ES2147162B1 - "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias". - Google Patents
"s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias".Info
- Publication number
- ES2147162B1 ES2147162B1 ES009900159A ES9900159A ES2147162B1 ES 2147162 B1 ES2147162 B1 ES 2147162B1 ES 009900159 A ES009900159 A ES 009900159A ES 9900159 A ES9900159 A ES 9900159A ES 2147162 B1 ES2147162 B1 ES 2147162B1
- Authority
- ES
- Spain
- Prior art keywords
- sup
- sub
- moiety
- treatment
- dysfunctions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
S-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias. Se describen nuevos S-nitrosotioles derivados de la penicilamina o el glutatión que responden a la fórmula general (I) en la que: A y B son grupos fenilo o bien, conjuntamente, conforman el resto -CH{sub,2 -Q-CH{sub,2 - constituyendo un anillo de seis unidades en el que Q representa un átomo de oxígeno o de azufre o un resto N-R{sup,3 , en el que R{sup,3 es hidrógeno o un grupo alquilo C{sub,1 -C{sub,4 ; R{sup,1 es un resto acilo, que puede ser un acilo alifático C{sub,1 -C{sub,5 o un resto de ácido glutámico unido por medio de su carboxilo no aminoacídico; R{sup,2 es un grupo hidroxilo o un resto de glicina unido mediante un enlace peptídico; de manera que cuando R{sup,1 es un resto acilo alifático R{sup,2 es un grupo hidroxilo, y cuando R{sup,1 es un resto de ácido glutámico R{sup,2 es un resto de glicina. Los nuevos compuestos presentan actividad vasodilatadora e inhibidora de la agregación de las plaquetas,lo que los hace útiles para el tratamiento de disfunciones del sistema circulatorio, especialmente a nivel cardiovascular.
Priority Applications (39)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009900159A ES2147162B1 (es) | 1999-01-27 | 1999-01-27 | "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias". |
KR1020017009522A KR100671878B1 (ko) | 1999-01-27 | 2000-01-19 | 순환기 장애 치료제로서의 s-니트로소티올 |
TR2001/02003T TR200102003T2 (tr) | 1999-01-27 | 2000-01-19 | Dolaşım bozukluklarının tedavisi için etkin madde olarak S-nitrozo tiyoller |
MXPA01007570A MXPA01007570A (es) | 1999-01-27 | 2000-01-19 | S-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias. |
AU30460/00A AU764725B2 (en) | 1999-01-27 | 2000-01-19 | S-nitrosothiols as agents for the treatment of circulatory dysfunctions |
BRPI0007395-4A BR0007395B1 (pt) | 1999-01-27 | 2000-01-19 | compostos de s-nitrosotióis como agentes para o tratamento de disfunções circulatórias. |
SI200030236T SI1157987T1 (en) | 1999-01-27 | 2000-01-19 | S-nitrosothiols as agents for the treatment of circulatory dysfunctions |
OA1200100195A OA11823A (en) | 1999-01-27 | 2000-01-19 | S-nitrosothiols as agents for the treatment of circulatory dysfunctions. |
APAP/P/2001/002247A AP1439A (en) | 1999-01-27 | 2000-01-19 | S-nitrosothiols as agents for the treatment of circulatory dysfunctions. |
GEAP20006075A GEP20043220B (en) | 1999-01-27 | 2000-01-19 | S-Nitrosothiols as Agents for The Treatment of Circulatory Dysfunctions |
IDW00200101662A ID29777A (id) | 1999-01-27 | 2000-01-19 | S-nitrosotiol sebagai zat-zat untuk pengobatan gangguan fungsi peredaran darah |
PCT/ES2000/000019 WO2000044714A1 (es) | 1999-01-27 | 2000-01-19 | S-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias |
DE10083902T DE10083902T1 (de) | 1999-01-27 | 2000-01-19 | S-Nitrosothiole als Mittel zur Behandlung von Kreislauf-Fehlfunktionen |
JP2000595971A JP3795330B2 (ja) | 1999-01-27 | 2000-01-19 | 循環器障害の治療薬としてのs−ニトロソチオール |
CNB008030847A CN1166631C (zh) | 1999-01-27 | 2000-01-19 | S-亚硝基硫醇作为治疗循环机能障碍的药剂 |
EA200100823A EA003577B1 (ru) | 1999-01-27 | 2000-01-19 | S-нитрозотиолы в качестве агентов для лечения нарушений кровообращения |
CA002359027A CA2359027C (en) | 1999-01-27 | 2000-01-19 | S-nitrosothiols as agents for the treatment of circulatory dysfunctions |
AT00900518T ATE249428T1 (de) | 1999-01-27 | 2000-01-19 | S-nitrosothiole als agentien zur behandlung von fehlfunktionen des kreislaufs |
EEP200100389A EE04524B1 (et) | 1999-01-27 | 2000-01-19 | S-nitrosotioolid kui ained vereringehirete raviks |
IL14438100A IL144381A (en) | 1999-01-27 | 2000-01-19 | S-nitrosothiols as agents for the treatment of circulatory dysfunctions |
NZ513162A NZ513162A (en) | 1999-01-27 | 2000-01-19 | S-nitrosothiols as agents for the treatment of circulatory dysfunctions |
EP00900518A EP1157987B1 (en) | 1999-01-27 | 2000-01-19 | S-nitrosothiols as agents for the treatment of circulatory dysfunctions |
PT00900518T PT1157987E (pt) | 1999-01-27 | 2000-01-19 | S-nitrosotiois como agentes para o tratamento de disfuncoes circulatorias |
DK00900518T DK1157987T3 (da) | 1999-01-27 | 2000-01-19 | S-nitrosothioler som midler til behandling af kredsløbsforstyrrelser |
GB0120581A GB2363604B (en) | 1999-01-27 | 2000-01-19 | S-nitrosothiols as agents for the treatment of circulatory dsyfunctions |
YUP-536/01A RS50072B (sr) | 1999-01-27 | 2000-01-19 | S-nitrozotioli kao agensi za tretman cirkulatornih poremećaja |
HU0105203A HUP0105203A3 (en) | 1999-01-27 | 2000-01-19 | S-nitrosothiols as agents for the treatment of circulatory dysfunctions and their use |
DE60005154T DE60005154T2 (de) | 1999-01-27 | 2000-01-19 | S-nitrosothiole als agentien zur behandlung von fehlfunktionen des kreislaufs |
PL349006A PL202372B1 (pl) | 1999-01-27 | 2000-01-19 | Pochodne S-nitrozotiolowe penicyloaminy lub glutationu oraz kompozycja farmaceutyczna je zawierająca do leczenia zaburzenia czynności krążenia |
CZ20012678A CZ298871B6 (cs) | 1999-01-27 | 2000-01-19 | S-Nitrosothioly jako prostredky pro lécení obehových dysfunkcí |
ES00900518T ES2206178T3 (es) | 1999-01-27 | 2000-01-19 | S-nitrosotrioles como agentes para el tratamiento de trastornos circulatorios. |
NO20013385A NO326806B1 (no) | 1999-01-27 | 2001-07-06 | S-nitrosotioler som midler for behandling av sirkulatoriske dysfunksjoner |
IS6020A IS2153B (is) | 1999-01-27 | 2001-07-23 | S-nítrósóþíól til meðferðar við blóðrásartruflunum |
US09/912,164 US6800612B2 (en) | 1999-01-27 | 2001-07-24 | S-nitrosothiols as agents for the treatment of circulatory dysfunctions |
ZA200106182A ZA200106182B (en) | 1999-01-27 | 2001-07-26 | S-nitrosothiols as agents for the treatment of circulatory dysfunctions. |
HR20010562A HRP20010562B1 (en) | 1999-01-27 | 2001-07-26 | S-nitrosothiols as agents for the treatment of circulatory dysfunctions |
CU20010181A CU23098A3 (es) | 1999-01-27 | 2001-07-30 | S-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias |
BG105824A BG64983B1 (bg) | 1999-01-27 | 2001-08-16 | S-нитрозотиоли като средства за лечение на нарушени функции на кръвообращението |
HK02103982.2A HK1043586A1 (zh) | 1999-01-27 | 2002-05-28 | S-亞硝基硫醇作為治療循環機能障礙的藥劑 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009900159A ES2147162B1 (es) | 1999-01-27 | 1999-01-27 | "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias". |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2147162A1 ES2147162A1 (es) | 2000-08-16 |
ES2147162B1 true ES2147162B1 (es) | 2001-03-16 |
Family
ID=8307080
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009900159A Expired - Fee Related ES2147162B1 (es) | 1999-01-27 | 1999-01-27 | "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias". |
ES00900518T Expired - Lifetime ES2206178T3 (es) | 1999-01-27 | 2000-01-19 | S-nitrosotrioles como agentes para el tratamiento de trastornos circulatorios. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES00900518T Expired - Lifetime ES2206178T3 (es) | 1999-01-27 | 2000-01-19 | S-nitrosotrioles como agentes para el tratamiento de trastornos circulatorios. |
Country Status (37)
Country | Link |
---|---|
US (1) | US6800612B2 (es) |
EP (1) | EP1157987B1 (es) |
JP (1) | JP3795330B2 (es) |
KR (1) | KR100671878B1 (es) |
CN (1) | CN1166631C (es) |
AP (1) | AP1439A (es) |
AT (1) | ATE249428T1 (es) |
AU (1) | AU764725B2 (es) |
BG (1) | BG64983B1 (es) |
BR (1) | BR0007395B1 (es) |
CA (1) | CA2359027C (es) |
CU (1) | CU23098A3 (es) |
CZ (1) | CZ298871B6 (es) |
DE (2) | DE10083902T1 (es) |
DK (1) | DK1157987T3 (es) |
EA (1) | EA003577B1 (es) |
EE (1) | EE04524B1 (es) |
ES (2) | ES2147162B1 (es) |
GB (1) | GB2363604B (es) |
GE (1) | GEP20043220B (es) |
HK (1) | HK1043586A1 (es) |
HR (1) | HRP20010562B1 (es) |
HU (1) | HUP0105203A3 (es) |
ID (1) | ID29777A (es) |
IL (1) | IL144381A (es) |
IS (1) | IS2153B (es) |
MX (1) | MXPA01007570A (es) |
NO (1) | NO326806B1 (es) |
NZ (1) | NZ513162A (es) |
OA (1) | OA11823A (es) |
PL (1) | PL202372B1 (es) |
PT (1) | PT1157987E (es) |
RS (1) | RS50072B (es) |
SI (1) | SI1157987T1 (es) |
TR (1) | TR200102003T2 (es) |
WO (1) | WO2000044714A1 (es) |
ZA (1) | ZA200106182B (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2173044B1 (es) * | 2001-03-13 | 2004-01-16 | Lacer Sa | Derivados de glicina, n-(n-l-gamma-glutamil-3-(nitrosotio)-l-valil) y sus aplicaciones. |
JP2007518697A (ja) * | 2003-09-26 | 2007-07-12 | ニトロメッド インコーポレーティッド | ニトロソ化グルタミン酸化合物、組成物、および使用方法 |
EP1939179A1 (en) * | 2006-12-28 | 2008-07-02 | Lacer, S.A. | Stable S-nitrosothiols, method of synthesis and use |
DK2197417T3 (da) | 2007-10-17 | 2012-06-25 | Pharmagenix Ag | Farmaceutisk sammensætning, omfattende s-nitrosoglutathion og polysaccharid |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US37839A (en) * | 1863-03-03 | Improved spoke-machine | ||
GB1567561A (en) | 1977-01-18 | 1980-05-14 | Ucb Sa | Amino-spiro(oxa-(orthia)cycloalkane-penam) - carboxylic acids |
GB2052497B (en) | 1979-06-25 | 1983-06-29 | Ucb Sa | 6 - amino - spiro - (penam - 2,4' - piperidine) - 3 - carboxylic acid derivatives |
DE3805965A1 (de) | 1988-02-25 | 1989-09-07 | Tamas Geb Szenasi Eszter | Verwendung der pflanze euphorbia hirta l. und ihrer extrakte sowie ihrer wirkstoffe |
US5025001A (en) | 1988-06-15 | 1991-06-18 | Brigham And Women's Hospital | S-nitroso derivatives of ACE inhibitors and the use thereof |
EP0412699B1 (en) * | 1989-08-07 | 1994-04-27 | Takeda Chemical Industries, Ltd. | Nitrosothiol derivatives, their production and use |
ES2093098T3 (es) | 1990-04-26 | 1996-12-16 | Senju Pharma Co | Derivado de glutation sustituido en s-acido graso inferior. |
US5187305A (en) * | 1990-11-26 | 1993-02-16 | Glaxo Inc. | S-nitroso-N-alkonoylpenicillamines |
EP1025853A3 (en) | 1991-11-14 | 2000-11-08 | Brigham And Women's Hospital | Pharmaceutical composition containing S-nitroso-heme proteins and use thereof |
AU662434B2 (en) | 1992-08-07 | 1995-08-31 | Sankyo Company Limited | Peptides capable of inhibiting the activity of HIV protease, their preparation and their use |
DE69433478T2 (de) * | 1993-09-17 | 2004-11-25 | Brigham And Women's Hospital, Boston | Verwendung von stickoxid-addukten zur verhütung von thrombosen auf artifiziellen und vaskulären oberflächen |
US5728705A (en) | 1993-10-04 | 1998-03-17 | The Trustees Of Columbia University In The City Of New York | Method of inducing vasorelaxation to treat pulmonary hypertension |
ES2149338T3 (es) | 1993-11-02 | 2000-11-01 | Us Health | Utilizacion de compuestos que liberan oxido nitrico para la fabricacion de un medicamento destinado al tratamiento de lesiones por reperfusion isquemica. |
GB9423868D0 (en) | 1994-11-25 | 1995-01-11 | Wellcome Found | Compounds for use in medicine |
US6627738B2 (en) | 1995-09-15 | 2003-09-30 | Duke University | No-modified hemoglobins and uses therefor |
AU6782198A (en) | 1997-03-27 | 1998-10-20 | Trustees Of Boston University | Novel antiplatelet agent |
-
1999
- 1999-01-27 ES ES009900159A patent/ES2147162B1/es not_active Expired - Fee Related
-
2000
- 2000-01-19 WO PCT/ES2000/000019 patent/WO2000044714A1/es active IP Right Grant
- 2000-01-19 AU AU30460/00A patent/AU764725B2/en not_active Ceased
- 2000-01-19 DE DE10083902T patent/DE10083902T1/de not_active Ceased
- 2000-01-19 DE DE60005154T patent/DE60005154T2/de not_active Expired - Lifetime
- 2000-01-19 BR BRPI0007395-4A patent/BR0007395B1/pt not_active IP Right Cessation
- 2000-01-19 CA CA002359027A patent/CA2359027C/en not_active Expired - Fee Related
- 2000-01-19 KR KR1020017009522A patent/KR100671878B1/ko not_active IP Right Cessation
- 2000-01-19 JP JP2000595971A patent/JP3795330B2/ja not_active Expired - Fee Related
- 2000-01-19 GB GB0120581A patent/GB2363604B/en not_active Expired - Fee Related
- 2000-01-19 EA EA200100823A patent/EA003577B1/ru not_active IP Right Cessation
- 2000-01-19 RS YUP-536/01A patent/RS50072B/sr unknown
- 2000-01-19 DK DK00900518T patent/DK1157987T3/da active
- 2000-01-19 OA OA1200100195A patent/OA11823A/en unknown
- 2000-01-19 EE EEP200100389A patent/EE04524B1/xx not_active IP Right Cessation
- 2000-01-19 SI SI200030236T patent/SI1157987T1/xx unknown
- 2000-01-19 PL PL349006A patent/PL202372B1/pl not_active IP Right Cessation
- 2000-01-19 AP APAP/P/2001/002247A patent/AP1439A/en active
- 2000-01-19 PT PT00900518T patent/PT1157987E/pt unknown
- 2000-01-19 CN CNB008030847A patent/CN1166631C/zh not_active Expired - Fee Related
- 2000-01-19 ES ES00900518T patent/ES2206178T3/es not_active Expired - Lifetime
- 2000-01-19 TR TR2001/02003T patent/TR200102003T2/xx unknown
- 2000-01-19 EP EP00900518A patent/EP1157987B1/en not_active Expired - Lifetime
- 2000-01-19 GE GEAP20006075A patent/GEP20043220B/en unknown
- 2000-01-19 IL IL14438100A patent/IL144381A/xx not_active IP Right Cessation
- 2000-01-19 MX MXPA01007570A patent/MXPA01007570A/es not_active IP Right Cessation
- 2000-01-19 CZ CZ20012678A patent/CZ298871B6/cs not_active IP Right Cessation
- 2000-01-19 HU HU0105203A patent/HUP0105203A3/hu unknown
- 2000-01-19 NZ NZ513162A patent/NZ513162A/xx not_active IP Right Cessation
- 2000-01-19 ID IDW00200101662A patent/ID29777A/id unknown
- 2000-01-19 AT AT00900518T patent/ATE249428T1/de not_active IP Right Cessation
-
2001
- 2001-07-06 NO NO20013385A patent/NO326806B1/no not_active IP Right Cessation
- 2001-07-23 IS IS6020A patent/IS2153B/is unknown
- 2001-07-24 US US09/912,164 patent/US6800612B2/en not_active Expired - Fee Related
- 2001-07-26 ZA ZA200106182A patent/ZA200106182B/en unknown
- 2001-07-26 HR HR20010562A patent/HRP20010562B1/xx not_active IP Right Cessation
- 2001-07-30 CU CU20010181A patent/CU23098A3/es not_active IP Right Cessation
- 2001-08-16 BG BG105824A patent/BG64983B1/bg unknown
-
2002
- 2002-05-28 HK HK02103982.2A patent/HK1043586A1/zh unknown
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