IT1178786B - Analoghi retro-inverso parzialmente modificati della neurotensina - Google Patents
Analoghi retro-inverso parzialmente modificati della neurotensinaInfo
- Publication number
- IT1178786B IT1178786B IT24197/84A IT2419784A IT1178786B IT 1178786 B IT1178786 B IT 1178786B IT 24197/84 A IT24197/84 A IT 24197/84A IT 2419784 A IT2419784 A IT 2419784A IT 1178786 B IT1178786 B IT 1178786B
- Authority
- IT
- Italy
- Prior art keywords
- neurotensin
- sub
- partially modified
- modified back
- analogs
- Prior art date
Links
- 102000050267 Neurotensin Human genes 0.000 title 1
- 101800001814 Neurotensin Proteins 0.000 title 1
- PCJGZPGTCUMMOT-ISULXFBGSA-N neurotensin Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 PCJGZPGTCUMMOT-ISULXFBGSA-N 0.000 title 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000005556 hormone Substances 0.000 abstract 1
- 229940088597 hormone Drugs 0.000 abstract 1
- 230000002045 lasting effect Effects 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 230000000304 vasodilatating effect Effects 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT24197/84A IT1178786B (it) | 1984-12-21 | 1984-12-21 | Analoghi retro-inverso parzialmente modificati della neurotensina |
| EP85115888A EP0185320B1 (en) | 1984-12-21 | 1985-12-12 | Partially modified, retro-inverso neurotensin analogs |
| AT85115888T ATE63317T1 (de) | 1984-12-21 | 1985-12-12 | Teilweise modifizierte analogen von retroinverso neurotensinen. |
| DE8585115888T DE3582786D1 (de) | 1984-12-21 | 1985-12-12 | Teilweise modifizierte analogen von retroinverso neurotensinen. |
| US06/808,617 US4716149A (en) | 1984-12-21 | 1985-12-13 | Partially modified, retro-inverso neurotensin analogs |
| JP60287645A JPS61155396A (ja) | 1984-12-21 | 1985-12-20 | ニユーロテンシン様ペプチド及びその製法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT24197/84A IT1178786B (it) | 1984-12-21 | 1984-12-21 | Analoghi retro-inverso parzialmente modificati della neurotensina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IT8424197A0 IT8424197A0 (it) | 1984-12-21 |
| IT1178786B true IT1178786B (it) | 1987-09-16 |
Family
ID=11212494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT24197/84A IT1178786B (it) | 1984-12-21 | 1984-12-21 | Analoghi retro-inverso parzialmente modificati della neurotensina |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US4716149A (it) |
| EP (1) | EP0185320B1 (it) |
| JP (1) | JPS61155396A (it) |
| AT (1) | ATE63317T1 (it) |
| DE (1) | DE3582786D1 (it) |
| IT (1) | IT1178786B (it) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1190389B (it) * | 1985-09-19 | 1988-02-16 | Eniricerche Spa | Esapeptidi ad attivita' ipotensiva |
| ES2052517T3 (es) * | 1986-07-16 | 1994-07-16 | Eniricerche Spa | Analogos de tuftsina parcialmente retroinversos, metodo de preparacion de los mismos y composiciones farmaceuticas que los contienen. |
| US5807979A (en) * | 1988-04-08 | 1998-09-15 | The Scripps Research Institute | Synthetic, three-dimensionally stabilized polypeptide mimics of HIV |
| AU3534989A (en) * | 1988-04-08 | 1989-11-03 | Scripps Clinic And Research Foundation | Polypeptides stabilized by covalent hydrogen bond replacements |
| US5374621A (en) * | 1991-09-13 | 1994-12-20 | Regents Of The University Of California | Neurotensin method for inhibiting vascular leakage |
| WO2019156565A1 (en) | 2018-02-12 | 2019-08-15 | Fast Forward Pharmaceuticals B.V. | Improved antagonistic anti-human cd40 monoclonal antibodies |
| WO2020102454A1 (en) | 2018-11-13 | 2020-05-22 | Regents Of The University Of Minnesota | Cd40 targeted peptides and uses thereof |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3929756A (en) * | 1973-11-21 | 1975-12-30 | Univ Brandeis | Synthetically produced tridecapeptide having the same activity as the hypothalamic substance, neurotensin |
| US4110321A (en) * | 1976-07-12 | 1978-08-29 | Folkers Karl | Synthetic tridecapeptide [Gln4 ]-neurotensin having hormonal activity |
| US4331661A (en) * | 1980-10-03 | 1982-05-25 | The Salk Institute For Biological Studies | Bombesin analogs |
| IT1212508B (it) * | 1981-12-22 | 1989-11-22 | Anic Spa | Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori |
| IT1190891B (it) * | 1982-06-24 | 1988-02-24 | Anic Spa | Metodo per la sintesi in fase solida di polipeptidi retroinvertiti |
| US4439359A (en) * | 1982-07-02 | 1984-03-27 | Merck & Co., Inc. | Cyclic octapeptide analogs of neurotensin |
| US4613586A (en) * | 1984-04-19 | 1986-09-23 | Board Of Trustees Of The Leland Stanford Junior University | Gastrin releasing peptide-like peptides |
-
1984
- 1984-12-21 IT IT24197/84A patent/IT1178786B/it active
-
1985
- 1985-12-12 DE DE8585115888T patent/DE3582786D1/de not_active Expired - Lifetime
- 1985-12-12 EP EP85115888A patent/EP0185320B1/en not_active Expired - Lifetime
- 1985-12-12 AT AT85115888T patent/ATE63317T1/de not_active IP Right Cessation
- 1985-12-13 US US06/808,617 patent/US4716149A/en not_active Expired - Fee Related
- 1985-12-20 JP JP60287645A patent/JPS61155396A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0185320A2 (en) | 1986-06-25 |
| US4716149A (en) | 1987-12-29 |
| EP0185320B1 (en) | 1991-05-08 |
| ATE63317T1 (de) | 1991-05-15 |
| IT8424197A0 (it) | 1984-12-21 |
| DE3582786D1 (de) | 1991-06-13 |
| EP0185320A3 (en) | 1988-03-16 |
| JPS61155396A (ja) | 1986-07-15 |
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