BR112012018947B1 - anticorpo anti-caprin-1 monoclonal, composição farmacêutica, combinação farmacêutica e usos de uma composição farmacêutica, de um anticorpo e de uma combinação farmacêutica - Google Patents
anticorpo anti-caprin-1 monoclonal, composição farmacêutica, combinação farmacêutica e usos de uma composição farmacêutica, de um anticorpo e de uma combinação farmacêutica Download PDFInfo
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- BR112012018947B1 BR112012018947B1 BR112012018947A BR112012018947A BR112012018947B1 BR 112012018947 B1 BR112012018947 B1 BR 112012018947B1 BR 112012018947 A BR112012018947 A BR 112012018947A BR 112012018947 A BR112012018947 A BR 112012018947A BR 112012018947 B1 BR112012018947 B1 BR 112012018947B1
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- Prior art keywords
- antibody
- pharmaceutical composition
- pharmaceutical
- caprin
- cancer
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
anticorpo anti-caprin-1 monoclonal, composição farmacêutica, combinação farmacêutica e usos de uma composição farmacêutica, de um anticorpo e de uma combinação farmacêutica de acordo com a presente invenção, foi identificada uma proteína antígeno do câncer que é especificamente expressa sobre as superfícies de células cancerosas e, portanto, é fornecido o uso de um anticorpo direcionado contra a proteína antígeno do câncer como um agente para o tratamento e/ou prevenção de um câncer. especificamente, a presente invenção fornece uma composição farmacêutica para o tratamento e/ou prevenção de um câncer, que compreende um anticorpo ou fragmento do mesmo como um ingrediente ativo possuindo reatividade imunológica a um polipeptídeo parcial da caprin-1, que é representada por qualquer uma das sequências pares numeradas como seq id nos: 2 a 30, em que o polipeptídeo tem a sequência de aminoácidos representada pela seq id no: 37 ou uma sequência de aminoácidos possuindo 80% ou mais de identidade de sequência com a sequência de aminoácidos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010023451 | 2010-02-04 | ||
| PCT/JP2011/052403 WO2011096528A1 (ja) | 2010-02-04 | 2011-02-04 | 癌の治療及び／又は予防用医薬組成物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| BR112012018947A2 BR112012018947A2 (pt) | 2017-06-27 |
| BR112012018947A8 BR112012018947A8 (pt) | 2017-12-19 |
| BR112012018947B1 true BR112012018947B1 (pt) | 2020-04-28 |
| BR112012018947B8 BR112012018947B8 (pt) | 2020-06-02 |
Family
ID=44355522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012018947A BR112012018947B8 (pt) | 2010-02-04 | 2011-02-04 | anticorpo anti-caprin-1 monoclonal, composição farmacêutica, combinação farmacêutica e usos de uma composição farmacêutica, de um anticorpo e de uma combinação farmacêutica |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9115200B2 (pt) |
| EP (1) | EP2532365B1 (pt) |
| JP (1) | JP5742714B2 (pt) |
| KR (1) | KR101842893B1 (pt) |
| CN (1) | CN102821788B (pt) |
| BR (1) | BR112012018947B8 (pt) |
| CA (1) | CA2788715C (pt) |
| DK (1) | DK2532365T3 (pt) |
| ES (1) | ES2583627T3 (pt) |
| HU (1) | HUE030103T2 (pt) |
| MX (1) | MX340014B (pt) |
| PL (1) | PL2532365T3 (pt) |
| PT (1) | PT2532365T (pt) |
| RU (1) | RU2607366C2 (pt) |
| WO (1) | WO2011096528A1 (pt) |
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| CN102170907A (zh) * | 2008-08-05 | 2011-08-31 | 东丽株式会社 | 用于治疗和预防癌症的药物组合物 |
| KR102009241B1 (ko) | 2008-08-05 | 2019-08-09 | 도레이 카부시키가이샤 | 면역 유도제 |
| PT2467401T (pt) | 2009-08-19 | 2017-04-26 | Merck Patent Gmbh | Anticorpos para a deteção de complexos de integrina em material ffpe |
| MX2012003404A (es) | 2009-09-22 | 2012-09-12 | Volker Sandig | Procedimiento para producir moleculas que contienen estructuras de glicano especializadas. |
| EP2325848B1 (en) | 2009-11-11 | 2017-07-19 | Samsung Electronics Co., Ltd. | Conductive paste and solar cell |
| CA2788716C (en) | 2010-02-04 | 2019-06-18 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
| PT2532367T (pt) | 2010-02-04 | 2018-11-09 | Toray Industries | Agente farmacêutico para o tratamento e/ou prevenção do cancro |
| BR112012018948B1 (pt) | 2010-02-04 | 2021-12-14 | Toray Industries, Inc | Composições farmacêuticas, anticorpos, combinação farmacêutica, usos de uma composição farmacêutica, uso de um anticorpo e uso de uma combinação farmacêutica |
| CA2788547C (en) | 2010-02-04 | 2018-06-05 | Toray Industries, Inc. | Pharmaceutical composition for treating and/or preventing cancer |
| MX340015B (es) | 2010-02-04 | 2016-06-22 | Toray Industries | Composicion farmaceutica para el tratamiento y/o prevencion del cancer. |
| US9115200B2 (en) | 2010-02-04 | 2015-08-25 | Toray Industries, Inc. | Pharmaceutical composition for treating cancer using a monoclonal antibody having immunological reactivity with CAPRIN-1 |
| PT2740489T (pt) | 2011-08-04 | 2017-01-10 | Toray Industries | Composição farmacêutica para o tratamento e/ou a prevenção do cancro pancreático |
| PL2740796T3 (pl) | 2011-08-04 | 2017-10-31 | Toray Industries | Kompozycja farmaceutyczna do leczenia nowotworu i/lub zapobiegania nowotworowi |
| CA2844033C (en) | 2011-08-04 | 2021-07-27 | Toray Industries, Inc. | Method for detecting pancreatic cancer |
| US9428581B2 (en) | 2012-03-30 | 2016-08-30 | Toray Industries, Inc. | Pharmaceutical composition for treatment and/or prevention of gallbladder cancer |
| PT2832365T (pt) | 2012-03-30 | 2018-01-24 | Toray Industries | Composição farmacêutica para o tratamento e/ou prevenção do cancro hepático |
-
2011
- 2011-02-04 US US13/576,969 patent/US9115200B2/en active Active
- 2011-02-04 CN CN201180017346.7A patent/CN102821788B/zh active Active
- 2011-02-04 ES ES11739876.8T patent/ES2583627T3/es active Active
- 2011-02-04 CA CA2788715A patent/CA2788715C/en active Active
- 2011-02-04 WO PCT/JP2011/052403 patent/WO2011096528A1/ja active Application Filing
- 2011-02-04 PL PL11739876.8T patent/PL2532365T3/pl unknown
- 2011-02-04 PT PT117398768T patent/PT2532365T/pt unknown
- 2011-02-04 KR KR1020127022734A patent/KR101842893B1/ko active IP Right Grant
- 2011-02-04 HU HUE11739876A patent/HUE030103T2/en unknown
- 2011-02-04 EP EP11739876.8A patent/EP2532365B1/en active Active
- 2011-02-04 RU RU2012137498A patent/RU2607366C2/ru active
- 2011-02-04 DK DK11739876.8T patent/DK2532365T3/en active
- 2011-02-04 BR BR112012018947A patent/BR112012018947B8/pt active IP Right Grant
- 2011-02-04 MX MX2012008999A patent/MX340014B/es active IP Right Grant
- 2011-02-04 JP JP2011510207A patent/JP5742714B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| MX340014B (es) | 2016-06-22 |
| PL2532365T3 (pl) | 2016-12-30 |
| US9115200B2 (en) | 2015-08-25 |
| CA2788715A1 (en) | 2011-08-11 |
| DK2532365T3 (en) | 2016-08-15 |
| RU2607366C2 (ru) | 2017-01-10 |
| BR112012018947A2 (pt) | 2017-06-27 |
| CN102821788B (zh) | 2016-11-16 |
| RU2012137498A (ru) | 2014-03-10 |
| KR20120123500A (ko) | 2012-11-08 |
| ES2583627T3 (es) | 2016-09-21 |
| CN102821788A (zh) | 2012-12-12 |
| US20120301476A1 (en) | 2012-11-29 |
| EP2532365A1 (en) | 2012-12-12 |
| EP2532365B1 (en) | 2016-05-04 |
| JPWO2011096528A1 (ja) | 2013-06-13 |
| WO2011096528A1 (ja) | 2011-08-11 |
| EP2532365A4 (en) | 2013-12-04 |
| KR101842893B1 (ko) | 2018-03-28 |
| CA2788715C (en) | 2021-06-08 |
| MX2012008999A (es) | 2012-08-31 |
| BR112012018947A8 (pt) | 2017-12-19 |
| AU2011211693A1 (en) | 2012-08-23 |
| HUE030103T2 (en) | 2017-04-28 |
| JP5742714B2 (ja) | 2015-07-01 |
| BR112012018947B8 (pt) | 2020-06-02 |
| PT2532365T (pt) | 2016-07-28 |
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