ES2189346T3 - Metalopeptido aislado: composiciones y procedimientos de sintesis. - Google Patents

Metalopeptido aislado: composiciones y procedimientos de sintesis.

Info

Publication number
ES2189346T3
ES2189346T3 ES99203078T ES99203078T ES2189346T3 ES 2189346 T3 ES2189346 T3 ES 2189346T3 ES 99203078 T ES99203078 T ES 99203078T ES 99203078 T ES99203078 T ES 99203078T ES 2189346 T3 ES2189346 T3 ES 2189346T3
Authority
ES
Spain
Prior art keywords
metalopeptide
isolated
compositions
amino acid
synthesis procedures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES99203078T
Other languages
English (en)
Inventor
M Reza Ghadiri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/591,988 external-priority patent/US5200504A/en
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Application granted granted Critical
Publication of ES2189346T3 publication Critical patent/ES2189346T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La invención se refiere a un metalopéptido que comprende un péptido unido a un catión metálico a dos residuos aminoácidos coordinados que son accesibles mediante un disolvente acuoso, el metalopéptido tiene una estructura secundaria que se estabiliza mediante el enlace de catión metálico. La estructura secundaria es una hoja {be} que tiene un giro {be}, y los residuos de aminoácidos de coordinación están situados en posiciones relativas respecto del aminoácido de i e i+3 ó i-1 e i+5 en el polipéptido.
ES99203078T 1990-10-02 1991-10-01 Metalopeptido aislado: composiciones y procedimientos de sintesis. Expired - Lifetime ES2189346T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/591,988 US5200504A (en) 1990-10-02 1990-10-02 Metallopeptides having stabilized secondary structures
US76962191A 1991-09-30 1991-09-30

Publications (1)

Publication Number Publication Date
ES2189346T3 true ES2189346T3 (es) 2003-07-01

Family

ID=27081322

Family Applications (2)

Application Number Title Priority Date Filing Date
ES91919635T Expired - Lifetime ES2143979T3 (es) 1990-10-02 1991-10-01 Metalopolipeptido aislado: composiciones y procedimientos de sintesis.
ES99203078T Expired - Lifetime ES2189346T3 (es) 1990-10-02 1991-10-01 Metalopeptido aislado: composiciones y procedimientos de sintesis.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES91919635T Expired - Lifetime ES2143979T3 (es) 1990-10-02 1991-10-01 Metalopolipeptido aislado: composiciones y procedimientos de sintesis.

Country Status (9)

Country Link
US (1) US5408036A (es)
EP (2) EP0992513B1 (es)
JP (1) JPH06502409A (es)
AT (2) ATE191222T1 (es)
AU (1) AU658840B2 (es)
CA (1) CA2093214C (es)
DE (2) DE69132084T2 (es)
ES (2) ES2143979T3 (es)
WO (1) WO1992006110A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7396814B2 (en) * 1995-06-07 2008-07-08 Palatin Technologies, Inc. Metallopeptide compositions for treatment of sexual dysfunction
US5891418A (en) * 1995-06-07 1999-04-06 Rhomed Incorporated Peptide-metal ion pharmaceutical constructs and applications
US6331285B1 (en) 1996-06-05 2001-12-18 Palatin Technologies, Inc. Structurally determined cyclic metallo-constructs and applications
WO2001009165A2 (en) * 1999-07-29 2001-02-08 The Johns Hopkins University ACTIVATION OF PEPTIDE PRODRUGS BY hK2
US7385025B2 (en) 2000-12-19 2008-06-10 Palatin Technologies, Inc. Metallopeptide compounds
DE10064896A1 (de) * 2000-12-23 2002-07-11 Robert Tampe Schaltbare biochemische Pinzetten und synthetische Rezeptoren zur molekularen Organisation und Manipulation von Biomolekülen
EP1730169A2 (en) * 2003-12-23 2006-12-13 Trustees Of Tufts College Metal-containing nanolayered composites, and applications thereof
US20080269065A1 (en) * 2007-04-30 2008-10-30 Syntrix Biosystems, Inc. Conformationally Constrained Analytical Probes
US11174288B2 (en) 2016-12-06 2021-11-16 Northeastern University Heparin-binding cationic peptide self-assembling peptide amphiphiles useful against drug-resistant bacteria

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4859765A (en) * 1983-10-17 1989-08-22 Syntex (U.S.A.) Inc. Synthetic peptide sequences useful in biological and pharmaceutical applications and methods of manufacture
US4849505A (en) * 1984-01-30 1989-07-18 Enzo Biochem, Inc. Detectable molecules, method of preparation and use
DE3613758A1 (de) * 1986-04-23 1987-10-29 Consortium Elektrochem Ind Cysteinreiche, (gamma)-glutaminsaeure- und (beta)-alanin-einheiten aufweisende peptide, verfahren zu deren herstellung und ihre verwendung

Also Published As

Publication number Publication date
JPH06502409A (ja) 1994-03-17
US5408036A (en) 1995-04-18
CA2093214C (en) 2000-02-08
EP0552284A4 (es) 1994-03-23
EP0992513B1 (en) 2002-12-18
CA2093214A1 (en) 1992-04-03
DE69132084D1 (de) 2000-05-04
EP0552284A1 (en) 1993-07-28
AU658840B2 (en) 1995-05-04
DE69133186D1 (de) 2003-01-30
EP0992513A3 (en) 2000-04-19
AU8871991A (en) 1992-04-28
DE69132084T2 (de) 2000-09-14
WO1992006110A1 (en) 1992-04-16
DE69133186T2 (de) 2003-04-30
EP0992513A2 (en) 2000-04-12
ATE191222T1 (de) 2000-04-15
EP0552284B1 (en) 2000-03-29
ES2143979T3 (es) 2000-06-01
ATE229975T1 (de) 2003-01-15

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