ATE30033T1 - Verfahren zur herstellung von retro-inverso polypeptiden in fester phase. - Google Patents

Verfahren zur herstellung von retro-inverso polypeptiden in fester phase.

Info

Publication number
ATE30033T1
ATE30033T1 AT83200889T AT83200889T ATE30033T1 AT E30033 T1 ATE30033 T1 AT E30033T1 AT 83200889 T AT83200889 T AT 83200889T AT 83200889 T AT83200889 T AT 83200889T AT E30033 T1 ATE30033 T1 AT E30033T1
Authority
AT
Austria
Prior art keywords
retro
inverso
production
bis
solid phase
Prior art date
Application number
AT83200889T
Other languages
English (en)
Inventor
Antonello Pessi
Massimo Pinori
Antonio Silvio Verdini
Giuseppe Claudio Viscomi
Original Assignee
Enichem Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enichem Spa filed Critical Enichem Spa
Application granted granted Critical
Publication of ATE30033T1 publication Critical patent/ATE30033T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/042—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers characterised by the nature of the carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
AT83200889T 1982-06-24 1983-06-17 Verfahren zur herstellung von retro-inverso polypeptiden in fester phase. ATE30033T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT22046/82A IT1190891B (it) 1982-06-24 1982-06-24 Metodo per la sintesi in fase solida di polipeptidi retroinvertiti
EP83200889A EP0097994B1 (de) 1982-06-24 1983-06-17 Verfahren zur Herstellung von retro-inverso Polypeptiden in fester Phase

Publications (1)

Publication Number Publication Date
ATE30033T1 true ATE30033T1 (de) 1987-10-15

Family

ID=11190672

Family Applications (1)

Application Number Title Priority Date Filing Date
AT83200889T ATE30033T1 (de) 1982-06-24 1983-06-17 Verfahren zur herstellung von retro-inverso polypeptiden in fester phase.

Country Status (4)

Country Link
EP (1) EP0097994B1 (de)
AT (1) ATE30033T1 (de)
DE (1) DE3373908D1 (de)
IT (1) IT1190891B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU573735B2 (en) * 1983-02-07 1988-06-23 Aktiebolaget Hassle Peptide analogue enzyme inhibitors
IT1164225B (it) * 1983-05-13 1987-04-08 Anic Spa Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione
IT1164240B (it) * 1983-05-25 1987-04-08 Anic Spa Decapeptide parzialmente retro-invertito inibitore specifico della renina con elevata resistenza alla idrolisi enzimatica
IT1164239B (it) * 1983-05-25 1987-04-08 Anic Spa Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimatica
US4668476A (en) * 1984-03-23 1987-05-26 Applied Biosystems, Inc. Automated polypeptide synthesis apparatus
IT1178786B (it) * 1984-12-21 1987-09-16 Assorenti Analoghi retro-inverso parzialmente modificati della neurotensina
IT1178789B (it) * 1984-12-21 1987-09-16 Assorenti Peptidi retro-invertiti analoghi del potenziatore della bradichinina bpp 5a
IT1184317B (it) * 1985-02-05 1987-10-28 Eniricerche Spa Retro-inverso analoghi del peptide potenziatore della bradichina bpp5a
IT1190389B (it) * 1985-09-19 1988-02-16 Eniricerche Spa Esapeptidi ad attivita' ipotensiva
IT1188206B (it) * 1985-11-28 1988-01-07 Eniricerche Spa Procedimento per la sintesi in fase solida di peptidi in cui almeno un legame ammidico e' retroinvertito
GB2187461A (en) * 1986-02-03 1987-09-09 Medical Res Council Monitoring method for the synthesis of a linear of amino acid residues
ES2052517T3 (es) * 1986-07-16 1994-07-16 Eniricerche Spa Analogos de tuftsina parcialmente retroinversos, metodo de preparacion de los mismos y composiciones farmaceuticas que los contienen.
IT1196500B (it) * 1986-07-16 1988-11-16 Eniricerche Spa Derivati dell'acido malonico e metodi per la loro sintesi
HUT71860A (en) * 1992-08-27 1996-02-28 Deakin Res Ltd Retro-, inverso-, and retro-inverso synthetic peptide analogues
FR2717081B1 (fr) * 1994-03-14 1996-06-21 Centre Nat Rech Scient Rétropeptides, anticorps dirigés contre ces derniers, et leurs utilisations pour la vaccination et le diagnostic in vitro.
US6916904B2 (en) 2002-04-24 2005-07-12 Zolaris Biosciences, Llc Inhibition of immune complex formation
EP1730170B1 (de) 2004-03-10 2020-02-19 Trinity Therapeutics, Inc. Verfahren zur inhibierung der immunkomplexbildung in einem probanden
WO2008124768A1 (en) 2007-04-09 2008-10-16 The General Hospital Corporation Hemojuvelin fusion proteins and uses thereof
AR071478A1 (es) 2008-04-17 2010-06-23 Baxter Healthcare Sa Peptidos de bajo peso molecular con actividad procoagulante para el tratamiento de pacientes con deficiencia de factor v (fv), fvii, fviii, fx y/o fxi
MY160699A (en) 2008-07-18 2017-03-15 Trinity Therapeutics Inc Methods for treating immune-mediated dengue fever infections and antibody-dependent enhancement of dengue fever infections, including dengue hemorrhagic fever and dengue shock syndrome
EP3406267A1 (de) 2011-03-25 2018-11-28 Children's Medical Center Corporation Lin28-vermittelte steuerung der let-7-biogenese
EP3527218A1 (de) 2011-06-10 2019-08-21 Bioverativ Therapeutics Inc. Gerinnungsfördernde verbindungen und verfahren zur verwendung davon
MX365403B (es) 2012-01-09 2019-05-31 Serpin Pharma Llc Peptidos y metodos para usarlos.
CA2877886A1 (en) 2012-06-25 2014-01-03 The Brigham And Women's Hospital, Inc. Targeted therapeutics comprising heparin binding protein
BR112015022181A8 (pt) 2013-03-12 2018-01-23 Massachusetts Eye & Ear Infirmary proteínas da substância de inibição mulleriana (mis) e usos das mesmas para o tratamento de doenças
WO2015070014A1 (en) 2013-11-08 2015-05-14 Biogen Idec Ma Inc. Procoagulant fusion compound
WO2016044707A1 (en) 2014-09-18 2016-03-24 Cedars-Sinai Medical Center Compositions and methods for treating fibrosis
WO2016172479A1 (en) 2015-04-22 2016-10-27 Cedars-Sinai Medical Center Enterically delivered bitter oligopeptides for the treatment for type 2 diabetes
US11020462B2 (en) 2015-08-28 2021-06-01 Serpin Pharma Methods for treatment of diseases
WO2017075465A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting gata3
EP3368689B1 (de) 2015-10-28 2020-06-17 The Broad Institute, Inc. Zusammensetzungen zur modulierung von immunantworten unter verwendung von immunzellgensignaturen
WO2017075451A1 (en) 2015-10-28 2017-05-04 The Broad Institute Inc. Compositions and methods for evaluating and modulating immune responses by detecting and targeting pou2af1
US20190262399A1 (en) 2016-09-07 2019-08-29 The Broad Institute, Inc. Compositions and methods for evaluating and modulating immune responses
AU2019339264A1 (en) 2018-09-10 2021-03-11 Board Of Regents, The University Of Texas System Dry powder formulation of caveolin-1 peptides and methods of use thereof
US11905336B2 (en) 2018-09-10 2024-02-20 Lung Therapeutics, Inc. Modified peptide fragments of CAV-1 protein and the use thereof in the treatment of fibrosis
US20230374153A1 (en) 2022-04-13 2023-11-23 Paradigm Immunoterapeutics, Inc. METHODS OF PREVENTING OR TREATING INFECTION BY RESPIRATORY VIRUSES INCLUDING SARS-CoV-2

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862114A (en) * 1971-11-22 1975-01-21 Ici Australia Ltd Analogs of substance p

Also Published As

Publication number Publication date
DE3373908D1 (en) 1987-11-05
EP0097994A3 (en) 1985-11-27
EP0097994B1 (de) 1987-09-30
EP0097994A2 (de) 1984-01-11
IT1190891B (it) 1988-02-24
IT8222046A0 (it) 1982-06-24

Similar Documents

Publication Publication Date Title
ATE30033T1 (de) Verfahren zur herstellung von retro-inverso polypeptiden in fester phase.
Büllesbach et al. Total synthesis of human relaxin and human relaxin derivatives by solid-phase peptide synthesis and site-directed chain combination
Sanger Chemistry of insulin: determination of the structure of insulin opens the way to greater understanding of life processes
US3929758A (en) Cyclization of cysteine-containing peptides
Kang et al. Amino acid sequence of cyanogen bromide peptides from the amino-terminal region of chick skin collagen
DeLange et al. Calf and Pea Histone IV: I. Amino acid compositions and the identical cooh-terminal 19-residue sequence
Han et al. The covalent structure of beef heart myoglobin
ATE168719T1 (de) Osteogene peptide
ATE123063T1 (de) Peptide zur diagnose von htlv-iii-antikörpern, deren herstellung und verwendung.
Wuu et al. Amino acid sequence of porcine neurophysin-I
DE3486154D1 (de) Cardiodilatin, ein neues peptidhormon und verfahren zu seiner herstellung.
Katsoyannis Synthesis of Insulin: Availability of A and B chains readily leads to the synthesis of this protein.
Dixon et al. The isolation and structure of α-melanocyte-stimulating hormone from horse pituitaries
HAN et al. The covalent structure of sheep‐heart myoglobin
US3903068A (en) Facile synthesis of human insulin by modification of porcine insulin
SU1423000A3 (ru) Способ получени пептидов
Dixon et al. The isolation and structure of β-melanocyte-stimulating hormone from horse pituitary glands
MX167236B (es) Peptidos sinteticos de timosina -1 y metodo para su obtencion
ES2044928T3 (es) Enzima alfa-amidante en terminal c y procedimiento para la produccion y el uso del mismo.
Peeters et al. Structural studies on rat prostatic binding protein: The primary structure of component C1 from subunit F
Poulsen et al. Partial amino acid sequence of the large subunit of ribulosebisphosphate carboxylase from barley
Kopeyan et al. Amino‐Acid Sequence of Toxin III of Naja haje
Davison et al. Identification of the sites in opsin modified by photoactivated azido [125I] iodobenzene
Timpl et al. Cyanogen bromide cleavage of bovine fibrinogen. Identification of a dimeric N-terminal peptide and two other disulfide containing fragments
KATSOYANNIS Synthetic insulins

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
REN Ceased due to non-payment of the annual fee