DE69233491D1 - Pharmazeutische Zusammensetzung enthaltend S-Nitrosolipoproteine und deren Verwendung - Google Patents
Pharmazeutische Zusammensetzung enthaltend S-Nitrosolipoproteine und deren VerwendungInfo
- Publication number
- DE69233491D1 DE69233491D1 DE69233491T DE69233491T DE69233491D1 DE 69233491 D1 DE69233491 D1 DE 69233491D1 DE 69233491 T DE69233491 T DE 69233491T DE 69233491 T DE69233491 T DE 69233491T DE 69233491 D1 DE69233491 D1 DE 69233491D1
- Authority
- DE
- Germany
- Prior art keywords
- nitrosolipoproteins
- pharmaceutical composition
- composition containing
- pharmaceutical
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6472—Cysteine endopeptidases (3.4.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
- C07K14/3153—Streptokinase
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
- C07K14/765—Serum albumin, e.g. HSA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/805—Haemoglobins; Myoglobins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US79166891A | 1991-11-14 | 1991-11-14 | |
US791668 | 1991-11-14 | ||
US94383592A | 1992-09-14 | 1992-09-14 | |
US943835 | 1992-09-14 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69233491D1 true DE69233491D1 (de) | 2005-04-21 |
DE69233491T2 DE69233491T2 (de) | 2006-04-06 |
Family
ID=27121187
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233491T Expired - Fee Related DE69233491T2 (de) | 1991-11-14 | 1992-11-13 | Pharmazeutische Zusammensetzung enthaltend S-Nitrosolipoproteine und deren Verwendung |
DE69233474T Expired - Fee Related DE69233474T2 (de) | 1991-11-14 | 1992-11-13 | Pharmazeutische Zusammensetzung enthaltend S-Nitrosoimmunoglobuline und Verwendung davon |
DE69231666T Expired - Fee Related DE69231666T2 (de) | 1991-11-14 | 1992-11-13 | Die nitrosylierung von enzym-sh gruppen als eine therapeutische massnahme |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69233474T Expired - Fee Related DE69233474T2 (de) | 1991-11-14 | 1992-11-13 | Pharmazeutische Zusammensetzung enthaltend S-Nitrosoimmunoglobuline und Verwendung davon |
DE69231666T Expired - Fee Related DE69231666T2 (de) | 1991-11-14 | 1992-11-13 | Die nitrosylierung von enzym-sh gruppen als eine therapeutische massnahme |
Country Status (7)
Country | Link |
---|---|
US (5) | US5593876A (de) |
EP (4) | EP0676964B1 (de) |
AU (2) | AU3071592A (de) |
CA (1) | CA2125037C (de) |
DE (3) | DE69233491T2 (de) |
DK (3) | DK1023905T3 (de) |
WO (1) | WO1993009806A1 (de) |
Families Citing this family (57)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6291424B1 (en) * | 1991-11-14 | 2001-09-18 | Brigham And Women's Hospital | Nitrosated and nitrosylated heme proteins |
EP0804244A1 (de) * | 1993-03-26 | 1997-11-05 | Biorelease Technologies, Inc. | Häm-proteine enthaltende zusammensetzungen und dazu gehörende methoden |
AU698748B2 (en) * | 1993-09-17 | 1998-11-05 | Brigham And Women's Hospital | Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces |
GB9423868D0 (en) * | 1994-11-25 | 1995-01-11 | Wellcome Found | Compounds for use in medicine |
US6043232A (en) * | 1997-07-23 | 2000-03-28 | Nitromed, Inc. | Nitroso esters of beta-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
US5703073A (en) * | 1995-04-19 | 1997-12-30 | Nitromed, Inc. | Compositions and methods to prevent toxicity induced by nonsteroidal antiinflammatory drugs |
US6051588A (en) * | 1995-04-19 | 2000-04-18 | Nitromed Inc | Nitroso esters of β-oxo-amides and aryl propionic acid derivatives of non-steroidal antiinflammatory drugs |
US5612314A (en) * | 1995-04-21 | 1997-03-18 | Brigham & Women's Hospital | Nitrosylated neuropeptides |
US6855691B1 (en) | 1995-09-15 | 2005-02-15 | Duke University | Methods for producing and using S-nitrosohemoglobins |
US6916471B2 (en) | 1995-09-15 | 2005-07-12 | Duke University | Red blood cells loaded with S-nitrosothiol and uses therefor |
US6197745B1 (en) | 1995-09-15 | 2001-03-06 | Duke University | Methods for producing nitrosated hemoglobins and therapeutic uses therefor |
US6911427B1 (en) | 1995-09-15 | 2005-06-28 | Duke University | No-modified hemoglobins and uses therefore |
US6627738B2 (en) | 1995-09-15 | 2003-09-30 | Duke University | No-modified hemoglobins and uses therefor |
US6153186A (en) * | 1995-09-15 | 2000-11-28 | Duke University Medical Center | Red blood cells loaded with S-nitrosothiol and uses therefor |
US20020143007A1 (en) * | 1996-02-02 | 2002-10-03 | Garvey David S. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonists, compositions and methods of use |
US5932538A (en) * | 1996-02-02 | 1999-08-03 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
US6294517B1 (en) | 1996-02-02 | 2001-09-25 | Nitromed, Inc. | Compositions and kits comprising alpha-adrenergic receptor antagonists and nitric oxide donors and methods of use |
US6469065B1 (en) | 1996-02-02 | 2002-10-22 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use |
US6323211B1 (en) | 1996-02-02 | 2001-11-27 | Nitromed, Inc. | Compositions and methods for treating sexual dysfunctions |
US20050065161A1 (en) * | 1996-02-02 | 2005-03-24 | Nitromed, Inc. | Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses |
US5994294A (en) * | 1996-02-02 | 1999-11-30 | Nitromed, Inc. | Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses |
US5824669A (en) | 1996-03-22 | 1998-10-20 | Nitromed, Inc. | Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders |
US6057367A (en) | 1996-08-30 | 2000-05-02 | Duke University | Manipulating nitrosative stress to kill pathologic microbes, pathologic helminths and pathologically proliferating cells or to upregulate nitrosative stress defenses |
EP0963435B1 (de) | 1997-01-08 | 2008-05-28 | Invitrogen Corporation | Verfahren zur herstellung von proteinen |
JP2002513400A (ja) * | 1997-02-06 | 2002-05-08 | デューク ユニバーシティ メディカル センター | No修飾ヘモグロビンおよびそのための使用 |
US6489290B2 (en) * | 1997-03-27 | 2002-12-03 | Trustees Of Boston University | Antiplatelet agent |
EP0979073A4 (de) * | 1997-03-31 | 2004-04-07 | Childrens Medical Center | Nitrosylierung zur inaktivierung apoptotischer enzyme |
WO1998052580A1 (en) * | 1997-05-21 | 1998-11-26 | Duke University | Treating asthma by preventing and/or accommodating for s-nitrosothiol breakdown |
DK1659178T3 (da) * | 1998-02-05 | 2010-07-12 | Glaxosmithkline Biolog Sa | Fremgangsmåde til oprensning eller fremstilling af et MAGE-protein |
CA2348741C (en) | 1998-10-30 | 2010-04-20 | Nitromed Inc. | Nitrosasted and nitrosylated nonsteroidal antiinflammatory compounds, comositions and methods of use |
ES2147162B1 (es) | 1999-01-27 | 2001-03-16 | Lacer Sa | "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias". |
US6314956B1 (en) | 1999-09-08 | 2001-11-13 | Duke University | Pulmonary delivery of NO group-containing compound in gas form to treat respiratory, cardiac and blood disorders |
US7045152B2 (en) | 1999-09-08 | 2006-05-16 | Duke University | Treating pulmonary disorders with gaseous agent causing repletion of GSNO |
JP2004506221A (ja) * | 2000-08-11 | 2004-02-26 | インヴィトロジェン コーポレーション | 高度に均一な電気泳動用分子マーカー |
US20040014082A1 (en) * | 2000-08-11 | 2004-01-22 | Invitrogen Corporation | Highly homogeneous molecular markers for electrophoresis |
US6417347B1 (en) | 2000-08-24 | 2002-07-09 | Scimed Life Systems, Inc. | High yield S-nitrosylation process |
US6780849B2 (en) | 2000-12-21 | 2004-08-24 | Scimed Life Systems, Inc. | Lipid-based nitric oxide donors |
CA2446064A1 (en) | 2001-05-02 | 2002-11-07 | Nitromed, Inc. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
AU2002326573B2 (en) * | 2001-08-20 | 2008-10-02 | University Of Louisville Research Foundation, Inc. | Use of S-nitrosothiol signaling to treat disordered control of breathing |
US20050261475A1 (en) * | 2004-02-13 | 2005-11-24 | Harvard Medical School | Solid-phase capture-release-tag methods for phosphoproteomic analyses |
GB0415757D0 (en) * | 2004-07-14 | 2004-08-18 | Nat Blood Authority | Methods |
SE0402221D0 (sv) * | 2004-09-14 | 2004-09-14 | Aerocrine Ab | Treatment of insufficient perfusion |
US8067464B2 (en) | 2004-10-04 | 2011-11-29 | Nitromed, Inc. | Compositions and methods using apocynin compounds and nitric oxide donors |
EP3556401A1 (de) | 2005-05-27 | 2019-10-23 | The University of North Carolina at Chapel Hill | Stickoxidfreisetzende partikel für stickoxidtherapeutika und biomedizinische anwendungen |
WO2007016677A2 (en) | 2005-08-02 | 2007-02-08 | Nitromed, Inc. | Nitric oxide enhancing antimicrobial compounds, compositions and methods of use |
CA2647859C (en) | 2006-03-29 | 2016-01-05 | Nitromed, Inc. | Nitric oxide enhancing prostaglandin compounds, compositions and methods of use |
EP1939179A1 (de) | 2006-12-28 | 2008-07-02 | Lacer, S.A. | Stabile S-Nitrosothiole, Syntheseverfahren und Verwendung |
US20090324685A1 (en) * | 2008-06-26 | 2009-12-31 | Boston Scientific Scimed, Inc. | Medical device coatings containing charged materials |
EP2334279A4 (de) * | 2008-10-16 | 2013-03-20 | Novan Inc | Stickoxid freisetzende partikel für mundpflegeanwendungen |
NO2440239T3 (de) | 2009-06-09 | 2018-02-10 | ||
ES2958410T3 (es) | 2009-08-21 | 2024-02-08 | Novan Inc | Geles tópicos |
EP2467173B8 (de) | 2009-08-21 | 2019-06-19 | Novan, Inc. | Wundverbände, verfahren zu ihrer anwendung und verfahren zu ihrer herstellung |
US20110086234A1 (en) * | 2009-10-13 | 2011-04-14 | Nathan Stasko | Nitric oxide-releasing coatings |
US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
WO2012118829A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same |
WO2016073835A1 (en) * | 2014-11-06 | 2016-05-12 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Compositions and methods of diazeniumdiolate-based prodrugs for treating cancer |
CN114025750A (zh) | 2019-03-07 | 2022-02-08 | 阿伯门蒂斯有限责任公司 | 包含神经可塑性作用物质的以非迷幻/致幻觉剂量和制剂给药的组合物和使用方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4666884A (en) * | 1984-04-10 | 1987-05-19 | New England Deaconess Hospital | Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls |
US5069936A (en) * | 1987-06-25 | 1991-12-03 | Yen Richard C K | Manufacturing protein microspheres |
US5002964A (en) * | 1988-06-15 | 1991-03-26 | Brigham & Women's Hospital | S-nitrosocaptopril compounds and the use thereof |
US5025001A (en) * | 1988-06-15 | 1991-06-18 | Brigham And Women's Hospital | S-nitroso derivatives of ACE inhibitors and the use thereof |
US4900719A (en) * | 1988-08-05 | 1990-02-13 | The Ohio State University | Nitrosothiols as hypotensive agents |
DE69008454T2 (de) * | 1989-08-07 | 1994-08-25 | Takeda Chemical Industries Ltd | Nitrolsothiolderivate, ihre Herstellung und Verwendung. |
US5380758A (en) * | 1991-03-29 | 1995-01-10 | Brigham And Women's Hospital | S-nitrosothiols as smooth muscle relaxants and therapeutic uses thereof |
US5385937A (en) * | 1991-04-10 | 1995-01-31 | Brigham & Women's Hospital | Nitrosation of homocysteine as a method for treating homocysteinemia |
US5459076A (en) * | 1992-04-22 | 1995-10-17 | Brigham And Women's Hospital | Method for detecting nitric oxide, nitrosonium equivalents, S-nitrosothiols and S-nitroso-proteins in biological systems |
US5298506A (en) * | 1992-05-08 | 1994-03-29 | Brigham And Women's Hospital | Use of guanylate cyclase inhibitors in the treatment of shock |
US5346599A (en) * | 1993-01-26 | 1994-09-13 | Jonathan Stamler | Capillary zone electrophoretic detection of biological thiols and their S-nitrosated and oxidized derivatives |
US5427797A (en) * | 1993-04-06 | 1995-06-27 | Brigham And Women's Hospital | Systemic effects of nitric oxide inhalation |
-
1992
- 1992-11-13 EP EP92924388A patent/EP0676964B1/de not_active Expired - Lifetime
- 1992-11-13 DK DK00108908T patent/DK1023905T3/da active
- 1992-11-13 EP EP00108908A patent/EP1023905B1/de not_active Expired - Lifetime
- 1992-11-13 DE DE69233491T patent/DE69233491T2/de not_active Expired - Fee Related
- 1992-11-13 AU AU30715/92A patent/AU3071592A/en not_active Abandoned
- 1992-11-13 EP EP00108906A patent/EP1025853A3/de not_active Withdrawn
- 1992-11-13 CA CA002125037A patent/CA2125037C/en not_active Expired - Fee Related
- 1992-11-13 WO PCT/US1992/009667 patent/WO1993009806A1/en active IP Right Grant
- 1992-11-13 DE DE69233474T patent/DE69233474T2/de not_active Expired - Fee Related
- 1992-11-13 DE DE69231666T patent/DE69231666T2/de not_active Expired - Fee Related
- 1992-11-13 DK DK92924388T patent/DK0676964T3/da active
- 1992-11-13 DK DK00108907T patent/DK1023900T3/da active
- 1992-11-13 EP EP00108907A patent/EP1023900B1/de not_active Expired - Lifetime
-
1994
- 1994-08-09 US US08/287,830 patent/US5593876A/en not_active Expired - Fee Related
-
1995
- 1995-05-09 US US08/437,884 patent/US6562344B1/en not_active Expired - Fee Related
-
1997
- 1997-07-03 AU AU28494/97A patent/AU709725B2/en not_active Ceased
- 1997-08-06 US US08/907,217 patent/US5863890A/en not_active Expired - Fee Related
-
2002
- 2002-08-13 US US10/216,865 patent/US7157500B2/en not_active Expired - Fee Related
-
2006
- 2006-05-05 US US11/418,367 patent/US20060198831A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
DE69231666T2 (de) | 2001-05-10 |
US7157500B2 (en) | 2007-01-02 |
US20060198831A1 (en) | 2006-09-07 |
US6562344B1 (en) | 2003-05-13 |
US5593876A (en) | 1997-01-14 |
EP1023900A3 (de) | 2000-11-08 |
DK1023900T3 (da) | 2005-06-06 |
US5863890A (en) | 1999-01-26 |
AU709725B2 (en) | 1999-09-02 |
CA2125037A1 (en) | 1993-05-27 |
CA2125037C (en) | 2001-02-20 |
WO1993009806A1 (en) | 1993-05-27 |
AU2849497A (en) | 1997-10-16 |
DK0676964T3 (da) | 2001-02-05 |
DE69231666D1 (de) | 2001-03-01 |
EP1025853A3 (de) | 2000-11-08 |
DE69233474T2 (de) | 2006-03-30 |
EP1023900A2 (de) | 2000-08-02 |
DK1023905T3 (da) | 2005-05-30 |
DE69233474D1 (de) | 2005-03-03 |
EP1023905B1 (de) | 2005-01-26 |
EP0676964A4 (de) | 1995-08-10 |
EP0676964B1 (de) | 2001-01-24 |
EP1023905A2 (de) | 2000-08-02 |
US20030007967A1 (en) | 2003-01-09 |
DE69233491T2 (de) | 2006-04-06 |
EP1023905A3 (de) | 2000-11-08 |
EP1025853A2 (de) | 2000-08-09 |
EP1023900B1 (de) | 2005-03-16 |
AU3071592A (en) | 1993-06-15 |
EP0676964A1 (de) | 1995-10-18 |
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