DK1023900T3 - Farmaceutisk præparat indeholdende S-nitroso-lipoproteiner og anvendelse deraf - Google Patents

Farmaceutisk præparat indeholdende S-nitroso-lipoproteiner og anvendelse deraf

Info

Publication number
DK1023900T3
DK1023900T3 DK00108907T DK00108907T DK1023900T3 DK 1023900 T3 DK1023900 T3 DK 1023900T3 DK 00108907 T DK00108907 T DK 00108907T DK 00108907 T DK00108907 T DK 00108907T DK 1023900 T3 DK1023900 T3 DK 1023900T3
Authority
DK
Denmark
Prior art keywords
lipoproteins
nitroso
pharmaceutical composition
composition containing
pharmaceutical
Prior art date
Application number
DK00108907T
Other languages
English (en)
Inventor
Jonathan Stamler
Joseph Loscalzo
Daniel Simon
David Singel
Original Assignee
Brigham & Womens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Brigham & Womens Hospital filed Critical Brigham & Womens Hospital
Application granted granted Critical
Publication of DK1023900T3 publication Critical patent/DK1023900T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DK00108907T 1991-11-14 1992-11-13 Farmaceutisk præparat indeholdende S-nitroso-lipoproteiner og anvendelse deraf DK1023900T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US79166891A 1991-11-14 1991-11-14
US94383592A 1992-09-14 1992-09-14
EP92924388A EP0676964B1 (en) 1991-11-14 1992-11-13 Nitrosylation of enzyme sh groups as a therapeutic modality

Publications (1)

Publication Number Publication Date
DK1023900T3 true DK1023900T3 (da) 2005-06-06

Family

ID=27121187

Family Applications (3)

Application Number Title Priority Date Filing Date
DK92924388T DK0676964T3 (da) 1991-11-14 1992-11-13 Nitrosylering af enzym-SH-grupper som en terapeutisk modalitet
DK00108908T DK1023905T3 (da) 1991-11-14 1992-11-13 Farmaceutisk præparat indeholdende S-nitroso-immunoglobuliner og anvendelse deraf
DK00108907T DK1023900T3 (da) 1991-11-14 1992-11-13 Farmaceutisk præparat indeholdende S-nitroso-lipoproteiner og anvendelse deraf

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK92924388T DK0676964T3 (da) 1991-11-14 1992-11-13 Nitrosylering af enzym-SH-grupper som en terapeutisk modalitet
DK00108908T DK1023905T3 (da) 1991-11-14 1992-11-13 Farmaceutisk præparat indeholdende S-nitroso-immunoglobuliner og anvendelse deraf

Country Status (7)

Country Link
US (5) US5593876A (da)
EP (4) EP1023905B1 (da)
AU (2) AU3071592A (da)
CA (1) CA2125037C (da)
DE (3) DE69231666T2 (da)
DK (3) DK0676964T3 (da)
WO (1) WO1993009806A1 (da)

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GB9423868D0 (en) * 1994-11-25 1995-01-11 Wellcome Found Compounds for use in medicine
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US6916471B2 (en) 1995-09-15 2005-07-12 Duke University Red blood cells loaded with S-nitrosothiol and uses therefor
US6855691B1 (en) 1995-09-15 2005-02-15 Duke University Methods for producing and using S-nitrosohemoglobins
US6153186A (en) 1995-09-15 2000-11-28 Duke University Medical Center Red blood cells loaded with S-nitrosothiol and uses therefor
US6911427B1 (en) 1995-09-15 2005-06-28 Duke University No-modified hemoglobins and uses therefore
US6323211B1 (en) 1996-02-02 2001-11-27 Nitromed, Inc. Compositions and methods for treating sexual dysfunctions
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US20050065161A1 (en) * 1996-02-02 2005-03-24 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US6294517B1 (en) 1996-02-02 2001-09-25 Nitromed, Inc. Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use
US5932538A (en) * 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
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US5994294A (en) * 1996-02-02 1999-11-30 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
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US6057367A (en) * 1996-08-30 2000-05-02 Duke University Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses
JP2001512306A (ja) * 1997-01-08 2001-08-21 ライフ テクノロジーズ，インコーポレイテッド タンパク質の産生方法
CA2278784A1 (en) * 1997-02-06 1998-08-13 Jonathan S. Stamler No-modified hemoglobins and uses therefor
AU6782198A (en) * 1997-03-27 1998-10-20 Trustees Of Boston University Novel antiplatelet agent
JP4777489B2 (ja) * 1997-03-31 2011-09-21 ザ チルドレンズ メディカル センター コーポレーション アポトーシス性酵素を不活性化するためのニトロシル化
US6617355B1 (en) * 1997-05-21 2003-09-09 The University Of Virginia Patent Foundation Treating asthma by preventing and/or accomodating S-nitrosothiol breakdown
EP1659179B1 (en) * 1998-02-05 2011-06-15 GlaxoSmithKline Biologicals s.a. Tumor-associated antigen derivatives from the mage family, and nucleic acid sequences encoding them, used for the preparation of fusion proteins and of compositions for vaccination
US6297260B1 (en) 1998-10-30 2001-10-02 Nitromed, Inc. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
ES2147162B1 (es) * 1999-01-27 2001-03-16 Lacer Sa "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias".
US6314956B1 (en) * 1999-09-08 2001-11-13 Duke University Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders
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Also Published As

Publication number Publication date
DE69233474T2 (de) 2006-03-30
EP1025853A3 (en) 2000-11-08
US20060198831A1 (en) 2006-09-07
DE69233474D1 (de) 2005-03-03
CA2125037A1 (en) 1993-05-27
EP1025853A2 (en) 2000-08-09
DE69233491T2 (de) 2006-04-06
US5863890A (en) 1999-01-26
DK0676964T3 (da) 2001-02-05
EP0676964A1 (en) 1995-10-18
US6562344B1 (en) 2003-05-13
US5593876A (en) 1997-01-14
EP0676964B1 (en) 2001-01-24
DE69231666D1 (de) 2001-03-01
AU709725B2 (en) 1999-09-02
AU3071592A (en) 1993-06-15
US20030007967A1 (en) 2003-01-09
DE69233491D1 (de) 2005-04-21
EP1023900A2 (en) 2000-08-02
EP1023900B1 (en) 2005-03-16
EP1023905A2 (en) 2000-08-02
EP0676964A4 (en) 1995-08-10
DK1023905T3 (da) 2005-05-30
AU2849497A (en) 1997-10-16
EP1023905A3 (en) 2000-11-08
EP1023905B1 (en) 2005-01-26
DE69231666T2 (de) 2001-05-10
US7157500B2 (en) 2007-01-02
EP1023900A3 (en) 2000-11-08
CA2125037C (en) 2001-02-20
WO1993009806A1 (en) 1993-05-27

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