ES2023746A6 - Procedimiento de preparacion de peptidos de serina-acido aspartico- lisina - Google Patents

Procedimiento de preparacion de peptidos de serina-acido aspartico- lisina

Info

Publication number
ES2023746A6
ES2023746A6 ES9000692A ES9000692A ES2023746A6 ES 2023746 A6 ES2023746 A6 ES 2023746A6 ES 9000692 A ES9000692 A ES 9000692A ES 9000692 A ES9000692 A ES 9000692A ES 2023746 A6 ES2023746 A6 ES 2023746A6
Authority
ES
Spain
Prior art keywords
compositions containing
therapeutic compositions
peptides
pro
residue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES9000692A
Other languages
English (en)
Inventor
Maryse Lenfant
Josiane Thierry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ipsen Pharma SAS
Original Assignee
Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS filed Critical Societe de Conseils de Recherches et dApplications Scientifiques SCRAS SAS
Publication of ES2023746A6 publication Critical patent/ES2023746A6/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/081—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE PEPTIDOS DE SERINA-ACIDO ASPARTICO-LISINA DE FORMULA HSI2N - W - SER - ASP - LYS - X - OH (A)*C *C DONDE <X> REPRESENTA PRO, LYS O UN ENLACE DE VALENCIA Y <W> REPRESENTA THR, PRO O UN ENLACE DE VALENCIA. COMPRENDE HACER REACCIONAR EL MONOACIDO <X> ( ) - OH, DONDE LOS PARENTESIS PUEDEN ESTAR VACIOS, CON LISINA PROTEGIDA CON Z = BENCILOXICARBONILO EN SU GRUPO AMINO TERMINAL, OBTENIENDOSE EL DIPEPTIDO BOC LYS(Z) - X( ) - OH, ELIMINAR EL GRUPO BOC DE ESTE DIPEPTIDO Y COPULAR SUCESIVAMENTE CON EL CORRESPONDIENTE AMINOACIDO ACTIVADO EN SU GRUPO CARBOXILO Y PROTEGIDO EN EL GRUPO AMINO TERMINAL Y EN LOS GRUPOS DE LA CADENA LATERAL, HASTA OBTENER EL PEPTIDO PROTEGIDO BOC W( ) - SER(BZL) - ASP(OBZL) - LYS(Z) - X( ) - OH*C *C DONDE BOC Y Z SON COMO ANTES, BZA ES BENCILO Y OBZL ES BENCILOXI, Y TRANSFORMAR ESTE ULTIMO COMPUESTO EN EL PEPTIDO (A) ELIMINANDO LOS GRUPOS PROTECTORES. LOS PEPTIDOS OBTENIDOS SON UTILES COMO INMUNO-MODULADORES.
ES9000692A 1989-03-11 1990-03-08 Procedimiento de preparacion de peptidos de serina-acido aspartico- lisina Expired - Fee Related ES2023746A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898905606A GB8905606D0 (en) 1989-03-11 1989-03-11 Peptides

Publications (1)

Publication Number Publication Date
ES2023746A6 true ES2023746A6 (es) 1992-02-01

Family

ID=10653152

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9000692A Expired - Fee Related ES2023746A6 (es) 1989-03-11 1990-03-08 Procedimiento de preparacion de peptidos de serina-acido aspartico- lisina

Country Status (32)

Country Link
US (1) US5112811A (es)
JP (1) JPH0347197A (es)
KR (1) KR0133850B1 (es)
AR (1) AR245139A1 (es)
AT (1) AT402822B (es)
AU (1) AU631197B2 (es)
BE (1) BE1003996A3 (es)
CA (1) CA2011874C (es)
CH (1) CH680666A5 (es)
DE (1) DE4007605B4 (es)
DK (1) DK173932B1 (es)
ES (1) ES2023746A6 (es)
FI (1) FI901196A0 (es)
FR (2) FR2644065B1 (es)
GB (2) GB8905606D0 (es)
GR (1) GR1000344B (es)
HK (1) HK95392A (es)
IE (1) IE64762B1 (es)
IN (1) IN173870B (es)
IT (1) IT1240933B (es)
LU (1) LU87696A1 (es)
MA (1) MA21770A1 (es)
MY (1) MY106274A (es)
NL (1) NL194918C (es)
NO (1) NO901129L (es)
NZ (1) NZ232815A (es)
OA (1) OA09197A (es)
PT (1) PT93380B (es)
SE (1) SE9000793L (es)
SG (1) SG91892G (es)
TN (1) TNSN90027A1 (es)
ZA (1) ZA901718B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK31991D0 (da) * 1991-02-25 1991-02-25 Carlbiotech Ltd As Peptid og farmaceutisk praeparat indeholdende et saadant peptid
GB9211668D0 (en) * 1992-06-02 1992-07-15 Nycomed Bioreg As Peptide compounds
DE4224509C2 (de) * 1992-07-24 1995-04-20 Ruhenstroth Bauer Gerhard Prof Wirkstoff zur Hemmung der Proliferationsrate von Leberzellen
RU2302870C1 (ru) * 2006-06-22 2007-07-20 Общество С Ограниченной Ответственностью "Сиа Пептайдс" Средство, обладающее геропротекторной активностью, и способ его получения

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US216088A (en) * 1879-06-03 Improvement in bale-ties
DE2602443A1 (de) * 1975-04-04 1976-10-21 Univ California Biologisch aktive polypeptide
US4816449A (en) * 1984-08-09 1989-03-28 Immunetech Pharmaceuticals Immunotherapeutic anti-inflammatory peptide agents
FR2565985B1 (fr) * 1984-06-19 1987-09-25 Rhone Poulenc Sante Nouvelles substances biologiquement actives obtenues a partir de la caseine bovine, leur procede de preparation et les compositions qui les contiennent
WO1986002381A1 (en) * 1984-10-15 1986-04-24 Cetus Corporation Human tumor necrosis factor
FR2601678B1 (fr) * 1986-07-18 1989-11-24 Inst Nat Sante Rech Med Peptides comprenant la sequence seryl-aspartyl-lysyl-prolyle, procede pour l'extraction du tetrapeptide correspondant, et applications, notamment a la protection de la moelle osseuse au cours de traitements anticancereux par la chimiotherapie
FR2622587B1 (fr) * 1987-10-30 1990-12-21 Inst Vaisseaux Sang Peptide lysyl-arginyl-aspartyl-serine et ses applications en tant que medicament, notamment antithrombotique
JPH0742313B2 (ja) * 1988-03-28 1995-05-10 日立化成工業株式会社 新規ペプチド、その塩及びペプチド性抗アレルギー剤

Also Published As

Publication number Publication date
DK62690D0 (da) 1990-03-09
SG91892G (en) 1992-12-04
FR2644065B1 (fr) 1994-10-07
KR0133850B1 (ko) 1998-04-21
NO901129D0 (no) 1990-03-09
FR2644065A1 (fr) 1990-09-14
KR900014426A (ko) 1990-10-23
PT93380A (pt) 1990-11-07
MY106274A (en) 1995-04-29
NL194918C (nl) 2003-07-04
MA21770A1 (fr) 1990-10-01
DK62690A (da) 1990-09-12
SE9000793L (sv) 1990-09-12
FR2644164A1 (fr) 1990-09-14
IN173870B (es) 1994-07-30
CA2011874C (en) 1998-07-21
TNSN90027A1 (fr) 1991-03-05
IE900850L (en) 1990-09-11
NZ232815A (en) 1992-06-25
GB8905606D0 (en) 1989-04-26
DK173932B1 (da) 2002-02-25
GR1000344B (el) 1992-06-25
GB2228937A (en) 1990-09-12
IT9019630A1 (it) 1991-09-09
AU631197B2 (en) 1992-11-19
CH680666A5 (en) 1992-10-15
AT402822B (de) 1997-09-25
DE4007605B4 (de) 2006-03-23
BE1003996A3 (fr) 1992-09-08
LU87696A1 (fr) 1990-07-24
DE4007605A1 (de) 1990-09-13
AU5117590A (en) 1990-09-13
US5112811A (en) 1992-05-12
OA09197A (fr) 1992-06-30
NL194918B (nl) 2003-03-03
AR245139A1 (es) 1993-12-30
IT1240933B (it) 1993-12-27
ATA53290A (de) 1997-01-15
GB2228937B (en) 1992-07-08
FI901196A0 (fi) 1990-03-09
JPH0347197A (ja) 1991-02-28
HK95392A (en) 1992-12-04
NO901129L (no) 1990-09-12
GR900100164A (en) 1990-07-31
ZA901718B (en) 1990-12-28
CA2011874A1 (en) 1990-09-11
IT9019630A0 (it) 1990-03-09
GB9005069D0 (en) 1990-05-02
PT93380B (pt) 1997-01-31
SE9000793D0 (sv) 1990-03-06
IE64762B1 (en) 1995-09-06
FR2644164B1 (es) 1995-03-17
NL9000551A (nl) 1990-10-01

Similar Documents

Publication Publication Date Title
MX166499B (es) Interferon recombinante inmune humano y composicion farmaceutica que lo incluye
GR82243B (es)
ES2107357A1 (es) Sales de peptidos con poliesteres carboxi-terminados.
UA34428C2 (uk) Заміщені фенілімідазолідини, спосіб їх одержання, фармацевтична композиція, проміжні сполуки
BG102172A (en) New stable medicamentous compositions for the preparation of propellant-free aerosols
CA1264740C (en) TETRAPYRROLE THERAPEUTIC AGENTS
IL103510A0 (en) Pharmaceutical compositions containing antibodies for causing immunosuppression
EP0241926A3 (en) Peptide, process for synthesizing it, pharmaceutical composition containing it and use
AU631681B2 (en) Radiolabeled anticoagulant peptides
AU580348B2 (en) A process for the cleavage of peptides and proteins at the methionyl bond
NZ234501A (en) Hemoregulatory peptides and pharmaceutical compositions containing them
FR2651435B1 (es)
GR852541B (es)
ES2023746A6 (es) Procedimiento de preparacion de peptidos de serina-acido aspartico- lisina
IL95863A0 (en) Anticoagulant peptides and compositions containing them
ES8605769A1 (es) Un procedimiento para la preparacion de un peptido
HU896448D0 (en) Process for the preparation of anticoagulant peptides
UA37217C2 (uk) Аналоги 15-дезоксиспергуаліну, спосіб їх одержання, фармацевтична композиція та проміжні сполуки
EP0717752A4 (en) THERAPEUTIC COMPOUNDS
WO1994024154A3 (en) Immuno modulated peptide derivatives of leukokinin fragments
IL85239A0 (en) Recombinant alveolar surfactant protein,its production and purification and pharmaceutical compositions containing it
GB2273710B (en) Peptide fragments of HIV
EP0342015A3 (en) Peptides, their use and pharmaceutical compositions containing them
JO1711B1 (en) Therapeutic agents
CA2024309A1 (en) Pharmaceutical compositions comprising modified and unmodified plasminogen activators and uses thereof

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20060309