YU53601A - S-nitrozotioli kao agensi za tretman cirkulatornih poremećaja - Google Patents

S-nitrozotioli kao agensi za tretman cirkulatornih poremećaja

Info

Publication number
YU53601A
YU53601A YU53601A YUP53601A YU53601A YU 53601 A YU53601 A YU 53601A YU 53601 A YU53601 A YU 53601A YU P53601 A YUP53601 A YU P53601A YU 53601 A YU53601 A YU 53601A
Authority
YU
Yugoslavia
Prior art keywords
residue
group
treatment
attached via
glutamic acid
Prior art date
Application number
YU53601A
Other languages
English (en)
Inventor
Moliner Jose Repolles
Perez-Rasilla Eduardo Salas
Coy Francisco Pubill
Riudavets Juan-Antonio Cerda
Rofes Cristina Negrie
Llorente Lydia Cabeza
Siso Alicia Ferrer
Adroher Nuria Trias
Banus Marcell Carbo
Moreno Jesus Murat
Llaguno Pedro Michelena
Original Assignee
Lacer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lacer S.A. filed Critical Lacer S.A.
Publication of YU53601A publication Critical patent/YU53601A/sh
Publication of RS50072B publication Critical patent/RS50072B/sr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

Novi S-nitrozotolni derivati penicilamina ili glutationa, koji odgovaraju opštoj formuli (I) naznačen time: što su A i B fenil grupe ili zajedno formiraju ostatak -CH2-Q-CH2- konstituišući šestočlani prsten u kome Q predstavlja atom kiseonika, sumpora ili grupu N-R3, u kojoj je R3 vodonik ili alkil grupa C1-C4; R1 je acil ostatak koji može biti alifatična acil grupa C1-C5 ili ostatak glutaminske kiseline vezan preko svog neaminokiselinskog karboksila; R2 je hidroksilna grupa ili glicinski ostatak vezan preko peptidne veze; uz uslov da ako je R1 alifatični acil ostatak, onda je R2 hidroksilna grupa i ako je R1 ostatak glutaminske kiseline, onda je R2 glicinski ostatak. Nova jedinjenja imaju vazodilataciono dejstvo i inhibiraju agregaciju krvnih pločica, što ih čini pogodnim za tretman disfunkcija cirkulatornog sistema, posebno na kardiovaskularnom nivou.
YUP-536/01A 1999-01-27 2000-01-19 S-nitrozotioli kao agensi za tretman cirkulatornih poremećaja RS50072B (sr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009900159A ES2147162B1 (es) 1999-01-27 1999-01-27 "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias".

Publications (2)

Publication Number Publication Date
YU53601A true YU53601A (sh) 2004-03-12
RS50072B RS50072B (sr) 2009-01-22

Family

ID=8307080

Country Status (37)

Country Link
US (1) US6800612B2 (sh)
EP (1) EP1157987B1 (sh)
JP (1) JP3795330B2 (sh)
KR (1) KR100671878B1 (sh)
CN (1) CN1166631C (sh)
AP (1) AP1439A (sh)
AT (1) ATE249428T1 (sh)
AU (1) AU764725B2 (sh)
BG (1) BG64983B1 (sh)
BR (1) BR0007395B1 (sh)
CA (1) CA2359027C (sh)
CU (1) CU23098A3 (sh)
CZ (1) CZ298871B6 (sh)
DE (2) DE10083902T1 (sh)
DK (1) DK1157987T3 (sh)
EA (1) EA003577B1 (sh)
EE (1) EE04524B1 (sh)
ES (2) ES2147162B1 (sh)
GB (1) GB2363604B (sh)
GE (1) GEP20043220B (sh)
HK (1) HK1043586A1 (sh)
HR (1) HRP20010562B1 (sh)
HU (1) HUP0105203A3 (sh)
ID (1) ID29777A (sh)
IL (1) IL144381A (sh)
IS (1) IS2153B (sh)
MX (1) MXPA01007570A (sh)
NO (1) NO326806B1 (sh)
NZ (1) NZ513162A (sh)
OA (1) OA11823A (sh)
PL (1) PL202372B1 (sh)
PT (1) PT1157987E (sh)
RS (1) RS50072B (sh)
SI (1) SI1157987T1 (sh)
TR (1) TR200102003T2 (sh)
WO (1) WO2000044714A1 (sh)
ZA (1) ZA200106182B (sh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2173044B1 (es) * 2001-03-13 2004-01-16 Lacer Sa Derivados de glicina, n-(n-l-gamma-glutamil-3-(nitrosotio)-l-valil) y sus aplicaciones.
JP2007518697A (ja) * 2003-09-26 2007-07-12 ニトロメッド インコーポレーティッド ニトロソ化グルタミン酸化合物、組成物、および使用方法
EP1939179A1 (en) * 2006-12-28 2008-07-02 Lacer, S.A. Stable S-nitrosothiols, method of synthesis and use
DK2197417T3 (da) 2007-10-17 2012-06-25 Pharmagenix Ag Farmaceutisk sammensætning, omfattende s-nitrosoglutathion og polysaccharid

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US37839A (en) * 1863-03-03 Improved spoke-machine
GB1567561A (en) 1977-01-18 1980-05-14 Ucb Sa Amino-spiro(oxa-(orthia)cycloalkane-penam) - carboxylic acids
GB2052497B (en) 1979-06-25 1983-06-29 Ucb Sa 6 - amino - spiro - (penam - 2,4' - piperidine) - 3 - carboxylic acid derivatives
DE3805965A1 (de) 1988-02-25 1989-09-07 Tamas Geb Szenasi Eszter Verwendung der pflanze euphorbia hirta l. und ihrer extrakte sowie ihrer wirkstoffe
US5025001A (en) 1988-06-15 1991-06-18 Brigham And Women's Hospital S-nitroso derivatives of ACE inhibitors and the use thereof
EP0412699B1 (en) * 1989-08-07 1994-04-27 Takeda Chemical Industries, Ltd. Nitrosothiol derivatives, their production and use
ES2093098T3 (es) 1990-04-26 1996-12-16 Senju Pharma Co Derivado de glutation sustituido en s-acido graso inferior.
US5187305A (en) * 1990-11-26 1993-02-16 Glaxo Inc. S-nitroso-N-alkonoylpenicillamines
EP1025853A3 (en) 1991-11-14 2000-11-08 Brigham And Women's Hospital Pharmaceutical composition containing S-nitroso-heme proteins and use thereof
AU662434B2 (en) 1992-08-07 1995-08-31 Sankyo Company Limited Peptides capable of inhibiting the activity of HIV protease, their preparation and their use
DE69433478T2 (de) * 1993-09-17 2004-11-25 Brigham And Women's Hospital, Boston Verwendung von stickoxid-addukten zur verhütung von thrombosen auf artifiziellen und vaskulären oberflächen
US5728705A (en) 1993-10-04 1998-03-17 The Trustees Of Columbia University In The City Of New York Method of inducing vasorelaxation to treat pulmonary hypertension
ES2149338T3 (es) 1993-11-02 2000-11-01 Us Health Utilizacion de compuestos que liberan oxido nitrico para la fabricacion de un medicamento destinado al tratamiento de lesiones por reperfusion isquemica.
GB9423868D0 (en) 1994-11-25 1995-01-11 Wellcome Found Compounds for use in medicine
US6627738B2 (en) 1995-09-15 2003-09-30 Duke University No-modified hemoglobins and uses therefor
AU6782198A (en) 1997-03-27 1998-10-20 Trustees Of Boston University Novel antiplatelet agent

Also Published As

Publication number Publication date
EP1157987A1 (en) 2001-11-28
GB2363604A (en) 2002-01-02
OA11823A (en) 2005-08-16
CA2359027C (en) 2008-10-28
BG64983B1 (bg) 2006-11-30
HRP20010562A2 (en) 2002-08-31
SI1157987T1 (en) 2004-02-29
ID29777A (id) 2001-10-11
AU764725B2 (en) 2003-08-28
KR100671878B1 (ko) 2007-01-19
DK1157987T3 (da) 2003-11-24
TR200102003T2 (tr) 2001-12-21
GB0120581D0 (en) 2001-10-17
CZ298871B6 (cs) 2008-02-27
EA200100823A1 (ru) 2002-02-28
IS2153B (is) 2006-10-13
HUP0105203A2 (en) 2002-06-29
HUP0105203A3 (en) 2002-08-28
CA2359027A1 (en) 2000-08-03
GEP20043220B (en) 2004-04-26
ZA200106182B (en) 2002-10-28
AU3046000A (en) 2000-08-18
KR20010101767A (ko) 2001-11-14
IL144381A0 (en) 2002-05-23
EE04524B1 (et) 2005-08-15
BG105824A (en) 2002-06-28
BR0007395A (pt) 2001-10-30
CN1337946A (zh) 2002-02-27
NO326806B1 (no) 2009-02-16
IL144381A (en) 2005-08-31
AP1439A (en) 2005-06-27
BR0007395B1 (pt) 2010-11-16
US20020058629A1 (en) 2002-05-16
PT1157987E (pt) 2004-01-30
HK1043586A1 (zh) 2002-09-20
DE60005154D1 (de) 2003-10-16
CN1166631C (zh) 2004-09-15
EP1157987B1 (en) 2003-09-10
DE10083902T1 (de) 2002-01-10
ES2147162A1 (es) 2000-08-16
WO2000044714A1 (es) 2000-08-03
US6800612B2 (en) 2004-10-05
MXPA01007570A (es) 2003-05-14
PL349006A1 (en) 2002-06-17
PL202372B1 (pl) 2009-06-30
JP3795330B2 (ja) 2006-07-12
ATE249428T1 (de) 2003-09-15
NO20013385D0 (no) 2001-07-06
NZ513162A (en) 2003-01-31
ES2147162B1 (es) 2001-03-16
HRP20010562B1 (en) 2010-08-31
EE200100389A (et) 2002-12-16
GB2363604B (en) 2003-09-10
AP2001002247A0 (en) 2001-09-30
EA003577B1 (ru) 2003-06-26
NO20013385L (no) 2001-09-17
ES2206178T3 (es) 2004-05-16
CU23098A3 (es) 2005-11-18
RS50072B (sr) 2009-01-22
CZ20012678A3 (cs) 2001-10-17
DE60005154T2 (de) 2004-07-08
JP2002535385A (ja) 2002-10-22
IS6020A (is) 2001-07-23

Similar Documents

Publication Publication Date Title
NI200900037A (es) Derivados de 2-aril-6-fenil-imidazo[1,2-alfa] piridinas, su preparación y su aplicación en terapéutica.
UY29702A1 (es) Inhibidores macrocíclicos del virus de hepatitis c
CO5640126A2 (es) Derivados de aminoalcohol y composiciones farmaceuticas que las contienen
TN2010000026A1 (fr) Nouveaux derives de 6-triazolopyridazine-sulfanyl benzothiazole et benzimidazole, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de met
DE50301525D1 (de) Dentalmaterialien auf der Basis von Acrylesterphosphonsäuren
ES2192081T3 (es) Derivados de purina antivirales.
AR063988A1 (es) Derivados heterociclicos, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
ECSP088150A (es) Inhibidores macrociclicos del virus de la hepatitis c
DK0783500T3 (da) Aminoheterocykliske derivater som antithrombotiske eller antikoagulerende midler
DK0685489T3 (da) Tripeptider, der antithrombotiske midler
PE2599A1 (es) Compuesto heterociclo inhibidor de metaloproteasa
AU2910600A (en) Phenyl urea and phenyl thiourea derivatives
AR062258A1 (es) Compuestos heterociclicos condensados de tieno-pirrol, composiciones farmaceuticas que los contienen y usos para el tratamiento de infecciones por hcv
CO6320143A1 (es) Nuevos derivados dihidroindolonas su procedimeinto de preparacion y composiciones farmaceuticas que los contienen
EE02948B1 (et) Metüleenbisfosfoonhappe derivaadid, meetod nende valmistamiseks ja farmatseutiline kompositsioon
YU53601A (sh) S-nitrozotioli kao agensi za tretman cirkulatornih poremećaja
HUP0303184A2 (hu) Szubsztituált C-ciklohexil-metil-amin-származékok és ezeket tartalmazó gyógyszerkészítmények
AR050335A1 (es) Prodrogas de estradiol, composicion farmaceutica en base al compuesto y procedimiento de preparacion de este
CO5640109A2 (es) Compuestos triciclicos inhibidores de la farnesisl proteino transferasa y composiciones farmaceuticas que los contienen
AR046310A1 (es) Compuestos nucleosidicos para el tratamiento de enfermedades virales. composiciones farmaceuticas.
AR012990A1 (es) Compuestos de benzo(5,6) cicloheptapiridina, composiciones farmaceuticas que los contienen, y el uso de dichos compuestos como inhibidores de laproteina farnesil transferasa.
AR061561A1 (es) Derivados amino de b- homoandrostanos y b- heteroandrostanos. procesos de obtencion y composiciones farmaceuticas
AR029468A1 (es) Derivados de aminoacidos n-mercaptoacilados, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen
CO4980875A1 (es) Nuevos derivados de la equinocandina, su procedimiento de preparacion y su aplicacion como fungicidas
AR015248A1 (es) Aminoguanidinas ciclicas, un proceso para su produccion, compuesto de partida,una composicion farmaceutica que las comprende y el uso de los mismos parala preparacion de un medicamento