BR112015022181A8 - proteínas da substância de inibição mulleriana (mis) e usos das mesmas para o tratamento de doenças - Google Patents

proteínas da substância de inibição mulleriana (mis) e usos das mesmas para o tratamento de doenças

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Publication number
BR112015022181A8
BR112015022181A8 BR112015022181A BR112015022181A BR112015022181A8 BR 112015022181 A8 BR112015022181 A8 BR 112015022181A8 BR 112015022181 A BR112015022181 A BR 112015022181A BR 112015022181 A BR112015022181 A BR 112015022181A BR 112015022181 A8 BR112015022181 A8 BR 112015022181A8
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Brazil
Prior art keywords
methods
mis
human protein
subject
another aspect
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Application number
BR112015022181A
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English (en)
Other versions
BR112015022181A2 (pt
Inventor
Pepin David
Vavvas Demetrios
Van Hoang Mien
K Donahoe Patricia
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Massachusetts Eye & Ear Infirmary
Massachusetts Gen Hospital
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Application filed by Massachusetts Eye & Ear Infirmary, Massachusetts Gen Hospital filed Critical Massachusetts Eye & Ear Infirmary
Publication of BR112015022181A2 publication Critical patent/BR112015022181A2/pt
Publication of BR112015022181A8 publication Critical patent/BR112015022181A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

resumo da patente de invenã§ã£o para: “proteãnas da substã‚ncia de inibiã‡ãƒo mulleriana (mis) e usos das mesmas para o tratamento de doenã‡as”. a presente invenã§ã£o refere-se ã  proteã­na mis humana recombinante modificada, a qual possui clivagem, bioatividade e potãªncia aprimorados em comparaã§ã£o com a proteã­na mis humana tipo selvagem. outros aspectos da invenã§ã£o referem-se aos mã©todos para prevenir e tratar cã¢nceres, tais como cã¢nceres que expressam o receptor mis tipo ii (misrii) atravã©s da administraã§ã£o a um indivã­duo de uma composiã§ã£o que compreende uma proteã­na mis humana recombinante. outro aspecto da presente invenã§ã£o refere-se aos mã©todos para reduzir os nã­veis de andrã³geno plasmã¡ticos em um indivã­duo, e/ou para o tratamento de um indivã­duo com uma doenã§a caracterizada por excesso de andrã³geno. outro aspecto fornece composiã§ãµes farmacãªuticas e kits e mã©todos para uso compreendendo uma proteã­na mis humana recombinante. outro aspecto da presente invenã§ã£o refere-se aos mã©todos para diminuir a dose de um agente quimioterapãªutico pela administraã§ã£o do agente quimioterapãªutico com a proteã­na mis recombinante, que diminui a dose efetiva do agente quimioterapãªutico.
BR112015022181A 2013-03-12 2014-03-12 proteínas da substância de inibição mulleriana (mis) e usos das mesmas para o tratamento de doenças BR112015022181A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361777135P 2013-03-12 2013-03-12
PCT/US2014/024010 WO2014164981A1 (en) 2013-03-12 2014-03-12 Modified mullerian inhibiting substance (mis) proteins and uses thereof for the treatment of diseases

Publications (2)

Publication Number Publication Date
BR112015022181A2 BR112015022181A2 (pt) 2017-11-21
BR112015022181A8 true BR112015022181A8 (pt) 2018-01-23

Family

ID=51659030

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015022181A BR112015022181A8 (pt) 2013-03-12 2014-03-12 proteínas da substância de inibição mulleriana (mis) e usos das mesmas para o tratamento de doenças

Country Status (14)

Country Link
US (2) US11084860B2 (pt)
EP (1) EP2968470B1 (pt)
JP (3) JP6698015B2 (pt)
KR (1) KR20160029731A (pt)
CN (1) CN105473154A (pt)
AU (1) AU2014248768A1 (pt)
BR (1) BR112015022181A8 (pt)
CA (1) CA2904978A1 (pt)
DK (1) DK2968470T3 (pt)
ES (1) ES2853935T3 (pt)
HK (1) HK1222331A1 (pt)
MX (1) MX2015011846A (pt)
PL (1) PL2968470T3 (pt)
WO (1) WO2014164981A1 (pt)

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MA41629A (fr) * 2015-03-04 2018-01-09 Center For Human Reproduction Compositions et méthodes d'utilisation de l'hormone anti-müllérienne pour le traitement de l'infertilité
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CN107523586B (zh) * 2017-10-20 2020-03-17 广州万孚生物技术股份有限公司 免疫质粒及用于检测抗穆勒氏管激素的单抗、杂交瘤细胞及其制备方法和应用
WO2020044298A1 (en) * 2018-08-30 2020-03-05 Preglem Sa A novel use of the anti-müllerian hormone
EP3976629A4 (en) 2019-05-31 2023-11-22 Detti, Laura ANTI-MÜLLERIAN HORMONE RECEPTOR BINDING PEPTIDES
CN112251444B (zh) * 2020-10-21 2023-05-16 恺佧生物科技(上海)有限公司 一种改造的amh基因序列及利用其制备amh的方法
RU2770003C1 (ru) * 2021-04-05 2022-04-14 Федеральное государственное унитарное предприятие «Государственный научно-исследовательский институт особо чистых биопрепаратов» Федерального медико-биологического агентства Моноклональное антитело к С-концевому фрагменту антимюллерова гормона
CN115554403B (zh) * 2022-08-16 2024-03-08 山东大学 类固醇激素dhea作为受体adgrg2激动剂配体的应用

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CA3151082A1 (en) 2013-12-11 2015-06-18 The General Hospital Corporation Use of mullerian inhibiting substance (mis) proteins for contraception and ovarian reserve preservation

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