ATE54154T1 - Retro-inverse analoga des bradykininpotentialisierenden peptids bpp-5a und verfahren zu ihrer herstellung. - Google Patents

Retro-inverse analoga des bradykininpotentialisierenden peptids bpp-5a und verfahren zu ihrer herstellung.

Info

Publication number
ATE54154T1
ATE54154T1 AT84200658T AT84200658T ATE54154T1 AT E54154 T1 ATE54154 T1 AT E54154T1 AT 84200658 T AT84200658 T AT 84200658T AT 84200658 T AT84200658 T AT 84200658T AT E54154 T1 ATE54154 T1 AT E54154T1
Authority
AT
Austria
Prior art keywords
bradykin
potentializing
retro
production
methods
Prior art date
Application number
AT84200658T
Other languages
English (en)
Inventor
Alessandro Sisto
Antonio Silvio Verdini
Antonino Virdia
Original Assignee
Eni Ente Naz Idrocarb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eni Ente Naz Idrocarb filed Critical Eni Ente Naz Idrocarb
Application granted granted Critical
Publication of ATE54154T1 publication Critical patent/ATE54154T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT84200658T 1983-05-13 1984-05-08 Retro-inverse analoga des bradykininpotentialisierenden peptids bpp-5a und verfahren zu ihrer herstellung. ATE54154T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8321083A IT1164225B (it) 1983-05-13 1983-05-13 Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione
EP84200658A EP0128602B1 (de) 1983-05-13 1984-05-08 Retro-inverse Analoga des bradykinin-potentialisierenden Peptids BPP-5A und Verfahren zu ihrer Herstellung

Publications (1)

Publication Number Publication Date
ATE54154T1 true ATE54154T1 (de) 1990-07-15

Family

ID=11176481

Family Applications (1)

Application Number Title Priority Date Filing Date
AT84200658T ATE54154T1 (de) 1983-05-13 1984-05-08 Retro-inverse analoga des bradykininpotentialisierenden peptids bpp-5a und verfahren zu ihrer herstellung.

Country Status (8)

Country Link
US (1) US4522752A (de)
EP (2) EP0301639A3 (de)
JP (1) JPH0635477B2 (de)
AT (1) ATE54154T1 (de)
AU (1) AU571225B2 (de)
CA (1) CA1252949A (de)
DE (1) DE3482589D1 (de)
IT (1) IT1164225B (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1178789B (it) * 1984-12-21 1987-09-16 Assorenti Peptidi retro-invertiti analoghi del potenziatore della bradichinina bpp 5a
IT1184317B (it) * 1985-02-05 1987-10-28 Eniricerche Spa Retro-inverso analoghi del peptide potenziatore della bradichina bpp5a
IT1184164B (it) * 1985-03-19 1987-10-22 Eniricerche Spa Triptidi ad azione ipotensiva e procedimento per la loro sintesi
IT1190389B (it) * 1985-09-19 1988-02-16 Eniricerche Spa Esapeptidi ad attivita' ipotensiva
AU667578B2 (en) * 1992-08-27 1996-03-28 Deakin Research Limited Retro-, inverso-, and retro-inverso synthetic peptide analogues
US5968895A (en) 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
JP2002501889A (ja) * 1998-02-02 2002-01-22 トラスティーズ オブ タフツ カレッジ グルコース代謝を調節する方法、およびそれに関連する試薬
US6465495B1 (en) 1998-07-30 2002-10-15 Osi Pharmaceuticals, Inc. Preparation of pyridone-based phosphotyrosine mimetics and uses thereof
US6984719B1 (en) 1998-09-17 2006-01-10 Hospital Sainte-Justine Peptide antagonists of prostaglandin F2α receptor
US7396905B1 (en) 1999-05-21 2008-07-08 Mckeon Frank Calcipressins: endogenous inhibitors of calcineurin, uses and reagents related thereto
US20040235749A1 (en) * 1999-09-15 2004-11-25 Sylvain Chemtob G-protein coupled receptor antagonists
US6560542B1 (en) * 2000-01-24 2003-05-06 The Cielo Institute Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
US20050119454A1 (en) * 2000-01-24 2005-06-02 The Cielo Institute, Inc. Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
US6865492B2 (en) * 2000-01-24 2005-03-08 The Cielo Institute, Inc. Algorithmic design of peptides for binding and/or modulation of the functions of receptors and/or other proteins
BR0101088A (pt) * 2001-03-19 2003-03-18 Biolab Sanus Farmaceutica Ltda Processo de isolamento e purificação de peptìdeos inibidores das vasopeptidases, com especificidade para o sìtio carboxìlico da enzima conversora da angiotensina, secretados pelas glândulas do veneno de serpentes (bpps), particularmente bothrops jararaca, ou produzidos endogenamente (evasins) possuindo ação vasodilatadora e anti-hipertensiva; processo de determinação da sequência de amido-ácidos dos peptìdios inibidores secretados pela glândula de veneno de serpentes (bpps) ou endógenos (evasins); processo de determinação da sequência de aminoácidos dos bpps por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca. processo de determinação da sequência de aminoácidos dos evasins por dedução do cdna dos precursores dessas moléculas expressos em tecidos de serpentes, especificamente bothrops jararaca, processo de amplificação do cdna a partir das bibliotecas de cdna de pâncreas e/ou cérebro de serpentes, especificamente bothrops jararaca; processo de sìntese em fase sólida de peptìdeos inibidores das vasopeptidases com ação vasodilatadora e anti-hipertensiva, peptìdeos inibidores das vasopeptidases com ação anti-hipertensiva; utilização dos peptìdeos inibidores das vaso peptidases com ação vasodilatadora e anti-hipertensiva na obtenção de composições farmacêuticas; processo de determinação da atividade inibitória sobre as vasopeptidases e de atividade biológica sobre músculo liso, sistema cardiovascular e microcirculatório.
DE02800437T1 (de) 2001-10-03 2004-11-11 The President And Fellows Of Harvard College, Cambridge Copolymere zur unterdrückung von autoimmunkrankheiten und anwendungsverfahren
CA2466870A1 (en) 2001-11-26 2003-06-05 Trustees Of Tufts College Methods for treating autoimmune disorders, and reagents related thereto
US7727964B2 (en) 2001-11-26 2010-06-01 Trustees Of Tufts College Peptidomimetic inhibitors of post-proline cleaving enzymes
US6935959B2 (en) * 2002-05-16 2005-08-30 Microsoft Corporation Use of multiple player real-time voice communications on a gaming device
US7521530B2 (en) * 2002-06-11 2009-04-21 Universite De Montreal Peptides and peptidomimetics useful for inhibiting the activity of prostaglandin F2α receptor
US7521481B2 (en) 2003-02-27 2009-04-21 Mclaurin Joanne Methods of preventing, treating and diagnosing disorders of protein aggregation
JP5060134B2 (ja) 2003-12-12 2012-10-31 ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ・アズ リプレゼンテッド バイ ザ セクレタリー・デパートメント オブ ヘルス アンド ヒューマン サービシーズ ヒト細胞傷害性Ｔリンパ球のエピトープ及びそのＭＵＣ−１の非ＶＮＴＲ（ｎｏｎ−ｖａｒｉａｂｌｅｎｕｍｂｅｒｏｆｔａｎｄｅｍｒｅｐｅａｔｓｅｑｕｅｎｃｅ）由来のアゴニストエピトープ
US7491263B2 (en) 2004-04-05 2009-02-17 Technology Innovation, Llc Storage assembly
CA2573720A1 (en) 2004-07-14 2006-02-23 University Of Utah Research Foundation Netrin-related compositions and uses
DE102004037356B4 (de) * 2004-07-30 2017-11-23 Ansaldo Energia Ip Uk Limited Wandstruktur zur Begrenzung eines Heißgaspfads
CN101102779A (zh) 2004-11-17 2008-01-09 乔安妮·麦克劳林 用于治疗蛋白聚集疾病的含鲨肌醇衍生物的组合物和方法
GB0426146D0 (en) 2004-11-29 2004-12-29 Bioxell Spa Therapeutic peptides and method
AU2006216635B2 (en) 2005-02-25 2011-11-17 University Of Utah Research Foundation Tropoelastin for promoting endothelial cell adhesion or migration
US20100041597A1 (en) 2005-08-05 2010-02-18 Jenny Phipps Peptides targeted to protein kinase c isoforms and uses thereof
WO2007109583A2 (en) 2006-03-17 2007-09-27 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Compositions and methods for prevention or treatment of neoplastic disease in a mammalian subject
EP3669894A3 (de) 2006-06-30 2020-08-26 Syntab Therapeutics GmbH Neuartige multifunktionale verbindungen für pharmazeutische zwecke
DK2148667T3 (da) 2007-04-12 2013-08-26 Waratah Pharmaceuticals Inc Anvendelse af cyclohexanhexolderivater til behandling af øjensygdomme
CN101795703B (zh) 2007-06-27 2015-05-06 里兰斯坦福初级大学理事会 肽酪氨酸酶抑制剂及其应用
CA2970108C (en) * 2007-06-27 2020-04-07 The Board Of Trustees Of The Leland Stanford Junior University Oligopeptide tyrosinase inhibitors and uses thereof
CN101821621A (zh) * 2007-07-23 2010-09-01 拜奥克塞尔有限公司 筛选、治疗和诊断
GB0821941D0 (en) 2008-12-01 2009-01-07 Renovo Ltd Non-surgical improvements of scars
US9296805B2 (en) 2009-06-18 2016-03-29 Dana-Farber Cancer Institute, Inc. Stabilized insulinotropic peptides and methods of use
ES2641325T3 (es) 2012-01-26 2017-11-08 Christopher J. Soares Antagonistas peptídicos de la familia calcitonina CGRP de hormonas peptídicas y su uso
CA2866819C (en) 2012-03-13 2022-01-04 James Cook University Method for treating inflammation
US10017551B2 (en) 2013-03-15 2018-07-10 The Regents Of The University Of California Peptides having reduced toxicity that stimulate cholesterol efflux
JP2016536343A (ja) 2013-09-18 2016-11-24 ジェームス・クック・ユニバーシティー 抗炎症性のタンパク質及び使用方法
JP6952685B2 (ja) 2015-06-05 2021-10-20 アイバイオ・インコーポレイテッドＩｂｉｏ， Ｉｎｃ． 線維症の治療において使用するためのエンドスタチン断片およびバリアント
GB201609083D0 (en) 2016-05-24 2016-07-06 Syntab Therapeutics Gmbh Synthetic compound
US11390654B2 (en) 2016-09-02 2022-07-19 Christopher Joseph Soares Use of CGRP receptor antagonists in neuroprotection and neurological disorders
US11858974B2 (en) 2017-05-22 2024-01-02 Resq Biotech Macrocyclic modulators of disease associated protein misfolding and aggregation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH568964A5 (de) * 1972-06-01 1975-11-14 Squibb & Sons Inc
HU185263B (en) * 1981-06-12 1984-12-28 Richter Gedeon Vegyeszet Process for producing peptides effective on the immuncontroll analogous with the tp5
IT1212508B (it) * 1981-12-22 1989-11-22 Anic Spa Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori
IT1190891B (it) * 1982-06-24 1988-02-24 Anic Spa Metodo per la sintesi in fase solida di polipeptidi retroinvertiti
FI77875C (fi) * 1982-11-26 1989-05-10 Nyegaard & Co As Foerfarande foer framstaellning av nya terapeutiskt anvaendbara peptider.
IT1164240B (it) * 1983-05-25 1987-04-08 Anic Spa Decapeptide parzialmente retro-invertito inibitore specifico della renina con elevata resistenza alla idrolisi enzimatica
IT1206339B (it) * 1984-01-13 1989-04-14 Anic Spa Analoghi retro-invertiti esapeptidici c-terminali della sostanza p.

Also Published As

Publication number Publication date
EP0301639A2 (de) 1989-02-01
IT8321083A1 (it) 1984-11-13
IT8321083A0 (it) 1983-05-13
EP0128602B1 (de) 1990-06-27
EP0128602A3 (en) 1987-01-14
CA1252949A (en) 1989-04-18
EP0128602A2 (de) 1984-12-19
AU571225B2 (en) 1988-04-14
DE3482589D1 (de) 1990-08-02
AU2791484A (en) 1984-11-15
JPH0635477B2 (ja) 1994-05-11
IT1164225B (it) 1987-04-08
JPS59212453A (ja) 1984-12-01
EP0301639A3 (de) 1989-10-18
US4522752A (en) 1985-06-11

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Legal Events

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REN Ceased due to non-payment of the annual fee