ATE10364T1 - Retro-inverso analoga von c-terminalen pentaund hexapeptiden der verbindung p. - Google Patents
Retro-inverso analoga von c-terminalen pentaund hexapeptiden der verbindung p.Info
- Publication number
- ATE10364T1 ATE10364T1 AT82201612T AT82201612T ATE10364T1 AT E10364 T1 ATE10364 T1 AT E10364T1 AT 82201612 T AT82201612 T AT 82201612T AT 82201612 T AT82201612 T AT 82201612T AT E10364 T1 ATE10364 T1 AT E10364T1
- Authority
- AT
- Austria
- Prior art keywords
- retro
- terminal
- pentaand
- hexapeptides
- compound
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 210000004899 c-terminal region Anatomy 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- CWWARWOPSKGELM-SARDKLJWSA-N methyl (2s)-2-[[(2s)-2-[[2-[[(2s)-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-5-amino-2-[[(2s)-1-[(2s)-6-amino-2-[[(2s)-1-[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-5 Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)OC)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 CWWARWOPSKGELM-SARDKLJWSA-N 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0212—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -N-C-N-C(=0)-, e.g. retro-inverso peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8125753A IT1212508B (it) | 1981-12-22 | 1981-12-22 | Analoghi retro - invertiti dei penta - ed esapeptidi c - terminali della sostanza p. utili come vasodilatatori |
| EP82201612A EP0082568B1 (de) | 1981-12-22 | 1982-12-16 | Retro-inverso Analoga von C-terminalen Penta- und Hexapeptiden der Verbindung P |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE10364T1 true ATE10364T1 (de) | 1984-12-15 |
Family
ID=11217635
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT82201612T ATE10364T1 (de) | 1981-12-22 | 1982-12-16 | Retro-inverso analoga von c-terminalen pentaund hexapeptiden der verbindung p. |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4439360A (de) |
| EP (1) | EP0082568B1 (de) |
| JP (1) | JPS58116443A (de) |
| AT (1) | ATE10364T1 (de) |
| CA (1) | CA1249698A (de) |
| DE (1) | DE3261304D1 (de) |
| IT (1) | IT1212508B (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0316965A3 (de) * | 1983-02-07 | 1989-08-09 | Aktiebolaget Hässle | Enzym-Inhibitoren |
| IT1164225B (it) * | 1983-05-13 | 1987-04-08 | Anic Spa | Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione |
| IT1164240B (it) * | 1983-05-25 | 1987-04-08 | Anic Spa | Decapeptide parzialmente retro-invertito inibitore specifico della renina con elevata resistenza alla idrolisi enzimatica |
| IT1164239B (it) * | 1983-05-25 | 1987-04-08 | Anic Spa | Un retro-inverso analogo del decapeptide (5-14)dell'angiotensinogeno equino inibitore specifico della renina con elevata resistenza all'idrolisi enzimatica |
| IT1206339B (it) * | 1984-01-13 | 1989-04-14 | Anic Spa | Analoghi retro-invertiti esapeptidici c-terminali della sostanza p. |
| JPS617209A (ja) * | 1984-06-20 | 1986-01-13 | Meiji Seika Kaisha Ltd | 育毛剤組成物 |
| IT1178786B (it) * | 1984-12-21 | 1987-09-16 | Assorenti | Analoghi retro-inverso parzialmente modificati della neurotensina |
| IT1184164B (it) * | 1985-03-19 | 1987-10-22 | Eniricerche Spa | Triptidi ad azione ipotensiva e procedimento per la loro sintesi |
| IT1190389B (it) * | 1985-09-19 | 1988-02-16 | Eniricerche Spa | Esapeptidi ad attivita' ipotensiva |
| EP0253190B1 (de) * | 1986-07-16 | 1992-12-30 | ENIRICERCHE S.p.A. | Teilweise retro-invertierte Analoge des Tuftsin, Methode zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten |
| IT1196500B (it) * | 1986-07-16 | 1988-11-16 | Eniricerche Spa | Derivati dell'acido malonico e metodi per la loro sintesi |
| US5877277A (en) | 1987-09-24 | 1999-03-02 | Biomeasure, Inc. | Octapeptide bombesin analogs |
| US5830863A (en) * | 1988-06-20 | 1998-11-03 | Merrell Pharmaceuticals Inc. | Neurokinin A antagonists |
| US6218364B1 (en) * | 1988-06-20 | 2001-04-17 | Scott L. Harbeson | Fluorinated neurokinin A antagonists |
| IT1228451B (it) * | 1989-02-22 | 1991-06-19 | Sclavo S P A Siena | Nuovi derivati diamminici geminali e loro impiego nelle sintesi di peptidi retro-inversi |
| IE77033B1 (en) * | 1989-08-16 | 1997-11-19 | Univ Tulane | Substance P antagonists |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862114A (en) * | 1971-11-22 | 1975-01-21 | Ici Australia Ltd | Analogs of substance p |
| JPS5411293A (en) * | 1977-05-23 | 1979-01-27 | Toyo Soda Mfg Co Ltd | Recovery of protease |
-
1981
- 1981-12-22 IT IT8125753A patent/IT1212508B/it active
-
1982
- 1982-12-10 US US06/448,832 patent/US4439360A/en not_active Expired - Fee Related
- 1982-12-16 AT AT82201612T patent/ATE10364T1/de not_active IP Right Cessation
- 1982-12-16 EP EP82201612A patent/EP0082568B1/de not_active Expired
- 1982-12-16 DE DE8282201612T patent/DE3261304D1/de not_active Expired
- 1982-12-21 CA CA000418173A patent/CA1249698A/en not_active Expired
- 1982-12-22 JP JP57224103A patent/JPS58116443A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0082568A2 (de) | 1983-06-29 |
| US4439360A (en) | 1984-03-27 |
| IT1212508B (it) | 1989-11-22 |
| CA1249698A (en) | 1989-01-31 |
| DE3261304D1 (en) | 1985-01-03 |
| IT8125753A0 (it) | 1981-12-22 |
| EP0082568B1 (de) | 1984-11-21 |
| JPS58116443A (ja) | 1983-07-11 |
| EP0082568A3 (en) | 1983-10-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EEIH | Change in the person of patent owner | ||
| EEIH | Change in the person of patent owner | ||
| REN | Ceased due to non-payment of the annual fee |