ATE54154T1 - Retro-inverse analoga des bradykininpotentialisierenden peptids bpp-5a und verfahren zu ihrer herstellung. - Google Patents

Retro-inverse analoga des bradykininpotentialisierenden peptids bpp-5a und verfahren zu ihrer herstellung.

Info

Publication number
ATE54154T1
ATE54154T1 AT84200658T AT84200658T ATE54154T1 AT E54154 T1 ATE54154 T1 AT E54154T1 AT 84200658 T AT84200658 T AT 84200658T AT 84200658 T AT84200658 T AT 84200658T AT E54154 T1 ATE54154 T1 AT E54154T1
Authority
AT
Austria
Prior art keywords
bradykin
potentializing
retro
production
methods
Prior art date
Application number
AT84200658T
Other languages
English (en)
Inventor
Alessandro Sisto
Antonio Silvio Verdini
Antonino Virdia
Original Assignee
Eni Ente Naz Idrocarb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eni Ente Naz Idrocarb filed Critical Eni Ente Naz Idrocarb
Application granted granted Critical
Publication of ATE54154T1 publication Critical patent/ATE54154T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/06Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT84200658T 1983-05-13 1984-05-08 Retro-inverse analoga des bradykininpotentialisierenden peptids bpp-5a und verfahren zu ihrer herstellung. ATE54154T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8321083A IT1164225B (it) 1983-05-13 1983-05-13 Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione
EP84200658A EP0128602B1 (de) 1983-05-13 1984-05-08 Retro-inverse Analoga des bradykinin-potentialisierenden Peptids BPP-5A und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ATE54154T1 true ATE54154T1 (de) 1990-07-15

Family

ID=11176481

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84200658T ATE54154T1 (de) 1983-05-13 1984-05-08 Retro-inverse analoga des bradykininpotentialisierenden peptids bpp-5a und verfahren zu ihrer herstellung.

Country Status (8)

Country Link
US (1) US4522752A (de)
EP (2) EP0128602B1 (de)
JP (1) JPH0635477B2 (de)
AT (1) ATE54154T1 (de)
AU (1) AU571225B2 (de)
CA (1) CA1252949A (de)
DE (1) DE3482589D1 (de)
IT (1) IT1164225B (de)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1178789B (it) * 1984-12-21 1987-09-16 Assorenti Peptidi retro-invertiti analoghi del potenziatore della bradichinina bpp 5a
IT1184317B (it) * 1985-02-05 1987-10-28 Eniricerche Spa Retro-inverso analoghi del peptide potenziatore della bradichina bpp5a
IT1184164B (it) * 1985-03-19 1987-10-22 Eniricerche Spa Triptidi ad azione ipotensiva e procedimento per la loro sintesi
IT1190389B (it) * 1985-09-19 1988-02-16 Eniricerche Spa Esapeptidi ad attivita' ipotensiva
WO1994005311A1 (en) * 1992-08-27 1994-03-17 Deakin Research Limited Retro-, inverso-, and retro-inverso synthetic peptide analogues
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
EP1520582A3 (de) 1998-02-02 2009-07-01 Trustees Of Tufts College Verwendung von Dipetidylpeptidasehemmer zur Regulierung des Glukosemetabolismus
US6465495B1 (en) 1998-07-30 2002-10-15 Osi Pharmaceuticals, Inc. Preparation of pyridone-based phosphotyrosine mimetics and uses thereof
US6984719B1 (en) 1998-09-17 2006-01-10 Hospital Sainte-Justine Peptide antagonists of prostaglandin F2α receptor
US7396905B1 (en) 1999-05-21 2008-07-08 Mckeon Frank Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
US20040235749A1 (en) * 1999-09-15 2004-11-25 Sylvain Chemtob G-protein coupled receptor antagonists
US6560542B1 (en) * 2000-01-24 2003-05-06 The Cielo Institute Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
US20050119454A1 (en) * 2000-01-24 2005-06-02 The Cielo Institute, Inc. Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
US6865492B2 (en) * 2000-01-24 2005-03-08 The Cielo Institute, Inc. Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
BR0101088A (pt) * 2001-03-19 2003-03-18 Biolab Sanus Farmaceutica Ltda Processo de isolamento e purificação de peptìdeos inibidores das vasopeptidases, com especificidade para o sìtio carboxìlico da enzima conversora da angiotensina, secretados pelas glândulas do veneno de serpentes (bpps), particularmente bothrops jararaca, ou produzidos endogenamente (evasins) possuindo ação vasodilatadora e anti-hipertensiva; processo de determinação da sequência de amido-ácidos dos peptìdios inibidores secretados pela glândula de veneno de serpentes (bpps) ou endógenos (evasins); processo de determinação da sequência de aminoácidos dos bpps por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca. processo de determinação da sequência de aminoácidos dos evasins por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca, processo de amplificação do cdna a partir das bibliotecas de cdna de pâncreas e/ou cérebro de serpentes, especificamente bothrops jararaca; processo de sìntese em fase sólida de peptìdeos inibidores das vasopeptidases com ação vasodilatadora e anti-hipertensiva, peptìdeos inibidores das vasopeptidases com ação anti-hipertensiva; utilização dos peptìdeos inibidores das vaso peptidases com ação vasodilatadora e anti-hipertensiva na obtenção de composições farmacêuticas; processo de determinação da atividade inibitória sobre as vasopeptidases e de atividade biológica sobre músculo liso, sistema cardiovascular e microcirculatório.
HUP0401863A3 (en) 2001-10-03 2012-09-28 Harvard College Amino acid-copolymers for suppression of autoimmune diseases, and methods of use
CA2468192A1 (en) 2001-11-26 2003-06-05 Trustees Of Tufts College Peptidomimetic inhibitors of post-proline cleaving enzymes
JP2005511636A (ja) 2001-11-26 2005-04-28 トラスティーズ オブ タフツ カレッジ 自己免疫疾患の治療方法及びそれに関する試薬
US6935959B2 (en) * 2002-05-16 2005-08-30 Microsoft Corporation Use of multiple player real-time voice communications on a gaming device
US7521530B2 (en) 2002-06-11 2009-04-21 Universite De Montreal Peptides and peptidomimetics useful for inhibiting the activity of prostaglandin F2α receptor
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
DK1697399T3 (en) 2003-12-12 2017-03-06 Government Of The United States Of America As Repr By The Secr Of The Dept Of Health And Human Servi Human cytotoxic t lymphocyte epitope and its agonist epitope from the non-variable number of muc-1 tandem repeat sequences
US7491263B2 (en) 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
WO2006019904A1 (en) 2004-07-14 2006-02-23 University Of Utha Research Foundation Netrin-related compositions and uses
DE102004037356B4 (de) * 2004-07-30 2017-11-23 Ansaldo Energia Ip Uk Limited Wandstruktur zur Begrenzung eines Heißgaspfads
EP1824496A4 (de) 2004-11-17 2008-07-16 Joanne Mclaurin Zusammensetzungen aus scyllo-inositol-derivaten und verfahren zur behandlung von störungen der proteinaggregation
GB0426146D0 (en) 2004-11-29 2004-12-29 Bioxell Spa Therapeutic peptides and method
WO2006091775A2 (en) 2005-02-25 2006-08-31 University Of Utah Research Foundation Tropoelastin for promoting endothelial cell adhesion or migration
US20100041597A1 (en) 2005-08-05 2010-02-18 Jenny Phipps Peptides targeted to protein kinase c isoforms and uses thereof
WO2007109583A2 (en) 2006-03-17 2007-09-27 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compositions and methods for prevention or treatment of neoplastic disease in a mammalian subject
EP3669894A3 (de) 2006-06-30 2020-08-26 Syntab Therapeutics GmbH Neuartige multifunktionale verbindungen für pharmazeutische zwecke
HRP20130768T1 (en) 2007-04-12 2013-10-25 Waratah Pharmaceuticals, Inc. Use of cyclohexanehexol derivatives in the treatment of ocular diseases
CN101795703B (zh) * 2007-06-27 2015-05-06 里兰斯坦福初级大学理事会 肽酪氨酸酶抑制剂及其应用
KR101561709B1 (ko) * 2007-06-27 2015-10-22 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 올리고펩티드 티로시나제 억제제 및 그의 용도
EP2174131A1 (de) * 2007-07-23 2010-04-14 Bioxell S.p.a. Screening, therapie und diagnose
GB0821941D0 (en) 2008-12-01 2009-01-07 Renovo Ltd Non-surgical improvements of scars
JP2013532172A (ja) 2010-07-09 2013-08-15 ダナ ファーバー キャンサー インスティテュート インコーポレイテッド 安定化したインスリン分泌促進ペプチド及び使用方法
MX347229B (es) 2012-01-26 2017-04-19 Christopher J Soares Antagonistas de péptido de la familia cgrp de calcitonina de hormonas de péptido y su uso.
US9637527B2 (en) 2012-03-13 2017-05-02 James Cook University Method for treating inflammation with an Ac-TMP-2 protein
US10017551B2 (en) 2013-03-15 2018-07-10 The Regents Of The University Of California Peptides having reduced toxicity that stimulate cholesterol efflux
AU2014324094B2 (en) 2013-09-18 2019-03-14 James Cook University Modified anti-inflammatory proteins and method of use
US20160235813A1 (en) 2013-09-18 2016-08-18 James Cook University Anti-inflammatory proteins and methods of use
BR112017026209A2 (pt) 2015-06-05 2018-11-27 Ibio, Inc. fragmentos e variantes de endostatinas para uso no tratamento de fibrose
GB201609083D0 (en) 2016-05-24 2016-07-06 Syntab Therapeutics Gmbh Synthetic compound
ES2965087T3 (es) 2016-09-02 2024-04-10 Soares Christopher J Uso de antagonistas de receptor de CGRP en el tratamiento de glaucoma
US11858974B2 (en) 2017-05-22 2024-01-02 Resq Biotech Macrocyclic modulators of disease associated protein misfolding and aggregation
CA3114911A1 (en) 2018-10-04 2020-04-09 Rutgers, The State University Of New Jersey Methods of reducing type 2 cytokine-mediated inflammation using neuromedin peptides
CA3228786A1 (en) 2021-08-25 2023-03-02 Ibio, Inc. Anti-cd25 antibody
WO2025262329A1 (en) 2024-06-21 2025-12-26 Syntab Therapeutics Gmbh Synthetic molecules comprising tlr2 ligands

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH568964A5 (de) * 1972-06-01 1975-11-14 Squibb & Sons Inc
HU185263B (en) * 1981-06-12 1984-12-28 Richter Gedeon Vegyeszet Process for producing peptides effective on the immuncontroll analogous with the tp5
IT1212508B (it) * 1981-12-22 1989-11-22 Anic Spa Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori
IT1190891B (it) * 1982-06-24 1988-02-24 Anic Spa Metodo per la sintesi in fase solida di polipeptidi retroinvertiti
ZA838780B (en) * 1982-11-26 1985-01-30 Nyegaard & Co As Peptide compounds
IT1164240B (it) * 1983-05-25 1987-04-08 Anic Spa Decapeptide parzialmente retro-invertito inibitore specifico della renina con elevata resistenza alla idrolisi enzimatica
IT1206339B (it) * 1984-01-13 1989-04-14 Anic Spa Analoghi retro-invertiti esapeptidici c-terminali della sostanza p.

Also Published As

Publication number Publication date
EP0301639A2 (de) 1989-02-01
IT1164225B (it) 1987-04-08
JPS59212453A (ja) 1984-12-01
JPH0635477B2 (ja) 1994-05-11
EP0128602A2 (de) 1984-12-19
EP0128602A3 (en) 1987-01-14
EP0128602B1 (de) 1990-06-27
US4522752A (en) 1985-06-11
IT8321083A1 (it) 1984-11-13
DE3482589D1 (de) 1990-08-02
IT8321083A0 (it) 1983-05-13
CA1252949A (en) 1989-04-18
AU571225B2 (en) 1988-04-14
EP0301639A3 (de) 1989-10-18
AU2791484A (en) 1984-11-15

Similar Documents

Publication Publication Date Title
ATE54154T1 (de) Retro-inverse analoga des bradykininpotentialisierenden peptids bpp-5a und verfahren zu ihrer herstellung.
DK0399731T3 (da) Azaindener
CY1107391T1 (el) Αρυλσυμπυκνωμενες αζαπολυκυκλικες ενωσεις
DE69713526D1 (de) Lösliche prodrugs von paclitaxel
ATE68495T1 (de) 4,5,6,7-tetrahydro-1h-imidazo(4,5c>pyridinderivate und analoge mit antihypertensiver wirkung.
EA199800752A1 (ru) Пентафторбензолсульфонамиды и их аналоги
BG100946A (bg) Нови аминокиселинни производни, метод за получаването им и фармацевтични състави съдържащи ги
EA199800794A1 (ru) Новые производные арилглициламида, способ их получения и фармацевтическая композиция, содержащая эти соединения
DE68901153D1 (de) Derivate von purin, verfahren zu ihrer herstellung und pharmazeutische zubereitung.
RU95111308A (ru) Производные 2-амино-4-фенил-4-оксомасляной кислоты, способы получения, фармацевтическая композиция
EA200500882A1 (ru) N-арилсульфонил-3-аминоалкоксииндолы
NO882239L (no) Fremgangsmaate for fremstilling av terapeutisk aktive cykliske peptider.
ATE258933T1 (de) Übergangszustand-analoga des kokains, ihre verwendung zur herstellung von kataltischen antikörpern gegen kokain und verwendung derselben in diagnose und therapie
NO882238D0 (no) Fremgangsmaate for fremstilling av terapeutisk aktive cykliske peptider.
MY104088A (en) Peptide-drugs compositions containing (alpha)-aminoboroic acid derivatives.
ATE10934T1 (de) Peptid, verfahren zu dessen herstellung und dessen verwendung.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee