ATE68495T1 - 4,5,6,7-tetrahydro-1h-imidazo(4,5c>pyridinderivate und analoge mit antihypertensiver wirkung. - Google Patents

4,5,6,7-tetrahydro-1h-imidazo(4,5c>pyridinderivate und analoge mit antihypertensiver wirkung.

Info

Publication number
ATE68495T1
ATE68495T1 AT87104736T AT87104736T ATE68495T1 AT E68495 T1 ATE68495 T1 AT E68495T1 AT 87104736 T AT87104736 T AT 87104736T AT 87104736 T AT87104736 T AT 87104736T AT E68495 T1 ATE68495 T1 AT E68495T1
Authority
AT
Austria
Prior art keywords
imidazo
tetrahydro
analogues
pyridine derivatives
antihypertensive action
Prior art date
Application number
AT87104736T
Other languages
English (en)
Inventor
C John Blankley
John C Hodges
John S Kiely
Sylvester R Klutchko
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Application granted granted Critical
Publication of ATE68495T1 publication Critical patent/ATE68495T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems
AT87104736T 1986-04-01 1987-03-31 4,5,6,7-tetrahydro-1h-imidazo(4,5c>pyridinderivate und analoge mit antihypertensiver wirkung. ATE68495T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/847,067 US4812462A (en) 1986-04-01 1986-04-01 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity
EP87104736A EP0245637B1 (de) 1986-04-01 1987-03-31 4,5,6,7-Tetrahydro-1H-imidazo[4,5-c]pyridinderivate und Analoge mit antihypertensiver Wirkung

Publications (1)

Publication Number Publication Date
ATE68495T1 true ATE68495T1 (de) 1991-11-15

Family

ID=25299665

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87104736T ATE68495T1 (de) 1986-04-01 1987-03-31 4,5,6,7-tetrahydro-1h-imidazo(4,5c>pyridinderivate und analoge mit antihypertensiver wirkung.

Country Status (7)

Country Link
US (1) US4812462A (de)
EP (1) EP0245637B1 (de)
JP (2) JP2506105B2 (de)
AT (1) ATE68495T1 (de)
DE (1) DE3773737D1 (de)
ES (1) ES2038613T3 (de)
GR (1) GR3002914T3 (de)

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US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
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US5442062A (en) * 1991-10-24 1995-08-15 The Upjohn Company Imidazole derivatives and pharmaceutical compositions containing the same
US5234923A (en) * 1991-12-16 1993-08-10 E. R. Squibb & Sons, Inc. Substitute indole and benzimidazole derivatives
US5212177A (en) * 1991-12-16 1993-05-18 E. R. Squibb & Sons, Inc. Indole and benzimidazole-substituted dihydropyrimidine derivatives
US5225408A (en) * 1991-12-20 1993-07-06 E. R. Squibb & Sons, Inc. Biphenyl oxadiazinone angiotensin II inhibitors
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US5246943A (en) * 1992-05-19 1993-09-21 Warner-Lambert Company Substituted 1,2,3,4-tetahydroisoquinolines with angiotensin II receptor antagonist properties
US5236934A (en) * 1992-08-26 1993-08-17 E. I. Du Pont De Nemours And Company 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders
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US6197954B1 (en) 1998-01-30 2001-03-06 The Trustees Of Columbia University In The City Of New York Intermediates for the synthesis of debromohymenialdisine and processes thereof
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US8242151B2 (en) * 2007-02-07 2012-08-14 Kyowa Hakko Kirin Co., Ltd. Tricyclic compounds
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JP6467404B2 (ja) 2013-03-14 2019-02-13 ヤンセン ファーマシューティカ エヌ．ベー． Ｐ２ｘ７モジュレーター
TWI644671B (zh) 2013-03-14 2018-12-21 比利時商健生藥品公司 Ｐ２ｘ７調節劑
US9604982B2 (en) 2013-03-14 2017-03-28 Janssen Pharmaceutica Nv P2X7 modulators
JO3509B1 (ar) 2013-03-14 2020-07-05 Janssen Pharmaceutica Nv معدلات p2x7
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GB201321749D0 (en) * 2013-12-09 2014-01-22 Ucb Pharma Sa Therapeutic agents
CN105218631A (zh) * 2014-06-13 2016-01-06 首都医科大学 咪唑并吡啶-6-甲酰-氨基酸苄酯、其合成、活性和应用
CN105237620A (zh) * 2014-07-10 2016-01-13 首都医科大学 咪唑并吡啶-6-甲酰-氨基酸苄酯、其合成、活性和应用
CN105254709A (zh) * 2014-07-10 2016-01-20 首都医科大学 咪唑并吡啶-6-甲酰-Met-AA-OBzl,其合成,活性和应用
CN105237619A (zh) * 2014-07-10 2016-01-13 首都医科大学 咪唑并吡啶-6-甲酰-Met-Ser-OBzl，其合成，活性和应用
CA2960968A1 (en) 2014-09-12 2016-03-17 Janssen Pharmaceutica Nv P2x7 modulators
JP2018527319A (ja) * 2015-07-16 2018-09-20 ロマ リンダ ユニバーシティ ヒトパピローマウイルスに関連する癌の予防用組成物
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AU2019335199A1 (en) * 2018-09-04 2021-03-11 Theravance Biopharma R&D Ip, Llc Process for preparing jak inhibitors and intermediates thereof
US20200102303A1 (en) 2018-09-28 2020-04-02 Janssen Pharmaceutica Nv Monoacylglycerol Lipase Modulators
BR112021005936A2 (pt) 2018-09-28 2021-06-29 Janssen Pharmaceutica Nv moduladores de monoacilglicerol lipase
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Also Published As

Publication number Publication date
DE3773737D1 (de) 1991-11-21
EP0245637B1 (de) 1991-10-16
GR3002914T3 (en) 1993-01-25
ES2038613T3 (es) 1993-08-01
US4812462A (en) 1989-03-14
EP0245637A1 (de) 1987-11-19
JPS62240683A (ja) 1987-10-21
JP2506105B2 (ja) 1996-06-12
JP2648793B2 (ja) 1997-09-03
JPH08208652A (ja) 1996-08-13

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee