IT1190891B - Metodo per la sintesi in fase solida di polipeptidi retroinvertiti - Google Patents

Metodo per la sintesi in fase solida di polipeptidi retroinvertiti

Info

Publication number
IT1190891B
IT1190891B IT22046/82A IT2204682A IT1190891B IT 1190891 B IT1190891 B IT 1190891B IT 22046/82 A IT22046/82 A IT 22046/82A IT 2204682 A IT2204682 A IT 2204682A IT 1190891 B IT1190891 B IT 1190891B
Authority
IT
Italy
Prior art keywords
phase synthesis
polypeptides
bis
retroinverted
solid phase
Prior art date
Application number
IT22046/82A
Other languages
English (en)
Other versions
IT8222046A0 (it
Inventor
Antonello Pessi
Massimo Pinori
Antonio Silvio Verdini
Giuseppe Claudio Viscomi
Original Assignee
Anic Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anic Spa filed Critical Anic Spa
Priority to IT22046/82A priority Critical patent/IT1190891B/it
Publication of IT8222046A0 publication Critical patent/IT8222046A0/it
Priority to EP83200889A priority patent/EP0097994B1/en
Priority to DE8383200889T priority patent/DE3373908D1/de
Priority to AT83200889T priority patent/ATE30033T1/de
Application granted granted Critical
Publication of IT1190891B publication Critical patent/IT1190891B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
IT22046/82A 1982-06-24 1982-06-24 Metodo per la sintesi in fase solida di polipeptidi retroinvertiti IT1190891B (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
IT22046/82A IT1190891B (it) 1982-06-24 1982-06-24 Metodo per la sintesi in fase solida di polipeptidi retroinvertiti
EP83200889A EP0097994B1 (en) 1982-06-24 1983-06-17 Method for the solid-phase synthesis of retro-inverso polypeptides
DE8383200889T DE3373908D1 (en) 1982-06-24 1983-06-17 Method for the solid-phase synthesis of retro-inverso polypeptides
AT83200889T ATE30033T1 (de) 1982-06-24 1983-06-17 Verfahren zur herstellung von retro-inverso polypeptiden in fester phase.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT22046/82A IT1190891B (it) 1982-06-24 1982-06-24 Metodo per la sintesi in fase solida di polipeptidi retroinvertiti

Publications (2)

Publication Number Publication Date
IT8222046A0 IT8222046A0 (it) 1982-06-24
IT1190891B true IT1190891B (it) 1988-02-24

Family

ID=11190672

Family Applications (1)

Application Number Title Priority Date Filing Date
IT22046/82A IT1190891B (it) 1982-06-24 1982-06-24 Metodo per la sintesi in fase solida di polipeptidi retroinvertiti

Country Status (4)

Country Link
EP (1) EP0097994B1 (it)
AT (1) ATE30033T1 (it)
DE (1) DE3373908D1 (it)
IT (1) IT1190891B (it)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI843837A0 (fi) * 1983-02-07 1984-09-28 Ferring Ab Enzyminhibitorer.
IT1164225B (it) * 1983-05-13 1987-04-08 Anic Spa Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione
IT1164240B (it) * 1983-05-25 1987-04-08 Anic Spa Decapeptide parzialmente retro-invertito inibitore specifico della renina con elevata resistenza alla idrolisi enzimatica
IT1164239B (it) * 1983-05-25 1987-04-08 Anic Spa Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimatica
US4668476A (en) * 1984-03-23 1987-05-26 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
IT1178789B (it) * 1984-12-21 1987-09-16 Assorenti Peptidi retro-invertiti analoghi del potenziatore della bradichinina bpp 5a
IT1178786B (it) * 1984-12-21 1987-09-16 Assorenti Analoghi retro-inverso parzialmente modificati della neurotensina
IT1184317B (it) * 1985-02-05 1987-10-28 Eniricerche Spa Retro-inverso analoghi del peptide potenziatore della bradichina bpp5a
IT1190389B (it) * 1985-09-19 1988-02-16 Eniricerche Spa Esapeptidi ad attivita' ipotensiva
IT1188206B (it) * 1985-11-28 1988-01-07 Eniricerche Spa Procedimento per la sintesi in fase solida di peptidi in cui almeno un legame ammidico e' retroinvertito
GB2187461A (en) * 1986-02-03 1987-09-09 Medical Res Council Monitoring method for the synthesis of a linear of amino acid residues
IT1196500B (it) * 1986-07-16 1988-11-16 Eniricerche Spa Derivati dell'acido malonico e metodi per la loro sintesi
EP0253190B1 (en) * 1986-07-16 1992-12-30 ENIRICERCHE S.p.A. Partially retro-inverted tuftsin analogues, method for the preparation thereof and pharmaceutical compositions containing them
WO1994005311A1 (en) * 1992-08-27 1994-03-17 Deakin Research Limited Retro-, inverso-, and retro-inverso synthetic peptide analogues
FR2717081B1 (fr) * 1994-03-14 1996-06-21 Centre Nat Rech Scient Rétropeptides, anticorps dirigés contre ces derniers, et leurs utilisations pour la vaccination et le diagnostic in vitro.
US6916904B2 (en) 2002-04-24 2005-07-12 Zolaris Biosciences, Llc Inhibition of immune complex formation
EP1730170B1 (en) 2004-03-10 2020-02-19 Trinity Therapeutics, Inc. Method for inhibiting immune complex formation in a subject
US8895002B2 (en) 2007-04-09 2014-11-25 The General Hospital Corporation Hemojuvelin fusion proteins and uses thereof
TWI541020B (zh) 2008-04-17 2016-07-11 巴克斯歐塔公司 生物活性胜肽
JP5806112B2 (ja) 2008-07-18 2015-11-10 トリニティー セラピューティクス インコーポレイテッド デング出血熱およびデングショック症候群を含む免疫介在性デング熱感染症およびデング熱感染症の抗体依存性増強を処置するための方法
EP3406267A1 (en) 2011-03-25 2018-11-28 Children's Medical Center Corporation Lin28-mediated control of let-7 biogenesis
ES2724778T3 (es) 2011-06-10 2019-09-16 Bioverativ Therapeutics Inc Compuestos procoagulantes y procedimientos de uso de los mismos
US9951104B2 (en) 2012-01-09 2018-04-24 Serpin Pharma, Llc Peptides and methods of using same
PT2864360T (pt) 2012-06-25 2018-01-05 The Brigham And Women`S Hospital Inc Terapêuticas dirigidas ao alvo
BR112015022181A8 (pt) 2013-03-12 2018-01-23 Massachusetts Eye & Ear Infirmary proteínas da substância de inibição mulleriana (mis) e usos das mesmas para o tratamento de doenças
US10584147B2 (en) 2013-11-08 2020-03-10 Biovertiv Therapeutics Inc. Procoagulant fusion compound
EP3194446B1 (en) 2014-09-18 2022-10-26 Cedars-Sinai Medical Center Compositions and methods for treating fibrosis
EP4194001B1 (en) 2015-04-22 2026-03-18 Cedars-Sinai Medical Center Enterically delivered bitter oligopeptides for the treatment of type 2 diabetes and obesity
CA2996975C (en) 2015-08-28 2022-02-15 Serpin Pharma, Llc Methods for treatment of diseases
WO2017075451A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
WO2017075465A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
WO2017075478A2 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by use of immune cell gene signatures
WO2018049025A2 (en) 2016-09-07 2018-03-15 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses
WO2020055824A1 (en) 2018-09-10 2020-03-19 Board of Regents, The University of the Texas System Dry powder formulation of caveolin-1 peptides and methods of use thereof
KR20210084453A (ko) 2018-09-10 2021-07-07 렁 세라퓨틱스, 인크. Cav-1 단백질의 변형된 펩타이드 단편 및 섬유증의 치료에 있어서 이의 용도
US20220160814A1 (en) 2019-03-11 2022-05-26 Lung Therapeutics, Inc. Compositions and methods for protecting type 2 alveolar epithelial cells (aec2)
US20230374153A1 (en) 2022-04-13 2023-11-23 Paradigm Immunoterapeutics, Inc. METHODS OF PREVENTING OR TREATING INFECTION BY RESPIRATORY VIRUSES INCLUDING SARS-CoV-2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862114A (en) * 1971-11-22 1975-01-21 Ici Australia Ltd Analogs of substance p

Also Published As

Publication number Publication date
IT8222046A0 (it) 1982-06-24
EP0097994A3 (en) 1985-11-27
EP0097994B1 (en) 1987-09-30
EP0097994A2 (en) 1984-01-11
ATE30033T1 (de) 1987-10-15
DE3373908D1 (en) 1987-11-05

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