL102633A0 (en) Compositions
KR960021056A (ko) 사이클로스포린-함유 연질캅셀제 조성물
DK0904064T3 (da) Orale farmaceutiske præparater indeholdende kønshormoner
CA2072509A1 (en) Cyclosporin emulsion compositions for oral administration
EP1039893A4 (en) PHARMACEUTICAL COMPOSITIONS CONTAINING OMEGA-3 FATTY ACID OIL
AP2000001943A0 (en) Orally administrable immediate-release and prolonged-release galenic form comprising an absorption-promoting agent and use of this absorption-promoting agent.
ATE276741T1 (de) Fenofibrathaltige galenische arzneizusammensetzungen und verfahren zu ihrer herstellung
RU2001119167A (ru) Самоэмульгирующиеся композиции для плохорастворимых в воде лекарственных препаратов
ES2177652T3 (es) Nuevas formas de preparacion de ciclosporina para la aplicacion oral con composicion simple y alta biodisponibilidad, y procedimiento para su obtencion.
MX9204382A (es) Composiciones
RU2001124597A (ru) Спонтанно диспергирующиеся композиции, содержащие N-бензоилстауроспорин
AU2003248969A1 (en) Pharmaceutical formulation comprising cyclosporin, propylene glycol ester and non-ionic surfactant
KR970706803A (ko) 경구용 시클로스포린 제형(oral cyclosporin formulations)
RU98105629A (ru) Препараты, содержащие циклоспорин, в виде капсул с мягким покрытием
MY117765A (en) Cyclosporin-containing soft capsule preparations.
RU99121398A (ru) Фармацевтические композиции
RU2000125560A (ru) Предварительно приготовленные эмульсионные концентраты, содержащие циклоспорин или макролид

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 670715

Country of ref document: ES