HRP20010562B1 - S-nitrosothiols as agents for the treatment of circulatory dysfunctions - Google Patents
S-nitrosothiols as agents for the treatment of circulatory dysfunctionsInfo
- Publication number
- HRP20010562B1 HRP20010562B1 HR20010562A HRP20010562A HRP20010562B1 HR P20010562 B1 HRP20010562 B1 HR P20010562B1 HR 20010562 A HR20010562 A HR 20010562A HR P20010562 A HRP20010562 A HR P20010562A HR P20010562 B1 HRP20010562 B1 HR P20010562B1
- Authority
- HR
- Croatia
- Prior art keywords
- residue
- group
- nitrosothiols
- agents
- treatment
- Prior art date
Links
- 230000005794 circulatory dysfunction Effects 0.000 title 1
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 abstract 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 abstract 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
- 108010024636 Glutathione Proteins 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 235000001014 amino acid Nutrition 0.000 abstract 1
- 229960003180 glutathione Drugs 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229960001639 penicillamine Drugs 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 125000004434 sulfur atom Chemical group 0.000 abstract 1
- ICRHORQIUXBEPA-UHFFFAOYSA-N thionitrous acid Chemical class SN=O ICRHORQIUXBEPA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C381/00—Compounds containing carbon and sulfur and having functional groups not covered by groups C07C301/00 - C07C337/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrane Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES009900159A ES2147162B1 (es) | 1999-01-27 | 1999-01-27 | "s-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias". |
| PCT/ES2000/000019 WO2000044714A1 (es) | 1999-01-27 | 2000-01-19 | S-nitrosotioles como agentes para el tratamiento de disfunciones circulatorias |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HRP20010562A2 HRP20010562A2 (en) | 2002-08-31 |
| HRP20010562B1 true HRP20010562B1 (en) | 2010-08-31 |
Family
ID=8307080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20010562A HRP20010562B1 (en) | 1999-01-27 | 2001-07-26 | S-nitrosothiols as agents for the treatment of circulatory dysfunctions |
Country Status (37)
| Country | Link |
|---|---|
| US (1) | US6800612B2 (es) |
| EP (1) | EP1157987B1 (es) |
| JP (1) | JP3795330B2 (es) |
| KR (1) | KR100671878B1 (es) |
| CN (1) | CN1166631C (es) |
| AP (1) | AP1439A (es) |
| AT (1) | ATE249428T1 (es) |
| AU (1) | AU764725B2 (es) |
| BG (1) | BG64983B1 (es) |
| BR (1) | BR0007395B1 (es) |
| CA (1) | CA2359027C (es) |
| CU (1) | CU23098A3 (es) |
| CZ (1) | CZ298871B6 (es) |
| DE (2) | DE60005154T2 (es) |
| DK (1) | DK1157987T3 (es) |
| EA (1) | EA003577B1 (es) |
| EE (1) | EE04524B1 (es) |
| ES (2) | ES2147162B1 (es) |
| GB (1) | GB2363604B (es) |
| GE (1) | GEP20043220B (es) |
| HK (1) | HK1043586A1 (es) |
| HR (1) | HRP20010562B1 (es) |
| HU (1) | HUP0105203A3 (es) |
| ID (1) | ID29777A (es) |
| IL (1) | IL144381A (es) |
| IS (1) | IS2153B (es) |
| MX (1) | MXPA01007570A (es) |
| NO (1) | NO326806B1 (es) |
| NZ (1) | NZ513162A (es) |
| OA (1) | OA11823A (es) |
| PL (1) | PL202372B1 (es) |
| PT (1) | PT1157987E (es) |
| RS (1) | RS50072B (es) |
| SI (1) | SI1157987T1 (es) |
| TR (1) | TR200102003T2 (es) |
| WO (1) | WO2000044714A1 (es) |
| ZA (1) | ZA200106182B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2173044B1 (es) * | 2001-03-13 | 2004-01-16 | Lacer Sa | Derivados de glicina, n-(n-l-gamma-glutamil-3-(nitrosotio)-l-valil) y sus aplicaciones. |
| WO2005030135A2 (en) * | 2003-09-26 | 2005-04-07 | Nitromed, Inc. | Nitrosated glutamic acid compounds, compositions and methods of use |
| EP1939179A1 (en) * | 2006-12-28 | 2008-07-02 | Lacer, S.A. | Stable S-nitrosothiols, method of synthesis and use |
| ES2383846T3 (es) | 2007-10-17 | 2012-06-26 | Pharmagenix Ag | Composición farmacéutica que comprende S-nitrosoglutatión y un polisacárido |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0412699A2 (en) * | 1989-08-07 | 1991-02-13 | Takeda Chemical Industries, Ltd. | Nitrosothiol derivatives, their production and use |
| US5187305A (en) * | 1990-11-26 | 1993-02-16 | Glaxo Inc. | S-nitroso-N-alkonoylpenicillamines |
| WO1995007691A1 (en) * | 1993-09-17 | 1995-03-23 | Brigham And Women's Hospital | Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US37839A (en) * | 1863-03-03 | Improved spoke-machine | ||
| GB1567561A (en) | 1977-01-18 | 1980-05-14 | Ucb Sa | Amino-spiro(oxa-(orthia)cycloalkane-penam) - carboxylic acids |
| GB2052497B (en) | 1979-06-25 | 1983-06-29 | Ucb Sa | 6 - amino - spiro - (penam - 2,4' - piperidine) - 3 - carboxylic acid derivatives |
| DE3805965A1 (de) | 1988-02-25 | 1989-09-07 | Tamas Geb Szenasi Eszter | Verwendung der pflanze euphorbia hirta l. und ihrer extrakte sowie ihrer wirkstoffe |
| US5025001A (en) | 1988-06-15 | 1991-06-18 | Brigham And Women's Hospital | S-nitroso derivatives of ACE inhibitors and the use thereof |
| ES2095317T3 (es) | 1990-04-26 | 1997-02-16 | Senju Pharma Co | Inhibidor de enfermedades hepaticas. |
| DK1023905T3 (da) | 1991-11-14 | 2005-05-30 | Brigham & Womens Hospital | Farmaceutisk præparat indeholdende S-nitroso-immunoglobuliner og anvendelse deraf |
| IL106600A (en) | 1992-08-07 | 1997-09-30 | Sankyo Co | Peptides, pharmaceutical compositions containing the same and processes for the preparation thereof |
| US5728705A (en) | 1993-10-04 | 1998-03-17 | The Trustees Of Columbia University In The City Of New York | Method of inducing vasorelaxation to treat pulmonary hypertension |
| AU704173B2 (en) | 1993-11-02 | 1999-04-15 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College, The | Use of nitric oxide releasing compounds as protective agents in ischemia reperfusion injury |
| GB9423868D0 (en) | 1994-11-25 | 1995-01-11 | Wellcome Found | Compounds for use in medicine |
| US6627738B2 (en) | 1995-09-15 | 2003-09-30 | Duke University | No-modified hemoglobins and uses therefor |
| WO1998042753A1 (en) | 1997-03-27 | 1998-10-01 | Trustees Of Boston University | Novel antiplatelet agent |
-
1999
- 1999-01-27 ES ES009900159A patent/ES2147162B1/es not_active Expired - Fee Related
-
2000
- 2000-01-19 AT AT00900518T patent/ATE249428T1/de not_active IP Right Cessation
- 2000-01-19 HU HU0105203A patent/HUP0105203A3/hu unknown
- 2000-01-19 BR BRPI0007395-4A patent/BR0007395B1/pt not_active IP Right Cessation
- 2000-01-19 ES ES00900518T patent/ES2206178T3/es not_active Expired - Lifetime
- 2000-01-19 GE GEAP20006075A patent/GEP20043220B/en unknown
- 2000-01-19 DE DE60005154T patent/DE60005154T2/de not_active Expired - Lifetime
- 2000-01-19 AU AU30460/00A patent/AU764725B2/en not_active Ceased
- 2000-01-19 DE DE10083902T patent/DE10083902T1/de not_active Ceased
- 2000-01-19 OA OA1200100195A patent/OA11823A/en unknown
- 2000-01-19 AP APAP/P/2001/002247A patent/AP1439A/en active
- 2000-01-19 EE EEP200100389A patent/EE04524B1/xx not_active IP Right Cessation
- 2000-01-19 ID IDW00200101662A patent/ID29777A/id unknown
- 2000-01-19 WO PCT/ES2000/000019 patent/WO2000044714A1/es active IP Right Grant
- 2000-01-19 JP JP2000595971A patent/JP3795330B2/ja not_active Expired - Fee Related
- 2000-01-19 EP EP00900518A patent/EP1157987B1/en not_active Expired - Lifetime
- 2000-01-19 IL IL14438100A patent/IL144381A/xx not_active IP Right Cessation
- 2000-01-19 SI SI200030236T patent/SI1157987T1/xx unknown
- 2000-01-19 TR TR2001/02003T patent/TR200102003T2/xx unknown
- 2000-01-19 CA CA002359027A patent/CA2359027C/en not_active Expired - Fee Related
- 2000-01-19 EA EA200100823A patent/EA003577B1/ru not_active IP Right Cessation
- 2000-01-19 NZ NZ513162A patent/NZ513162A/xx not_active IP Right Cessation
- 2000-01-19 CN CNB008030847A patent/CN1166631C/zh not_active Expired - Fee Related
- 2000-01-19 DK DK00900518T patent/DK1157987T3/da active
- 2000-01-19 PL PL349006A patent/PL202372B1/pl not_active IP Right Cessation
- 2000-01-19 KR KR1020017009522A patent/KR100671878B1/ko not_active IP Right Cessation
- 2000-01-19 PT PT00900518T patent/PT1157987E/pt unknown
- 2000-01-19 CZ CZ20012678A patent/CZ298871B6/cs not_active IP Right Cessation
- 2000-01-19 GB GB0120581A patent/GB2363604B/en not_active Expired - Fee Related
- 2000-01-19 MX MXPA01007570A patent/MXPA01007570A/es not_active IP Right Cessation
- 2000-01-19 RS YUP-536/01A patent/RS50072B/sr unknown
-
2001
- 2001-07-06 NO NO20013385A patent/NO326806B1/no not_active IP Right Cessation
- 2001-07-23 IS IS6020A patent/IS2153B/is unknown
- 2001-07-24 US US09/912,164 patent/US6800612B2/en not_active Expired - Fee Related
- 2001-07-26 ZA ZA200106182A patent/ZA200106182B/en unknown
- 2001-07-26 HR HR20010562A patent/HRP20010562B1/xx not_active IP Right Cessation
- 2001-07-30 CU CU20010181A patent/CU23098A3/es not_active IP Right Cessation
- 2001-08-16 BG BG105824A patent/BG64983B1/bg unknown
-
2002
- 2002-05-28 HK HK02103982.2A patent/HK1043586A1/zh unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0412699A2 (en) * | 1989-08-07 | 1991-02-13 | Takeda Chemical Industries, Ltd. | Nitrosothiol derivatives, their production and use |
| US5187305A (en) * | 1990-11-26 | 1993-02-16 | Glaxo Inc. | S-nitroso-N-alkonoylpenicillamines |
| WO1995007691A1 (en) * | 1993-09-17 | 1995-03-23 | Brigham And Women's Hospital | Use of nitric oxide-adducts to prevent thrombosis on artificial and vascular surfaces |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| ARAI | Request for the grant of a patent on the basis of the submitted results of a substantive examination of a patent application | ||
| ODRP | Renewal fee for the maintenance of a patent |
Payment date: 20100713 Year of fee payment: 11 |
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| B1PR | Patent granted | ||
| PBON | Lapse due to non-payment of renewal fee |
Effective date: 20110120 |