DK3386500T3 - Benzothiophen-baserede selektive østrogenreceptor ned-regulatorer - Google Patents

Benzothiophen-baserede selektive østrogenreceptor ned-regulatorer Download PDF

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Publication number
DK3386500T3
DK3386500T3 DK16874012.4T DK16874012T DK3386500T3 DK 3386500 T3 DK3386500 T3 DK 3386500T3 DK 16874012 T DK16874012 T DK 16874012T DK 3386500 T3 DK3386500 T3 DK 3386500T3
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DK
Denmark
Prior art keywords
benzothiophen
regulators
estrogen receptor
selective estrogen
receptor down
Prior art date
Application number
DK16874012.4T
Other languages
English (en)
Inventor
Gregory R Thatcher
Rui Xiong
Jiong Zhao
Debra A Tonetti
Original Assignee
Univ Illinois
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Publication of DK3386500T3 publication Critical patent/DK3386500T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/64—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Compounds Of Unknown Constitution (AREA)
DK16874012.4T 2015-12-09 2016-12-09 Benzothiophen-baserede selektive østrogenreceptor ned-regulatorer DK3386500T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562264971P 2015-12-09 2015-12-09
US201662322878P 2016-04-15 2016-04-15
PCT/US2016/066023 WO2017100712A1 (en) 2015-12-09 2016-12-09 Benzothiophene-based selective estrogen receptor downregulators

Publications (1)

Publication Number Publication Date
DK3386500T3 true DK3386500T3 (da) 2022-12-12

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Family Applications (1)

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DK16874012.4T DK3386500T3 (da) 2015-12-09 2016-12-09 Benzothiophen-baserede selektive østrogenreceptor ned-regulatorer

Country Status (24)

Country Link
US (7) US20170166551A1 (da)
EP (2) EP3386968A4 (da)
JP (2) JP6920709B2 (da)
KR (1) KR20180088457A (da)
CN (2) CN108495628B (da)
AU (1) AU2016366680B2 (da)
BR (1) BR112018011607B1 (da)
CA (1) CA3008020C (da)
DK (1) DK3386500T3 (da)
EA (1) EA038180B1 (da)
ES (1) ES2935125T3 (da)
HR (1) HRP20221462T1 (da)
HU (1) HUE061065T2 (da)
IL (1) IL259566B (da)
LT (1) LT3386500T (da)
MX (2) MX2018007079A (da)
NZ (1) NZ743651A (da)
PL (1) PL3386500T3 (da)
PT (1) PT3386500T (da)
RS (1) RS63791B1 (da)
RU (1) RU2747802C2 (da)
SI (1) SI3386500T1 (da)
WO (2) WO2017100715A1 (da)
ZA (2) ZA201803422B (da)

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EP3749654A4 (en) 2018-02-06 2021-11-03 The Board of Trustees of the University of Illinois BENZOTHIOPHENE ANALOGUES SUBSTITUTED AS SELECTIVE ESTROGEN RECEPTOR DEGRADATION AGENTS
CN112839646A (zh) * 2018-08-16 2021-05-25 G1治疗公司 用于治疗医学疾病的苯并噻吩雌激素受体调节剂
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WO2021007330A1 (en) * 2019-07-08 2021-01-14 Dermavant Sciences GmbH Cerdulatinib-containing topical skin pharmaceutical compositions and uses thereof
CN115710248B (zh) * 2022-11-18 2024-06-21 南京中医药大学 新型选择性雌激素受体下调剂化合物、制备方法及用途
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Publication number Publication date
US20170166551A1 (en) 2017-06-15
JP2019502675A (ja) 2019-01-31
EP3386500B1 (en) 2022-09-07
HUE061065T2 (hu) 2023-05-28
CN108699024A (zh) 2018-10-23
US20170166550A1 (en) 2017-06-15
JP6920709B2 (ja) 2021-08-18
EP3386500A1 (en) 2018-10-17
US11447461B2 (en) 2022-09-20
WO2017100712A1 (en) 2017-06-15
HRP20221462T1 (hr) 2023-01-20
PL3386500T3 (pl) 2023-03-13
ES2935125T3 (es) 2023-03-01
EP3386500A4 (en) 2019-05-22
EP3386968A1 (en) 2018-10-17
NZ743651A (en) 2023-07-28
SI3386500T1 (sl) 2023-01-31
ZA202003023B (en) 2022-12-21
PT3386500T (pt) 2023-01-06
BR112018011607B1 (pt) 2024-01-30
AU2016366680B2 (en) 2021-06-24
US10118910B2 (en) 2018-11-06
CA3008020C (en) 2024-02-20
IL259566A (en) 2018-07-31
LT3386500T (lt) 2022-12-27
CN108495628A (zh) 2018-09-04
RU2747802C2 (ru) 2021-05-14
RS63791B1 (sr) 2022-12-30
RU2018125046A (ru) 2020-01-09
US20200123126A1 (en) 2020-04-23
EA038180B1 (ru) 2021-07-20
US10377735B2 (en) 2019-08-13
CN108699024B (zh) 2022-03-11
US20210047286A1 (en) 2021-02-18
RU2018125046A3 (da) 2020-02-10
EP3386968A4 (en) 2019-09-25
US11072595B2 (en) 2021-07-27
BR112018011607A2 (pt) 2018-11-27
EA201891376A1 (ru) 2019-02-28
CN108495628B (zh) 2022-01-11
MX2020006991A (es) 2022-07-14
ZA201803422B (en) 2020-08-26
US20200079752A1 (en) 2020-03-12
WO2017100715A1 (en) 2017-06-15
KR20180088457A (ko) 2018-08-03
US10807964B2 (en) 2020-10-20
IL259566B (en) 2021-09-30
US12054469B2 (en) 2024-08-06
US20220194917A1 (en) 2022-06-23
AU2016366680A1 (en) 2018-07-12
MX2018007079A (es) 2018-11-12
US20190055209A1 (en) 2019-02-21
CA3008020A1 (en) 2017-06-15
JP2021169498A (ja) 2021-10-28

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