BR112018011607A2 - composto, composição farmacêutica, métodos para tratamento de um distúrbio relacionado ao estrogênio e de um câncer, para fabricação de um medicamento para uso terapêutico no tratamento de um distúrbio e para prevenção de um distúrbio relacionado ao estrogênio, uso de um composto ou de uma composição farmacêutica, e, processo para preparação de um produto farmacêutico. - Google Patents

composto, composição farmacêutica, métodos para tratamento de um distúrbio relacionado ao estrogênio e de um câncer, para fabricação de um medicamento para uso terapêutico no tratamento de um distúrbio e para prevenção de um distúrbio relacionado ao estrogênio, uso de um composto ou de uma composição farmacêutica, e, processo para preparação de um produto farmacêutico.

Info

Publication number
BR112018011607A2
BR112018011607A2 BR112018011607A BR112018011607A BR112018011607A2 BR 112018011607 A2 BR112018011607 A2 BR 112018011607A2 BR 112018011607 A BR112018011607 A BR 112018011607A BR 112018011607 A BR112018011607 A BR 112018011607A BR 112018011607 A2 BR112018011607 A2 BR 112018011607A2
Authority
BR
Brazil
Prior art keywords
estrogen
compound
disorder
related disorder
composition
Prior art date
Application number
BR112018011607A
Other languages
English (en)
Other versions
BR112018011607B1 (pt
Inventor
A Tonetti Debra
R Thatcher Gregory
zhao Jiong
Xiong Rui
Original Assignee
Univ Illinois
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Illinois filed Critical Univ Illinois
Publication of BR112018011607A2 publication Critical patent/BR112018011607A2/pt
Publication of BR112018011607B1 publication Critical patent/BR112018011607B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

esta invenção refere-se aos infrarreguladores de receptor estrogênico baseados em benzotiofeno e às composições dos mesmos e aos usos dos mesmos para o tratamento de distúrbios médicos relacionados ao estrogênio.
BR112018011607-6A 2015-12-09 2016-12-09 Composto, composição farmacêutica, uso de um composto ou de uma composição farmacêutica, processo para preparação de um produto farmacêutico BR112018011607B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562264971P 2015-12-09 2015-12-09
US62/264,971 2015-12-09
US201662322878P 2016-04-15 2016-04-15
US62/322,878 2016-04-15
PCT/US2016/066023 WO2017100712A1 (en) 2015-12-09 2016-12-09 Benzothiophene-based selective estrogen receptor downregulators

Publications (2)

Publication Number Publication Date
BR112018011607A2 true BR112018011607A2 (pt) 2018-11-27
BR112018011607B1 BR112018011607B1 (pt) 2024-01-30

Family

ID=59013340

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018011607-6A BR112018011607B1 (pt) 2015-12-09 2016-12-09 Composto, composição farmacêutica, uso de um composto ou de uma composição farmacêutica, processo para preparação de um produto farmacêutico

Country Status (24)

Country Link
US (7) US20170166551A1 (pt)
EP (2) EP3386500B1 (pt)
JP (2) JP6920709B2 (pt)
KR (1) KR20180088457A (pt)
CN (2) CN108699024B (pt)
AU (1) AU2016366680B2 (pt)
BR (1) BR112018011607B1 (pt)
CA (1) CA3008020C (pt)
DK (1) DK3386500T3 (pt)
EA (1) EA038180B1 (pt)
ES (1) ES2935125T3 (pt)
HR (1) HRP20221462T1 (pt)
HU (1) HUE061065T2 (pt)
IL (1) IL259566B (pt)
LT (1) LT3386500T (pt)
MX (2) MX2020006991A (pt)
NZ (1) NZ743651A (pt)
PL (1) PL3386500T3 (pt)
PT (1) PT3386500T (pt)
RS (1) RS63791B1 (pt)
RU (1) RU2747802C2 (pt)
SI (1) SI3386500T1 (pt)
WO (2) WO2017100715A1 (pt)
ZA (2) ZA201803422B (pt)

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