GR3002914T3 - 4,5,6,7-tetrahydro-1h-imidazo(4,5-c)pyridine derivatives and analogs having antihypertensive activity - Google Patents

4,5,6,7-tetrahydro-1h-imidazo(4,5-c)pyridine derivatives and analogs having antihypertensive activity

Info

Publication number
GR3002914T3
GR3002914T3 GR91401424T GR910401424T GR3002914T3 GR 3002914 T3 GR3002914 T3 GR 3002914T3 GR 91401424 T GR91401424 T GR 91401424T GR 910401424 T GR910401424 T GR 910401424T GR 3002914 T3 GR3002914 T3 GR 3002914T3
Authority
GR
Greece
Prior art keywords
imidazo
tetrahydro
analogs
pyridine derivatives
antihypertensive activity
Prior art date
Application number
GR91401424T
Other languages
English (en)
Inventor
C John Blankley
John C Hodges
John S Kiely
Sylvester R Klutchko
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of GR3002914T3 publication Critical patent/GR3002914T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D497/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D497/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having oxygen and sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D497/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GR91401424T 1986-04-01 1991-10-17 4,5,6,7-tetrahydro-1h-imidazo(4,5-c)pyridine derivatives and analogs having antihypertensive activity GR3002914T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/847,067 US4812462A (en) 1986-04-01 1986-04-01 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid analogs having antihypertensive activity

Publications (1)

Publication Number Publication Date
GR3002914T3 true GR3002914T3 (en) 1993-01-25

Family

ID=25299665

Family Applications (1)

Application Number Title Priority Date Filing Date
GR91401424T GR3002914T3 (en) 1986-04-01 1991-10-17 4,5,6,7-tetrahydro-1h-imidazo(4,5-c)pyridine derivatives and analogs having antihypertensive activity

Country Status (7)

Country Link
US (1) US4812462A (el)
EP (1) EP0245637B1 (el)
JP (2) JP2506105B2 (el)
AT (1) ATE68495T1 (el)
DE (1) DE3773737D1 (el)
ES (1) ES2038613T3 (el)
GR (1) GR3002914T3 (el)

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IL102183A (en) * 1991-06-27 1999-11-30 Takeda Chemical Industries Ltd The heterocyclic compounds are converted into biphenyl groups, their production and the pharmaceutical compositions containing them
US5177097A (en) * 1991-07-24 1993-01-05 E. R. Squibb & Sons, Inc. Acyl amidine and acyl, guanidine substituted biphenyl derivatives
IL103020A (en) * 1991-09-10 1998-10-30 Tanabe Seiyaku Co History of acid 3) 1, '1 in biphenyl 4 Methyl (4,5,6,7 tetrahydro H3 imidazo] C 4,5 [pyridine 4 carboxylic acid, preparation and pharmaceutical preparations containing them
ATE146474T1 (de) * 1991-09-10 1997-01-15 Tanabe Seiyaku Co Imidazoindolizinderivate mit angiotensin-ii hemmwirkung
US5442062A (en) * 1991-10-24 1995-08-15 The Upjohn Company Imidazole derivatives and pharmaceutical compositions containing the same
US5234923A (en) * 1991-12-16 1993-08-10 E. R. Squibb & Sons, Inc. Substitute indole and benzimidazole derivatives
US5212177A (en) * 1991-12-16 1993-05-18 E. R. Squibb & Sons, Inc. Indole and benzimidazole-substituted dihydropyrimidine derivatives
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US5294722A (en) * 1992-04-16 1994-03-15 E. R. Squibb & Sons, Inc. Process for the preparation of imidazoles useful in angiotensin II antagonism
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US5236934A (en) * 1992-08-26 1993-08-17 E. I. Du Pont De Nemours And Company 1,2,3,4-tetrahydroisoquinolines useful in the treatment of CNS disorders
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US6974815B2 (en) * 2002-10-11 2005-12-13 Bristol-Myers Squibb Company Hexahydro-benzimidazolone compounds useful as anti-inflammatory agents
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TWI627174B (zh) 2013-03-14 2018-06-21 比利時商健生藥品公司 Ｐ２ｘ７調控劑
WO2014152589A1 (en) 2013-03-14 2014-09-25 Janssen Pharmaceutica Nv P2x7 modulators
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CN105237619A (zh) * 2014-07-10 2016-01-13 首都医科大学 咪唑并吡啶-6-甲酰-Met-Ser-OBzl，其合成，活性和应用
CN105237620A (zh) * 2014-07-10 2016-01-13 首都医科大学 咪唑并吡啶-6-甲酰-氨基酸苄酯、其合成、活性和应用
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Also Published As

Publication number Publication date
ES2038613T3 (es) 1993-08-01
JPH08208652A (ja) 1996-08-13
US4812462A (en) 1989-03-14
DE3773737D1 (de) 1991-11-21
EP0245637A1 (en) 1987-11-19
EP0245637B1 (en) 1991-10-16
JP2648793B2 (ja) 1997-09-03
ATE68495T1 (de) 1991-11-15
JP2506105B2 (ja) 1996-06-12
JPS62240683A (ja) 1987-10-21

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