DK0953630T3 - Omesterificeringsprodukter af majsolie og glycerol og deres anvendelse i farmaceutiske sammensætninger - Google Patents

Omesterificeringsprodukter af majsolie og glycerol og deres anvendelse i farmaceutiske sammensætninger

Info

Publication number
DK0953630T3
DK0953630T3 DK99106122T DK99106122T DK0953630T3 DK 0953630 T3 DK0953630 T3 DK 0953630T3 DK 99106122 T DK99106122 T DK 99106122T DK 99106122 T DK99106122 T DK 99106122T DK 0953630 T3 DK0953630 T3 DK 0953630T3
Authority
DK
Denmark
Prior art keywords
glycerol
pharmaceutical compositions
corn oil
rearranging products
rearranging
Prior art date
Application number
DK99106122T
Other languages
English (en)
Inventor
Armin Meinzer
Birgit Hauer
Ulrich Posanski
Jacky Vonderscher
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10697415&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0953630(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK0953630T3 publication Critical patent/DK0953630T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/20Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • CCHEMISTRY; METALLURGY
    • C11ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11CFATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/04Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils
    • C11C3/06Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fats or fatty oils with glycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13Cyclosporins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/107Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841Filling excipients; Inactive ingredients
    • A61K9/4858Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fats And Perfumes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Confectionery (AREA)
DK99106122T 1991-06-27 1992-06-23 Omesterificeringsprodukter af majsolie og glycerol og deres anvendelse i farmaceutiske sammensætninger DK0953630T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919113872A GB9113872D0 (en) 1991-06-27 1991-06-27 Improvements in or relating to organic compounds
EP92810479A EP0539319B1 (en) 1991-06-27 1992-06-23 Pharmaceutical cyclosporin composition

Publications (1)

Publication Number Publication Date
DK0953630T3 true DK0953630T3 (da) 2004-11-01

Family

ID=10697415

Family Applications (2)

Application Number Title Priority Date Filing Date
DK99106122T DK0953630T3 (da) 1991-06-27 1992-06-23 Omesterificeringsprodukter af majsolie og glycerol og deres anvendelse i farmaceutiske sammensætninger
DK92810479T DK0539319T3 (da) 1991-06-27 1992-06-23 Farmaceutisk cyclosporinpræparat

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK92810479T DK0539319T3 (da) 1991-06-27 1992-06-23 Farmaceutisk cyclosporinpræparat

Country Status (38)

Country Link
EP (2) EP0953630B1 (da)
JP (2) JP2653958B2 (da)
KR (3) KR0131064B1 (da)
CN (1) CN1077798C (da)
AT (1) AT403436B (da)
AU (1) AU659460B2 (da)
CA (2) CA2072509C (da)
CH (2) CH685764A5 (da)
CY (1) CY1906A (da)
CZ (1) CZ281790B6 (da)
DE (3) DE4244930C2 (da)
DK (2) DK0953630T3 (da)
EE (1) EE03108B1 (da)
ES (2) ES2142818T3 (da)
FI (2) FI109454B (da)
FR (2) FR2678169B1 (da)
GB (2) GB9113872D0 (da)
GR (1) GR3032366T3 (da)
HK (2) HK57196A (da)
HU (1) HU216792B (da)
IE (1) IE73662B1 (da)
IL (3) IL118546A (da)
IT (1) IT1254401B (da)
LU (1) LU88138A1 (da)
MX (1) MX9203236A (da)
MY (1) MY109512A (da)
NO (2) NO303964B1 (da)
NZ (1) NZ243309A (da)
PH (1) PH30337A (da)
PT (2) PT953630E (da)
RO (2) RO111021B1 (da)
RU (1) RU2143919C1 (da)
SA (1) SA92130213B1 (da)
SK (1) SK278759B6 (da)
TW (1) TW267943B (da)
UA (1) UA35559C2 (da)
UY (1) UY23864A1 (da)
ZA (1) ZA924719B (da)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds
DK0589843T3 (da) * 1992-09-25 2002-04-02 Novartis Ag Cyclosporinholdige farmaceutiske præparater
NZ247516A (en) * 1993-04-28 1995-02-24 Bernard Charles Sherman Water dispersible pharmaceutical compositions comprising drug dissolved in solvent system comprising at least one alcohol and at least one surfactant
GB2278780B (en) * 1993-05-27 1998-10-14 Sandoz Ltd Macrolide formulations
AT408520B (de) * 1993-05-27 2001-12-27 Novartis Erfind Verwalt Gmbh Galenische formulierungen
CH686761A5 (de) * 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
EP1033128B2 (en) 1993-09-28 2011-11-23 R.P. Scherer GmbH Soft gelatin capsule manufacture
DE4340781C3 (de) * 1993-11-30 2000-01-27 Novartis Ag Cyclosporin enthaltende flüssige Zubereitungen und Verfahren zu ihrer Herstellung
EP0694308A4 (en) * 1994-02-17 1997-09-10 Shiseido Co Ltd CYCLOSPORIN EMULSION COMPOSITION
US5891846A (en) * 1994-02-17 1999-04-06 Shiseido Company, Ltd. Cyclosporin-containing emulsion composition
NZ270145A (en) * 1994-03-01 1996-08-27 Lilly Co Eli Non-aqueous pharmaceutical formulation for oral administration comprising water-insoluble active agent, fatty acid solubilising agent, an oil and a surface active agent
GB9405304D0 (en) * 1994-03-16 1994-04-27 Scherer Ltd R P Delivery systems for hydrophobic drugs
DE69510404T2 (de) * 1994-03-31 2000-01-20 Loders Croklaan B.V., Wormerveer Öle mit niedrigem Gehalt an gesättigter Fettsäure
GB2308545B (en) * 1994-10-26 1999-06-02 Novartis Ag Pharmaceutical microemulsion preconcentrates
IL115742A (en) 1994-10-26 2000-06-01 Novartis Ag Pharmaceutical compositions comprising a difficultly soluble active agent a hydrophilic phase a lipophilic phase and a surfactant
DE59510233D1 (de) 1994-11-03 2002-07-11 Novartis Ag Neue zubereitungsformen des cyclosporins zur oralen applikation mit einfacher zusammensetzung und hoher bioverfügbarkeit und verfahren zu deren herstellung
HU215966B (hu) * 1994-11-21 1999-07-28 BIOGAL Gyógyszergyár Rt. Orálisan alkalmazható, ciklosporint tartalmazó, összetett emulzió-előkoncentrátum
WO1996036330A2 (en) * 1995-05-17 1996-11-21 Cedars-Sinai Medical Center Compositions containing fatty acids for improving digestion and absorption in the small intestine
JPH11505258A (ja) * 1995-05-17 1999-05-18 セダーシナイ メディカル センター 小腸における消化および吸収を改善させる脂肪酸を含む組成物
US7048906B2 (en) 1995-05-17 2006-05-23 Cedars-Sinai Medical Center Methods of diagnosing and treating small intestinal bacterial overgrowth (SIBO) and SIBO-related conditions
US6861053B1 (en) 1999-08-11 2005-03-01 Cedars-Sinai Medical Center Methods of diagnosing or treating irritable bowel syndrome and other disorders caused by small intestinal bacterial overgrowth
US6008228A (en) * 1995-06-06 1999-12-28 Hoffman-La Roche Inc. Pharmaceutical compositions containing proteinase inhibitors
US6696413B2 (en) * 1995-06-16 2004-02-24 Hexal Ag Pharmaceutical preparation with cyclosporin A
SE504582C2 (sv) * 1995-07-06 1997-03-10 Gs Dev Ab Cyklosporinkomposition baserad på en L2-fas
DE19549852B4 (de) * 1995-11-29 2009-06-04 Novartis Ag Cyclosporin enthaltende Präparate
US5858401A (en) 1996-01-22 1999-01-12 Sidmak Laboratories, Inc. Pharmaceutical composition for cyclosporines
CN1104258C (zh) * 1996-05-29 2003-04-02 周德和 用于环孢霉素a的赋形剂
CN1127350C (zh) * 1996-06-19 2003-11-12 诺瓦提斯公司 含有环孢菌素的软胶囊制剂
US5958876A (en) * 1996-06-19 1999-09-28 Novartis Ag Cyclosporin-containing pharmaceutical compositions
KR980008239A (ko) * 1996-07-26 1998-04-30 김충환 사이클로스포린-함유 약학적 조성물
FR2752732B1 (fr) * 1996-08-28 1998-11-20 Pf Medicament Forme galenique a liberation prolongee de milnacipran
ZA9711732B (en) 1996-12-31 1998-12-28 Quadrant Holdings Cambridge Methods and compositions for improvement bioavailability of bioactive agents for mucosal delivery
US6306434B1 (en) * 1997-02-12 2001-10-23 Chong Kun Dang Corp. Pharmaceutical composition comprising cyclosporin solid-state microemulsion
SI0969856T1 (en) * 1997-03-12 2005-06-30 Abbott Laboratories Hydrophilic binary systems for the administration of cyclosporine
NZ314702A (en) * 1997-04-29 1998-07-28 Bernard Charles Sherman Pharmaceutical composition comprising a cyclosporin in a solvent system of acetylated monoglycerides and a surfactant and optionally a hydrophilic solvent
CA2285983A1 (en) 1997-04-29 1998-11-05 Bernard Charles Sherman Emulsion preconcentrate comprising a cyclosporin and acetylated monoglyceride
GB2326337A (en) * 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
CA2294033C (en) 1997-07-29 2007-01-09 Pharmacia & Upjohn Company Pharmaceutical composition for acidic lipophilic compounds in a form of a self-emulsifying formulation
SI0999826T1 (en) * 1997-07-29 2004-12-31 Pharmacia & Upjohn Company Self-emulsifying formulation for lipophilic compounds
AU728695B2 (en) * 1997-07-29 2001-01-18 Boehringer Ingelheim International Gmbh Self-emulsifying formulation for lipophilic compounds
US6657104B1 (en) 1997-10-16 2003-12-02 Texas Systems, University Of The Board Of The Regents Transgenic mouse model for cardiac hypertrophy and methods of use thereof
DE69842121D1 (de) 1997-12-10 2011-03-17 Cyclosporine Therapeutics Ltd Omega-3 fettsäure enthaltende pharmazeutische zusammensetzungen
ID25908A (id) * 1998-03-06 2000-11-09 Novartis Ag Prakonsentrat-prakonsentrat emulsi yang mengandung siklosporin atau makrolida
DK0982035T3 (da) * 1998-08-18 2004-06-28 Panacea Biotec Ltd Cyclosporinpræparater
GB9903547D0 (en) 1999-02-16 1999-04-07 Novartis Ag Organic compounds
CN1167462C (zh) * 1999-03-09 2004-09-22 杭州华东医药集团生物工程研究所有限公司 一种含环孢素的药物组合物
US6956048B2 (en) 1999-03-31 2005-10-18 Pharmacia & Upjohn Company Pharmaceutical emulsions for retroviral protease inhibitors
AU2127400A (en) * 1999-11-02 2001-05-14 Cipla Limited A pharmaceutical composition for the administration of water-insoluble pharmaceutically active substances and process for preparation thereof
US7732404B2 (en) 1999-12-30 2010-06-08 Dexcel Ltd Pro-nanodispersion for the delivery of cyclosporin
GB0008785D0 (en) 2000-04-10 2000-05-31 Novartis Ag Organic compounds
EP1430783B1 (en) * 2000-08-08 2006-10-11 Kao Corporation Oil/fat composition
US7115565B2 (en) 2001-01-18 2006-10-03 Pharmacia & Upjohn Company Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability
PL210795B1 (pl) 2001-10-19 2012-03-30 Isotechnika Inc Sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (E), sposób wytwarzania mieszaniny ISATX247 wzbogaconej w izomer (Z), sposób stereoselektywnej syntezy izomeru (E) ISATX247, sposób stereoselektywnej syntezy izomeru (Z) ISATX247 i sposób wytwarzania mieszaniny izomerów ISATX247
KR100441167B1 (ko) * 2001-12-27 2004-07-21 씨제이 주식회사 마이크로에멀젼 예비 농축액 조성물
KR100525234B1 (ko) * 2003-02-19 2005-10-28 한국유나이티드제약 주식회사 사이클로스포린 함유 연질캅셀제 및 그 제조방법
GT200500310A (es) 2004-11-19 2006-06-19 Compuestos organicos
GB0504950D0 (en) 2005-03-10 2005-04-20 Novartis Ag Organic compositions
JP4889262B2 (ja) * 2005-08-19 2012-03-07 理研ビタミン株式会社 脂溶性薬剤組成物
MD3347G2 (ro) * 2006-12-26 2008-01-31 Институт Сельскохозяйственной Техники "Mecagro" Procedeu de obţinere a esterilor metilici din ulei de rapiţă
ITPD20070049A1 (it) * 2007-02-14 2008-08-15 Sila S R L Prodotto a base di acido linoleico coniugato e processo per la sua fabbricazione
CA2683409A1 (en) 2007-04-04 2008-10-16 Sigmoid Pharma Limited A pharmaceutical composition of tacrolimus
CN101199836B (zh) * 2007-11-07 2011-03-30 安徽省药物研究所 一种阶段释放型环孢素a固体微乳制剂及其微乳固化方法
EP2432455B1 (en) 2009-05-18 2014-11-12 Sigmoid Pharma Limited Composition comprising oil drops
CA2770570A1 (en) 2009-08-12 2011-02-17 Sigmoid Pharma Limited Immunomodulatory compositions comprising a polymer matrix and an oil phase
GB201020032D0 (en) 2010-11-25 2011-01-12 Sigmoid Pharma Ltd Composition
JO3337B1 (ar) 2010-12-13 2019-03-13 Debiopharm Sa تركيبات صيدلية تشمل أليسبوريفير
FR2971941B1 (fr) 2011-02-24 2013-08-02 Physica Pharma Compositions pharmaceutiques administrables par voie cutanee et destinees au traitement local de la dermatite atopique canine
GB201304662D0 (en) 2013-03-14 2013-05-01 Sigmoid Pharma Ltd Compositions
PL3215127T3 (pl) 2014-11-07 2021-05-17 Sublimity Therapeutics Limited Kompozycje zawierające cyklosporynę
WO2020050182A1 (ja) * 2018-09-06 2020-03-12 株式会社カマタ カプセル充填用液状組成物及びカプセル剤
PT3886813T (pt) * 2018-11-26 2023-04-26 Hepion Pharmaceuticals Inc Formulações farmacêuticas de análogos de ciclosporina

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1274354A (fr) * 1956-03-10 1961-10-27 Agents tensio-actifs obtenus à partir de triglycérides et polyéthylène glycol
DE2907460A1 (de) * 1978-03-07 1979-09-13 Sandoz Ag Neue resorbierbare galenische kompositionen
CH641356A5 (en) * 1979-02-27 1984-02-29 Sandoz Ag Pharmaceutical compositions containing cyclosporin
AU558155B2 (en) * 1982-02-01 1987-01-22 Sandoz Ltd. Treating multiple sclerosis with dihydro-cyclosporin d
GB8903804D0 (en) * 1989-02-20 1989-04-05 Sandoz Ltd Improvements in or relating to organic compounds
JPS62201591A (ja) * 1986-02-28 1987-09-05 Shoichi Shimizu 油脂のグリセロリシス法
JP2632010B2 (ja) * 1988-01-29 1997-07-16 三共株式会社 シクロスポリン製剤
CH679119A5 (da) * 1988-05-13 1991-12-31 Sandoz Ag
HU201567B (en) * 1988-07-21 1990-11-28 Gyogyszerkutato Intezet Process for production of intravenous medical compositions containing cyclosphorin
GB2222770B (en) * 1988-09-16 1992-07-29 Sandoz Ltd Pharmaceutical compositions containing cyclosporins
GB8823621D0 (en) * 1988-10-07 1988-11-16 Madhok R Compositions containing cyclosporins
JPH0738771B2 (ja) * 1989-01-17 1995-05-01 花王株式会社 液状食用油組成物
BE1003009A5 (fr) * 1989-02-09 1991-10-22 Sandoz Sa Nouvelles compositions pharmaceutiques a base de cyclosporines.
AU6785490A (en) * 1989-12-18 1991-06-20 Kraft General Foods, Inc. Low-saturate edible oils and transesterification methods for production thereof
GB9113872D0 (en) * 1991-06-27 1991-08-14 Sandoz Ag Improvements in or relating to organic compounds

Also Published As

Publication number Publication date
NO922506D0 (no) 1992-06-25
AU1852792A (en) 1993-03-11
PH30337A (en) 1997-04-02
UY23864A1 (es) 1995-05-29
MY109512A (en) 1997-02-28
HUT62201A (en) 1993-04-28
GR3032366T3 (en) 2000-04-27
IL102310A0 (en) 1993-01-14
CY1906A (en) 1992-06-24
KR100231384B1 (en) 1999-11-15
AU659460B2 (en) 1995-05-18
EP0539319A3 (en) 1993-06-09
FR2685706A1 (fr) 1993-07-02
RU2143919C1 (ru) 2000-01-10
GB9113872D0 (en) 1991-08-14
JPH09118894A (ja) 1997-05-06
NO922506L (no) 1992-12-28
NO964382L (no) 1992-12-28
DE4244986B4 (de) 2008-07-24
CN1079907A (zh) 1993-12-29
FR2678169A1 (fr) 1992-12-31
ES2142818T3 (es) 2000-05-01
IL118546A0 (en) 1996-10-16
CN1077798C (zh) 2002-01-16
IL102310A (en) 1997-03-18
DE4244930C2 (de) 1999-11-11
FI961513A0 (fi) 1996-04-03
RO111110B1 (ro) 1996-06-28
FI961513A (fi) 1996-04-03
IT1254401B (it) 1995-09-14
FI116199B (fi) 2005-10-14
IE73662B1 (en) 1997-06-18
NO325267B1 (no) 2008-03-17
GB2257359A (en) 1993-01-13
RO111021B1 (ro) 1996-06-28
HK57196A (en) 1996-04-12
SK197792A3 (en) 1994-03-09
EP0953630A1 (en) 1999-11-03
JP2653958B2 (ja) 1997-09-17
DE4219526C2 (de) 1999-04-22
ZA924719B (en) 1993-12-27
PT539319E (pt) 2000-05-31
FR2685706B1 (da) 1994-12-23
ITRM920476A1 (it) 1993-12-23
EP0539319A2 (en) 1993-04-28
AT403436B (de) 1998-02-25
CH684163A5 (de) 1994-07-29
JP3420897B2 (ja) 2003-06-30
GB9213393D0 (en) 1992-08-05
FI922958A0 (fi) 1992-06-25
HK157696A (en) 1996-08-30
CZ281790B6 (cs) 1997-01-15
FI922958A (fi) 1992-12-28
DK0539319T3 (da) 2000-05-22
KR0131064B1 (ko) 1998-04-17
EP0539319B1 (en) 1999-12-08
IL118546A (en) 1998-09-24
CA2175842A1 (en) 1992-12-28
FR2678169B1 (fr) 1994-08-26
CA2175842C (en) 2002-05-07
ATA129892A (de) 1997-07-15
EE03108B1 (et) 1998-08-17
EP0953630B1 (en) 2004-09-08
DE4219526A1 (de) 1993-03-18
MX9203236A (es) 1992-12-01
SA92130213B1 (ar) 2004-07-24
KR100231385B1 (en) 1999-11-15
KR930000113A (ko) 1993-01-15
GB2257359B (en) 1996-01-10
CA2072509C (en) 1996-07-30
LU88138A1 (fr) 1994-03-01
TW267943B (da) 1996-01-11
CA2072509A1 (en) 1992-12-28
NO303964B1 (no) 1998-10-05
PT953630E (pt) 2004-11-30
UA35559C2 (uk) 2001-04-16
ES2227921T3 (es) 2005-04-01
CZ197792A3 (en) 1993-01-13
FI109454B (fi) 2002-08-15
CH685764A5 (de) 1995-09-29
HU9201975D0 (en) 1992-09-28
HU216792B (hu) 1999-08-30
NZ243309A (en) 1995-02-24
SK278759B6 (sk) 1998-02-04
IE922082A1 (en) 1992-12-30
ITRM920476A0 (it) 1992-06-23
JPH05186365A (ja) 1993-07-27
NO964382D0 (no) 1996-10-15

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